LTC4S(leukotriene C4 synthase)

基因基本信息

基因基本信息

基因简称(symbol)
    [HGNC]     [GeneCards]     [NCBI]
基因种类(locus group)
同源简称(alias symbol)
基因家族代码(gene_family_id)
    [HGNC]     [GenScript]
omim代码
entrez码
    [Vega]
vega基因码
ensembl基因码
    [Ensembl]
基因家族(gene family)
refseq数据库代号

更多...

基因种类(locus_type)
基因名称状态(status)
location_sortable
同源基因名称(alias name)
基因名称批准使用时间(date_approved_reserved)
基因简称更名时间(date_symbol_changed)
基因名称更名时间(date_name_changed)
更新时间(date_modified)
ucsc码
ena
ccds数据码
uniprot数据码
pubmed代码
mgd码
rgd码
生命科学数据库(lsdb)
更新时间(date modified)
cosmic
mirbase
基因曾用简称(prev symbol)
基因曾用名称(prev name)
homeodb
cosmic
snornabase
bioparadigms slc
orphanet
假基因信息(pseudogeneorg)
horde id
merops
imgt
iuphar
kznf基因类别
mamit-trnadb
cd
LncRNA数据库
酶代码
中间纤维数据库

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基因染色体位置

基因染色体位置

5q35
基因染色体位置图

基因简述

基因简述

The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family includes a number of human proteins, several of which are involved the production of leukotrienes. This gene encodes an enzyme that catalyzes the first step in the biosynthesis of cysteinyl leukotrienes, potent biological compounds derived from arachidonic acid. Leukotrienes have been implicated as mediators of anaphylaxis and inflammatory conditions such as human bronchial asthma. This protein localizes to the nuclear envelope and adjacent endoplasmic reticulum. [provided by RefSeq, Jul 2008]

[中文简述(自动翻译):]  的MAPEG（膜相关蛋白的类花生酸和谷胱甘肽代谢）系列产品包含了人体蛋白质，其中一些涉及的白介素产生的。这个基因编码催化半胱氨酰白三烯，从花生四烯酸衍生的强效生物化合物的生物合成的第一个步骤的酶。白三烯有牵连的过敏反应和炎症性疾病的介体如人支气管哮喘。此蛋白质定位于核膜和相邻的内质网。 [由RefSeq的，2008年7月提供]

OMIM数据库中对LTC4S基因的介绍     Wikipedia数据库中对LTC4S基因的介绍

基因序列

基因序列

LTC4S基因的碱基序列：[NCBI]

基因突变

基因突变

LTC4S基因的碱基突变：           显示全部snp
rs272431       rs730012       rs2306795       rs3756614       rs3776944       rs7706693       rs11541078       rs13162195       rs28365145       rs28365146       rs28365147       rs28365148       rs28365149       rs41458244       rs58826518       rs61330504       rs73349925       rs75759006       rs76018357       rs76396053       rs77590779       rs79329237       rs80086381       rs112139437       rs115264576       rs116280439       rs137887093       rs137961528       rs138945650       rs140301841       rs140560648       rs140697852       rs141041263       rs141623722       rs141731393       rs142929648       rs143548537      
rs145247560       rs145738814       rs146614595       rs146880351       rs147221320       rs147395798       rs147425644       rs148468341       rs149149685       rs149458266       rs150331511       rs150644191       rs181293842       rs182123489       rs183050031       rs183808429       rs183975298       rs184250216       rs186263070       rs187337162       rs188234584       rs188919983       rs188921067       rs190736573       rs191716896       rs192579256       rs193071638       rs200212829       rs200261371       rs200522167       rs201270274       rs201438621       rs368527006       rs368740449       rs369543970       rs369783912       rs369800948       rs370555009       rs372785497       rs373563671       rs376663667       rs376998290       rs527657015       rs528098272       rs529065064       rs530481281       rs530649684       rs530972500       rs531534413       rs533330702       rs534691041       rs535037049       rs535221826       rs535344572       rs536074458       rs536199646       rs536435941       rs536474288       rs537198261       rs537648373       rs538587613       rs538963153       rs540027891       rs540238590       rs540964088       rs541009518       rs542223683       rs542702448       rs543273391       rs544805951       rs545201267       rs546157038       rs546667368       rs546997286       rs548127353       rs549036217       rs549560929       rs549597664       rs551141089       rs551985667       rs553345764       rs553378595       rs554671997       rs554833354       rs555157256       rs555333988       rs555809532       rs556904129       rs557239059       rs557943535       rs558155480       rs558381167       rs559176466       rs560510373       rs560905665       rs561200242       rs561615359       rs563644134       rs564093147       rs564387771       rs564945464       rs565632104       rs565662356       rs566102079       rs566385747       rs567283587       rs567435148       rs567792811       rs568716460       rs568748049       rs569192482       rs569795765       rs569830545       rs569958461       rs570674842       rs571020323       rs571103937       rs571576037       rs572497874       rs572929001       rs573200214       rs573636091       rs574207694       rs575400315       rs575923141       rs575982440       rs577733234       rs577901357       rs578182066       rs745434101       rs746302157       rs746604309       rs746662706       rs746870334       rs747176466       rs747406298       rs747571082       rs747734547       rs747953529       rs747960489       rs748214513       rs748304315       rs749209459       rs749433047       rs749710362       rs750325836       rs750415850       rs750506337       rs750799831       rs750925670       rs751120439       rs751680281       rs751908833       rs752247231       rs752253029       rs752371914       rs752896378       rs753153049       rs753370261       rs753555908       rs753564727       rs753710336       rs754523169       rs755046190       rs755390168       rs755485728       rs755619985       rs755815874       rs756033144       rs756314046       rs756542919       rs757316428       rs757364586       rs757658923       rs757983312       rs758359505       rs758419838       rs758495959       rs758672759       rs758790720       rs759348394       rs759509233       rs759627589       rs759999581       rs760187640       rs761321034       rs761669777       rs761711830       rs762084059       rs762138895       rs762204910       rs762272493       rs762397151       rs762428947       rs762495545       rs762624373       rs762876374       rs763281547       rs763477744       rs763797556       rs764204220       rs764391756       rs764440587       rs764579009       rs764919413       rs765055294       rs765145315       rs765576287       rs765726486       rs766013207       rs766022707       rs766035350       rs766469666       rs766938653       rs767422865       rs767519213       rs768037337       rs768403452       rs768441568       rs768557264       rs769661517       rs769706186       rs769937154       rs770084179       rs770181084       rs770783952       rs771229196       rs771230210       rs771318153       rs771887865       rs772068301       rs772069106       rs773196362       rs773563514       rs773573863       rs773576827       rs773594909       rs774155756       rs774378612       rs774827080       rs774845515       rs775199756       rs775397986       rs775692778       rs775860886       rs776562798       rs776580942       rs776802617       rs776995507       rs777376888       rs777587042       rs778820943       rs779046826       rs779203042       rs779575455       rs780041214       rs780238607       rs780288135       rs780704843       rs780911726       rs781363298       rs781754364      

基因表达

基因表达

LTC4S基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向引物Tm值
反向引物序列
反向引物Tm值
rank
GAGGTAGCTCTACTGGCTG
59
CCTTCATGAAAGAAGATGCCG
59
CTACTTCTCCCTGCAGGTG
59
CCTTCATGAAAGAAGATGCCG
59
CTACTTCTCCCTGCAGGTG
59
CCCTTCATGAAAGAAGATGCC
59

转录因子

转录因子

      尚未收录相关数据

基因本体信息

LTC4S基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 溶酶体
  • 内涵体
  • 细胞核
  • 细胞质
  • 液泡
  • 细胞膜
  • 细胞外基质
  • 内质网
  • 线粒体
  • 高尔基体
  • 细胞骨架

LTC4S基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0016021
B5MCC3(UniProtKB)
IEA
GO:0004364
Q16873(UniProtKB)
IBA
GO:0004464
Q16873(UniProtKB)
IDA
GO:0004602
Q16873(UniProtKB)
IBA
GO:0005515
Q16873(UniProtKB)
IPI
GO:0005515
Q16873(UniProtKB)
IPI
GO:0005635
Q16873(UniProtKB)
IDA
GO:0005635
Q16873(UniProtKB)
IDA
GO:0005635
Q16873(UniProtKB)
TAS
GO:0005635
Q16873(UniProtKB)
TAS
GO:0005635
Q16873(UniProtKB)
TAS
GO:0005635
Q16873(UniProtKB)
TAS
GO:0005635
Q16873(UniProtKB)
TAS
GO:0005635
Q16873(UniProtKB)
TAS
GO:0005640
Q16873(UniProtKB)
IEA
GO:0005783
Q16873(UniProtKB)
IDA
GO:0005789
Q16873(UniProtKB)
IEA
GO:0006691
Q16873(UniProtKB)
IDA
GO:0006691
Q16873(UniProtKB)
TAS
GO:0008047
Q16873(UniProtKB)
IEA
GO:0008289
Q16873(UniProtKB)
IDA
GO:0010035
Q16873(UniProtKB)
IEA
GO:0016021
Q16873(UniProtKB)
IEA
GO:0019370
Q16873(UniProtKB)
IBA
GO:0019372
Q16873(UniProtKB)
TAS
GO:0042493
Q16873(UniProtKB)
IEA
GO:0043085
Q16873(UniProtKB)
IEA
GO:0043231
Q16873(UniProtKB)
TAS
GO:0043295
Q16873(UniProtKB)
IEA
GO:0046982
Q16873(UniProtKB)
IEA
GO:0048678
Q16873(UniProtKB)
IEA
GO:0071222
Q16873(UniProtKB)
IEA
GO:0071299
Q16873(UniProtKB)
IEA
GO:0098869
Q16873(UniProtKB)
IEA
GO:2001300
Q16873(UniProtKB)
TAS

基因相互作用关系

基因相互作用关系

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因相关microRNA

基因相关microRNA

可能调控LTC4S基因的相关microRNA：     

基因通路图

基因通路图

基因的通路属性图
通路基因列表

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Asthma, Aspirin-Induced 0.126362715 11 0 BeFree_CTD_human_GAD
Drug Allergy 0.122367032 2 0 CTD_human_GAD
Leukotriene C4 Synthase Deficiency 0.12 0 0 ORPHANET
Glomerulonephritis 0.08 1 0 RGD
Peripheral Neuropathy 0.08 1 0 RGD
Liver Failure, Acute 0.08 1 0 RGD
Asthma 0.06864864 39 1 BeFree_GAD_LHGDN
Cerebrovascular accident 0.010096888 5 1 BeFree_GAD_LHGDN
Inflammation 0.007101096 3 0 GAD
Sinusitis 0.005005506 2 0 BeFree_GAD
Carotid Artery Diseases 0.004734064 2 0 GAD
Diabetes Mellitus, Non-Insulin-Dependent 0.004734064 2 0 GAD
Immediate hypersensitivity 0.004734064 2 0 GAD
Bronchial Hyperreactivity 0.003181358 4 0 BeFree_GAD
aspirin intolerance 0.002909916 2 0 BeFree_GAD
Cardiovascular Diseases 0.002909916 2 0 BeFree_GAD
Urticaria 0.002909916 3 1 BeFree_GAD
Colorectal Neoplasms 0.00272435 1 0 LHGDN
Coronary Artery Disease 0.002638474 2 0 BeFree_GAD
Allergic rhinitis (disorder) 0.002638474 1 1 BeFree_GAD
Alzheimer's Disease 0.002367032 1 0 GAD
Brain Ischemia 0.002367032 1 0 GAD
Cerebrovascular Disorders 0.002367032 1 0 GAD
Chlamydia Infections 0.002367032 1 0 GAD
Hodgkin Disease 0.002367032 1 0 GAD
Ischemia 0.002367032 1 0 GAD
Rhinitis 0.002367032 1 0 GAD
Trachoma 0.002367032 1 0 GAD
Venous Thrombosis 0.002367032 1 0 GAD
Atopy 0.002367032 1 0 GAD
Venous Thromboembolism 0.002367032 1 0 GAD
Myeloid Leukemia, Chronic 0.000814326 3 0 BeFree
Ischemic stroke 0.000814326 3 3 BeFree
Ischemic Cerebrovascular Accident 0.000814326 3 3 BeFree
Allergic asthma 0.000542884 2 0 BeFree
aspirin sensitivity 0.000542884 2 0 BeFree
Asthma, Exercise-Induced 0.000271442 1 0 BeFree
Transient Ischemic Attack 0.000271442 1 0 BeFree
Coronary Arteriosclerosis 0.000271442 1 0 BeFree
Coronary heart disease 0.000271442 1 0 BeFree
Cardiac Arrest 0.000271442 1 1 BeFree
Chronic Obstructive Airway Disease 0.000271442 1 0 BeFree
Myocardial Infarction 0.000271442 1 0 BeFree
Nasal Polyps 0.000271442 1 0 BeFree
Pulmonary Eosinophilia 0.000271442 1 0 BeFree
Thromboembolism 0.000271442 1 0 BeFree
Myocardial Ischemia 0.000271442 1 0 BeFree
Asthmatic pulmonary eosinophilia 0.000271442 1 0 BeFree
Chronic idiopathic urticaria 0.000271442 1 0 BeFree
Lung Diseases, Obstructive 0.000271442 1 0 BeFree
Transient Cerebral Ischemia 0.000271442 1 0 BeFree

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