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The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  由该基因编码的蛋白是属于MAP激酶激酶家族的双特异性蛋白激酶。这种激酶被促有丝分裂和环境压力激活,并且在MAP激酶介导的信号传导级联参与。它磷酸化,从而激活MAP??K14 / P38-MAPK。这种激酶可通过胰岛素被激活,是必需的葡萄糖转运的表达。被发现的RAS癌基因的??表达以导致这种激酶,这从而导致MAPK14的组成性活化的活性形式的积累,并赋予初级细胞的致癌性转化。这种激酶的抑制是参与假耶尔森的发病机制。编码不同同种型的多个可变剪接转录物变体已经报道了这个基因。 [由RefSeq的,2008年7月提供]
MAP2K3基因(以及对应的蛋白质)的细胞分布位置:
MAP2K3基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Diabetes Mellitus, Experimental | 0.08 | 1 | 0 | RGD |
| Retinal Diseases | 0.08 | 1 | 0 | RGD |
| Myocardial Ischemia | 0.08 | 1 | 0 | RGD |
| Mammary Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
| Rheumatoid Arthritis | 0.002367032 | 1 | 0 | GAD |
| Tumor Progression | 0.000542884 | 2 | 0 | BeFree |
| Arthritis | 0.000271442 | 1 | 0 | BeFree |
| Asthma | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of breast | 0.000271442 | 1 | 0 | BeFree |
| Non-Small Cell Lung Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Eosinophilia | 0.000271442 | 1 | 0 | BeFree |
| Glioma | 0.000271442 | 1 | 0 | BeFree |
| Heart failure | 0.000271442 | 1 | 0 | BeFree |
| Congestive heart failure | 0.000271442 | 1 | 0 | BeFree |
| Lung Neoplasms | 0.000271442 | 1 | 0 | BeFree |
| Obesity | 0.000271442 | 1 | 0 | BeFree |
| Carcinogenesis | 0.000271442 | 1 | 0 | BeFree |
| Breast Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Eosinophilic disorder | 0.000271442 | 1 | 0 | BeFree |
| Disorder characterized by eosinophilia | 0.000271442 | 1 | 0 | BeFree |
| Liver carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Neutrophilia (disorder) | 0.000271442 | 1 | 0 | BeFree |
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