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Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The protein encoded by this gene cleaves type II collagen more efficiently than types I and III. It may be involved in articular cartilage turnover and cartilage pathophysiology associated with osteoarthritis. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  基质金属蛋白酶(MMP)家族的蛋白质是参与细胞外基质的在正常生理过程,诸如胚胎发育,生殖和组织重塑,以及在疾病过程,如关节炎和转移的击穿。大多数的MMP的分泌为当由胞外蛋白酶裂解其中被激活无活性原蛋白。由该基因裂解II型胶原比更有效类型的第一和第三编码的蛋白质。它可能参与骨关节炎相关的关节软骨的营业额和软骨病理生理学。该基因是定位于染色体11q22.3基质金属蛋白酶的基因簇的一部分。 [由RefSeq的,2008年7月提供]
MMP13基因(以及对应的蛋白质)的细胞分布位置:
MMP13基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Spondyloepimetaphyseal Dysplasia, Missouri Type | 0.48 | 2 | 2 | CLINVAR_CTD_human_ORPHANET_UNIPROT |
Metaphyseal chondrodysplasia Spahr type | 0.36 | 1 | 3 | CLINVAR_ORPHANET_UNIPROT |
Liver Cirrhosis, Experimental | 0.200271442 | 3 | 0 | BeFree_CTD_human_RGD |
Metaphyseal anadysplasia | 0.120814326 | 3 | 0 | BeFree_ORPHANET |
Prostatic Neoplasms | 0.12 | 1 | 0 | CTD_human |
Craniofacial Abnormalities | 0.12 | 1 | 0 | CTD_human |
Degenerative polyarthritis | 0.113175498 | 68 | 0 | BeFree_LHGDN_RGD |
Periodontitis | 0.080271442 | 2 | 0 | BeFree_RGD |
Brain Ischemia | 0.08 | 1 | 0 | RGD |
Heart failure | 0.08 | 2 | 0 | RGD |
Liver Cirrhosis, Alcoholic | 0.08 | 1 | 0 | RGD |
Biliary cirrhosis | 0.08 | 1 | 0 | RGD |
Meningococcal meningitis | 0.08 | 1 | 0 | RGD |
Myocardial Infarction | 0.08 | 1 | 0 | RGD |
Osteoarthritis of hip | 0.08 | 1 | 0 | RGD |
Silicosis | 0.08 | 1 | 0 | RGD |
Gastric ulcer | 0.08 | 1 | 0 | RGD |
Subarachnoid Hemorrhage | 0.08 | 1 | 0 | RGD |
Intervertebral Disc Degeneration | 0.08 | 3 | 0 | RGD |
Fetal Hypoxia | 0.08 | 1 | 0 | RGD |
Arthritis, Experimental | 0.08 | 2 | 0 | RGD |
Rheumatoid Arthritis | 0.01261581 | 21 | 0 | BeFree_GAD_LHGDN |
Squamous cell carcinoma | 0.011073035 | 14 | 0 | BeFree_GAD_LHGDN |
Malignant neoplasm of breast | 0.009620018 | 19 | 0 | BeFree_GAD |
Neoplasm Metastasis | 0.009510397 | 26 | 0 | BeFree_LHGDN |
Mucocutaneous Lymph Node Syndrome | 0.007729856 | 2 | 0 | BeFree_GAD_LHGDN |
Mammary Neoplasms | 0.005991584 | 4 | 0 | BeFree_LHGDN |
Chondrosarcoma | 0.005710211 | 12 | 0 | BeFree_LHGDN |
Atherosclerosis | 0.00554839 | 4 | 0 | BeFree_GAD |
Breast Carcinoma | 0.005428837 | 20 | 0 | BeFree |
Alveolar Bone Loss | 0.005091382 | 2 | 0 | GAD_LHGDN |
Mouth Neoplasms | 0.005091382 | 1 | 0 | GAD_LHGDN |
ovarian neoplasm | 0.004734064 | 2 | 0 | GAD |
melanoma | 0.003810118 | 5 | 0 | BeFree_LHGDN |
Renal Cell Carcinoma | 0.003267234 | 2 | 0 | BeFree_LHGDN |
Nerve Sheath Tumors | 0.003267234 | 2 | 0 | BeFree_LHGDN |
Aortic Aneurysm, Abdominal | 0.002909916 | 3 | 1 | BeFree_GAD |
Coronary Artery Disease | 0.002909916 | 3 | 1 | BeFree_GAD |
Primary Myelofibrosis | 0.00272435 | 1 | 0 | LHGDN |
Colonic Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
Lyme Disease | 0.00272435 | 1 | 0 | LHGDN |
Osteochondritis Dissecans | 0.00272435 | 1 | 0 | LHGDN |
Periodontal Diseases | 0.00272435 | 1 | 0 | LHGDN |
Endometriosis | 0.002638474 | 1 | 0 | BeFree_GAD |
Liver Cirrhosis | 0.002638474 | 2 | 0 | BeFree_GAD |
Chronic Periodontitis | 0.002638474 | 1 | 0 | BeFree_GAD |
Chorioamnionitis | 0.002367032 | 1 | 0 | GAD |
Cleft Lip | 0.002367032 | 1 | 0 | GAD |
Cleft Palate | 0.002367032 | 1 | 0 | GAD |
Coronary Aneurysm | 0.002367032 | 1 | 0 | GAD |
Fetal Membranes, Premature Rupture | 0.002367032 | 1 | 0 | GAD |
Gingival Hemorrhage | 0.002367032 | 1 | 0 | GAD |
Intervertebral Disk Displacement | 0.002367032 | 1 | 0 | GAD |
Premature Obstetric Labor | 0.002367032 | 1 | 0 | GAD |
Moyamoya Disease | 0.002367032 | 1 | 0 | GAD |
Neoplasms, Glandular and Epithelial | 0.002367032 | 1 | 0 | GAD |
Pre-Eclampsia | 0.002367032 | 1 | 0 | GAD |
Premature Birth | 0.002367032 | 1 | 0 | GAD |
Periodontal Attachment Loss | 0.002367032 | 1 | 0 | GAD |
Hepatitis C, Chronic | 0.002367032 | 1 | 0 | GAD |
Infection of amniotic sac and membranes, unspecified, unspecified trimester, not applicable or unspecified | 0.002367032 | 1 | 0 | GAD |
Arthritis | 0.001900093 | 7 | 0 | BeFree |
Colorectal Carcinoma | 0.001357209 | 5 | 0 | BeFree |
Malignant neoplasm of prostate | 0.001357209 | 5 | 0 | BeFree |
Prostate carcinoma | 0.001357209 | 5 | 0 | BeFree |
Colorectal Cancer | 0.001357209 | 5 | 0 | BeFree |
Secondary malignant neoplasm of lymph node | 0.001085767 | 4 | 0 | BeFree |
Liver carcinoma | 0.001085767 | 4 | 0 | BeFree |
Aortic Aneurysm | 0.000814326 | 3 | 7 | BeFree |
Arteriosclerosis | 0.000814326 | 3 | 0 | BeFree |
Malignant tumor of colon | 0.000814326 | 3 | 0 | BeFree |
Colitis | 0.000814326 | 3 | 0 | BeFree |
Inflammatory Bowel Diseases | 0.000814326 | 3 | 0 | BeFree |
Arthropathy | 0.000814326 | 3 | 0 | BeFree |
Osteosarcoma | 0.000814326 | 3 | 0 | BeFree |
Severe Combined Immunodeficiency | 0.000814326 | 3 | 0 | BeFree |
Giant Cell Tumor of Bone | 0.000814326 | 3 | 0 | BeFree |
Carcinoma breast stage IV | 0.000814326 | 3 | 0 | BeFree |
Osteosarcoma of bone | 0.000814326 | 3 | 0 | BeFree |
Colon Carcinoma | 0.000814326 | 3 | 0 | BeFree |
Coronary Arteriosclerosis | 0.000542884 | 2 | 1 | BeFree |
Coronary heart disease | 0.000542884 | 2 | 1 | BeFree |
Diverticulitis | 0.000542884 | 2 | 0 | BeFree |
Malignant neoplasm of stomach | 0.000542884 | 2 | 0 | BeFree |
Osteoporosis | 0.000542884 | 2 | 0 | BeFree |
Septicemia | 0.000542884 | 2 | 0 | BeFree |
Thyroid Neoplasm | 0.000542884 | 2 | 0 | BeFree |
Benign Neoplasm | 0.000542884 | 2 | 0 | BeFree |
Secondary malignant neoplasm of lung | 0.000542884 | 2 | 0 | BeFree |
Secondary malignant neoplasm of bone | 0.000542884 | 2 | 0 | BeFree |
Fibrosis, Liver | 0.000542884 | 2 | 0 | BeFree |
Sepsis | 0.000542884 | 2 | 0 | BeFree |
Solid tumour | 0.000542884 | 2 | 0 | BeFree |
Superficial ulcer | 0.000542884 | 2 | 0 | BeFree |
Secondary malignant neoplasm of liver | 0.000542884 | 2 | 0 | BeFree |
Epithelial ovarian cancer | 0.000542884 | 2 | 0 | BeFree |
Carcinoma of lung | 0.000542884 | 2 | 1 | BeFree |
Stomach Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Carcinoma of bladder | 0.000542884 | 2 | 0 | BeFree |
Malignant Peripheral Nerve Sheath Tumor | 0.000542884 | 2 | 0 | BeFree |
Adenocarcinoma of large intestine | 0.000542884 | 2 | 0 | BeFree |
Epithelioma | 0.000542884 | 2 | 0 | BeFree |
Collagenopathy, type 2 alpha 1 | 0.000542884 | 2 | 0 | BeFree |
Nasopharyngeal carcinoma | 0.000542884 | 2 | 0 | BeFree |
Experimental Organism Basal Cell Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Congenital Abnormality | 0.000271442 | 1 | 0 | BeFree |
Adenocarcinoma | 0.000271442 | 1 | 0 | BeFree |
Barrett Esophagus | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of urinary bladder | 0.000271442 | 1 | 0 | BeFree |
Noninfiltrating Intraductal Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Mucinous Adenocarcinoma | 0.000271442 | 1 | 0 | BeFree |
Carcinoma, Transitional Cell | 0.000271442 | 1 | 0 | BeFree |
Cyst | 0.000271442 | 1 | 0 | BeFree |
Dwarfism | 0.000271442 | 1 | 0 | BeFree |
Endometrial Neoplasms | 0.000271442 | 1 | 0 | BeFree |
Fibrosarcoma | 0.000271442 | 1 | 0 | BeFree |
Glioma | 0.000271442 | 1 | 0 | BeFree |
Immunologic Deficiency Syndromes | 0.000271442 | 1 | 0 | BeFree |
Keloid | 0.000271442 | 1 | 0 | BeFree |
keratoacanthoma | 0.000271442 | 1 | 0 | BeFree |
Liver diseases | 0.000271442 | 1 | 0 | BeFree |
Chronic Obstructive Airway Disease | 0.000271442 | 1 | 1 | BeFree |
Multiple Myeloma | 0.000271442 | 1 | 0 | BeFree |
neurofibroma | 0.000271442 | 1 | 0 | BeFree |
Osteomyelitis | 0.000271442 | 1 | 0 | BeFree |
Ovarian Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Plasmacytoma | 0.000271442 | 1 | 0 | BeFree |
Pneumonia | 0.000271442 | 1 | 0 | BeFree |
Pulmonary Fibrosis | 0.000271442 | 1 | 0 | BeFree |
Kaposi Sarcoma | 0.000271442 | 1 | 0 | BeFree |
Synovitis | 0.000271442 | 1 | 0 | BeFree |
Vascular Diseases | 0.000271442 | 1 | 0 | BeFree |
Meningitis, Bacterial | 0.000271442 | 1 | 0 | BeFree |
Esophageal carcinoma | 0.000271442 | 1 | 0 | BeFree |
Corneal pannus | 0.000271442 | 1 | 0 | BeFree |
Cleft palate with cleft lip | 0.000271442 | 1 | 0 | BeFree |
Glomerulosclerosis (disorder) | 0.000271442 | 1 | 0 | BeFree |
Microinvasive tumor | 0.000271442 | 1 | 0 | BeFree |
Fibroadenoma | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of lung | 0.000271442 | 1 | 0 | BeFree |
Age related macular degeneration | 0.000271442 | 1 | 0 | BeFree |
Pyle metaphyseal dysplasia | 0.000271442 | 1 | 0 | BeFree |
Metastatic melanoma | 0.000271442 | 1 | 0 | BeFree |
Squamous cell carcinoma of esophagus | 0.000271442 | 1 | 0 | BeFree |
Adenocarcinoma Of Esophagus | 0.000271442 | 1 | 0 | BeFree |
Transitional cell carcinoma of bladder | 0.000271442 | 1 | 0 | BeFree |
Squamous cell carcinoma of the hypopharynx | 0.000271442 | 1 | 0 | BeFree |
Malignant mesothelioma | 0.000271442 | 1 | 0 | BeFree |
Disseminated Malignant Neoplasm | 0.000271442 | 1 | 0 | BeFree |
Non-alcoholic Fatty Liver Disease | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of esophagus | 0.000271442 | 1 | 0 | BeFree |
Carcinogenesis | 0.000271442 | 1 | 0 | BeFree |
Strudwick syndrome | 0.000271442 | 1 | 0 | BeFree |
Malignant Squamous Cell Neoplasm | 0.000271442 | 1 | 0 | BeFree |
Pseudomonas aeruginosa infection | 0.000271442 | 1 | 0 | BeFree |
Cerebral Aneurysm | 0.000271442 | 1 | 0 | BeFree |
Recurrent Malignant Peripheral Nerve Sheath Tumor | 0.000271442 | 1 | 0 | BeFree |
Cardiac fibrosis | 0.000271442 | 1 | 0 | BeFree |
Cardiomyopathy, Familial Idiopathic | 0.000271442 | 1 | 0 | BeFree |
Skin Carcinogenesis | 0.000271442 | 1 | 0 | BeFree |
Xenograft Model | 0.000271442 | 1 | 0 | BeFree |
Enchondroma | 0.000271442 | 1 | 0 | BeFree |
Idiopathic Pulmonary Fibrosis | 0.000271442 | 1 | 0 | BeFree |
Triple Negative Breast Neoplasms | 0.000271442 | 1 | 0 | BeFree |
Pneumonitis | 0.000271442 | 1 | 0 | BeFree |
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