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This gene encodes a member of the MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) protein family. Members of this family are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. This gene encodes an enzyme which catalyzes the conjugation of leukotriene A4 and reduced glutathione to produce leukotriene C4. This enzyme also demonstrates glutathione-dependent peroxidase activity towards lipid hydroperoxides.[provided by RefSeq, May 2011]
[中文简述(自动翻译):]  该基因编码的MAPEG(膜相关蛋白的类花生酸和谷胱甘肽代谢)蛋白家族中的一员。这个家庭的成员参与制作白三烯和前列腺素E,炎症的重要介质。该基因编码一种催化白三烯A4的共轭和还原的谷胱甘肽,以产生白三烯C 4的酶。这种酶也显示出对脂质氢过氧化物谷胱甘肽依赖的过氧化物酶的活性。[由RefSeq的,2011年5月提供]
MGST3基因(以及对应的蛋白质)的细胞分布位置:
MGST3基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Diabetes Mellitus, Non-Insulin-Dependent | 0.002638474 | 1 | 0 | BeFree_GAD |
Alzheimer's Disease | 0.002367032 | 1 | 1 | GAD |
Hypertensive disease | 0.002367032 | 1 | 0 | GAD |
Osteoporosis | 0.002367032 | 1 | 0 | GAD |
Tobacco Use Disorder | 0.002367032 | 1 | 0 | GAD |
Neurodegenerative Disorders | 0.000271442 | 1 | 0 | BeFree |
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