LUM(lumican)

基因基本信息

基因基本信息

基因简称(symbol)
    [HGNC]     [GeneCards]     [NCBI]
基因种类(locus group)
同源简称(alias symbol)
基因家族代码(gene_family_id)
    [HGNC]     [GenScript]
omim代码
entrez码
    [Vega]
vega基因码
ensembl基因码
    [Ensembl]
基因家族(gene family)
refseq数据库代号

更多...

基因种类(locus_type)
基因名称状态(status)
location_sortable
同源基因名称(alias name)
基因名称批准使用时间(date_approved_reserved)
基因简称更名时间(date_symbol_changed)
基因名称更名时间(date_name_changed)
更新时间(date_modified)
ucsc码
ena
ccds数据码
uniprot数据码
pubmed代码
mgd码
rgd码
生命科学数据库(lsdb)
更新时间(date modified)
cosmic
mirbase
基因曾用简称(prev symbol)
基因曾用名称(prev name)
homeodb
cosmic
snornabase
bioparadigms slc
orphanet
假基因信息(pseudogeneorg)
horde id
merops
imgt
iuphar
kznf基因类别
mamit-trnadb
cd
LncRNA数据库
酶代码
中间纤维数据库

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基因染色体位置

基因染色体位置

12q21.33
基因染色体位置图

基因简述

基因简述

This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family that includes decorin, biglycan, fibromodulin, keratocan, epiphycan, and osteoglycin. In these bifunctional molecules, the protein moiety binds collagen fibrils and the highly charged hydrophilic glycosaminoglycans regulate interfibrillar spacings. Lumican is the major keratan sulfate proteoglycan of the cornea but is also distributed in interstitial collagenous matrices throughout the body. Lumican may regulate collagen fibril organization and circumferential growth, corneal transparency, and epithelial cell migration and tissue repair. [provided by RefSeq, Jul 2008]

[中文简述(自动翻译):]  该基因编码的小的富含亮氨酸的蛋白聚糖（SLRP）家族，其包括核心蛋白聚糖，双链蛋白聚糖biglycan，纤维调节，keratocan，epiphycan和osteoglycin的成员。在这些双官能的分子，蛋白部分结合的胶原纤维和高电荷的亲水性粘多糖调节interfibrillar间距。基膜聚糖是角膜的主要硫酸角质素蛋白聚糖，但在身体中也分布在间质胶原基质。基膜聚糖可调节胶原纤维组织和圆周增长，角膜的透明性，和上皮细胞迁移和组织修复。 [由RefSeq的，2008年7月提供]

OMIM数据库中对LUM基因的介绍     Wikipedia数据库中对LUM基因的介绍

基因序列

基因序列

LUM基因的碱基序列：[NCBI]

基因突变

基因突变

LUM基因的碱基突变：           显示全部snp
rs11478       rs11756       rs11855       rs14956       rs1019270       rs1882144       rs1920716       rs1920717       rs2268578       rs2300588       rs3071441       rs3168534       rs3741834       rs3741835       rs3741836       rs3759222       rs3759223       rs3782579       rs3782580       rs3832846       rs7131690       rs7135740       rs9669189       rs10735285       rs10745553       rs10777291       rs10859110       rs11105988       rs11105989       rs11105990       rs11105991       rs11105992       rs11105995       rs11105996       rs11105997       rs11105998       rs11105999      
rs12230115       rs12231718       rs17018715       rs17018718       rs17018731       rs17018757       rs17840863       rs17853500       rs34073084       rs61731069       rs61731070       rs71097876       rs73358035       rs74237872       rs74350251       rs74477702       rs74596575       rs74855582       rs75114105       rs75191100       rs75409608       rs75671162       rs76430523       rs76656200       rs76769321       rs76838890       rs76869463       rs76994535       rs77017683       rs77289134       rs77482296       rs77628679       rs77774889       rs77862148       rs77935559       rs77939810       rs78277685       rs78599391       rs78650453       rs78752096       rs78773272       rs78845670       rs78887822       rs79146891       rs79168784       rs79752608       rs80228231       rs80275453       rs111235537       rs111410015       rs111503607       rs111511953       rs111724211       rs112139485       rs112420991       rs113183204       rs113365821       rs113578625       rs113669305       rs114102814       rs114330989       rs116004665       rs116119153       rs116361933       rs117422278       rs117614132       rs117688003       rs118185343       rs138211809       rs138794025       rs138795198       rs138814410       rs138834430       rs139085108       rs139664405       rs139704429       rs139919924       rs140169262       rs140250163       rs140250411       rs140257786       rs140850607       rs140997412       rs141834639       rs141944101       rs142198539       rs142268075       rs142290672       rs142500140       rs143136933       rs143511085       rs143538369       rs143833238       rs144214151       rs144529317       rs144708376       rs144878773       rs144967519       rs145039396       rs145490848       rs145916763       rs145926415       rs146369172       rs146379752       rs147650480       rs147848362       rs147975710       rs148089996       rs148836813       rs148855501       rs148888594       rs149693096       rs149849523       rs149895879       rs150440653       rs150661507       rs150704567       rs151071512       rs180687240       rs181341907       rs181810280       rs181894639       rs181915277       rs182049831       rs182309434       rs182893152       rs183091891       rs183237601       rs183512340       rs183671289       rs183792487       rs184216108       rs184862799       rs184907635       rs185870782       rs186420450       rs186426646       rs186530810       rs186683805       rs186863808       rs187578020       rs188523523       rs189166312       rs189271973       rs189377915       rs189693400       rs190193597       rs190889416       rs191285969       rs191436548       rs191692991       rs191713268       rs192439599       rs192474317       rs192555284       rs192984049       rs200452244       rs200635075       rs200667565       rs200870507       rs201548822       rs202184645       rs367568539       rs367992395       rs368836782       rs370112399       rs370419881       rs370488262       rs372082535       rs372220672       rs373860046       rs373881223       rs374072112       rs374315529       rs375040780       rs375444776       rs377346746       rs397716655       rs398020575       rs527446594       rs527770605       rs527830295       rs528583600       rs528658593       rs528819769       rs528880335       rs529027487       rs529776431       rs529989373       rs530257477       rs530958344       rs530971645       rs531153417       rs531215350       rs531414857       rs531500243       rs532477465       rs532751432       rs532863277       rs534065388       rs534067495       rs534099358       rs534231044       rs534724633       rs535267191       rs535573888       rs535584940       rs535748038       rs535810735       rs535819052       rs536958218       rs537156318       rs537611883       rs537752984       rs537940148       rs537954926       rs538076281       rs538665289       rs539329228       rs539874730       rs540987153       rs541533230       rs542529006       rs543142606       rs543630625       rs543912121       rs545528825       rs545690883       rs545704843       rs546220783       rs546245361       rs547059307       rs547626066       rs547644130       rs547733755       rs548208664       rs548553673       rs548685937       rs549085673       rs549821634       rs549960490       rs550343061       rs550388218       rs551456124       rs551623612       rs552248256       rs552732669       rs552839956       rs552925787       rs553988462       rs554052428       rs554413383       rs554669873       rs554752736       rs555515621       rs555519091       rs555871971       rs556723198       rs557438851       rs557914677       rs558114211       rs559189471       rs559293522       rs559991760       rs560084031       rs560915351       rs561053629       rs561065382       rs561251118       rs561261935       rs561335186       rs561544806       rs562295046       rs562491595       rs562551184       rs563215072       rs563746193       rs563771991       rs564596115       rs564942588       rs564944146       rs565081672       rs565693914       rs566345177       rs566887307       rs567759123       rs567775423       rs567924349       rs567985189       rs568059818       rs568908799       rs569091277       rs569166967       rs569231412       rs569688594       rs569816982       rs570109117       rs570877250       rs571298475       rs571411498       rs571436303       rs571436376       rs571471433       rs571524268       rs572022752       rs572147239       rs572210634       rs572311933       rs573542643       rs574028433       rs574510264       rs574569794       rs574702102       rs574796499       rs575768329       rs575968532       rs576064509       rs576247686       rs576644589       rs576705819       rs577456426       rs577768080       rs577888608       rs577894187       rs577957934       rs745481318       rs745529650       rs745924489       rs746433265       rs746468269       rs746927123       rs747157419       rs747348925       rs747377151       rs747899454       rs748011213       rs748141794       rs748312313       rs748779402       rs748928194       rs749360955       rs749757256       rs750083412       rs750269447       rs750582301       rs750708394       rs751583998       rs751659902       rs751848189       rs752068504       rs752230089       rs752561714       rs753003234       rs753326557       rs753433133       rs753554928       rs753651991       rs754001312       rs754025249       rs754178989       rs754811152       rs754865952       rs755133231       rs755353878       rs755542891       rs755824968       rs756036172       rs756538448       rs756589791       rs756945757       rs757453748       rs757687677       rs757893965       rs758412888       rs758455472       rs758973987       rs759345158       rs760543022       rs760667728       rs761268671       rs761403563       rs761460799       rs761563469       rs762077138       rs762391190       rs762522861       rs762690769       rs763111214       rs763936254       rs764011671       rs764293616       rs764479785       rs764684672       rs765342841       rs765687225       rs765844518       rs766046776       rs766397086       rs766564295       rs766830259       rs767179237       rs767198470       rs767401384       rs767470844       rs767705068       rs768110502       rs768276682       rs768374028       rs768880335       rs768941643       rs769516936       rs769642101       rs769933175       rs769985750       rs770165114       rs770509533       rs770828473       rs770986108       rs770987670       rs771222112       rs771455004       rs771646592       rs772498826       rs772883605       rs772958918       rs773762375       rs773943638       rs774135249       rs774890895       rs775746788       rs775926017       rs776086544       rs776597480       rs776985085       rs776986873       rs777101297       rs777232934       rs777345268       rs777568966       rs777573489       rs778856373       rs778865513       rs779003400       rs779388844       rs780120475       rs780673913       rs781102371       rs781653407       rs781697866      

基因表达

基因表达

LUM基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向引物Tm值
反向引物序列
反向引物Tm值
rank
GTGGATTCTTGTCCATAGTGC
59
GTGAGATAAACGCAGATACTTACTG
60
CAAGACAGTAAGGATTCAAACC
57
TGGTACCACCAATCAATGC
58
TCAAGACAGTAAGATCACAACC
58
GGTTTATATGCAGCTTCTTCAG
58
CAAGACAGTAAGGATTCAAACC
57
TAATCATAGTACTGGCCACTG
57
CAAGACAGTAAGATCACAACCT
58
GGTTTATATGCAGCTTCTTCAG
58
GACAGTAAGTATCTGCGTTTATCTC
60
ACAGATCCAGCTCAACCAG
59
GACAGTAAGTATCTGCGTTTATCTC
60
GACAGATCCAGCTCAACCA
59
AGTGTCAAGACAGTAAGATCAC
58
GGTTTATATGCAGCTTCTTCAG
58
CAAGACAGTAAGGATTCAAACC
57
AATCATAGTACTGGCCACTG
57

转录因子

转录因子

      尚未收录相关数据

基因本体信息

LUM基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 溶酶体
  • 内涵体
  • 细胞核
  • 细胞质
  • 液泡
  • 细胞膜
  • 细胞外基质
  • 内质网
  • 线粒体
  • 高尔基体
  • 细胞骨架

LUM基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0005201
P51884(UniProtKB)
NAS
GO:0005515
P51884(UniProtKB)
IPI
GO:0005518
P51884(UniProtKB)
IDA
GO:0005576
P51884(UniProtKB)
NAS
GO:0005576
P51884(UniProtKB)
TAS
GO:0005576
P51884(UniProtKB)
TAS
GO:0005576
P51884(UniProtKB)
TAS
GO:0005578
P51884(UniProtKB)
TAS
GO:0005583
P51884(UniProtKB)
IDA
GO:0005615
P51884(UniProtKB)
IDA
GO:0005796
P51884(UniProtKB)
TAS
GO:0005796
P51884(UniProtKB)
TAS
GO:0005796
P51884(UniProtKB)
TAS
GO:0005796
P51884(UniProtKB)
TAS
GO:0005796
P51884(UniProtKB)
TAS
GO:0005796
P51884(UniProtKB)
TAS
GO:0005796
P51884(UniProtKB)
TAS
GO:0005796
P51884(UniProtKB)
TAS
GO:0005796
P51884(UniProtKB)
TAS
GO:0005796
P51884(UniProtKB)
TAS
GO:0005796
P51884(UniProtKB)
TAS
GO:0007601
P51884(UniProtKB)
IEA
GO:0014070
P51884(UniProtKB)
IEA
GO:0018146
P51884(UniProtKB)
TAS
GO:0030198
P51884(UniProtKB)
TAS
GO:0030199
P51884(UniProtKB)
NAS
GO:0032914
P51884(UniProtKB)
IEA
GO:0042340
P51884(UniProtKB)
TAS
GO:0043202
P51884(UniProtKB)
TAS
GO:0043202
P51884(UniProtKB)
TAS
GO:0045944
P51884(UniProtKB)
IEA
GO:0051216
P51884(UniProtKB)
IEA
GO:0070062
P51884(UniProtKB)
IDA
GO:0070062
P51884(UniProtKB)
IDA
GO:0070848
P51884(UniProtKB)
IEA
GO:0007409
P51884(UniProtKB)
IBA
GO:0031012
P51884(UniProtKB)
IDA
GO:0031012
P51884(UniProtKB)
ISS

基因相互作用关系

基因相互作用关系

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因相关microRNA

基因相关microRNA

可能调控LUM基因的相关microRNA：     

基因通路图

基因通路图

基因的通路属性图
通路基因列表

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Muscular Dystrophy, Facioscapulohumeral 0.12 1 0 CTD_human
Fibrosis 0.08 2 0 RGD
Myocardial Reperfusion Injury 0.08 1 0 RGD
Ureteral obstruction 0.08 1 0 RGD
Ehlers-Danlos syndrome type 1 0.08 0 0 MGD
melanoma 0.007077352 6 0 BeFree_LHGDN
Malignant neoplasm of breast 0.006905599 9 0 BeFree_GAD
Myopia 0.00554839 5 2 BeFree_GAD
Myopia, Degenerative 0.004734064 2 0 GAD
Adenocarcinoma 0.003267234 2 0 BeFree_LHGDN
Osteosarcoma 0.003267234 2 0 BeFree_LHGDN
Severe myopia 0.003257302 12 1 BeFree
Squamous cell carcinoma 0.002995792 1 0 BeFree_LHGDN
Uterine Cervical Neoplasm 0.00272435 1 0 LHGDN
Colorectal Neoplasms 0.00272435 1 0 LHGDN
Pancreatic Neoplasm 0.00272435 1 0 LHGDN
Breast Carcinoma 0.002171535 8 0 BeFree
Pancreatic carcinoma 0.001900093 7 2 BeFree
Malignant neoplasm of pancreas 0.001900093 7 2 BeFree
Pancreatic Ductal Adenocarcinoma 0.001357209 5 0 BeFree
Neoplasm Metastasis 0.001085767 4 0 BeFree
Colorectal Carcinoma 0.000814326 3 0 BeFree
Mammary Neoplasms 0.000814326 3 0 BeFree
Colorectal Cancer 0.000814326 3 0 BeFree
Carcinoid Tumor 0.000542884 2 0 BeFree
Pancreatitis, Chronic 0.000542884 2 0 BeFree
Adenocarcinoma of lung (disorder) 0.000542884 2 0 BeFree
Tumor Progression 0.000542884 2 0 BeFree
Fibrosis, Liver 0.000542884 2 0 BeFree
Malignant neoplasm of lung 0.000542884 2 0 BeFree
Carcinoid tumor no ICD-O subtype 0.000542884 2 0 BeFree
Osteosarcoma of bone 0.000542884 2 0 BeFree
Carcinoma of lung 0.000542884 2 0 BeFree
Malignant tumor of colon 0.000271442 1 0 BeFree
Carcinoma, Papillary 0.000271442 1 0 BeFree
Contracture 0.000271442 1 0 BeFree
Coronary Arteriosclerosis 0.000271442 1 0 BeFree
Glioma 0.000271442 1 0 BeFree
Heart failure 0.000271442 1 0 BeFree
Congestive heart failure 0.000271442 1 0 BeFree
Hepatitis C 0.000271442 1 0 BeFree
Kidney Failure, Chronic 0.000271442 1 0 BeFree
Liver diseases 0.000271442 1 0 BeFree
Lupus Erythematosus, Systemic 0.000271442 1 0 BeFree
Mixed Salivary Gland Tumor 0.000271442 1 0 BeFree
Pleural effusion disorder 0.000271442 1 0 BeFree
Pulmonary Fibrosis 0.000271442 1 0 BeFree
Virus Diseases 0.000271442 1 0 BeFree
Gestational Diabetes 0.000271442 1 0 BeFree
Secondary malignant neoplasm of lung 0.000271442 1 0 BeFree
Giant Cell Tumor of Bone 0.000271442 1 0 BeFree
Carcinoma, Neuroendocrine 0.000271442 1 0 BeFree
Metastatic melanoma 0.000271442 1 0 BeFree
Adenocarcinoma of pancreas 0.000271442 1 0 BeFree
Adenocarcinoma of colon 0.000271442 1 0 BeFree
Intraocular pressure disorder 0.000271442 1 0 BeFree
Carcinogenesis 0.000271442 1 0 BeFree
Colon Carcinoma 0.000271442 1 0 BeFree
Pelvic Organ Prolapse 0.000271442 1 0 BeFree
Cardiomyopathies 0.000271442 1 0 BeFree
Nonalcoholic Steatohepatitis 0.000271442 1 0 BeFree

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