LSM1(LSM1, U6 small nuclear RNA associated) 转至新版数据库

基因基本信息

基因基本信息

基因简称(symbol)
    [HGNC]     [GeneCards]     [NCBI]
基因种类(locus group)
同源简称(alias symbol)
基因家族代码(gene_family_id)
    [HGNC]     [GenScript]
omim代码
entrez码
    [Vega]
vega基因码
ensembl基因码
    [Ensembl]
基因家族(gene family)
refseq数据库代号

更多...

基因种类(locus_type)
基因名称状态(status)
location_sortable
同源基因名称(alias name)
基因名称批准使用时间(date_approved_reserved)
基因简称更名时间(date_symbol_changed)
基因名称更名时间(date_name_changed)
更新时间(date_modified)
ucsc码
ena
ccds数据码
uniprot数据码
pubmed代码
mgd码
rgd码
生命科学数据库(lsdb)
更新时间(date modified)
cosmic
mirbase
基因曾用简称(prev symbol)
基因曾用名称(prev name)
homeodb
cosmic
snornabase
bioparadigms slc
orphanet
假基因信息(pseudogeneorg)
horde id
merops
imgt
iuphar
kznf基因类别
mamit-trnadb
cd
LncRNA数据库
酶代码
中间纤维数据库

收起

基因染色体位置

基因染色体位置

8p11.2
基因染色体位置图

基因简述

基因简述

This gene encodes a member of the LSm family of RNA-binding proteins. LSm proteins form stable heteromers that bind specifically to the 3'-terminal oligo(U) tract of U6 snRNA and may play a role in pre-mRNA splicing by mediating U4/U6 snRNP formation. Increased expression of this gene may play a role in cellular transformation and the progression of several malignancies including lung cancer, mesothelioma and breast cancer. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, Nov 2011]

[中文简述(自动翻译):]  该基因编码的LSM家族RNA结合蛋白中的一员。 LSM蛋白形成特异性结合U6 snRNA启动的3‘-末端的寡（U）道，并且可以通过介导U4 / U6核蛋白的形成起到前mRNA剪接作用稳定异聚。该基因的表达增加可能在细胞转化作用和几个恶性肿瘤包括肺癌，间皮瘤和乳腺癌的进展。另外剪接转录变体已经观察到这种基因，而这种基因的假基因位于[由RefSeq的，2011年11月提供的]的9号染色体短臂

OMIM数据库中对LSM1基因的介绍     Wikipedia数据库中对LSM1基因的介绍

基因序列

基因序列

LSM1基因的碱基序列：[NCBI]

基因突变

基因突变

LSM1基因的碱基突变：           显示全部snp
rs2270376       rs3824288       rs7000184       rs10099971       rs11783967       rs12681876       rs13273494       rs16887245       rs17435276       rs28546327       rs55962869       rs59911155       rs61731142       rs61731143       rs73674130       rs74703048       rs75791635       rs76634925       rs77263158       rs77568784       rs112961317       rs113937856       rs116406736       rs142126523       rs143677476       rs143722071       rs143749283       rs148018686       rs148606556       rs149779609       rs150735540       rs183258355       rs184100922       rs185336631       rs185358350       rs186984154       rs187851568      
rs190171220       rs190213515       rs191581375       rs192035136       rs199744372       rs200527438       rs369110965       rs369282129       rs369467061       rs369540202       rs369666639       rs373206411       rs373501380       rs373975174       rs375202565       rs375842095       rs376268617       rs528054595       rs528102964       rs528643030       rs528711479       rs528926788       rs529337326       rs530408462       rs531109207       rs531117886       rs533144505       rs533995034       rs534199032       rs534728028       rs534797558       rs535490179       rs537935039       rs538643317       rs539124699       rs539349832       rs540386714       rs540447037       rs542205362       rs544250244       rs544349035       rs544811119       rs544989354       rs545208987       rs545861224       rs546734409       rs547675306       rs548886876       rs548947843       rs549211547       rs549348207       rs550571183       rs550710106       rs551632963       rs552496699       rs552608522       rs553099227       rs553202252       rs553739443       rs555536846       rs555582776       rs555673945       rs555873998       rs556802890       rs556864174       rs558813445       rs560048572       rs560144844       rs561666385       rs561943349       rs562792081       rs563013655       rs563131702       rs564060586       rs564162683       rs564834700       rs566399308       rs566411997       rs567449068       rs568229557       rs569079072       rs569136524       rs571342761       rs571755647       rs573040624       rs573204297       rs573647909       rs573786065       rs573925073       rs574391786       rs574531417       rs577156480       rs577611064       rs745399615       rs746371989       rs747350656       rs748133543       rs748527070       rs748742846       rs749569625       rs750055261       rs751093887       rs751511799       rs751718502       rs752005025       rs753059246       rs753220569       rs753461799       rs753811910       rs754247709       rs755722694       rs755880275       rs756522380       rs756974966       rs757869191       rs758401627       rs758874491       rs759104949       rs760520384       rs760711712       rs761399465       rs761628692       rs762455304       rs762707914       rs763152667       rs763796427       rs763994352       rs764875237       rs765403049       rs765793594       rs766057908       rs766370792       rs766459858       rs767182319       rs767329801       rs767357184       rs768542077       rs769547218       rs770097684       rs770152517       rs770881318       rs771247507       rs772627490       rs772731815       rs773116442       rs773481835       rs773692892       rs774560193       rs775868603       rs776346173       rs776741008       rs777550365       rs778161511       rs778318816       rs778383079       rs778438032       rs780459338       rs781640921       rs781772073       rs1845       rs2843726       rs5891007       rs11551204       rs55736052       rs77493408       rs112053141       rs117235344       rs138805927       rs141144159       rs142070867       rs145024106       rs182372064       rs187041451       rs188033861       rs191343440       rs192081694       rs370074152       rs372428495       rs529118799       rs539421938       rs545830003       rs546835041       rs551412169       rs553552186       rs557212704       rs557413484       rs557736804       rs561929447       rs568627073       rs569027177       rs571131763       rs572826221       rs745440412       rs745676237       rs747041639       rs750687126       rs750856441       rs752184193       rs754371640       rs755027535       rs757876995       rs758491210       rs758812966       rs759101177       rs760456370       rs763669019       rs764644449       rs765787346       rs767217307       rs769434967       rs770757790       rs773956422       rs775307737       rs776349391       rs779139978       rs780355621       rs780980149       rs781288230       rs2720051       rs2843738       rs2843739       rs2843744       rs2843745       rs2843746       rs2954117       rs3015656       rs6988336       rs7823144       rs10095098       rs11322150       rs11785571       rs11787211       rs11998075       rs12542153       rs16887236       rs16887244       rs28593236       rs33931136       rs34599833       rs60177680       rs60959241       rs61438198       rs62503943       rs66755601       rs72547255       rs72643084       rs72643087       rs74488574       rs75301334       rs76007265       rs76873509       rs77659380       rs79270269       rs79882318       rs111528122       rs112341951       rs112665070       rs112829516       rs113729750       rs113798975       rs114182541       rs117984088       rs138240491       rs138600330       rs138824104       rs139429683       rs139467150       rs139539590       rs139664208       rs140511083       rs140846565       rs141117467       rs141336387       rs141712717       rs142398268       rs142784385       rs142921099       rs143680362       rs144079383       rs144546839       rs144926627       rs145151767       rs145170094       rs145368949       rs145699114       rs146323794       rs146865306       rs147432282       rs147780286       rs148084386       rs148458925       rs148660021       rs148981955       rs149305183       rs149587737       rs149689283       rs150213275       rs150589043       rs150930487       rs151088048       rs180728515       rs180730521       rs181287330       rs181492776       rs181704485       rs181913000       rs182502588       rs182732173       rs182947110       rs182953569       rs182961368       rs183782240       rs184121280       rs184335601       rs184403098       rs184538854       rs184638597       rs184654962       rs184663202       rs184876809       rs185090685       rs185126554       rs186107949       rs186128388       rs186348952       rs186732018       rs186802881       rs187098446       rs187152810       rs187363782       rs187861921       rs188392531       rs188641034       rs189141135       rs189174462       rs189409975       rs189675812       rs189908196       rs189968175       rs190415752       rs190713805       rs190845121       rs191471824       rs191522904       rs192215593       rs192269563       rs192374669       rs192519657       rs192728535       rs192806409       rs192855227       rs193193172       rs193262840       rs200599876       rs201050111       rs201060186       rs201992884       rs367711462       rs367945831       rs368341544       rs369425901       rs370970373       rs371187393       rs371861507       rs372103926       rs374811193       rs375090659       rs375691357       rs375917571       rs376821606       rs527322742       rs527649234       rs527784768       rs528191931       rs528323822       rs528784325       rs528848880       rs529135412       rs529412823       rs529566107       rs529868831       rs530003019       rs530602988       rs530660902       rs531636726       rs531645873       rs531785106       rs532180335       rs532446343       rs532459239       rs532597044       rs533002283       rs533262637       rs533335440       rs533395524       rs533944340       rs533968374       rs534160143       rs534344459       rs535430268       rs535562998       rs535955875       rs536477445       rs536880309       rs537174267       rs537281851       rs537616793       rs537756904       rs538008426       rs538015643       rs538071564       rs538150158       rs538807732       rs538861377       rs538933975       rs539308494       rs539346143       rs540301743       rs540512278       rs540549584       rs541021832       rs541298263       rs541433654       rs541891609       rs542101047       rs542623681       rs542751135       rs542807381       rs543002629       rs543239738       rs543932234       rs544426259       rs544942499       rs545112452       rs545148613       rs545545694       rs545608958       rs546419769       rs546900177       rs547129734       rs547143335       rs547355690       rs547754379       rs547868916       rs549128772       rs549315395       rs549378526       rs550056405       rs550212273       rs550710161       rs550918142       rs551440530       rs551490575       rs551500500       rs551833477       rs551894005       rs552942502       rs553339403       rs553496338       rs553666176       rs553878487       rs553885369       rs554013877       rs554051087       rs554155444       rs554214090       rs554352000       rs554355209       rs554699547       rs555217231       rs555423207       rs555613033       rs556257223       rs556395622       rs556395788       rs556402508       rs556470634       rs556802989       rs557509650       rs557659489       rs558130227       rs558492970       rs558902712       rs559186563       rs559200433       rs559360494       rs559497895       rs560333559       rs560354364       rs560667588       rs561189826       rs561255010       rs561352106       rs561395341       rs561796107       rs562132570       rs562270317       rs562380895       rs562568148       rs562599141       rs563269526       rs563930485       rs564986836       rs565201993       rs565257160       rs565270638       rs565729868       rs566202910       rs566660903       rs566721577       rs566751268       rs567579542       rs568492769       rs568890695       rs569025259       rs569057427       rs569291243       rs569601576       rs569710244       rs569750905       rs570246040       rs570318719       rs570381498       rs570818994       rs571323351       rs571463085       rs571520950       rs571601852       rs571931996       rs572046242       rs572047154       rs572069192       rs572503802       rs572713070       rs573079641       rs573924153       rs575153655       rs576029177       rs576468697       rs576471795       rs576613908       rs577438661       rs577693304       rs577769625       rs577833368       rs577873082       rs577908682       rs745604377       rs746197556       rs746657086       rs748237700       rs748749451       rs750994112       rs751360478       rs751748019       rs751976708       rs752675339       rs752945697       rs753926143       rs755131896       rs756244674       rs757072391       rs759921716       rs760941207       rs761391962       rs763408982       rs763541506       rs764232315       rs764238698       rs766723906       rs766777263       rs767682361       rs768357945       rs769000785       rs769315257       rs769909686       rs771383767       rs771438714       rs771881434       rs772398907       rs774628782       rs774815329       rs774857883       rs775468919       rs775787618       rs776707467       rs777276257       rs777767327       rs778945816       rs779984212       rs780146058       rs780888716       rs781233539      

基因表达

基因表达

LSM1基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向引物Tm值
反向引物序列
反向引物Tm值
rank
TGGAGCGTATTCATGTGGG
60
TTCCAAGTCTATTTCTCCTAGTAGG
59
TGCAAACTTAGTGCTACATCAG
59
TTCCAAGTCTATTTCTCCTAGTAGG
59
GCATTGATCAATTTGGACTTGG
59
TTTCAACTTCTCTGCTTCCAG
59
TGCAAACTTAGTGCTACATCAG
59
TTCCAAGTCTATTTCTCCTAGTAGG
59
GTGGAGCGTATTCATGTGG
59
TTCCAAGTCTATTTCTCCTAGTAGG
59
TGGAGCGTATTCATGTGGG
60
TTCCAAGTCTATTTCTCCTAGTAGG
59
TGCAAACTTAGTGCTACATCAG
59
TTCCAAGTCTATTTCTCCTAGTAGG
59
TGGAAGGACACTTATAGGCT
58
GCACTAAGTTTGGTTTCTTCC
58
GTGGAGCGTATTCATGTGG
59
TTCCAAGTCTATTTCTCCTAGTAGG
59
GATGGAAGGACACTTATAGGC
58
CACTAAGTTTGGTTTCTTCCTC
57

转录因子

转录因子

      尚未收录相关数据

基因本体信息

LSM1基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 溶酶体
  • 内涵体
  • 细胞核
  • 细胞质
  • 液泡
  • 细胞膜
  • 细胞外基质
  • 内质网
  • 线粒体
  • 高尔基体
  • 细胞骨架

LSM1基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0000290
O15116(UniProtKB)
IBA
GO:0000339
O15116(UniProtKB)
IBA
GO:0000375
O15116(UniProtKB)
TAS
GO:0000932
O15116(UniProtKB)
IBA
GO:0003729
O15116(UniProtKB)
IEA
GO:0005515
O15116(UniProtKB)
IPI
GO:0005515
O15116(UniProtKB)
IPI
GO:0005515
O15116(UniProtKB)
IPI
GO:0005515
O15116(UniProtKB)
IPI
GO:0005515
O15116(UniProtKB)
IPI
GO:0005515
O15116(UniProtKB)
IPI
GO:0005515
O15116(UniProtKB)
IPI
GO:0005634
O15116(UniProtKB)
IDA
GO:0005737
O15116(UniProtKB)
IDA
GO:0005829
O15116(UniProtKB)
TAS
GO:0005829
O15116(UniProtKB)
TAS
GO:0006397
O15116(UniProtKB)
IEA
GO:0008380
O15116(UniProtKB)
TAS
GO:0019827
O15116(UniProtKB)
IEA
GO:0030424
O15116(UniProtKB)
IEA
GO:0030425
O15116(UniProtKB)
IEA
GO:0036002
O15116(UniProtKB)
IEA
GO:0043025
O15116(UniProtKB)
IEA
GO:0043928
O15116(UniProtKB)
TAS
GO:0044822
O15116(UniProtKB)
IDA
GO:0044822
O15116(UniProtKB)
IDA
GO:0045665
O15116(UniProtKB)
IEA
GO:0071044
O15116(UniProtKB)
IMP
GO:1990124
O15116(UniProtKB)
IEA

基因相互作用关系

基因相互作用关系

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因相关microRNA

基因相关microRNA

可能调控LSM1基因的相关microRNA：     

基因通路图

基因通路图

基因的通路属性图
通路基因列表

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Schizophrenia 0.122367032 1 1 GAD_GWASCAT
Peripheral Neuropathy 0.12 1 0 CTD_human
Prostatic Neoplasms 0.00272435 1 0 LHGDN
Mammary Neoplasms 0.00272435 1 0 LHGDN
Tobacco Use Disorder 0.002367032 1 0 GAD
Malignant neoplasm of breast 0.000542884 2 0 BeFree
Pancreatic Neoplasm 0.000542884 2 0 BeFree
Pancreatic carcinoma 0.000542884 2 0 BeFree
Malignant neoplasm of pancreas 0.000542884 2 0 BeFree
Breast Carcinoma 0.000542884 2 0 BeFree
Mesothelioma 0.000271442 1 0 BeFree
Malignant neoplasm of lung 0.000271442 1 0 BeFree
Malignant neoplasm of prostate 0.000271442 1 0 BeFree
Prostate carcinoma 0.000271442 1 0 BeFree
Carcinoma of lung 0.000271442 1 0 BeFree

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