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There are believed to be over 100 different glycosyltransferases involved in the synthesis of protein-bound and lipid-bound oligosaccharides. UDP-N-acetylglucosamine:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I is a medial-Golgi enzyme essential for the synthesis of hybrid and complex N-glycans. The protein, encoded by a single exon, shows typical features of a type II transmembrane protein. The protein is believed to be essential for normal embryogenesis. Several variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  有被认为是参与蛋白结合和脂质结合的寡糖的合成中超过100种不同糖基转移酶。 UDP-N-乙酰葡糖胺:阿尔法-3--D-甘露糖苷的β-1,2-N-二乙酰氨基I是一个内侧 - 高尔基体酶为杂合和复杂N-聚糖的合成是必不可少的。该蛋白质,由一个单一的外显子编码的,示出了II型跨膜蛋白的典型特征。该蛋白被认为是正常胚胎发育是必不可少的。已发现了该基因编码相同的蛋白质几个变种。 [由RefSeq的,2008年7月提供]
MGAT1基因(以及对应的蛋白质)的细胞分布位置:
MGAT1基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Obesity | 0.003181358 | 3 | 0 | BeFree_GAD |
Schizophrenia | 0.001085767 | 4 | 0 | BeFree |
Multiple Sclerosis | 0.000542884 | 2 | 0 | BeFree |
Malignant neoplasm of breast | 0.000271442 | 1 | 0 | BeFree |
CNS disorder | 0.000271442 | 1 | 0 | BeFree |
Diabetes | 0.000271442 | 1 | 0 | BeFree |
Diabetes Mellitus | 0.000271442 | 1 | 0 | BeFree |
Diabetes Mellitus, Insulin-Dependent | 0.000271442 | 1 | 0 | BeFree |
Psychotic Disorders | 0.000271442 | 1 | 0 | BeFree |
Secondary malignant neoplasm of lung | 0.000271442 | 1 | 0 | BeFree |
Impaired cognition | 0.000271442 | 1 | 0 | BeFree |
Nonorganic psychosis | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of prostate | 0.000271442 | 1 | 0 | BeFree |
Prostate carcinoma | 0.000271442 | 1 | 0 | BeFree |
Breast Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Psychotic symptom | 0.000271442 | 1 | 0 | BeFree |
Methamphetamine dependence | 0.000271442 | 1 | 0 | BeFree |
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