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This gene encodes a member of the Ras family of small GTPases. These membrane-associated proteins function as signal transducers in multiple processes including cell growth and differentiation, and dysregulation of Ras signaling has been associated with many types of cancer. The encoded protein may play a role in the tumor necrosis factor-alpha and MAP kinase signaling pathways. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
[中文简述(自动翻译):]  该基??因编码的Ras家族小GTP酶中的一员。这些膜结合蛋白用作在多个进程,包括细胞生长和分化,并已与多种癌症相关的Ras信号的失调信号转导。所编码的蛋白质可能在肿瘤坏死因子-α和MAP激酶信号传导途径的作用。编码多种亚型选择性剪接的转录物变体已经观察到这种基因。 [由RefSeq的,2011年11月提供]
MRAS基因(以及对应的蛋白质)的细胞分布位置:
MRAS基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Coronary Artery Disease | 0.248186863 | 7 | 2 | BeFree_CTD_human_GAD_GWASCAT |
Coronary heart disease | 0.122638474 | 4 | 2 | BeFree_GAD_GWASCAT |
Carotid Artery Diseases | 0.12 | 1 | 0 | CTD_human |
Myocardial Infarction | 0.002367032 | 1 | 0 | GAD |
Parkinson Disease | 0.002367032 | 1 | 0 | GAD |
Colorectal Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Colorectal Cancer | 0.000271442 | 1 | 0 | BeFree |
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