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This gene encodes a protein that is secreted by white adipocytes, and which plays a major role in the regulation of body weight. This protein, which acts through the leptin receptor, functions as part of a signaling pathway that can inhibit food intake and/or regulate energy expenditure to maintain constancy of the adipose mass. This protein also has several endocrine functions, and is involved in the regulation of immune and inflammatory responses, hematopoiesis, angiogenesis and wound healing. Mutations in this gene and/or its regulatory regions cause severe obesity, and morbid obesity with hypogonadism. This gene has also been linked to type 2 diabetes mellitus development. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):] 该基因编码由白色脂肪细胞分泌的蛋白质,并起着在体重调节中起主要作用。这种蛋白质,它通过瘦素受体的作用,起到可以抑制食物摄入和/或调节能量消耗以维持脂肪质量的恒定信号传导途径的一部分。这种蛋白也有几个内分泌功能,并参与的免疫和炎症反应,造血,血管发生和伤口愈合的调节。在此基因和/或它的调控区的突变导致严重的肥胖和与性腺功能减退病态肥胖。这种基因也被链接到2型糖尿病的发展。 [由RefSeq的,2008年7月提供]
LEP基因(以及对应的蛋白质)的细胞分布位置:
LEP基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Obesity | 0.44 | 598 | 31 | BeFree_CTD_human_GAD_MGD_RGD |
LEPTIN DEFICIENCY OR DYSFUNCTION | 0.367600372 | 29 | 1 | BeFree_CLINVAR_ORPHANET_UNIPROT |
Diabetes Mellitus, Non-Insulin-Dependent | 0.321224284 | 61 | 5 | BeFree_CTD_human_GAD_LHGDN_MGD_RGD |
Hypertensive disease | 0.240158379 | 38 | 2 | BeFree_CTD_human_GAD_LHGDN_RGD |
Metabolic Syndrome X | 0.216948948 | 48 | 1 | BeFree_CTD_human_GAD_RGD |
Insulin Resistance | 0.202367032 | 4 | 0 | CTD_human_GAD_RGD |
Hypogonadism | 0.201357209 | 7 | 0 | BeFree_CTD_human_RGD |
Alzheimer's Disease | 0.200542884 | 4 | 0 | BeFree_CTD_human_RGD |
Liver Cirrhosis, Experimental | 0.2 | 2 | 0 | CTD_human_RGD |
Mammary Neoplasms | 0.150143487 | 23 | 0 | BeFree_CTD_human_GAD_LHGDN |
Inflammation | 0.139070452 | 8 | 0 | CTD_human_LHGDN |
Weight Gain | 0.138936256 | 11 | 0 | CTD_human_GAD |
Polycystic Ovary Syndrome | 0.136521735 | 17 | 0 | BeFree_CTD_human_GAD_LHGDN |
Hyperinsulinism | 0.134687656 | 28 | 0 | BeFree_CTD_human_LHGDN |
Gestational Diabetes | 0.131430353 | 16 | 0 | BeFree_CTD_human_LHGDN |
Fatty Liver | 0.130530151 | 17 | 0 | BeFree_CTD_human_GAD_LHGDN |
Obesity, Morbid | 0.128338753 | 24 | 0 | BeFree_CTD_human_GAD |
Prostatic Neoplasms | 0.128173051 | 4 | 0 | CTD_human_LHGDN |
Colonic Neoplasms | 0.127729856 | 5 | 0 | BeFree_CTD_human_GAD_LHGDN |
Hyperphagia | 0.122442977 | 10 | 1 | BeFree_CTD_human |
Crohn Disease | 0.121085767 | 4 | 0 | BeFree_CTD_human |
Non-alcoholic Fatty Liver Disease | 0.121085767 | 5 | 1 | BeFree_CTD_human |
Seizures | 0.120542884 | 3 | 0 | BeFree_CTD_human |
Hypercholesterolemia | 0.120271442 | 2 | 0 | BeFree_CTD_human |
Polyuria | 0.120271442 | 2 | 0 | BeFree_CTD_human |
Autistic Disorder | 0.12 | 1 | 0 | CTD_human |
Heroin Dependence | 0.12 | 1 | 0 | CTD_human |
Female infertility | 0.12 | 1 | 0 | CTD_human |
Nerve Degeneration | 0.12 | 1 | 0 | CTD_human |
Proteinuria | 0.12 | 1 | 0 | CTD_human |
Gastric ulcer | 0.12 | 6 | 0 | CTD_human |
Tachycardia | 0.12 | 1 | 0 | CTD_human |
Polydipsia | 0.12 | 1 | 0 | CTD_human |
Oral Ulcer | 0.12 | 1 | 0 | CTD_human |
Hepatitis, Autoimmune | 0.12 | 1 | 0 | CTD_human |
Arthritis, Experimental | 0.12 | 1 | 0 | CTD_human |
Pre-Eclampsia | 0.102732561 | 8 | 0 | GAD_LHGDN_RGD |
Huntington Disease | 0.082995792 | 3 | 0 | BeFree_LHGDN_RGD |
Fetal Growth Retardation | 0.08272435 | 2 | 0 | LHGDN_RGD |
Osteoporosis | 0.081085767 | 6 | 0 | BeFree_RGD |
Hyperlipidemia | 0.080814326 | 4 | 0 | BeFree_RGD |
Sepsis | 0.080271442 | 2 | 0 | BeFree_RGD |
Body Weight Changes | 0.08 | 1 | 0 | RGD |
Diabetes Mellitus, Experimental | 0.08 | 2 | 0 | RGD |
Mammary Neoplasms, Experimental | 0.08 | 1 | 0 | RGD |
Myocardial Reperfusion Injury | 0.08 | 1 | 0 | RGD |
Parkinson Disease | 0.08 | 1 | 0 | RGD |
Reperfusion Injury | 0.08 | 1 | 0 | RGD |
Short Bowel Syndrome | 0.08 | 1 | 0 | RGD |
Choroidal Neovascularization | 0.08 | 1 | 0 | RGD |
Abdominal obesity metabolic syndrome | 0.08 | 0 | 0 | MGD |
Malignant neoplasm of breast | 0.022920669 | 68 | 0 | BeFree_GAD |
Weight Gain Adverse Event | 0.018936256 | 8 | 0 | GAD |
Breast Carcinoma | 0.017915164 | 66 | 0 | BeFree |
Anorexia Nervosa | 0.014707519 | 9 | 0 | BeFree_LHGDN |
Endometriosis | 0.011983168 | 7 | 0 | BeFree_LHGDN |
Diabetes Mellitus | 0.011681932 | 34 | 0 | BeFree_LHGDN |
Overweight | 0.010977227 | 24 | 0 | BeFree_GAD |
Diabetes Mellitus, Insulin-Dependent | 0.010086957 | 12 | 0 | BeFree_GAD |
Neoplasm Metastasis | 0.00979177 | 18 | 0 | BeFree_LHGDN |
Cardiovascular Diseases | 0.009705894 | 18 | 1 | BeFree_GAD_LHGDN |
Dyslipidemias | 0.009444384 | 9 | 0 | BeFree_GAD_LHGDN |
Malignant neoplasm of prostate | 0.009272631 | 10 | 0 | BeFree_GAD |
Schizophrenia | 0.008815624 | 7 | 0 | BeFree_GAD_LHGDN |
Colorectal Cancer | 0.008805692 | 15 | 1 | BeFree_GAD |
Lipodystrophy | 0.008706003 | 14 | 0 | BeFree_LHGDN |
Liver carcinoma | 0.008706003 | 12 | 0 | BeFree_LHGDN |
Diabetes | 0.008414698 | 31 | 0 | BeFree |
Asthma | 0.008358616 | 3 | 0 | BeFree_GAD_LHGDN |
Infection | 0.008173051 | 3 | 0 | LHGDN |
Carcinogenesis | 0.008143256 | 30 | 0 | BeFree |
Kidney Failure, Chronic | 0.008087174 | 4 | 0 | BeFree_GAD_LHGDN |
Sleep Apnea, Obstructive | 0.008001298 | 4 | 0 | BeFree_GAD_LHGDN |
Anoxia | 0.007815732 | 3 | 0 | GAD_LHGDN |
Lymphoma | 0.00764398 | 5 | 1 | BeFree_GAD |
Anorexia | 0.00706742 | 17 | 0 | BeFree_LHGDN |
Coronary heart disease | 0.006263026 | 5 | 0 | BeFree_LHGDN |
Metabolic Diseases | 0.005981653 | 12 | 0 | BeFree_LHGDN |
Malignant neoplasm of lung | 0.005819831 | 5 | 0 | BeFree_GAD |
Behcet Syndrome | 0.005634266 | 3 | 0 | BeFree_GAD_LHGDN |
Kidney Diseases | 0.005634266 | 3 | 0 | BeFree_GAD_LHGDN |
Chronic Obstructive Airway Disease | 0.005634266 | 4 | 0 | BeFree_GAD_LHGDN |
Liver Cirrhosis | 0.0054487 | 2 | 0 | LHGDN |
Nephrotic Syndrome | 0.0054487 | 2 | 0 | LHGDN |
Stomach Neoplasms | 0.0054487 | 2 | 0 | LHGDN |
Immune thrombocytopenic purpura | 0.0054487 | 2 | 0 | LHGDN |
Degenerative polyarthritis | 0.005438769 | 11 | 0 | BeFree_LHGDN |
Pituitary Diseases | 0.005157396 | 19 | 0 | BeFree |
Pregnancy associated hypertension | 0.005091382 | 2 | 0 | GAD_LHGDN |
Pregnancy in Diabetics | 0.005005506 | 3 | 0 | BeFree_GAD |
body mass | 0.004734064 | 2 | 0 | GAD |
Leukemia, Myelocytic, Acute | 0.00408156 | 6 | 0 | BeFree_LHGDN |
Colorectal Carcinoma | 0.004071628 | 15 | 1 | BeFree |
Coronary Artery Disease | 0.003810118 | 5 | 0 | BeFree_LHGDN |
Rheumatoid Arthritis | 0.003538676 | 4 | 1 | BeFree_LHGDN |
Choriocarcinoma | 0.003538676 | 4 | 0 | BeFree_LHGDN |
Lupus Erythematosus, Systemic | 0.003538676 | 4 | 0 | BeFree_LHGDN |
Mental Depression | 0.003452799 | 4 | 0 | BeFree_GAD |
Adenocarcinoma | 0.003267234 | 3 | 0 | BeFree_LHGDN |
Ulcerative Colitis | 0.003267234 | 3 | 0 | BeFree_LHGDN |
HIV Infections | 0.003267234 | 3 | 0 | BeFree_LHGDN |
Myoma | 0.003267234 | 2 | 0 | BeFree_LHGDN |
Psoriasis | 0.003267234 | 2 | 0 | BeFree_LHGDN |
Rett Syndrome | 0.003267234 | 3 | 0 | BeFree_LHGDN |
Precursor Cell Lymphoblastic Leukemia Lymphoma | 0.003267234 | 3 | 0 | BeFree_LHGDN |
Heart failure | 0.003181358 | 4 | 0 | BeFree_GAD |
Liver diseases | 0.003181358 | 4 | 0 | BeFree_GAD |
Lymphoma, Non-Hodgkin | 0.003181358 | 4 | 0 | BeFree_GAD |
Arthritis | 0.002995792 | 2 | 0 | BeFree_LHGDN |
Hypothyroidism | 0.002995792 | 2 | 0 | BeFree_LHGDN |
Placental Insufficiency | 0.002995792 | 1 | 0 | BeFree_LHGDN |
Ankylosing spondylitis | 0.002995792 | 2 | 0 | BeFree_LHGDN |
Uremia | 0.002995792 | 2 | 0 | BeFree_LHGDN |
Multiple Sclerosis, Relapsing-Remitting | 0.002995792 | 2 | 0 | BeFree_LHGDN |
Major Depressive Disorder | 0.002995792 | 2 | 0 | BeFree_LHGDN |
Arteriosclerosis | 0.002985861 | 11 | 2 | BeFree |
Atherosclerosis | 0.002985861 | 11 | 2 | BeFree |
Ovarian Diseases | 0.002985861 | 11 | 0 | BeFree |
Multiple Sclerosis | 0.002909916 | 3 | 0 | BeFree_GAD |
HELLP Syndrome | 0.002909916 | 2 | 0 | BeFree_GAD |
Congenital adrenal hyperplasia | 0.00272435 | 1 | 0 | LHGDN |
Angina, Unstable | 0.00272435 | 1 | 0 | LHGDN |
Metabolic Bone Disorder | 0.00272435 | 1 | 0 | LHGDN |
Cognition Disorders | 0.00272435 | 1 | 0 | LHGDN |
Colorectal Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
Dysautonomia | 0.00272435 | 1 | 0 | LHGDN |
Hyperplasia | 0.00272435 | 1 | 0 | LHGDN |
Infertility | 0.00272435 | 1 | 0 | LHGDN |
Biliary cirrhosis | 0.00272435 | 1 | 0 | LHGDN |
Lung Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
Pregnancy Complications | 0.00272435 | 1 | 0 | LHGDN |
Scoliosis, unspecified | 0.00272435 | 1 | 0 | LHGDN |
Starvation | 0.00272435 | 1 | 0 | LHGDN |
Thrombosis | 0.00272435 | 1 | 0 | LHGDN |
Vascular Diseases | 0.00272435 | 1 | 0 | LHGDN |
Venous Thrombosis | 0.00272435 | 1 | 0 | LHGDN |
Ovarian Hyperstimulation Syndrome | 0.00272435 | 1 | 0 | LHGDN |
Pancreatitis, Chronic | 0.00272435 | 1 | 0 | LHGDN |
Aortic Aneurysm, Abdominal | 0.00272435 | 1 | 0 | LHGDN |
Biliary calculi | 0.00272435 | 1 | 0 | LHGDN |
Eclampsia | 0.002714419 | 10 | 0 | BeFree |
Malignant neoplasm of urinary bladder | 0.002638474 | 2 | 0 | BeFree_GAD |
Squamous cell carcinoma | 0.002638474 | 2 | 0 | BeFree_GAD |
Churg-Strauss Syndrome | 0.002638474 | 2 | 0 | BeFree_GAD |
Osteoarthritis, Knee | 0.002638474 | 1 | 0 | BeFree_GAD |
Malignant tumor of colon | 0.002442977 | 9 | 0 | BeFree |
Colon Carcinoma | 0.002442977 | 9 | 0 | BeFree |
Albuminuria | 0.002367032 | 1 | 0 | GAD |
Amyotrophic Lateral Sclerosis | 0.002367032 | 1 | 0 | GAD |
Chorioamnionitis | 0.002367032 | 1 | 0 | GAD |
Endometrial Neoplasms | 0.002367032 | 1 | 0 | GAD |
Fetal Membranes, Premature Rupture | 0.002367032 | 1 | 0 | GAD |
Premature Obstetric Labor | 0.002367032 | 1 | 0 | GAD |
Animal Mammary Neoplasms | 0.002367032 | 1 | 0 | GAD |
Mouth Neoplasms | 0.002367032 | 1 | 0 | GAD |
Pathologic Neovascularization | 0.002367032 | 1 | 0 | GAD |
Pregnancy Complications, Cardiovascular | 0.002367032 | 1 | 0 | GAD |
Uterine Neoplasms | 0.002367032 | 1 | 0 | GAD |
Premature Birth | 0.002367032 | 1 | 0 | GAD |
Malignant neoplasm of esophagus | 0.002367032 | 1 | 0 | GAD |
Microsatellite Instability | 0.002367032 | 1 | 0 | GAD |
Coronary Restenosis | 0.002367032 | 1 | 0 | GAD |
Age at menarche | 0.002367032 | 1 | 0 | GAD |
Weight Loss Adverse Event | 0.002367032 | 1 | 0 | GAD |
Infection of amniotic sac and membranes, unspecified, unspecified trimester, not applicable or unspecified | 0.002367032 | 1 | 0 | GAD |
Granulomatosis with polyangiitis | 0.002367032 | 1 | 0 | GAD |
Hyperglycemia | 0.002171535 | 8 | 0 | BeFree |
Liver neoplasms | 0.002171535 | 8 | 0 | BeFree |
Tumor Progression | 0.002171535 | 8 | 0 | BeFree |
Endometrial Carcinoma | 0.002171535 | 8 | 0 | BeFree |
Prostate carcinoma | 0.002171535 | 8 | 0 | BeFree |
Malignant neoplasm of endometrium | 0.001900093 | 7 | 0 | BeFree |
Malignant neoplasm of stomach | 0.001900093 | 7 | 0 | BeFree |
Prader-Willi Syndrome | 0.001900093 | 7 | 0 | BeFree |
Essential Hypertension | 0.001900093 | 7 | 0 | BeFree |
Malnutrition | 0.001900093 | 7 | 0 | BeFree |
Stomach Carcinoma | 0.001900093 | 7 | 0 | BeFree |
Uterine Corpus Cancer | 0.001900093 | 7 | 0 | BeFree |
Congenital leptin deficiency | 0.001900093 | 7 | 0 | BeFree |
Cachexia | 0.001628651 | 6 | 0 | BeFree |
Hunger | 0.001628651 | 6 | 0 | BeFree |
Secondary malignant neoplasm of lymph node | 0.001628651 | 6 | 0 | BeFree |
Steatohepatitis | 0.001628651 | 6 | 0 | BeFree |
Ovarian Carcinoma | 0.001357209 | 5 | 0 | BeFree |
Pituitary Adenoma | 0.001357209 | 5 | 0 | BeFree |
Impaired glucose tolerance | 0.001357209 | 5 | 0 | BeFree |
Malignant neoplasm of ovary | 0.001357209 | 5 | 0 | BeFree |
Adenoma | 0.001085767 | 4 | 0 | BeFree |
Autoimmune Diseases | 0.001085767 | 4 | 0 | BeFree |
Depressive disorder | 0.001085767 | 4 | 0 | BeFree |
Eating Disorders | 0.001085767 | 4 | 0 | BeFree |
Congestive heart failure | 0.001085767 | 4 | 4 | BeFree |
Hepatitis C | 0.001085767 | 4 | 0 | BeFree |
Immune System Diseases | 0.001085767 | 4 | 0 | BeFree |
leukemia | 0.001085767 | 4 | 0 | BeFree |
Familial generalized lipodystrophy | 0.001085767 | 4 | 0 | BeFree |
Fibrosis, Liver | 0.001085767 | 4 | 0 | BeFree |
Somatotropin deficiency | 0.001085767 | 4 | 0 | BeFree |
Hypothalamic amenorrhea | 0.001085767 | 4 | 0 | BeFree |
Hepatitis C, Chronic | 0.001085767 | 4 | 0 | BeFree |
Carcinoma of lung | 0.001085767 | 4 | 0 | BeFree |
Pediatric Obesity | 0.001085767 | 4 | 0 | BeFree |
Nonalcoholic Steatohepatitis | 0.001085767 | 4 | 0 | BeFree |
Coronary Arteriosclerosis | 0.000814326 | 3 | 0 | BeFree |
Experimental Autoimmune Encephalomyelitis | 0.000814326 | 3 | 0 | BeFree |
Klinefelter Syndrome | 0.000814326 | 3 | 0 | BeFree |
Myeloid Leukemia, Chronic | 0.000814326 | 3 | 0 | BeFree |
Acquired partial lipodystrophy | 0.000814326 | 3 | 1 | BeFree |
Decrease in appetite | 0.000814326 | 3 | 0 | BeFree |
Alcohol withdrawal syndrome | 0.000814326 | 3 | 0 | BeFree |
Papillary thyroid carcinoma | 0.000814326 | 3 | 0 | BeFree |
Adenocarcinoma Of Esophagus | 0.000814326 | 3 | 0 | BeFree |
Obesity, Abdominal | 0.000814326 | 3 | 0 | BeFree |
Thyroid associated opthalmopathies | 0.000814326 | 3 | 0 | BeFree |
Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site | 0.000814326 | 3 | 0 | BeFree |
Bardet-Biedl Syndrome | 0.000814326 | 3 | 0 | BeFree |
Helicobacter pylori infection | 0.000814326 | 3 | 0 | BeFree |
Xenograft Model | 0.000814326 | 3 | 0 | BeFree |
Bulimia Nervosa | 0.000814326 | 3 | 0 | BeFree |
Allergic rhinitis (disorder) | 0.000814326 | 3 | 0 | BeFree |
Insulin resistance syndrome | 0.000814326 | 3 | 0 | BeFree |
Adrenal Gland Neoplasms | 0.000542884 | 2 | 0 | BeFree |
Bipolar Disorder | 0.000542884 | 2 | 0 | BeFree |
Bulimia | 0.000542884 | 2 | 0 | BeFree |
Down Syndrome | 0.000542884 | 2 | 0 | BeFree |
Dwarfism | 0.000542884 | 2 | 0 | BeFree |
Gastritis | 0.000542884 | 2 | 0 | BeFree |
Glioblastoma | 0.000542884 | 2 | 0 | BeFree |
Glioma | 0.000542884 | 2 | 0 | BeFree |
Hydatidiform Mole | 0.000542884 | 2 | 0 | BeFree |
Inflammatory Bowel Diseases | 0.000542884 | 2 | 0 | BeFree |
insulinoma | 0.000542884 | 2 | 0 | BeFree |
Ischemia | 0.000542884 | 2 | 0 | BeFree |
Acute lymphocytic leukemia | 0.000542884 | 2 | 0 | BeFree |
Lipoma | 0.000542884 | 2 | 0 | BeFree |
Lymphoma, Follicular | 0.000542884 | 2 | 0 | BeFree |
Narcolepsy | 0.000542884 | 2 | 0 | BeFree |
Nasal Polyps | 0.000542884 | 2 | 0 | BeFree |
Neuroblastoma | 0.000542884 | 2 | 0 | BeFree |
Psychotic Disorders | 0.000542884 | 2 | 1 | BeFree |
Kidney Failure | 0.000542884 | 2 | 0 | BeFree |
Cerebrovascular accident | 0.000542884 | 2 | 0 | BeFree |
Acute leukemia | 0.000542884 | 2 | 1 | BeFree |
Depressive Symptoms | 0.000542884 | 2 | 0 | BeFree |
Lip and Oral Cavity Carcinoma | 0.000542884 | 2 | 1 | BeFree |
Congenital hypoplasia of adrenal gland | 0.000542884 | 2 | 0 | BeFree |
Chronic schizophrenia | 0.000542884 | 2 | 0 | BeFree |
Sore to touch | 0.000542884 | 2 | 0 | BeFree |
Hypogonadotropic hypogonadism | 0.000542884 | 2 | 0 | BeFree |
Familial partial lipodystrophy | 0.000542884 | 2 | 0 | BeFree |
Liver and Intrahepatic Biliary Tract Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Restenosis | 0.000542884 | 2 | 0 | BeFree |
Malignant neoplasm of liver | 0.000542884 | 2 | 0 | BeFree |
Hematopoietic Neoplasms | 0.000542884 | 2 | 0 | BeFree |
Epithelial ovarian cancer | 0.000542884 | 2 | 0 | BeFree |
Central neuroblastoma | 0.000542884 | 2 | 0 | BeFree |
Ductal Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Adenoma of large intestine | 0.000542884 | 2 | 0 | BeFree |
Mammary Tumorigenesis | 0.000542884 | 2 | 0 | BeFree |
Chronic Kidney Diseases | 0.000542884 | 2 | 0 | BeFree |
androgen independent prostate cancer | 0.000542884 | 2 | 0 | BeFree |
HYDATIDIFORM MOLE, RECURRENT, 1 | 0.000542884 | 2 | 0 | BeFree |
Lipomatosis, Multiple | 0.000542884 | 2 | 0 | BeFree |
LEPTIN RECEPTOR DEFICIENCY | 0.000542884 | 2 | 0 | BeFree |
Isolated somatotropin deficiency | 0.000542884 | 2 | 0 | BeFree |
Adenolymphoma | 0.000271442 | 1 | 0 | BeFree |
Alcoholic Intoxication, Chronic | 0.000271442 | 1 | 0 | BeFree |
Anemia | 0.000271442 | 1 | 0 | BeFree |
Anemia of chronic disease | 0.000271442 | 1 | 0 | BeFree |
Aneurysm | 0.000271442 | 1 | 0 | BeFree |
Anxiety Disorders | 0.000271442 | 1 | 0 | BeFree |
Aortic Aneurysm | 0.000271442 | 1 | 0 | BeFree |
Mental disorders | 0.000271442 | 1 | 0 | BeFree |
Brain Neoplasms | 0.000271442 | 1 | 0 | BeFree |
Non-Small Cell Lung Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Renal Cell Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Transient Ischemic Attack | 0.000271442 | 1 | 0 | BeFree |
Cholera | 0.000271442 | 1 | 0 | BeFree |
Cushing Syndrome | 0.000271442 | 1 | 0 | BeFree |
Diabetic Nephropathy | 0.000271442 | 1 | 0 | BeFree |
Diverticulitis | 0.000271442 | 1 | 0 | BeFree |
Drug abuse | 0.000271442 | 1 | 0 | BeFree |
Dysentery | 0.000271442 | 1 | 0 | BeFree |
Endocrine System Diseases | 0.000271442 | 1 | 0 | BeFree |
External exotoses | 0.000271442 | 1 | 0 | BeFree |
Gastritis, Atrophic | 0.000271442 | 1 | 0 | BeFree |
Heart Diseases | 0.000271442 | 1 | 0 | BeFree |
Hemangioma | 0.000271442 | 1 | 0 | BeFree |
Hepatitis | 0.000271442 | 1 | 0 | BeFree |
Hepatitis A | 0.000271442 | 1 | 0 | BeFree |
Hodgkin Disease | 0.000271442 | 1 | 0 | BeFree |
Hyperlipidemia, Familial Combined | 0.000271442 | 1 | 0 | BeFree |
Hyperparathyroidism | 0.000271442 | 1 | 0 | BeFree |
Pulmonary Hypertension | 0.000271442 | 1 | 0 | BeFree |
Hyperthyroidism | 0.000271442 | 1 | 0 | BeFree |
Immunologic Deficiency Syndromes | 0.000271442 | 1 | 0 | BeFree |
Influenza | 0.000271442 | 1 | 0 | BeFree |
Lethargy | 0.000271442 | 1 | 0 | BeFree |
Acute Erythroblastic Leukemia | 0.000271442 | 1 | 0 | BeFree |
Leukemia, Lymphocytic, Acute, L1 | 0.000271442 | 1 | 2 | BeFree |
liposarcoma | 0.000271442 | 1 | 0 | BeFree |
Lupus Nephritis | 0.000271442 | 1 | 0 | BeFree |
Malabsorption Syndrome | 0.000271442 | 1 | 0 | BeFree |
melanoma | 0.000271442 | 1 | 0 | BeFree |
Premature Menopause | 0.000271442 | 1 | 4 | BeFree |
Mixed Salivary Gland Tumor | 0.000271442 | 1 | 0 | BeFree |
Multiple Myeloma | 0.000271442 | 1 | 0 | BeFree |
Muscular Dystrophy | 0.000271442 | 1 | 0 | BeFree |
Myocardial Infarction | 0.000271442 | 1 | 0 | BeFree |
Myotonic Dystrophy | 0.000271442 | 1 | 0 | BeFree |
Parotid Neoplasms | 0.000271442 | 1 | 0 | BeFree |
Pituitary Neoplasms | 0.000271442 | 1 | 0 | BeFree |
Adenomatous Polyposis Coli | 0.000271442 | 1 | 0 | BeFree |
Precancerous Conditions | 0.000271442 | 1 | 0 | BeFree |
Pyruvate Carboxylase Deficiency Disease | 0.000271442 | 1 | 0 | BeFree |
Retinoblastoma | 0.000271442 | 1 | 0 | BeFree |
Septicemia | 0.000271442 | 1 | 0 | BeFree |
Sleep disturbances | 0.000271442 | 1 | 0 | BeFree |
Stress, Psychological | 0.000271442 | 1 | 0 | BeFree |
Thyroid Diseases | 0.000271442 | 1 | 0 | BeFree |
Attention Deficit Disorder | 0.000271442 | 1 | 0 | BeFree |
Uterine Fibroids | 0.000271442 | 1 | 0 | BeFree |
B-Cell Lymphomas | 0.000271442 | 1 | 0 | BeFree |
Diffuse Large B-Cell Lymphoma | 0.000271442 | 1 | 0 | BeFree |
Lymphoma, Large-Cell, Follicular | 0.000271442 | 1 | 0 | BeFree |
Severe Combined Immunodeficiency | 0.000271442 | 1 | 0 | BeFree |
Burning sensation | 0.000271442 | 1 | 0 | BeFree |
Alcohol abuse | 0.000271442 | 1 | 0 | BeFree |
Disorder of pregnancy | 0.000271442 | 1 | 0 | BeFree |
Arterial thrombosis | 0.000271442 | 1 | 0 | BeFree |
Idiopathic pulmonary hypertension | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of mouth | 0.000271442 | 1 | 1 | BeFree |
Glomerulosclerosis (disorder) | 0.000271442 | 1 | 0 | BeFree |
Liposarcoma, Pleomorphic | 0.000271442 | 1 | 0 | BeFree |
Diabetic Foot | 0.000271442 | 1 | 0 | BeFree |
Nose symptoms | 0.000271442 | 1 | 0 | BeFree |
Congenital diaphragmatic hernia | 0.000271442 | 1 | 0 | BeFree |
Liver mass | 0.000271442 | 1 | 0 | BeFree |
Parathyroid Adenoma | 0.000271442 | 1 | 0 | BeFree |
Congenital hypoplasia of lung | 0.000271442 | 1 | 0 | BeFree |
Endometrioma | 0.000271442 | 1 | 0 | BeFree |
Rabson-Mendenhall Syndrome | 0.000271442 | 1 | 0 | BeFree |
Parathyroid hyperplasia | 0.000271442 | 1 | 0 | BeFree |
Carcinoma breast stage IV | 0.000271442 | 1 | 0 | BeFree |
Healing ulcer | 0.000271442 | 1 | 0 | BeFree |
Senile Plaques | 0.000271442 | 1 | 0 | BeFree |
Impaired cognition | 0.000271442 | 1 | 0 | BeFree |
Aortic aneurysm without mention of rupture NOS | 0.000271442 | 1 | 0 | BeFree |
Constitutional delay of growth and puberty | 0.000271442 | 1 | 0 | BeFree |
Precocious Puberty, Central | 0.000271442 | 1 | 0 | BeFree |
Growth Hormone-Secreting Pituitary Adenoma | 0.000271442 | 1 | 0 | BeFree |
Chronic superficial gastritis | 0.000271442 | 1 | 0 | BeFree |
Nonorganic psychosis | 0.000271442 | 1 | 0 | BeFree |
Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site | 0.000271442 | 1 | 0 | BeFree |
Chronic Kidney Insufficiency | 0.000271442 | 1 | 0 | BeFree |
Congenital Myotonic Dystrophy | 0.000271442 | 1 | 0 | BeFree |
Gastrointestinal symptom | 0.000271442 | 1 | 0 | BeFree |
Klinefelter's syndrome - male with more than two X chromosomes | 0.000271442 | 1 | 0 | BeFree |
Chronic active hepatitis | 0.000271442 | 1 | 0 | BeFree |
Peritoneal Fibrosis | 0.000271442 | 1 | 0 | BeFree |
Carotid Atherosclerosis | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of gastrointestinal tract | 0.000271442 | 1 | 0 | BeFree |
Diabetic peripheral neuropathy | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of kidney | 0.000271442 | 1 | 0 | BeFree |
Premenopausal breast cancer | 0.000271442 | 1 | 0 | BeFree |
Hypothalamic Dysfunction Syndromes | 0.000271442 | 1 | 0 | BeFree |
Narcolepsy-Cataplexy Syndrome | 0.000271442 | 1 | 0 | BeFree |
Viral hepatitis, type G | 0.000271442 | 1 | 0 | BeFree |
Sleep Disorders | 0.000271442 | 1 | 0 | BeFree |
Invasive breast carcinoma | 0.000271442 | 1 | 0 | BeFree |
Diabetic Cardiomyopathies | 0.000271442 | 1 | 0 | BeFree |
Advanced cancer | 0.000271442 | 1 | 0 | BeFree |
Acute Coronary Syndrome | 0.000271442 | 1 | 0 | BeFree |
Gestational Trophoblastic Neoplasms | 0.000271442 | 1 | 0 | BeFree |
Compensatory Hyperinsulinemia | 0.000271442 | 1 | 1 | BeFree |
Attention deficit hyperactivity disorder | 0.000271442 | 1 | 0 | BeFree |
Cardiovascular morbidity | 0.000271442 | 1 | 0 | BeFree |
Sporadic Breast Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Epithelioma | 0.000271442 | 1 | 0 | BeFree |
Renal carcinoma | 0.000271442 | 1 | 0 | BeFree |
Secondary Peritonitis | 0.000271442 | 1 | 0 | BeFree |
Diabetic foot ulcer | 0.000271442 | 1 | 0 | BeFree |
Skin Carcinogenesis | 0.000271442 | 1 | 0 | BeFree |
Neoplasms, Intracranial | 0.000271442 | 1 | 0 | BeFree |
Glioblastoma Multiforme | 0.000271442 | 1 | 0 | BeFree |
Familial Partial Lipodystrophy, Type 1 | 0.000271442 | 1 | 0 | BeFree |
Osteophyte | 0.000271442 | 1 | 0 | BeFree |
Adiponectin Deficiency | 0.000271442 | 1 | 0 | BeFree |
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis | 0.000271442 | 1 | 0 | BeFree |
Obesity, Visceral | 0.000271442 | 1 | 0 | BeFree |
Plaque, Amyloid | 0.000271442 | 1 | 0 | BeFree |
Pulmonary arterial hypertension | 0.000271442 | 1 | 0 | BeFree |
Diabetic Heart Disease | 0.000271442 | 1 | 0 | BeFree |
dowling-degos disease | 0.000271442 | 1 | 0 | BeFree |
Pulmonary Hypertension, Primary, 1, With Hereditary Hemorrhagic Telangiectasia | 0.000271442 | 1 | 0 | BeFree |
Obesity in animals | 0.000271442 | 1 | 0 | BeFree |
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