更多...
收起
This gene is a member of the transferrin family of genes and its protein product is found in the secondary granules of neutrophils. The protein is a major iron-binding protein in milk and body secretions with an antimicrobial activity, making it an important component of the non-specific immune system. The protein demonstrates a broad spectrum of properties, including regulation of iron homeostasis, host defense against a broad range of microbial infections, anti-inflammatory activity, regulation of cellular growth and differentiation and protection against cancer development and metastasis. Antimicrobial, antiviral, antifungal and antiparasitic activity has been found for this protein and its peptides. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]
[中文简述(自动翻译):]  此基因是转基因家族的成员,并且其蛋白质产物在嗜中性粒细胞的次级颗粒中发现。蛋白质是主要的铁结合在牛奶和身体分泌物的蛋白质具有抗微生物活性,从而使其成为非特异性免疫系统的重要组成部分。蛋白质展示属性的广谱,包括铁稳态的调节,宿主防御广泛微生物感染,抗炎活性,细胞生长和分化和防止癌症发展和转移的调节。抗微生物,抗病毒,抗真菌和抗寄生虫活性,已经发现这种蛋白质和其肽。另外剪接转录变体ENCoding不同的亚型已经发现了这种基因。 [由RefSeq的,2014年9月提供]
LTF基因(以及对应的蛋白质)的细胞分布位置:
LTF基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Endometriosis | 0.12272435 | 2 | 0 | CTD_human_LHGDN |
| Inflammation | 0.12272435 | 2 | 0 | CTD_human_LHGDN |
| Osteoporosis | 0.12272435 | 2 | 0 | CTD_human_LHGDN |
| Diarrhea | 0.122638474 | 2 | 0 | BeFree_CTD_human_GAD |
| Premature Birth | 0.122367032 | 2 | 0 | CTD_human_GAD |
| Oral candidiasis | 0.12 | 1 | 0 | CTD_human |
| Ulcerative Colitis | 0.12 | 1 | 0 | CTD_human |
| Colonic Neoplasms | 0.12 | 1 | 0 | CTD_human |
| Gastrointestinal Hemorrhage | 0.12 | 1 | 0 | CTD_human |
| Hypertensive disease | 0.12 | 1 | 0 | CTD_human |
| Hypotension | 0.12 | 1 | 0 | CTD_human |
| Arthropathy | 0.12 | 1 | 0 | CTD_human |
| Liver neoplasms | 0.12 | 1 | 0 | CTD_human |
| Toxic effect of carbon tetrachloride | 0.12 | 1 | 0 | CTD_human |
| Necrotizing Enterocolitis | 0.12 | 1 | 0 | CTD_human |
| Candidiasis, Vulvovaginal | 0.12 | 1 | 0 | CTD_human |
| Drug-Induced Liver Injury | 0.12 | 1 | 0 | CTD_human |
| Weight decreased | 0.12 | 1 | 0 | CTD_human |
| Dental caries | 0.003181358 | 3 | 0 | BeFree_GAD |
| Periodontitis | 0.002995792 | 2 | 0 | BeFree_LHGDN |
| Mammary Neoplasms | 0.002995792 | 2 | 0 | BeFree_LHGDN |
| Anemia | 0.00272435 | 1 | 0 | LHGDN |
| Tick-Borne Encephalitis | 0.00272435 | 1 | 0 | LHGDN |
| Enteritis | 0.00272435 | 1 | 0 | LHGDN |
| Escherichia coli Infections | 0.00272435 | 1 | 0 | LHGDN |
| Keratitis | 0.00272435 | 1 | 0 | LHGDN |
| Lung Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
| Ovarian Cysts | 0.00272435 | 1 | 0 | LHGDN |
| Infection | 0.00272435 | 1 | 0 | LHGDN |
| Periodontitis, Juvenile | 0.002638474 | 1 | 0 | BeFree_GAD |
| Dyslipidemias | 0.002638474 | 1 | 0 | BeFree_GAD |
| Spontaneous abortion | 0.002367032 | 1 | 0 | GAD |
| Asthma | 0.002367032 | 1 | 0 | GAD |
| Bronchiolitis, Viral | 0.002367032 | 1 | 0 | GAD |
| Chorioamnionitis | 0.002367032 | 1 | 0 | GAD |
| Fetal Membranes, Premature Rupture | 0.002367032 | 1 | 0 | GAD |
| IGA Glomerulonephritis | 0.002367032 | 1 | 0 | GAD |
| Keratitis, Herpetic | 0.002367032 | 1 | 0 | GAD |
| Premature Obstetric Labor | 0.002367032 | 1 | 0 | GAD |
| Obesity | 0.002367032 | 1 | 0 | GAD |
| Pre-Eclampsia | 0.002367032 | 1 | 0 | GAD |
| Respiratory Syncytial Virus Infections | 0.002367032 | 1 | 0 | GAD |
| Tobacco Use Disorder | 0.002367032 | 1 | 0 | GAD |
| Chronic Periodontitis | 0.002367032 | 1 | 0 | GAD |
| Impaired glucose tolerance | 0.002367032 | 1 | 0 | GAD |
| Infection of amniotic sac and membranes, unspecified, unspecified trimester, not applicable or unspecified | 0.002367032 | 1 | 0 | GAD |
| Nasopharyngeal carcinoma | 0.001628651 | 6 | 0 | BeFree |
| Malignant neoplasm of breast | 0.001085767 | 4 | 0 | BeFree |
| Breast Carcinoma | 0.001085767 | 4 | 0 | BeFree |
| Neoplasm Metastasis | 0.000814326 | 3 | 0 | BeFree |
| Endometrial Carcinoma | 0.000814326 | 3 | 0 | BeFree |
| Caries (morphologic abnormality) | 0.000542884 | 2 | 0 | BeFree |
| Malignant neoplasm of prostate | 0.000542884 | 2 | 0 | BeFree |
| Specific granule deficiency | 0.000542884 | 2 | 0 | BeFree |
| Prostate carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Non-Small Cell Lung Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Gonorrhea | 0.000271442 | 1 | 0 | BeFree |
| Herpes Simplex Infections | 0.000271442 | 1 | 0 | BeFree |
| Immunologic Deficiency Syndromes | 0.000271442 | 1 | 0 | BeFree |
| Myeloid Leukemia, Chronic | 0.000271442 | 1 | 0 | BeFree |
| melanoma | 0.000271442 | 1 | 0 | BeFree |
| Severe Combined Immunodeficiency | 0.000271442 | 1 | 0 | BeFree |
| Acute leukemia | 0.000271442 | 1 | 0 | BeFree |
| Small cell carcinoma of lung | 0.000271442 | 1 | 0 | BeFree |
| Intervertebral Disc Degeneration | 0.000271442 | 1 | 0 | BeFree |
| Carcinoma, Endometrioid | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of lung | 0.000271442 | 1 | 0 | BeFree |
| Congenital neutropenia | 0.000271442 | 1 | 0 | BeFree |
| Carcinoma of lung | 0.000271442 | 1 | 0 | BeFree |
| Secondary malignant neoplasm of lymph node | 0.000271442 | 1 | 0 | BeFree |
| Epithelioma | 0.000271442 | 1 | 0 | BeFree |
| Pneumonia, Ventilator-Associated | 0.000271442 | 1 | 0 | BeFree |
| Severe congenital neutropenia | 0.000271442 | 1 | 0 | BeFree |
| Early childhood caries | 0.000271442 | 1 | 5 | BeFree |
忘记密码? 点击找回密码.
扫一扫右方二维码,关注微信订阅号,实时查看信息,关注医学生物学动态。