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This gene is a maternally expressed imprinted gene. Multiple alternatively spliced transcript variants have been transcribed from this gene and all of them are long non-coding RNAs (lncRNAs). This gene is expressed in many normal tissues, but its expression is lost in multiple cancer cell lines of various tissue origins. It inhibits tumor cell proliferation in vitro. It also interacts with the tumor suppressor p53, and regulates p53 target gene expression. Its deletion enhances angiogenesis in vivo. Many experimental evidences demonstrate that this gene is a lncRNA tumor suppressor. [provided by RefSeq, Mar 2012]
[中文简述(自动翻译):]  该基因是一个母系表达印记基因。多重选择性剪接转录变异体已经从该基因转录和所有的人都长非编码RNA(lncRNAs)。该基因在许多正常组织中表达,但是其表达在各种组织来源的多种癌细胞系丢失。它抑制肿瘤细胞的增殖在体外。它也与肿瘤抑制基因p53相互作用,并调节p53目标基因的表达。其缺失增强了体内血管生成。许多实验证据表明,该基因是一个lncRNA肿瘤抑制基因。 [由RefSeq的,2012年3月提供]
MEG3基因(以及对应的蛋白质)的细胞分布位置:
MEG3基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Uniparental disomy, paternal, chromosome 14 | 0.240271442 | 1 | 0 | BeFree_CLINVAR_ORPHANET |
| Diabetes Mellitus, Insulin-Dependent | 0.122638474 | 1 | 1 | BeFree_GAD_GWASCAT |
| Pituitary Neoplasms | 0.006263026 | 4 | 0 | BeFree_LHGDN |
| Pituitary Adenoma | 0.001628651 | 6 | 0 | BeFree |
| Carcinogenesis | 0.001628651 | 6 | 0 | BeFree |
| Pituitary Diseases | 0.001357209 | 5 | 0 | BeFree |
| Malignant neoplasm of stomach | 0.000814326 | 3 | 0 | BeFree |
| Meningioma | 0.000814326 | 3 | 0 | BeFree |
| Stomach Carcinoma | 0.000814326 | 3 | 0 | BeFree |
| Nephroblastoma | 0.000542884 | 2 | 0 | BeFree |
| Obesity | 0.000542884 | 2 | 0 | BeFree |
| Non-Functioning Pituitary Gland Neoplasm | 0.000542884 | 2 | 0 | BeFree |
| Malignant neoplasm of liver | 0.000542884 | 2 | 0 | BeFree |
| Non-Neoplastic Disorder | 0.000542884 | 2 | 0 | BeFree |
| Liver carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Malignant neoplasm of urinary bladder | 0.000271442 | 1 | 0 | BeFree |
| Non-Small Cell Lung Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Renal Cell Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Colorectal Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Giant Cell Tumors | 0.000271442 | 1 | 0 | BeFree |
| Glioma | 0.000271442 | 1 | 0 | BeFree |
| HIV Infections | 0.000271442 | 1 | 0 | BeFree |
| Liver neoplasms | 0.000271442 | 1 | 0 | BeFree |
| Muscle hypotonia | 0.000271442 | 1 | 0 | BeFree |
| Neuroblastoma | 0.000271442 | 1 | 0 | BeFree |
| Nicotine Dependence | 0.000271442 | 1 | 0 | BeFree |
| Rhabdomyosarcoma | 0.000271442 | 1 | 0 | BeFree |
| Seminoma | 0.000271442 | 1 | 0 | BeFree |
| Tumor Progression | 0.000271442 | 1 | 0 | BeFree |
| Alveolar rhabdomyosarcoma | 0.000271442 | 1 | 0 | BeFree |
| Squamous cell carcinoma of tongue | 0.000271442 | 1 | 0 | BeFree |
| Carcinoma of bladder | 0.000271442 | 1 | 0 | BeFree |
| Central neuroblastoma | 0.000271442 | 1 | 0 | BeFree |
| ACTH-Secreting Pituitary Adenoma | 0.000271442 | 1 | 0 | BeFree |
| Colorectal Cancer | 0.000271442 | 1 | 0 | BeFree |
| Meningioma, benign, no ICD-O subtype | 0.000271442 | 1 | 0 | BeFree |
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