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The protein encoded by this gene has a long and a short form, generated by use of alternative translational start codons. The long form is expressed in steroidogenic tissues such as testis, where it converts cholesteryl esters to free cholesterol for steroid hormone production. The short form is expressed in adipose tissue, among others, where it hydrolyzes stored triglycerides to free fatty acids. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  由该基因编码的蛋白质有很长的和短的形式,通过使用替代翻译起始密码子产生的。长形式是类固醇组织,如睾丸,它的胆固醇酯转化为类固醇激素的生产不含胆固醇表示。短形式是在脂肪组织中表达,在其他中,在那里它水解存储甘油三酯为游离脂肪酸。 [由RefSeq的,2008年7月提供]
LIPE基因(以及对应的蛋白质)的细胞分布位置:
LIPE基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| LIPODYSTROPHY, FAMILIAL PARTIAL, TYPE 6 | 0.12 | 0 | 0 | ORPHANET |
| Obesity | 0.102345448 | 34 | 0 | BeFree_GAD_RGD |
| Arteriosclerosis | 0.080271442 | 2 | 0 | BeFree_RGD |
| Heart Diseases | 0.08 | 1 | 0 | RGD |
| Hypertriglyceridemia | 0.08 | 1 | 0 | RGD |
| Coronary heart disease | 0.004734064 | 2 | 0 | GAD |
| Insulin Sensitivity | 0.004734064 | 2 | 0 | GAD |
| Diabetes Mellitus, Non-Insulin-Dependent | 0.004624443 | 7 | 0 | BeFree_LHGDN |
| Hyperinsulinism | 0.002995792 | 1 | 0 | BeFree_LHGDN |
| Polycystic Ovary Syndrome | 0.00272435 | 1 | 0 | LHGDN |
| Pregnancy associated hypertension | 0.00272435 | 1 | 0 | LHGDN |
| Male infertility | 0.002638474 | 2 | 0 | BeFree_GAD |
| Obesity, Morbid | 0.002638474 | 2 | 0 | BeFree_GAD |
| Overweight | 0.002638474 | 1 | 0 | BeFree_GAD |
| Azoospermia | 0.002367032 | 1 | 0 | GAD |
| Inflammation | 0.002367032 | 1 | 0 | GAD |
| Insulin Resistance | 0.002367032 | 1 | 0 | GAD |
| Oligospermia | 0.002367032 | 1 | 0 | GAD |
| body mass | 0.002367032 | 1 | 0 | GAD |
| Hyperlipidemia, Familial Combined | 0.001085767 | 4 | 0 | BeFree |
| Cachexia | 0.000542884 | 2 | 0 | BeFree |
| Dyslipidemias | 0.000542884 | 2 | 0 | BeFree |
| Metabolic Syndrome X | 0.000542884 | 2 | 0 | BeFree |
| Atherosclerosis | 0.000271442 | 1 | 0 | BeFree |
| Colorectal Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Cystic Fibrosis | 0.000271442 | 1 | 0 | BeFree |
| Hyperglycemia | 0.000271442 | 1 | 0 | BeFree |
| Lipodystrophy | 0.000271442 | 1 | 0 | BeFree |
| Liver neoplasms | 0.000271442 | 1 | 0 | BeFree |
| Ovarian Diseases | 0.000271442 | 1 | 0 | BeFree |
| Familial partial lipodystrophy | 0.000271442 | 1 | 0 | BeFree |
| Obesity, Abdominal | 0.000271442 | 1 | 0 | BeFree |
| growth hormone treatment | 0.000271442 | 1 | 0 | BeFree |
| Infectious disease of lung | 0.000271442 | 1 | 0 | BeFree |
| Colorectal Cancer | 0.000271442 | 1 | 0 | BeFree |
| Liver carcinoma | 0.000271442 | 1 | 0 | BeFree |
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