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N-glycosylation of proteins is initiated in the endoplasmic reticulum (ER) by the transfer of the preassembled oligosaccharide glucose-3-mannose-9-N-acetylglucosamine-2 from dolichyl pyrophosphate to acceptor sites on the target protein by an oligosaccharyltransferase complex. This core oligosaccharide is sequentially processed by several ER glycosidases and by an endomannosidase (E.C. 3.2.1.130), such as MANEA, in the Golgi. MANEA catalyzes the release of mono-, di-, and triglucosylmannose oligosaccharides by cleaving the alpha-1,2-mannosidic bond that links them to high-mannose glycans (Hamilton et al., 2005 [PubMed 15677381]).[supplied by OMIM, Sep 2008]
[中文简述(自动翻译):]  蛋白质的N-糖基化的内质网(ER)由预组装的寡糖的传送发起葡萄糖-3-甘露糖9-N-乙酰氨基葡糖-2-从多萜醇基焦磷酸由一个靶蛋白上受体位点寡糖复杂。这个核心寡糖依次由几个ER糖苷酶和由endomannosidase(E.C. 3.2.1.130),例如MANEA处理,在高尔基体。 MANEA通过切割α-1,2- mannosidic键即它们链接到高甘露糖聚糖催化单,二,和triglucosylmannose寡糖的释放(Hamilton等人,2005 [搜索PubMed 15677381])。[由OMIM供给,2008年9月]
MANEA基因(以及对应的蛋白质)的细胞分布位置:
MANEA基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Cocaine-Related Disorders | 0.124734064 | 2 | 0 | CTD_human_GAD |
Polycystic Ovary Syndrome | 0.12 | 1 | 0 | CTD_human |
Paranoia | 0.12 | 1 | 0 | CTD_human |
Opioid-Related Disorders | 0.002367032 | 1 | 0 | GAD |
Tobacco Use Disorder | 0.002367032 | 1 | 0 | GAD |
Substance-Related Disorders | 0.002367032 | 1 | 0 | GAD |
Anxiety Disorders | 0.000271442 | 1 | 1 | BeFree |
Mental disorders | 0.000271442 | 1 | 1 | BeFree |
Panic Disorder | 0.000271442 | 1 | 0 | BeFree |
Phobia, Social | 0.000271442 | 1 | 0 | BeFree |
PANIC DISORDER 1 | 0.000271442 | 1 | 0 | BeFree |
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