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This gene encodes a protein that interacts with the low density lipoprotein (LDL) receptor-related protein and facilitates its proper folding and localization by preventing the binding of ligands. Mutations in this gene have been identified in individuals with myopia 23. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
[中文简述(自动翻译):]  该基因编码,与低密度脂蛋白(LDL)受体相关蛋白相互作用并通过防止配体的结合有利于它的正确折叠和本地化的蛋白质。在这个基因的突变已在个人被确定在多个抄本变形近视23选择性剪接的结果。 [由RefSeq的,2013年12月提供]
LRPAP1基因(以及对应的蛋白质)的细胞分布位置:
LRPAP1基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| MYOPIA 23, AUTOSOMAL RECESSIVE | 0.12 | 0 | 3 | CLINVAR |
| Membranous glomerulonephritis | 0.08 | 2 | 0 | RGD |
| Cholelithiasis | 0.010282454 | 5 | 0 | BeFree_GAD |
| Alzheimer's Disease | 0.00973957 | 5 | 0 | BeFree_GAD |
| Cholecystolithiasis | 0.00973957 | 5 | 0 | BeFree_GAD |
| Biliary calculi | 0.0054487 | 2 | 0 | LHGDN |
| Hypothyroidism | 0.005362824 | 1 | 0 | BeFree_GAD_LHGDN |
| Dementia | 0.005362824 | 1 | 0 | BeFree_GAD_LHGDN |
| von Willebrand Disease | 0.00272435 | 1 | 0 | LHGDN |
| Diabetes Mellitus, Non-Insulin-Dependent | 0.002638474 | 2 | 0 | BeFree_GAD |
| Biliary Tract Neoplasm | 0.002367032 | 1 | 0 | GAD |
| Malignant neoplasm of urinary bladder | 0.002367032 | 1 | 0 | GAD |
| Dementia, Vascular | 0.002367032 | 1 | 0 | GAD |
| Goiter | 0.002367032 | 1 | 0 | GAD |
| Myocardial Infarction | 0.002367032 | 1 | 0 | GAD |
| Cerebrovascular accident | 0.002367032 | 1 | 0 | GAD |
| Subarachnoid Hemorrhage | 0.002367032 | 1 | 0 | GAD |
| Venous Thrombosis | 0.002367032 | 1 | 0 | GAD |
| Intracranial Hemorrhages | 0.002367032 | 1 | 0 | GAD |
| Lipid Metabolism Disorders | 0.002367032 | 1 | 0 | GAD |
| Neurodegenerative Disorders | 0.002367032 | 1 | 0 | GAD |
| Cerebral Hemorrhage | 0.002367032 | 1 | 0 | GAD |
| Rheumatoid Arthritis | 0.000542884 | 2 | 0 | BeFree |
| Severe myopia | 0.000542884 | 2 | 0 | BeFree |
| Malignant neoplasm of prostate | 0.000542884 | 2 | 0 | BeFree |
| Prostate carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Glucocorticoid deficiency | 0.000542884 | 2 | 0 | BeFree |
| Renal Cell Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Presenile dementia | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of stomach | 0.000271442 | 1 | 0 | BeFree |
| Mixed Salivary Gland Tumor | 0.000271442 | 1 | 0 | BeFree |
| Myopia | 0.000271442 | 1 | 0 | BeFree |
| Degenerative polyarthritis | 0.000271442 | 1 | 0 | BeFree |
| Osteoporosis | 0.000271442 | 1 | 0 | BeFree |
| Ovarian Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| polyps | 0.000271442 | 1 | 0 | BeFree |
| Systemic Scleroderma | 0.000271442 | 1 | 0 | BeFree |
| Thyroid Neoplasm | 0.000271442 | 1 | 0 | BeFree |
| Vomiting | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of lung | 0.000271442 | 1 | 0 | BeFree |
| Glucocorticoid deficiency with achalasia | 0.000271442 | 1 | 0 | BeFree |
| Conventional (Clear Cell) Renal Cell Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Beta thalassemia intermedia | 0.000271442 | 1 | 0 | BeFree |
| Carcinoma of lung | 0.000271442 | 1 | 0 | BeFree |
| Biliary Tract Cancer | 0.000271442 | 1 | 0 | BeFree |
| Adenomatous polyp of colon | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of ovary | 0.000271442 | 1 | 0 | BeFree |
| Geographic Atrophy | 0.000271442 | 1 | 0 | BeFree |
| Liver carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Recurrent abdominal pain | 0.000271442 | 1 | 0 | BeFree |
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