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The protein encoded by this gene is a member of the lipin family of proteins, and all family members share strong homology in their C-terminal region. This protein is thought to form hetero-oligomers with other lipin family members, while one family member, lipin 1, can also form homo-oligomers. This protein contains conserved motifs for phosphatidate phosphatase 1 (PAP1) activity as well as a domain that interacts with a transcriptional co-activator. Lipin complexes act in the cytoplasm to catalyze the dephosphorylation of phosphatidic acid to produce diacylglycerol, which is the precursor of both triglycerides and phospholipids. Lipin complexes are also thought to regulate gene expression as transcriptional co-activators in the nucleus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]
[中文简述(自动翻译):]  由该基因编码的蛋白质是脂质蛋白质家族的一员,并且所有的家庭成员共享在它们的C-末端区强烈的同源性。这种蛋白质被认为以形成异低聚物与其他脂质的家庭成员,而一个家庭成员,油脂1,也可形成同型寡聚体。该蛋白质包含磷脂磷酸酶1(PAP1)活性保守基序以及与转录共活化剂相互作用的结构域。脂质复合物作用于细胞质催化磷脂酸的去磷酸化,以产生二酰基甘油,这既是甘油三酯和磷脂的前体。脂质复合物也被认为调节基因表达在细胞核转录共活化剂。选择性剪接结果在多个抄本变形。 [由RefSeq的,2014年9月提供]
LPIN3基因(以及对应的蛋白质)的细胞分布位置:
LPIN3基因的本体(GO)信息:
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