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The protein encoded by this gene is an adaptor protein which contains five LIM domains, or double zinc fingers. The protein is likely involved in integrin signaling through its LIM domain-mediated interaction with integrin-linked kinase, found in focal adhesion plaques. It is also thought to act as a bridge linking integrin-linked kinase to NCK adaptor protein 2, which is involved in growth factor receptor kinase signaling pathways. Its localization to the periphery of spreading cells also suggests that this protein may play a role in integrin-mediated cell adhesion or spreading. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
[中文简述(自动翻译):]  由该基因编码的蛋白质是含有5个LIM结构域,或双锌指一个衔接蛋白。该蛋白可能参与整合,通过与整合素连接激酶其LIM结构域介导的互动,黏着斑发现信号。它也被认为是作为整合素连接激酶链接到NCK衔接蛋白2,这是参与生长因子受体激酶信号传导途径的桥梁。其定位到扩频单元的周边还表明,该蛋白可能在整合素介导的细胞粘附或扩散的作用。已发现该基因编码不同亚型的几个抄本变形。 [由RefSeq的,2010年7月提供]
LIMS1基因(以及对应的蛋白质)的细胞分布位置:
LIMS1基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Neoplasm Metastasis | 0.003267234 | 3 | 0 | BeFree_LHGDN |
| Squamous cell carcinoma | 0.00272435 | 1 | 0 | LHGDN |
| Glioma | 0.00272435 | 1 | 0 | LHGDN |
| Carcinogenesis | 0.000542884 | 2 | 0 | BeFree |
| Malignant neoplasm of breast | 0.000271442 | 1 | 0 | BeFree |
| Malignant tumor of colon | 0.000271442 | 1 | 0 | BeFree |
| Kidney Diseases | 0.000271442 | 1 | 0 | BeFree |
| Leukemia, Myelocytic, Acute | 0.000271442 | 1 | 0 | BeFree |
| Renal fibrosis | 0.000271442 | 1 | 0 | BeFree |
| Adenocarcinoma, Clear Cell | 0.000271442 | 1 | 0 | BeFree |
| Carcinoma breast stage IV | 0.000271442 | 1 | 0 | BeFree |
| Breast Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Colon Carcinoma | 0.000271442 | 1 | 0 | BeFree |
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