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The protein encoded by this gene is a substrate for protein kinase C. It is localized to the plasma membrane and is an actin filament crosslinking protein. Phosphorylation by protein kinase C or binding to calcium-calmodulin inhibits its association with actin and with the plasma membrane, leading to its presence in the cytoplasm. The protein is thought to be involved in cell motility, phagocytosis, membrane trafficking and mitogenesis. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  由该基因编码的蛋白是蛋白激酶C的衬底它被定位于质膜,是一种肌动蛋白丝的交联蛋白质。磷酸化的蛋白激酶C或结合钙调蛋白抑制其关联与肌动蛋白和与质膜,导致其在细胞质中的存在。该蛋白被认为是参与细胞运动,吞噬作用,膜运输和有丝分裂发生。 [由RefSeq的,2008年7月提供]
MARCKS基因(以及对应的蛋白质)的细胞分布位置:
MARCKS基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Rheumatoid Arthritis | 0.12 | 1 | 0 | CTD_human |
| Adenoid Cystic Carcinoma | 0.12 | 1 | 0 | CTD_human |
| IGA Glomerulonephritis | 0.12 | 1 | 0 | CTD_human |
| Salivary Gland Neoplasms | 0.12 | 1 | 0 | CTD_human |
| Seizures | 0.08 | 1 | 0 | RGD |
| Hyperplasia | 0.00272435 | 1 | 0 | LHGDN |
| Neuroblastoma | 0.001628651 | 6 | 0 | BeFree |
| Central neuroblastoma | 0.001628651 | 6 | 0 | BeFree |
| Glioma | 0.001085767 | 4 | 0 | BeFree |
| Adenocarcinoma | 0.000814326 | 3 | 0 | BeFree |
| Colorectal Carcinoma | 0.000814326 | 3 | 0 | BeFree |
| Carcinogenesis | 0.000814326 | 3 | 0 | BeFree |
| Neoplasm Metastasis | 0.000542884 | 2 | 0 | BeFree |
| Malignant neoplasm of lung | 0.000542884 | 2 | 0 | BeFree |
| Carcinoma of lung | 0.000542884 | 2 | 0 | BeFree |
| Colon Carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Colorectal Cancer | 0.000542884 | 2 | 0 | BeFree |
| Liver carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Alzheimer's Disease | 0.000271442 | 1 | 0 | BeFree |
| Asthma | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of breast | 0.000271442 | 1 | 0 | BeFree |
| Malignant tumor of colon | 0.000271442 | 1 | 0 | BeFree |
| Squamous cell carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Choriocarcinoma | 0.000271442 | 1 | 0 | BeFree |
| Cystic Fibrosis | 0.000271442 | 1 | 0 | BeFree |
| Mental Depression | 0.000271442 | 1 | 0 | BeFree |
| Depressive disorder | 0.000271442 | 1 | 0 | BeFree |
| Hepatitis | 0.000271442 | 1 | 0 | BeFree |
| Hepatitis A | 0.000271442 | 1 | 0 | BeFree |
| Hepatitis, Chronic | 0.000271442 | 1 | 0 | BeFree |
| HIV Infections | 0.000271442 | 1 | 0 | BeFree |
| Acute lymphocytic leukemia | 0.000271442 | 1 | 0 | BeFree |
| Liver Cirrhosis | 0.000271442 | 1 | 0 | BeFree |
| Lung Neoplasms | 0.000271442 | 1 | 0 | BeFree |
| melanoma | 0.000271442 | 1 | 0 | BeFree |
| Meningomyelocele | 0.000271442 | 1 | 0 | BeFree |
| Multiple Myeloma | 0.000271442 | 1 | 0 | BeFree |
| Cholangiocarcinoma | 0.000271442 | 1 | 0 | BeFree |
| Liver and Intrahepatic Biliary Tract Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of liver | 0.000271442 | 1 | 0 | BeFree |
| Metabolic Syndrome X | 0.000271442 | 1 | 1 | BeFree |
| Breast Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Biliary Tract Cancer | 0.000271442 | 1 | 0 | BeFree |
| Mammary Neoplasms | 0.000271442 | 1 | 0 | BeFree |
| Xenograft Model | 0.000271442 | 1 | 0 | BeFree |
| Glioblastoma Multiforme | 0.000271442 | 1 | 0 | BeFree |
| Cirrhosis | 0.000271442 | 1 | 0 | BeFree |
| Precursor Cell Lymphoblastic Leukemia Lymphoma | 0.000271442 | 1 | 0 | BeFree |
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