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The protein encoded by this gene is a DNA-binding transcription factor that activates many muscle-specific, growth factor-induced, and stress-induced genes. The encoded protein can act as a homodimer or as a heterodimer and is involved in several cellular processes, including muscle development, neuronal differentiation, cell growth control, and apoptosis. Defects in this gene could be a cause of autosomal dominant coronary artery disease 1 with myocardial infarction (ADCAD1). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2010]
[中文简述(自动翻译):]  由该基因编码的蛋白质是激活许多肌肉特异性的,生长因子诱导,以及应力诱导的基因的DNA结合转录因子。所编码的蛋白质可以作为同二聚体或异二聚体,并参与几个细胞过程,包括肌肉发育,神经元分化,细胞生长控制和凋亡。在这个基因的缺陷可能是常染色体显性冠心病1与心肌梗死(ADCAD1)的一个原因。一些转录变异体的编码不同亚型也发现了这种基因。[由RefSeq的,2010年1月提供]
MEF2A基因(以及对应的蛋白质)的细胞分布位置:
MEF2A基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| CORONARY ARTERY DISEASE, AUTOSOMAL DOMINANT, 1 | 0.24 | 0 | 0 | CLINVAR_CTD_human |
| Diabetes Mellitus, Experimental | 0.08 | 1 | 0 | RGD |
| Myocardial Infarction | 0.022451187 | 13 | 1 | BeFree_GAD_LHGDN |
| Coronary Artery Disease | 0.01869327 | 21 | 0 | BeFree_GAD_LHGDN |
| Coronary Arteriosclerosis | 0.014354082 | 19 | 0 | BeFree_GAD |
| Coronary heart disease | 0.007338862 | 17 | 0 | BeFree_LHGDN |
| Diaphragmatic Hernia | 0.002995792 | 1 | 0 | BeFree_LHGDN |
| Liver carcinoma | 0.002995792 | 2 | 0 | BeFree_LHGDN |
| Alzheimer's Disease | 0.00272435 | 1 | 0 | LHGDN |
| Hypertrophic Cardiomyopathy | 0.002638474 | 2 | 0 | BeFree_GAD |
| Diabetes Mellitus | 0.002638474 | 2 | 0 | BeFree_GAD |
| Diabetes Mellitus, Non-Insulin-Dependent | 0.002638474 | 2 | 0 | BeFree_GAD |
| Hypertensive disease | 0.002638474 | 1 | 0 | BeFree_GAD |
| Tobacco Use Disorder | 0.002367032 | 1 | 0 | GAD |
| Left Ventricular Hypertrophy | 0.002367032 | 1 | 0 | GAD |
| Systemic arterial pressure | 0.002367032 | 1 | 0 | GAD |
| Heart failure | 0.000814326 | 3 | 0 | BeFree |
| Congestive heart failure | 0.000814326 | 3 | 0 | BeFree |
| Cardiomyopathy, Dilated | 0.000542884 | 2 | 0 | BeFree |
| Myotonic Dystrophy | 0.000542884 | 2 | 0 | BeFree |
| Polycystic Ovary Syndrome | 0.000542884 | 2 | 0 | BeFree |
| Congenital Myotonic Dystrophy | 0.000542884 | 2 | 0 | BeFree |
| Cardiomyopathies | 0.000542884 | 2 | 0 | BeFree |
| Sarcoma | 0.000542884 | 2 | 0 | BeFree |
| Autistic Disorder | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of breast | 0.000271442 | 1 | 0 | BeFree |
| Cardiovascular Diseases | 0.000271442 | 1 | 0 | BeFree |
| Diabetes | 0.000271442 | 1 | 0 | BeFree |
| Epilepsy | 0.000271442 | 1 | 0 | BeFree |
| Heart Diseases | 0.000271442 | 1 | 0 | BeFree |
| Medulloblastoma | 0.000271442 | 1 | 0 | BeFree |
| nervous system disorder | 0.000271442 | 1 | 0 | BeFree |
| Retinal Degeneration | 0.000271442 | 1 | 0 | BeFree |
| Retinal Diseases | 0.000271442 | 1 | 0 | BeFree |
| Rhabdomyosarcoma, Embryonal | 0.000271442 | 1 | 0 | BeFree |
| Impaired cognition | 0.000271442 | 1 | 0 | BeFree |
| Familial dilated cardiomyopathy | 0.000271442 | 1 | 0 | BeFree |
| Carcinogenesis | 0.000271442 | 1 | 0 | BeFree |
| Breast Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Mammary Neoplasms | 0.000271442 | 1 | 0 | BeFree |
| Autism Spectrum Disorders | 0.000271442 | 1 | 0 | BeFree |
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