MAL(mal, T-cell differentiation protein) 转至新版数据库

基因简称(symbol)
    [HGNC]     [GeneCards]     [NCBI]
基因种类(locus group)
同源简称(alias symbol)
基因家族代码(gene_family_id)
    [HGNC]     [GenScript]
omim代码
entrez码
    [Vega]
vega基因码
ensembl基因码
    [Ensembl]
基因家族(gene family)
refseq数据库代号

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基因种类(locus_type)
基因名称状态(status)
location_sortable
同源基因名称(alias name)
基因名称批准使用时间(date_approved_reserved)
基因简称更名时间(date_symbol_changed)
基因名称更名时间(date_name_changed)
更新时间(date_modified)
ucsc码
ena
ccds数据码
uniprot数据码
pubmed代码
mgd码
rgd码
生命科学数据库(lsdb)
更新时间(date modified)
cosmic
mirbase
基因曾用简称(prev symbol)
基因曾用名称(prev name)
homeodb
cosmic
snornabase
bioparadigms slc
orphanet
假基因信息(pseudogeneorg)
horde id
merops
imgt
iuphar
kznf基因类别
mamit-trnadb
cd
LncRNA数据库
酶代码
中间纤维数据库

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2q11.1
基因染色体位置图

The protein encoded by this gene is a highly hydrophobic integral membrane protein belonging to the MAL family of proteolipids. The protein has been localized to the endoplasmic reticulum of T-cells and is a candidate linker protein in T-cell signal transduction. In addition, this proteolipid is localized in compact myelin of cells in the nervous system and has been implicated in myelin biogenesis and/or function. The protein plays a role in the formation, stabilization and maintenance of glycosphingolipid-enriched membrane microdomains. Down-regulation of this gene has been associated with a variety of human epithelial malignancies. Alternative splicing produces four transcript variants which vary from each other by the presence or absence of alternatively spliced exons 2 and 3. [provided by RefSeq, May 2012]

[中文简述(自动翻译):]  由该基因编码的蛋白质是属于MAL家族蛋白脂质的高度疏水整合膜蛋白。该蛋白质已被定位于T细胞的内质网并在T细胞信号转导的候选连接蛋白。此外,此蛋白脂质是定位于细胞的紧凑髓鞘的神经系统和在髓磷脂生物合成和/或功能有牵连。该蛋白在形成,稳定和鞘糖脂富集膜微维持的作用。下调该基因的已与多种人类上皮恶性肿瘤相关联。选择性剪接生产四种转录变体,其彼此通过[通过的RefSeq,2012年5月提供]的存在或不存在可变剪接的外显子2和3的变化

MAL基因的碱基序列:[NCBI]
MAL基因的碱基突变:           显示全部snp
rs2033       rs1316873       rs2279785       rs2874283       rs3105098       rs3105099       rs3112982       rs3112983       rs3113002       rs4854242       rs7560571       rs7601411       rs7604716       rs10201886       rs10617795       rs11553832       rs12471542       rs12616843       rs12997969       rs13396163       rs34383647       rs34738006       rs41310787       rs56001663       rs57134756       rs61734216       rs62148039       rs62637956       rs62648028       rs71382807       rs71427011       rs72942251       rs72942260       rs72942262       rs74427302       rs74514093       rs74728561      
rs75040964       rs75051637       rs75271202       rs75350514       rs75667162       rs75837863       rs76404315       rs76704182       rs77125116       rs77422469       rs77549157       rs77562769       rs78021477       rs78440397       rs78713623       rs79023722       rs79066966       rs79641586       rs79845078       rs79889185       rs80121082       rs80346221       rs111162557       rs111207425       rs111207426       rs111207428       rs111283435       rs111289247       rs111381524       rs111935771       rs112032328       rs112065268       rs112106393       rs112945696       rs112982413       rs113447743       rs113474318       rs113758064       rs113895068       rs113908427       rs114424327       rs114580901       rs114848478       rs114873791       rs114909760       rs115109454       rs115188351       rs115512379       rs115529990       rs115668348       rs116064298       rs116135355       rs116170525       rs116258011       rs116340415       rs116376223       rs116450974       rs116607248       rs116702219       rs116778080       rs116832079       rs117462708       rs118021304       rs137867670       rs137890625       rs138130505       rs138243705       rs138267698       rs138359280       rs138435313       rs138821070       rs138931615       rs139096597       rs139187744       rs139229664       rs139261945       rs139540672       rs139621459       rs139854298       rs139868261       rs139989847       rs140063378       rs140165788       rs140231886       rs140265685       rs140401108       rs140594132       rs140601925       rs140971618       rs141116927       rs141198927       rs141330601       rs141343004       rs141438781       rs141511881       rs141636399       rs141986969       rs142019488       rs142384898       rs142570660       rs142850733       rs143011599       rs143014059       rs143231192       rs143239169       rs143340247       rs143427326       rs143484180       rs143570445       rs143755007       rs143845650       rs144248915       rs144443202       rs144581168       rs144759450       rs145008901       rs145013092       rs145099440       rs145146615       rs145207470       rs145526738       rs145708853       rs146587240       rs146612900       rs146710044       rs146723187       rs146765038       rs146844114       rs147090133       rs147187158       rs147251990       rs147509029       rs147528030       rs147657459       rs148037681       rs148076777       rs148232511       rs148395340       rs148545146       rs148758733       rs148848936       rs149009378       rs149130013       rs149271799       rs149416032       rs149586389       rs149629339       rs149780159       rs149892333       rs149945692       rs149950864       rs150013155       rs150066000       rs150098531       rs150343756       rs150397299       rs150666301       rs150683583       rs150773771       rs150827595       rs150858137       rs150966415       rs150973119       rs151139951       rs180671891       rs180920206       rs180963502       rs181221795       rs181434996       rs182323207       rs182324905       rs182333286       rs182863096       rs182918350       rs183179860       rs183287096       rs183306339       rs183546502       rs183630468       rs183703993       rs183951911       rs184020892       rs184084160       rs184131438       rs184540655       rs184555330       rs184556458       rs184563477       rs184630057       rs184779179       rs184907125       rs185029171       rs185286753       rs185289020       rs185304203       rs185703471       rs185818184       rs185819875       rs185829011       rs185834883       rs186061840       rs186192265       rs186379664       rs186469933       rs186603729       rs186655452       rs186743188       rs187074390       rs187563390       rs187668025       rs187682944       rs187711368       rs187774189       rs187786567       rs187813106       rs187945498       rs187956167       rs188166172       rs188313529       rs188322787       rs188338196       rs188594185       rs188706889       rs188994804       rs189075371       rs189136327       rs189332539       rs189337769       rs189350205       rs189368924       rs189882245       rs189992320       rs190259513       rs190384602       rs190433407       rs190628237       rs190651545       rs190678750       rs190907416       rs191017132       rs191035128       rs191115114       rs191128509       rs191192497       rs191410986       rs191437530       rs191665895       rs191733098       rs191982018       rs191995511       rs192041175       rs192256858       rs192295403       rs192445468       rs192773473       rs192893161       rs192956297       rs193180462       rs193246792       rs199509227       rs199670889       rs199705314       rs200135924       rs200154509       rs200191863       rs200296629       rs200341801       rs200487878       rs200555575       rs200818368       rs201690416       rs201691542       rs201902217       rs202002524       rs202196698       rs367581116       rs367966598       rs368252205       rs368741134       rs368956568       rs368992625       rs369165873       rs369308407       rs369551081       rs369660570       rs370135940       rs370156665       rs370168457       rs370317076       rs372074903       rs372222607       rs372472322       rs372719044       rs373798004       rs374217109       rs374841762       rs374847504       rs374848643       rs375041224       rs375112234       rs375281173       rs375539323       rs375567486       rs377378131       rs527271444       rs527328465       rs527801964       rs527866635       rs527867665       rs527926970       rs527931283       rs528065838       rs528212043       rs528228848       rs528290879       rs528334160       rs528409331       rs528523862       rs528589237       rs528740163       rs528776536       rs528873033       rs528932620       rs528954675       rs529140311       rs529208559       rs529492475       rs529575729       rs529623766       rs529720923       rs529898608       rs529950474       rs530013742       rs530073098       rs530135284       rs530277707       rs530323323       rs530345014       rs530678876       rs530859597       rs530919416       rs530978762       rs531084769       rs531184627       rs531247497       rs531308363       rs531310324       rs531729038       rs531734366       rs531987339       rs531999764       rs532048492       rs532084852       rs532177256       rs532307462       rs532367000       rs532368730       rs532490138       rs532522546       rs532584930       rs532709936       rs532725812       rs532763834       rs532790884       rs532793861       rs532968902       rs533005839       rs533335936       rs533392275       rs533475380       rs533560560       rs533624399       rs533632209       rs533662581       rs533704358       rs533721800       rs533783314       rs533912787       rs534103938       rs534169545       rs534637718       rs534758572       rs534821858       rs534938216       rs535063913       rs535130816       rs535146147       rs535212581       rs535378065       rs535614544       rs535625050       rs535677892       rs535817218       rs535876466       rs535955568       rs536280804       rs536291149       rs536473456       rs536475329       rs536537917       rs536693627       rs536755965       rs537017111       rs537035830       rs537097062       rs537197712       rs537214871       rs537275982       rs537277954       rs537339954       rs537366799       rs537492406       rs537545043       rs537555643       rs537680553       rs537680794       rs537706027       rs537822970       rs537886513       rs538304709       rs538350432       rs538362107       rs538414783       rs538533559       rs538542817       rs538624807       rs538704638       rs538766899       rs538798182       rs538861105       rs538895723       rs539106812       rs539171071       rs539295144       rs539324893       rs539362016       rs539423091       rs539668396       rs539963624       rs540023168       rs540097967       rs540143916       rs540160713       rs540204318       rs540239647       rs540280681       rs540370495       rs540638699       rs540660294       rs540701786       rs541057897       rs541115307       rs541184038       rs541249462       rs541354495       rs541377946       rs541396439       rs541544919       rs541545017       rs541642173       rs541706406       rs541858670       rs541887238       rs541950598       rs542053986       rs542176352       rs542241469       rs542272883       rs542331828       rs542395139       rs542549379       rs542690338       rs542751622       rs542816800       rs542820496       rs542905198       rs542907638       rs542967198       rs543014714       rs543081827       rs543174501       rs543431025       rs543497951       rs543655724       rs543658210       rs543718142       rs543746614       rs543875766       rs543961409       rs544044648       rs544108440       rs544150297       rs544151992       rs544358124       rs544504207       rs544730050       rs544972520       rs545073815       rs545134860       rs545136729       rs545183243       rs545246481       rs545344775       rs545437241       rs545690040       rs545702895       rs545731585       rs545756189       rs545853876       rs545972231       rs546151135       rs546212587       rs546362510       rs546374228       rs546390999       rs546532809       rs546597094       rs546621260       rs546688720       rs546898236       rs546949196       rs546961595       rs547317053       rs547417287       rs547590757       rs547653797       rs547668149       rs547816299       rs547879091       rs547942545       rs547983715       rs548039382       rs548046603       rs548048291       rs548387590       rs548654138       rs548878653       rs548939506       rs549132571       rs549170540       rs549192468       rs549234252       rs549422697       rs549456809       rs549604279       rs549903718       rs549965475       rs550136644       rs550138225       rs550199665       rs550555752       rs550575437       rs550618011       rs550638671       rs550655751       rs550782369       rs550811022       rs550844309       rs550895681       rs550963899       rs550969090       rs551030317       rs551292618       rs551439643       rs551500888       rs551574979       rs551636781       rs551667401       rs551835687       rs551892149       rs551962487       rs552102597       rs552169951       rs552180146       rs552241119       rs552441271       rs552514896       rs552653853       rs552693375       rs552885006       rs552900738       rs552937397       rs553026235       rs553077728       rs553087625       rs553112803       rs553150750       rs553174456       rs553191134       rs553233821       rs553368111       rs553436761       rs553511523       rs553564836       rs553566647       rs553611412       rs553761075       rs554139811       rs554300779       rs554302133       rs554367877       rs554424931       rs554486207       rs554502142       rs554551736       rs554555260       rs554897834       rs554959873       rs555161427       rs555240373       rs555306634       rs555369842       rs555411967       rs555625619       rs555694272       rs555750202       rs555754967       rs555822493       rs555879571       rs555883889       rs555893285       rs555933883       rs555942745       rs556103009       rs556164181       rs556599830       rs556660769       rs557079262       rs557134283       rs557142739       rs557214733       rs557216062       rs557279250       rs557346964       rs557409808       rs557474252       rs557553859       rs557798631       rs557853207       rs557914281       rs557947579       rs557997306       rs558011998       rs558133756       rs558198854       rs558270047       rs558311544       rs558332246       rs558335854       rs558473595       rs558602445       rs558603767       rs558740167       rs558800830       rs559161511       rs559323186       rs559417048       rs559475117       rs559480799       rs559602889       rs559630575       rs559652508       rs559666735       rs559670657       rs559721712       rs559751138       rs559990197       rs560029934       rs560290782       rs560602187       rs560892533       rs560953761       rs561017528       rs561320261       rs561355680       rs561475825       rs561732434       rs561912698       rs562154349       rs562198650       rs562274684       rs562276910       rs562279977       rs562484680       rs562548377       rs562950273       rs563045885       rs563075426       rs563148408       rs563157498       rs563220038       rs563470569       rs563479767       rs563483953       rs563548712       rs563751609       rs563766569       rs563812288       rs563992778       rs564055197       rs564109666       rs564135802       rs564146772       rs564261810       rs564295777       rs564325544       rs564470809       rs564547594       rs564609774       rs564738254       rs564826802       rs564849288       rs564863843       rs564926258       rs564954415       rs564989222       rs565059899       rs565073649       rs565079366       rs565151969       rs565217715       rs565278414       rs565517368       rs565736758       rs565808544       rs565943705       rs565997143       rs566004738       rs566006588       rs566068683       rs566243695       rs566333082       rs566395079       rs566513021       rs566529195       rs566574471       rs566774562       rs566816850       rs566883044       rs567041973       rs567146623       rs567185921       rs567392358       rs567453813       rs567561943       rs567578241       rs567601164       rs567627780       rs567780909       rs567842120       rs567884784       rs567965823       rs568218251       rs568361862       rs568509701       rs568571092       rs568648786       rs568649368       rs568710531       rs568742031       rs568768191       rs568797319       rs568803443       rs568903529       rs568994146       rs569060860       rs569299773       rs569429594       rs569443017       rs569460765       rs569486359       rs569506968       rs569709901       rs569762432       rs569777551       rs569969517       rs569997111       rs570059934       rs570059991       rs570180102       rs570444524       rs570556170       rs570606622       rs570607569       rs570739790       rs570773923       rs570836885       rs571035837       rs571061063       rs571127677       rs571193529       rs571262389       rs571471087       rs571568287       rs571595120       rs571687678       rs571939100       rs571972795       rs572048816       rs572269424       rs572522868       rs572590384       rs572591174       rs572887811       rs572970197       rs573032397       rs573077734       rs573095156       rs573214718       rs573317762       rs573350966       rs573572458       rs573607985       rs573796219       rs573796453       rs573823349       rs573859473       rs573891884       rs573955181       rs574054210       rs574086517       rs574114950       rs574150684       rs574281873       rs574449839       rs574475779       rs574819619       rs575395740       rs575439273       rs575996898       rs576356583       rs576416734       rs576442311       rs576563843       rs576631572       rs576631775       rs576662182       rs576694490       rs576697619       rs576913309       rs576949466       rs577096478       rs577166355       rs577179281       rs577290749       rs577334086       rs577565886       rs577642227       rs577773920       rs577941138       rs578073415       rs578106788       rs578122601       rs745452422       rs745729561       rs745931858       rs746316841       rs746387184       rs747181152       rs747348029       rs747719195       rs748513184       rs748518384       rs749735071       rs749751444       rs750589227       rs750821753       rs751162202       rs751581717       rs751842663       rs751983118       rs752335452       rs753178087       rs753710631       rs753813068       rs754054137       rs754426713       rs754765108       rs755950135       rs755962876       rs756256436       rs756272728       rs756474748       rs756706491       rs756956650       rs757245847       rs757384612       rs757617050       rs757977215       rs758493164       rs758986088       rs759026833       rs759549552       rs759806636       rs759950832       rs760185446       rs760450781       rs760723204       rs761322906       rs761387881       rs761679063       rs761855577       rs762657496       rs762798081       rs763188371       rs763384911       rs763887722       rs763894637       rs764075737       rs764966929       rs765007780       rs765314357       rs766371823       rs766630796       rs766676589       rs766683445       rs766878872       rs768067073       rs768969496       rs769164854       rs769278316       rs769467078       rs769681793       rs770370071       rs770475641       rs770786417       rs770848870       rs770874447       rs771527865       rs772072593       rs772160362       rs772319664       rs772914357       rs773233622       rs774139243       rs774420361       rs775300945       rs775591411       rs776125016       rs776162591       rs776450028       rs776572875       rs776987437       rs777212629       rs777372192       rs777861979       rs778160897       rs778409734       rs779106964       rs780706526       rs780812100       rs780966454       rs781097048      

MAL基因在不同组织中的表达:    [UniProt]

基因在不同组织中的表达图
正向引物序列
正向引物Tm值
反向引物序列
反向引物Tm值
rank
CATCTTTGAGTTTGTGTTCTCC
58
AAAGAGAACACCGCATGGA
60
GAGTTTGTGATGACAATGTTCC
58
TATTCGCAGATACGTGCGT
60
TCTTTGAGTTTGACGCAGC
59
GTCTTGCATCGTGATGGTG
59
TCATCTTTGAGTTTGACGCAG
59
GTCTTGCATCGTGATGGTG
59
CATCTTTGAGTTTGTGTTCTCC
58
TAAAGAGAACACCGCATGGA
60
GACTTGCTCTTCATCTTTGAG
57
CTATGTAGGAGAACACCACG
58
CATCTTTGAGTTTGTGTTCTCC
58
TAAAGAGAACACCGCATGG
58
CGACTTGCTCTTCATCTTTGAG
60
ATATTCGCAGATACGTGCG
58
CATCTTTGAGTTTATCTTCGGG
57
ACACAGACACGAACATCAC
58
CATCTTTGAGTTTATCTTCGGG
57
CAGGATGATCAAGGTGGTG
58
转录因子
影响类型
PubMed链接
MMP9
Unknown
MYL9
Unknown

MAL基因(以及对应的蛋白质)的细胞分布位置:

[UniProt]     [GenomeNet]

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 溶酶体
  • 内涵体
  • 细胞核
  • 细胞质
  • 液泡
  • 细胞膜
  • 细胞外基质
  • 内质网
  • 线粒体
  • 高尔基体
  • 细胞骨架

MAL基因的本体(GO)信息:

GO库代码
对应的蛋白质
来源代码
GO:0001766
P21145(UniProtKB)
TAS
GO:0005515
P21145(UniProtKB)
IPI
GO:0005515
P21145(UniProtKB)
IPI
GO:0005515
P21145(UniProtKB)
IPI
GO:0005515
P21145(UniProtKB)
IPI
GO:0005515
P21145(UniProtKB)
IPI
GO:0005515
P21145(UniProtKB)
IPI
GO:0005515
P21145(UniProtKB)
IPI
GO:0005515
P21145(UniProtKB)
IPI
GO:0005515
P21145(UniProtKB)
IPI
GO:0005768
P21145(UniProtKB)
TAS
GO:0005783
P21145(UniProtKB)
IDA
GO:0005887
P21145(UniProtKB)
TAS
GO:0006915
P21145(UniProtKB)
NAS
GO:0007417
P21145(UniProtKB)
TAS
GO:0008289
P21145(UniProtKB)
TAS
GO:0015267
P21145(UniProtKB)
TAS
GO:0016324
P21145(UniProtKB)
TAS
GO:0016505
P21145(UniProtKB)
NAS
GO:0019898
P21145(UniProtKB)
IEA
GO:0019911
P21145(UniProtKB)
IDA
GO:0030154
P21145(UniProtKB)
TAS
GO:0042552
P21145(UniProtKB)
TAS
GO:0042552
P21145(UniProtKB)
NAS
GO:0045121
P21145(UniProtKB)
IDA
GO:0045121
P21145(UniProtKB)
IDA
GO:0045176
P21145(UniProtKB)
TAS
GO:0055085
P21145(UniProtKB)
IEA
GO:1902043
P21145(UniProtKB)
IEA
基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

可能调控MAL基因的相关microRNA:     


通路基因列表
疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Squamous cell carcinoma 0.123267234 3 0 BeFree_CTD_human_LHGDN
Mammary Neoplasms 0.12272435 1 0 CTD_human_LHGDN
Head and Neck Neoplasms 0.12 1 0 CTD_human
Rheumatoid Arthritis 0.005091382 2 0 GAD_LHGDN
Adenoma 0.00272435 1 0 LHGDN
Colorectal Neoplasms 0.00272435 1 0 LHGDN
Prostatic Neoplasms 0.00272435 1 0 LHGDN
Stomach Neoplasms 0.00272435 1 0 LHGDN
Epithelial ovarian cancer 0.002638474 2 0 BeFree_GAD
HIV Infections 0.001628651 6 0 BeFree
Acute Megakaryocytic Leukemias 0.001357209 5 0 BeFree
Carcinogenesis 0.001357209 5 0 BeFree
Malignant tumor of cervix 0.001085767 4 0 BeFree
Mediastinal (Thymic) Large B-Cell Lymphoma 0.001085767 4 0 BeFree
Malignant neoplasm of breast 0.000814326 3 0 BeFree
Leukemia, Myelocytic, Acute 0.000814326 3 0 BeFree
Neoplasm Metastasis 0.000814326 3 0 BeFree
Esophageal carcinoma 0.000814326 3 0 BeFree
Cervical Intraepithelial Neoplasia 0.000814326 3 0 BeFree
Cervix carcinoma 0.000814326 3 0 BeFree
Breast Carcinoma 0.000814326 3 0 BeFree
Liver carcinoma 0.000814326 3 0 BeFree
Cervix Diseases 0.000542884 2 0 BeFree
Down Syndrome 0.000542884 2 0 BeFree
Esophageal Neoplasms 0.000542884 2 0 BeFree
Liver neoplasms 0.000542884 2 0 BeFree
Malaria 0.000542884 2 0 BeFree
Malignant neoplasm of stomach 0.000542884 2 0 BeFree
Cervical intraepithelial neoplasia grade 2 0.000542884 2 0 BeFree
Malignant neoplasm of esophagus 0.000542884 2 0 BeFree
Stomach Carcinoma 0.000542884 2 0 BeFree
Squamous cell carcinoma of the head and neck 0.000542884 2 0 BeFree
Heavy Chain Disease 0.000271442 1 0 BeFree
Hodgkin Disease 0.000271442 1 0 BeFree
Keloid 0.000271442 1 0 BeFree
leukemia 0.000271442 1 0 BeFree
Lung Neoplasms 0.000271442 1 0 BeFree
Obesity 0.000271442 1 0 BeFree
Ovarian Carcinoma 0.000271442 1 0 BeFree
Trisomy 0.000271442 1 0 BeFree
Pancreatic carcinoma 0.000271442 1 0 BeFree
Cancer of Head and Neck 0.000271442 1 0 BeFree
Malignant neoplasm of pancreas 0.000271442 1 0 BeFree
Leukemogenesis 0.000271442 1 0 BeFree
Malignant neoplasm of gastrointestinal tract 0.000271442 1 0 BeFree
Plasmodium ovale infection 0.000271442 1 0 BeFree
Malignant neoplasm of ovary 0.000271442 1 0 BeFree
Classical Hodgkin's Lymphoma 0.000271442 1 0 BeFree
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