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The recognition of complex carbohydrate structures on glycoproteins is an important part of several biological processes, including cell-cell recognition, serum glycoprotein turnover, and neutralization of pathogens. The protein encoded by this gene is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. The protein has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment.[provided by RefSeq, Apr 2011]
[中文简述(自动翻译):]  复杂碳水化合物结构的糖蛋白的识别是几个生物过程,包括细胞 - 细胞识别,血清糖蛋白周转和病原体中和的一个重要部分。由该基因编码的蛋白质是I型膜受体介导的糖蛋白被巨噬细胞的内吞作用。蛋白质已显示结合的潜在病原性病毒,细菌和真菌的表面上的高甘露糖结构,以便它们可以通过吞噬吞噬中和。[通过的RefSeq,2011年4月提供]
MRC1基因(以及对应的蛋白质)的细胞分布位置:
MRC1基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Dermatitis, Allergic Contact | 0.12 | 1 | 0 | CTD_human |
| Hereditary Nonpolyposis Colorectal Cancer | 0.08 | 314 | 2 | BeFree |
| Colorectal Cancer | 0.041454662 | 144 | 0 | BeFree_GAD |
| Colorectal Carcinoma | 0.039901955 | 147 | 0 | BeFree |
| Endometrial Carcinoma | 0.015200745 | 56 | 2 | BeFree |
| Malignant tumor of colon | 0.010314791 | 38 | 1 | BeFree |
| Malignant neoplasm of endometrium | 0.010043349 | 37 | 2 | BeFree |
| Uterine Corpus Cancer | 0.010043349 | 37 | 2 | BeFree |
| Carcinogenesis | 0.009229024 | 34 | 0 | BeFree |
| Colon Carcinoma | 0.007328931 | 27 | 1 | BeFree |
| Turcot syndrome (disorder) | 0.004885954 | 18 | 0 | BeFree |
| Ovarian Carcinoma | 0.004614512 | 17 | 0 | BeFree |
| Multiple polyps | 0.004071628 | 15 | 0 | BeFree |
| Malignant neoplasm of breast | 0.003800186 | 14 | 0 | BeFree |
| Colorectal Neoplasms | 0.003528744 | 13 | 0 | BeFree |
| Breast Carcinoma | 0.003528744 | 13 | 0 | BeFree |
| Malignant neoplasm of ovary | 0.003528744 | 13 | 0 | BeFree |
| Malignant neoplasm of prostate | 0.003257302 | 12 | 0 | BeFree |
| Tuberculosis | 0.002995792 | 2 | 0 | BeFree_LHGDN |
| Malignant neoplasm of stomach | 0.002985861 | 11 | 0 | BeFree |
| Stomach Carcinoma | 0.002985861 | 11 | 0 | BeFree |
| Torre-Muir syndrome | 0.002985861 | 11 | 0 | BeFree |
| Sarcoidosis | 0.002909916 | 2 | 0 | BeFree_GAD |
| Pneumocystis Infections | 0.00272435 | 1 | 0 | LHGDN |
| Prostate carcinoma | 0.002714419 | 10 | 0 | BeFree |
| Asthma | 0.002638474 | 1 | 0 | BeFree_GAD |
| Adenoma | 0.002171535 | 8 | 0 | BeFree |
| Neoplastic Syndromes, Hereditary | 0.002171535 | 8 | 0 | BeFree |
| Malignant neoplasm of urinary bladder | 0.001628651 | 6 | 4 | BeFree |
| melanoma | 0.001628651 | 6 | 0 | BeFree |
| Mumps | 0.001628651 | 6 | 0 | BeFree |
| Neurofibromatosis 1 | 0.001628651 | 6 | 0 | BeFree |
| Tumor Progression | 0.001628651 | 6 | 0 | BeFree |
| Carcinoma of bladder | 0.001628651 | 6 | 4 | BeFree |
| Adenomatous Polyposis Coli | 0.001357209 | 5 | 0 | BeFree |
| Hereditary Malignant Neoplasm | 0.001357209 | 5 | 0 | BeFree |
| Adenocarcinoma | 0.001085767 | 4 | 0 | BeFree |
| Glioma | 0.001085767 | 4 | 0 | BeFree |
| Pancreatic carcinoma | 0.001085767 | 4 | 0 | BeFree |
| Malignant neoplasm of pancreas | 0.001085767 | 4 | 0 | BeFree |
| Hematologic Neoplasms | 0.001085767 | 4 | 0 | BeFree |
| Epithelial ovarian cancer | 0.001085767 | 4 | 0 | BeFree |
| ovarian neoplasm | 0.001085767 | 4 | 0 | BeFree |
| Astrocytoma | 0.000814326 | 3 | 0 | BeFree |
| Autistic Disorder | 0.000814326 | 3 | 0 | BeFree |
| Rectal Carcinoma | 0.000814326 | 3 | 0 | BeFree |
| Non-Small Cell Lung Carcinoma | 0.000814326 | 3 | 0 | BeFree |
| Glioblastoma | 0.000814326 | 3 | 0 | BeFree |
| Rubella | 0.000814326 | 3 | 1 | BeFree |
| Sebaceous Gland Neoplasms | 0.000814326 | 3 | 0 | BeFree |
| Central Nervous System Neoplasms | 0.000814326 | 3 | 0 | BeFree |
| Multiple tumors | 0.000814326 | 3 | 0 | BeFree |
| Cervix carcinoma | 0.000814326 | 3 | 0 | BeFree |
| Skin carcinoma | 0.000814326 | 3 | 0 | BeFree |
| Sarcoma | 0.000814326 | 3 | 0 | BeFree |
| Cafe au lait spots, multiple | 0.000814326 | 3 | 0 | BeFree |
| Liver carcinoma | 0.000814326 | 3 | 0 | BeFree |
| Autoimmune Diseases | 0.000542884 | 2 | 0 | BeFree |
| Bladder Neoplasm | 0.000542884 | 2 | 0 | BeFree |
| Brain Neoplasms | 0.000542884 | 2 | 0 | BeFree |
| Renal Cell Carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Squamous cell carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Carcinoma, Transitional Cell | 0.000542884 | 2 | 0 | BeFree |
| Endometriosis | 0.000542884 | 2 | 0 | BeFree |
| Leprosy | 0.000542884 | 2 | 0 | BeFree |
| leukemia | 0.000542884 | 2 | 0 | BeFree |
| Lymphoma | 0.000542884 | 2 | 0 | BeFree |
| Measles | 0.000542884 | 2 | 0 | BeFree |
| Degenerative polyarthritis | 0.000542884 | 2 | 0 | BeFree |
| Protein Deficiency | 0.000542884 | 2 | 0 | BeFree |
| Skin Neoplasms | 0.000542884 | 2 | 0 | BeFree |
| Tuberculosis, Pulmonary | 0.000542884 | 2 | 0 | BeFree |
| Adenomatous Polyps | 0.000542884 | 2 | 0 | BeFree |
| Carcinoma, Endometrioid | 0.000542884 | 2 | 0 | BeFree |
| Malignant neoplasm of lung | 0.000542884 | 2 | 0 | BeFree |
| Adenocarcinoma of pancreas | 0.000542884 | 2 | 0 | BeFree |
| Carcinoma of lung | 0.000542884 | 2 | 0 | BeFree |
| Malignant Female Reproductive System Neoplasm | 0.000542884 | 2 | 0 | BeFree |
| Squamous cell carcinoma of the head and neck | 0.000542884 | 2 | 0 | BeFree |
| Mammary Neoplasms | 0.000542884 | 2 | 0 | BeFree |
| Arthritis | 0.000271442 | 1 | 0 | BeFree |
| Rheumatoid Arthritis | 0.000271442 | 1 | 0 | BeFree |
| Carcinoid Tumor | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of skin | 0.000271442 | 1 | 0 | BeFree |
| Mucinous Adenocarcinoma | 0.000271442 | 1 | 0 | BeFree |
| Malignant tumor of cervix | 0.000271442 | 1 | 0 | BeFree |
| Colonic Neoplasms | 0.000271442 | 1 | 0 | BeFree |
| Dermatitis, Atopic | 0.000271442 | 1 | 0 | BeFree |
| Eczema | 0.000271442 | 1 | 0 | BeFree |
| Encephalitis | 0.000271442 | 1 | 0 | BeFree |
| Endometrial Neoplasms | 0.000271442 | 1 | 0 | BeFree |
| Endometrial Hyperplasia | 0.000271442 | 1 | 0 | BeFree |
| Fanconi Anemia | 0.000271442 | 1 | 0 | BeFree |
| Hematological Disease | 0.000271442 | 1 | 0 | BeFree |
| Hepatitis B | 0.000271442 | 1 | 0 | BeFree |
| Hepatitis C | 0.000271442 | 1 | 0 | BeFree |
| HIV Infections | 0.000271442 | 1 | 0 | BeFree |
| Male infertility | 0.000271442 | 1 | 0 | BeFree |
| Inflammatory Bowel Diseases | 0.000271442 | 1 | 0 | BeFree |
| insulinoma | 0.000271442 | 1 | 0 | BeFree |
| keratoacanthoma | 0.000271442 | 1 | 0 | BeFree |
| Leukemia, T-Cell | 0.000271442 | 1 | 0 | BeFree |
| Adult T-Cell Lymphoma/Leukemia | 0.000271442 | 1 | 0 | BeFree |
| Chronic Obstructive Airway Disease | 0.000271442 | 1 | 0 | BeFree |
| Lymphoproliferative Disorders | 0.000271442 | 1 | 0 | BeFree |
| Aseptic Meningitis | 0.000271442 | 1 | 0 | BeFree |
| Premature Menopause | 0.000271442 | 1 | 0 | BeFree |
| Multiple Myeloma | 0.000271442 | 1 | 0 | BeFree |
| Neoplasm Metastasis | 0.000271442 | 1 | 0 | BeFree |
| Pancreatic Neoplasm | 0.000271442 | 1 | 0 | BeFree |
| Bullous pemphigoid | 0.000271442 | 1 | 0 | BeFree |
| Pemphigus Vulgaris | 0.000271442 | 1 | 0 | BeFree |
| Pneumonia | 0.000271442 | 1 | 0 | BeFree |
| polyps | 0.000271442 | 1 | 0 | BeFree |
| Precancerous Conditions | 0.000271442 | 1 | 0 | BeFree |
| Prostatic Neoplasms | 0.000271442 | 1 | 0 | BeFree |
| Psoriasis | 0.000271442 | 1 | 0 | BeFree |
| Pulmonary Fibrosis | 0.000271442 | 1 | 0 | BeFree |
| Virus Diseases | 0.000271442 | 1 | 0 | BeFree |
| Polyendocrinopathies, Autoimmune | 0.000271442 | 1 | 0 | BeFree |
| Idiopathic pulmonary hypertension | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of mouth | 0.000271442 | 1 | 0 | BeFree |
| Uterine Cancer | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of testis | 0.000271442 | 1 | 0 | BeFree |
| Agenesis of corpus callosum | 0.000271442 | 1 | 0 | BeFree |
| Sarcoma, Clear Cell | 0.000271442 | 1 | 0 | BeFree |
| Neuroendocrine Tumors | 0.000271442 | 1 | 0 | BeFree |
| Lip and Oral Cavity Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Autoimmune thrombocytopenia | 0.000271442 | 1 | 0 | BeFree |
| Autosomal dominant hereditary disorder | 0.000271442 | 1 | 0 | BeFree |
| Streptococcal lymphadenitis of swine | 0.000271442 | 1 | 0 | BeFree |
| Gastric Adenocarcinoma | 0.000271442 | 1 | 0 | BeFree |
| Adenocarcinoma of small intestine | 0.000271442 | 1 | 0 | BeFree |
| Cancer of Head and Neck | 0.000271442 | 1 | 0 | BeFree |
| Squamous cell carcinoma of esophagus | 0.000271442 | 1 | 0 | BeFree |
| Transitional cell carcinoma of bladder | 0.000271442 | 1 | 0 | BeFree |
| Solid tumour | 0.000271442 | 1 | 0 | BeFree |
| stage, cervical cancer | 0.000271442 | 1 | 0 | BeFree |
| Hyperplastic Polyp | 0.000271442 | 1 | 0 | BeFree |
| Insulinoma, malignant | 0.000271442 | 1 | 0 | BeFree |
| Carcinoid tumor no ICD-O subtype | 0.000271442 | 1 | 0 | BeFree |
| Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse | 0.000271442 | 1 | 0 | BeFree |
| Immune thrombocytopenic purpura | 0.000271442 | 1 | 0 | BeFree |
| Gastrointestinal symptom | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of esophagus | 0.000271442 | 1 | 0 | BeFree |
| Leukemogenesis | 0.000271442 | 1 | 0 | BeFree |
| Sentinel node (disorder) | 0.000271442 | 1 | 0 | BeFree |
| Secondary malignant neoplasm of lymph node | 0.000271442 | 1 | 0 | BeFree |
| Severe chronic obstructive pulmonary disease | 0.000271442 | 1 | 0 | BeFree |
| Idiopathic Inflammatory Myopathies | 0.000271442 | 1 | 0 | BeFree |
| Pancreatic carcinoma resectable | 0.000271442 | 1 | 0 | BeFree |
| Testicular malignant germ cell tumor | 0.000271442 | 1 | 0 | BeFree |
| Colorectal cancer metastatic | 0.000271442 | 1 | 0 | BeFree |
| Sporadic Breast Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Testicular Germ Cell Tumor | 0.000271442 | 1 | 0 | BeFree |
| Thymic Lymphoma | 0.000271442 | 1 | 0 | BeFree |
| Autism Spectrum Disorders | 0.000271442 | 1 | 0 | BeFree |
| Hepatocarcinogenesis | 0.000271442 | 1 | 0 | BeFree |
| Turcot Syndrome Type 1 | 0.000271442 | 1 | 0 | BeFree |
| Leprosy, Multibacillary | 0.000271442 | 1 | 3 | BeFree |
| Leprosy, Paucibacillary | 0.000271442 | 1 | 3 | BeFree |
| tumor vasculature | 0.000271442 | 1 | 0 | BeFree |
| Hereditary Diffuse Gastric Cancer | 0.000271442 | 1 | 0 | BeFree |
| Developmental regression | 0.000271442 | 1 | 0 | BeFree |
| Pulmonary arterial hypertension | 0.000271442 | 1 | 0 | BeFree |
| FANCONI ANEMIA, COMPLEMENTATION GROUP A (disorder) | 0.000271442 | 1 | 0 | BeFree |
| Serrated adenocarcinoma | 0.000271442 | 1 | 0 | BeFree |
| Pulmonary Hypertension, Primary, 1, With Hereditary Hemorrhagic Telangiectasia | 0.000271442 | 1 | 0 | BeFree |
| Experimental Organism Basal Cell Carcinoma | 0.000271442 | 1 | 0 | BeFree |
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