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This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  该基因编码的赖氨酰氧化酶基因家族的一个成员。该家族的原型成员是结缔组织的生物合成必需的,编码胞外铜 - 依赖性胺氧化酶催化,在胶原和弹性蛋白的形成交联的第一个步骤。在C末端端部的高度保守的氨基酸序列显示为足以胺氧化酶的活性,这表明每个家庭成员可以保留该功能。 N末端是保守性差,可能传授发育调控,衰老,抑制肿瘤细胞的生长控制和趋化其他角色家庭的每个成员。 [由RefSeq的,2008年7月提供]
LOXL4基因(以及对应的蛋白质)的细胞分布位置:
LOXL4基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Bladder Neoplasm | 0.120271442 | 1 | 0 | BeFree_CTD_human |
Squamous cell carcinoma | 0.005720142 | 3 | 0 | BeFree_LHGDN |
Squamous cell carcinoma of the head and neck | 0.001085767 | 4 | 0 | BeFree |
Malignant neoplasm of urinary bladder | 0.000542884 | 2 | 0 | BeFree |
Malignant neoplasm of breast | 0.000542884 | 2 | 0 | BeFree |
Breast Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Carcinoma of bladder | 0.000542884 | 2 | 0 | BeFree |
Intracranial Aneurysm | 0.000271442 | 1 | 0 | BeFree |
Endometriosis | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of stomach | 0.000271442 | 1 | 0 | BeFree |
Neoplasm Metastasis | 0.000271442 | 1 | 0 | BeFree |
Idiopathic pulmonary hypertension | 0.000271442 | 1 | 0 | BeFree |
Tumor Progression | 0.000271442 | 1 | 0 | BeFree |
Secondary malignant neoplasm of lymph node | 0.000271442 | 1 | 0 | BeFree |
Stomach Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Idiopathic pulmonary arterial hypertension | 0.000271442 | 1 | 0 | BeFree |
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