LEP(leptin)

基因简称(symbol)
    [HGNC]     [GeneCards]     [NCBI]
基因种类(locus group)
同源简称(alias symbol)
基因家族代码(gene_family_id)
    [HGNC]     [GenScript]
omim代码
entrez码
    [Vega]
vega基因码
ensembl基因码
    [Ensembl]
基因家族(gene family)
refseq数据库代号

更多...

基因种类(locus_type)
基因名称状态(status)
location_sortable
同源基因名称(alias name)
基因名称批准使用时间(date_approved_reserved)
基因简称更名时间(date_symbol_changed)
基因名称更名时间(date_name_changed)
更新时间(date_modified)
ucsc码
ena
ccds数据码
uniprot数据码
pubmed代码
mgd码
rgd码
生命科学数据库(lsdb)
更新时间(date modified)
cosmic
mirbase
基因曾用简称(prev symbol)
基因曾用名称(prev name)
homeodb
cosmic
snornabase
bioparadigms slc
orphanet
假基因信息(pseudogeneorg)
horde id
merops
imgt
iuphar
kznf基因类别
mamit-trnadb
cd
LncRNA数据库
酶代码
中间纤维数据库
7q31

This gene encodes a protein that is secreted by white adipocytes, and which plays a major role in the regulation of body weight. This protein, which acts through the leptin receptor, functions as part of a signaling pathway that can inhibit food intake and/or regulate energy expenditure to maintain constancy of the adipose mass. This protein also has several endocrine functions, and is involved in the regulation of immune and inflammatory responses, hematopoiesis, angiogenesis and wound healing. Mutations in this gene and/or its regulatory regions cause severe obesity, and morbid obesity with hypogonadism. This gene has also been linked to type 2 diabetes mellitus development. [provided by RefSeq, Jul 2008]

[中文简述(自动翻译):]  该基因编码由白色脂肪细胞分泌的蛋白质,并起着在体重调节中起主要作用。这种蛋白质,它通过瘦素受体的作用,起到可以抑制食物摄入和/或调节能量消耗以维持脂肪质量的恒定信号传导途径的一部分。这种蛋白也有几个内分泌功能,并参与的免疫和炎症反应,造血,血管发生和伤口愈合的调节。在此基因和/或它的调控区的突变导致严重的肥胖和与性腺功能减退病态肥胖。这种基因也被链接到2型糖尿病的发展。 [由RefSeq的,2008年7月提供]

LEP基因的碱基序列:[NCBI]
LEP基因的碱基突变:           显示全部snp
rs791616       rs791617       rs791618       rs791619       rs791620       rs1031340       rs1349398       rs1800564       rs1800583       rs2060713       rs2071045       rs2122627       rs2167270       rs2278814       rs2278815       rs3750034       rs3793162       rs3828942       rs4236625       rs4728096       rs4731426       rs4731427       rs6956510       rs6966536       rs6976701       rs7788818       rs7791621       rs7795794       rs7796202       rs10243710       rs10244329       rs10257175       rs10258300       rs10262600       rs10264361       rs10277407       rs10676401      
rs10954174       rs11380467       rs11760956       rs11761556       rs11763517       rs11973652       rs11978419       rs11980266       rs12536535       rs12706831       rs12706832       rs13228377       rs13306516       rs13306517       rs13306518       rs17151913       rs17151914       rs17151919       rs17151922       rs17617757       rs28391558       rs28756049       rs28954080       rs28954081       rs28954083       rs28954084       rs28954086       rs28954087       rs28954088       rs28954089       rs28954090       rs28954091       rs28954092       rs28954093       rs28954094       rs28954095       rs28954096       rs28954097       rs28954098       rs28954099       rs28954100       rs28954101       rs28954102       rs28954103       rs28954104       rs28954105       rs28954106       rs28954107       rs28954108       rs28954109       rs28954110       rs28954111       rs28954112       rs28954113       rs28954114       rs28954115       rs28954116       rs28954117       rs28954118       rs28954369       rs28954370       rs28954371       rs28954372       rs28954373       rs28954374       rs28954375       rs28954376       rs28954377       rs28954378       rs28954379       rs28959468       rs28959469       rs28959470       rs28959471       rs28959472       rs28959473       rs28959474       rs28959475       rs28959476       rs28959477       rs28959478       rs34104384       rs35048003       rs36219262       rs41434248       rs41457646       rs41474844       rs41526944       rs41528456       rs56247456       rs56394457       rs57191509       rs59357245       rs61153576       rs61520280       rs62481073       rs66818646       rs70940807       rs70940808       rs71578254       rs71904498       rs71973524       rs73226681       rs73721326       rs74423439       rs75062545       rs75506045       rs76601079       rs77268534       rs77281811       rs77448332       rs77515392       rs111305916       rs111365240       rs111413395       rs111544798       rs111616216       rs111628365       rs111650508       rs111880866       rs112067975       rs112070222       rs112128511       rs112193540       rs112344366       rs112734810       rs113112089       rs113200967       rs113277332       rs113405088       rs113837181       rs114122063       rs114650087       rs114834517       rs114840134       rs114915388       rs114915709       rs114964194       rs115650748       rs116086890       rs116857910       rs117049059       rs118143276       rs137975623       rs138049608       rs138251528       rs138289049       rs138636985       rs138908051       rs139082407       rs139392472       rs139459016       rs139576122       rs139781325       rs139962194       rs140383020       rs140447473       rs140483549       rs140510728       rs140782690       rs140880909       rs140936524       rs140945619       rs141046416       rs141256175       rs141314857       rs141758001       rs142057007       rs142396524       rs142560926       rs142623551       rs142904532       rs142998315       rs143088141       rs143229153       rs143352223       rs143983443       rs144164446       rs144195028       rs144755411       rs145044661       rs145064090       rs145542727       rs145609186       rs145625824       rs145663745       rs145691400       rs145707401       rs146236504       rs146556007       rs146574563       rs147031287       rs147166686       rs147743935       rs147921807       rs147938367       rs148057336       rs148407750       rs148577397       rs148703404       rs148774522       rs148861526       rs149228774       rs149386046       rs149734198       rs149859930       rs149911234       rs150204746       rs150257621       rs151325384       rs180675592       rs180968923       rs181029455       rs181271386       rs181616136       rs181791569       rs181836716       rs182123400       rs182126597       rs182169554       rs182552738       rs182792491       rs182961864       rs182970851       rs182979954       rs183582933       rs183801334       rs183846952       rs183910300       rs184172933       rs184444762       rs184483586       rs184715984       rs184775528       rs184900134       rs185102245       rs185297141       rs185451543       rs185545324       rs186091007       rs186347613       rs186624903       rs186896865       rs187235717       rs187363668       rs187586889       rs187705106       rs187788556       rs188026445       rs188329717       rs188789653       rs188857005       rs188857788       rs189036735       rs189202459       rs189428321       rs189445518       rs189498205       rs189864892       rs189957581       rs190027670       rs190178572       rs190504107       rs190525190       rs191070405       rs191349329       rs191600447       rs191625064       rs191666811       rs191912842       rs191998411       rs192215645       rs192232228       rs192448737       rs192460908       rs192469663       rs192559065       rs192659102       rs192696222       rs192763413       rs193025377       rs199506740       rs199647957       rs199851800       rs199879263       rs199886391       rs200061184       rs200090823       rs200092598       rs200128238       rs200179130       rs200202828       rs200215279       rs200343690       rs200487172       rs200556203       rs200680655       rs200738664       rs200748706       rs200783954       rs200819049       rs200887574       rs200893300       rs200983754       rs201075060       rs201114917       rs201185232       rs201335762       rs201425072       rs201430198       rs201523305       rs201563706       rs201644572       rs201666040       rs201666212       rs202158844       rs202169453       rs367606905       rs367989355       rs368669939       rs369326860       rs369454561       rs369666776       rs369973417       rs370628994       rs370747795       rs371212476       rs372064089       rs372892330       rs374067243       rs376720962       rs376797492       rs377652380       rs527269851       rs527270386       rs527426473       rs527944139       rs527982022       rs528263164       rs528344404       rs528417186       rs528475040       rs528618720       rs528670205       rs528803344       rs528907372       rs529044416       rs529261199       rs529352001       rs529415881       rs529969253       rs530223433       rs530356788       rs530488455       rs530691140       rs530798163       rs530870581       rs530887343       rs531020721       rs531200319       rs531320870       rs532593154       rs532728166       rs532895974       rs533124780       rs533213771       rs533377154       rs533915494       rs534368735       rs534766922       rs534801388       rs534946367       rs535059179       rs535189535       rs535484770       rs536171617       rs536300548       rs536449594       rs536845351       rs536850931       rs537044765       rs537154218       rs537238364       rs537408501       rs537668679       rs538575372       rs538776321       rs538843747       rs539043923       rs539216918       rs539231793       rs539375230       rs539703785       rs540002541       rs540145077       rs540583697       rs540732424       rs540784718       rs540861814       rs540869327       rs540887934       rs541083926       rs541808422       rs542065935       rs542451402       rs542496835       rs542509256       rs542634302       rs542693763       rs542767893       rs542785092       rs542938394       rs543120440       rs543426453       rs543500887       rs543986826       rs544124121       rs544172584       rs544656411       rs544740653       rs544785437       rs544915771       rs544918586       rs545055335       rs545168567       rs545231600       rs545503888       rs545511953       rs545535648       rs545969860       rs546297631       rs546442259       rs546822017       rs547565590       rs547611951       rs548287563       rs548406290       rs548421466       rs548473596       rs548512531       rs548547891       rs548622986       rs548750183       rs548830222       rs548986509       rs549084379       rs549387574       rs549572152       rs549666685       rs549755515       rs549787749       rs550268192       rs550407244       rs550481265       rs550483834       rs550660002       rs550819996       rs550934343       rs550980386       rs551039970       rs551057181       rs551066627       rs551205215       rs551460466       rs551777942       rs551841070       rs552233482       rs552257532       rs552331304       rs552396011       rs552396420       rs552504144       rs552525781       rs552804950       rs552905919       rs553227670       rs553533124       rs553883123       rs553893087       rs554045650       rs554046612       rs554048528       rs554363383       rs554553746       rs554578326       rs554636687       rs554698703       rs554774511       rs554912094       rs555391338       rs555803469       rs555809676       rs556030836       rs556118513       rs556176595       rs556312424       rs556570807       rs556571059       rs556613564       rs556887264       rs557166360       rs557226136       rs557295451       rs557356868       rs557762124       rs558361243       rs558538763       rs558558883       rs558711204       rs558751063       rs559409892       rs559480281       rs559602267       rs559791973       rs560126792       rs560192542       rs560330702       rs560478489       rs560548660       rs560557436       rs560764984       rs561034891       rs561138870       rs561366927       rs561502579       rs561565672       rs561644263       rs561831965       rs562177484       rs562297564       rs562357481       rs562435647       rs562446260       rs562582185       rs562645794       rs562823740       rs562917906       rs562963651       rs562963741       rs562977237       rs563494919       rs563496952       rs563632426       rs563847116       rs564293280       rs564459772       rs564819686       rs565610542       rs565819571       rs565962151       rs566092459       rs566098165       rs566222394       rs566757746       rs567270356       rs567832706       rs567986053       rs568002113       rs568046253       rs568183388       rs568205722       rs568266509       rs568321962       rs568589480       rs569625961       rs569793640       rs569795585       rs569856687       rs569945748       rs570474073       rs570649154       rs570757178       rs570780403       rs570962832       rs571251915       rs571287629       rs571871678       rs571947076       rs572010306       rs572074659       rs572146155       rs572411756       rs572430608       rs572493327       rs572525410       rs572547898       rs572552624       rs572771182       rs573183887       rs573393701       rs573441193       rs573473094       rs573626161       rs573997147       rs574100483       rs574229695       rs574288758       rs574318825       rs574355293       rs574454243       rs574488332       rs574760338       rs574796481       rs574894662       rs574895005       rs575035900       rs575918652       rs576032290       rs576114940       rs576172645       rs576230987       rs576386071       rs576502923       rs576773371       rs577075127       rs577639649       rs577856938       rs577978474       rs578073103       rs578134035       rs578179592       rs578230598       rs724159998       rs745576625       rs746345055       rs746638855       rs747703977       rs748045988       rs748355602       rs748408158       rs748689932       rs749036875       rs749826393       rs749909441       rs750649453       rs751272426       rs751787424       rs752116983       rs752496962       rs753250158       rs754347841       rs754432094       rs754814806       rs755102882       rs755477612       rs755602975       rs756180416       rs757461967       rs757558286       rs757560540       rs757709363       rs758826659       rs759018010       rs759056593       rs759465484       rs759854910       rs760165439       rs760301529       rs760494076       rs761170909       rs761690570       rs763150646       rs763338727       rs764638610       rs764732607       rs765203455       rs765418389       rs765869630       rs765889494       rs766459987       rs767150017       rs768219399       rs768428766       rs768906704       rs769051518       rs770122731       rs770247453       rs770663636       rs770761500       rs771139087       rs771590018       rs771956117       rs772575402       rs772913958       rs773031071       rs773667205       rs774152821       rs774906243       rs775557183       rs775675640       rs775874401       rs776318015       rs776443424       rs777124610       rs777989230       rs778907825       rs779193447       rs779227922       rs779501960       rs779508377       rs779780275       rs780163329       rs780470938       rs780990529       rs781301976      

LEP基因在不同组织中的表达:    [UniProt]

基因在不同组织中的表达图
正向引物序列
正向引物Tm值
反向引物序列
反向引物Tm值
rank
TCATCAAGACAATTGTCACCAG
59
TTTGGAGGAGACTGACTGC
59
CTCATCAAGACAATTGTCACCA
59
TTTGGAGGAGACTGACTGC
59
CATCAAGACAATTGTCACCAG
58
TTTGGAGGAGACTGACTGC
59
      尚未收录相关数据

LEP基因(以及对应的蛋白质)的细胞分布位置:

[UniProt]     [GenomeNet]

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 溶酶体
  • 内涵体
  • 细胞核
  • 细胞质
  • 液泡
  • 细胞膜
  • 细胞外基质
  • 内质网
  • 线粒体
  • 高尔基体
  • 细胞骨架

LEP基因的本体(GO)信息:

GO库代码
对应的蛋白质
来源代码
GO:0000122
P41159(UniProtKB)
IEA
GO:0001525
P41159(UniProtKB)
IDA
GO:0001525
P41159(UniProtKB)
IDA
GO:0001542
P41159(UniProtKB)
IEA
GO:0001666
P41159(UniProtKB)
IEA
GO:0001819
P41159(UniProtKB)
IEA
GO:0001890
P41159(UniProtKB)
IDA
GO:0001936
P41159(UniProtKB)
IDA
GO:0002021
P41159(UniProtKB)
IEA
GO:0002021
P41159(UniProtKB)
IEA
GO:0003300
P41159(UniProtKB)
IEA
GO:0005179
P41159(UniProtKB)
IBA
GO:0005576
P41159(UniProtKB)
TAS
GO:0005576
P41159(UniProtKB)
TAS
GO:0005576
P41159(UniProtKB)
TAS
GO:0005576
P41159(UniProtKB)
TAS
GO:0005615
P41159(UniProtKB)
ISS
GO:0005737
P41159(UniProtKB)
IEA
GO:0006006
P41159(UniProtKB)
IEA
GO:0006111
P41159(UniProtKB)
IEA
GO:0006112
P41159(UniProtKB)
IEA
GO:0006114
P41159(UniProtKB)
IEA
GO:0006629
P41159(UniProtKB)
IBA
GO:0006635
P41159(UniProtKB)
IEA
GO:0007260
P41159(UniProtKB)
IBA
GO:0007565
P41159(UniProtKB)
IEA
GO:0007623
P41159(UniProtKB)
IEA
GO:0008083
P41159(UniProtKB)
IEA
GO:0008203
P41159(UniProtKB)
IEA
GO:0008206
P41159(UniProtKB)
IEA
GO:0008217
P41159(UniProtKB)
IEA
GO:0008343
P41159(UniProtKB)
ISS
GO:0010507
P41159(UniProtKB)
IDA
GO:0010888
P41159(UniProtKB)
IEA
GO:0014068
P41159(UniProtKB)
ISS
GO:0014068
P41159(UniProtKB)
ISS
GO:0014068
P41159(UniProtKB)
IDA
GO:0014823
P41159(UniProtKB)
IEA
GO:0019953
P41159(UniProtKB)
IMP
GO:0021954
P41159(UniProtKB)
IEA
GO:0030073
P41159(UniProtKB)
IEA
GO:0030217
P41159(UniProtKB)
ISS
GO:0030300
P41159(UniProtKB)
IEA
GO:0032008
P41159(UniProtKB)
IDA
GO:0032099
P41159(UniProtKB)
ISS
GO:0032310
P41159(UniProtKB)
IDA
GO:0032355
P41159(UniProtKB)
IEA
GO:0032814
P41159(UniProtKB)
IDA
GO:0032817
P41159(UniProtKB)
IDA
GO:0032868
P41159(UniProtKB)
IBA
GO:0033197
P41159(UniProtKB)
IEA
GO:0033210
P41159(UniProtKB)
ISS
GO:0033210
P41159(UniProtKB)
ISS
GO:0033686
P41159(UniProtKB)
IEA
GO:0035360
P41159(UniProtKB)
IEA
GO:0035630
P41159(UniProtKB)
IEA
GO:0038108
P41159(UniProtKB)
ISS
GO:0038108
P41159(UniProtKB)
IBA
GO:0042102
P41159(UniProtKB)
IDA
GO:0042269
P41159(UniProtKB)
IDA
GO:0042445
P41159(UniProtKB)
IEA
GO:0042517
P41159(UniProtKB)
IEA
GO:0042593
P41159(UniProtKB)
IEA
GO:0042755
P41159(UniProtKB)
IEA
GO:0043066
P41159(UniProtKB)
IEA
GO:0043270
P41159(UniProtKB)
IEA
GO:0043410
P41159(UniProtKB)
ISS
GO:0043410
P41159(UniProtKB)
IDA
GO:0044320
P41159(UniProtKB)
IDA
GO:0045471
P41159(UniProtKB)
IEA
GO:0045639
P41159(UniProtKB)
IEA
GO:0045765
P41159(UniProtKB)
IDA
GO:0045906
P41159(UniProtKB)
IEA
GO:0046325
P41159(UniProtKB)
IDA
GO:0046427
P41159(UniProtKB)
IDA
GO:0046628
P41159(UniProtKB)
IEA
GO:0046850
P41159(UniProtKB)
ISS
GO:0046881
P41159(UniProtKB)
IEA
GO:0048639
P41159(UniProtKB)
IDA
GO:0050796
P41159(UniProtKB)
IEA
GO:0050810
P41159(UniProtKB)
IEA
GO:0050892
P41159(UniProtKB)
IDA
GO:0050901
P41159(UniProtKB)
IEA
GO:0050999
P41159(UniProtKB)
IDA
GO:0051428
P41159(UniProtKB)
IBA
GO:0051726
P41159(UniProtKB)
IDA
GO:0051897
P41159(UniProtKB)
ISS
GO:0060587
P41159(UniProtKB)
IEA
GO:0060612
P41159(UniProtKB)
IEA
GO:0061037
P41159(UniProtKB)
IEA
GO:0070093
P41159(UniProtKB)
IEA
GO:0071298
P41159(UniProtKB)
IEA
GO:0071300
P41159(UniProtKB)
IEA
GO:0072604
P41159(UniProtKB)
IDA
GO:0072606
P41159(UniProtKB)
IDA
GO:0090335
P41159(UniProtKB)
ISS
GO:0098868
P41159(UniProtKB)
ISS
GO:1900015
P41159(UniProtKB)
IDA
GO:1900745
P41159(UniProtKB)
IDA
GO:1904651
P41159(UniProtKB)
IEA
GO:1990051
P41159(UniProtKB)
IDA
GO:2000366
P41159(UniProtKB)
IBA
GO:2000379
P41159(UniProtKB)
IEA
GO:2000486
P41159(UniProtKB)
IEA
GO:2000491
P41159(UniProtKB)
IEA
基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

可能调控LEP基因的相关microRNA:     


通路基因列表
疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Obesity 0.44 598 31 BeFree_CTD_human_GAD_MGD_RGD
LEPTIN DEFICIENCY OR DYSFUNCTION 0.367600372 29 1 BeFree_CLINVAR_ORPHANET_UNIPROT
Diabetes Mellitus, Non-Insulin-Dependent 0.321224284 61 5 BeFree_CTD_human_GAD_LHGDN_MGD_RGD
Hypertensive disease 0.240158379 38 2 BeFree_CTD_human_GAD_LHGDN_RGD
Metabolic Syndrome X 0.216948948 48 1 BeFree_CTD_human_GAD_RGD
Insulin Resistance 0.202367032 4 0 CTD_human_GAD_RGD
Hypogonadism 0.201357209 7 0 BeFree_CTD_human_RGD
Alzheimer's Disease 0.200542884 4 0 BeFree_CTD_human_RGD
Liver Cirrhosis, Experimental 0.2 2 0 CTD_human_RGD
Mammary Neoplasms 0.150143487 23 0 BeFree_CTD_human_GAD_LHGDN
Inflammation 0.139070452 8 0 CTD_human_LHGDN
Weight Gain 0.138936256 11 0 CTD_human_GAD
Polycystic Ovary Syndrome 0.136521735 17 0 BeFree_CTD_human_GAD_LHGDN
Hyperinsulinism 0.134687656 28 0 BeFree_CTD_human_LHGDN
Gestational Diabetes 0.131430353 16 0 BeFree_CTD_human_LHGDN
Fatty Liver 0.130530151 17 0 BeFree_CTD_human_GAD_LHGDN
Obesity, Morbid 0.128338753 24 0 BeFree_CTD_human_GAD
Prostatic Neoplasms 0.128173051 4 0 CTD_human_LHGDN
Colonic Neoplasms 0.127729856 5 0 BeFree_CTD_human_GAD_LHGDN
Hyperphagia 0.122442977 10 1 BeFree_CTD_human
Crohn Disease 0.121085767 4 0 BeFree_CTD_human
Non-alcoholic Fatty Liver Disease 0.121085767 5 1 BeFree_CTD_human
Seizures 0.120542884 3 0 BeFree_CTD_human
Hypercholesterolemia 0.120271442 2 0 BeFree_CTD_human
Polyuria 0.120271442 2 0 BeFree_CTD_human
Autistic Disorder 0.12 1 0 CTD_human
Heroin Dependence 0.12 1 0 CTD_human
Female infertility 0.12 1 0 CTD_human
Nerve Degeneration 0.12 1 0 CTD_human
Proteinuria 0.12 1 0 CTD_human
Gastric ulcer 0.12 6 0 CTD_human
Tachycardia 0.12 1 0 CTD_human
Polydipsia 0.12 1 0 CTD_human
Oral Ulcer 0.12 1 0 CTD_human
Hepatitis, Autoimmune 0.12 1 0 CTD_human
Arthritis, Experimental 0.12 1 0 CTD_human
Pre-Eclampsia 0.102732561 8 0 GAD_LHGDN_RGD
Huntington Disease 0.082995792 3 0 BeFree_LHGDN_RGD
Fetal Growth Retardation 0.08272435 2 0 LHGDN_RGD
Osteoporosis 0.081085767 6 0 BeFree_RGD
Hyperlipidemia 0.080814326 4 0 BeFree_RGD
Sepsis 0.080271442 2 0 BeFree_RGD
Body Weight Changes 0.08 1 0 RGD
Diabetes Mellitus, Experimental 0.08 2 0 RGD
Mammary Neoplasms, Experimental 0.08 1 0 RGD
Myocardial Reperfusion Injury 0.08 1 0 RGD
Parkinson Disease 0.08 1 0 RGD
Reperfusion Injury 0.08 1 0 RGD
Short Bowel Syndrome 0.08 1 0 RGD
Choroidal Neovascularization 0.08 1 0 RGD
Abdominal obesity metabolic syndrome 0.08 0 0 MGD
Malignant neoplasm of breast 0.022920669 68 0 BeFree_GAD
Weight Gain Adverse Event 0.018936256 8 0 GAD
Breast Carcinoma 0.017915164 66 0 BeFree
Anorexia Nervosa 0.014707519 9 0 BeFree_LHGDN
Endometriosis 0.011983168 7 0 BeFree_LHGDN
Diabetes Mellitus 0.011681932 34 0 BeFree_LHGDN
Overweight 0.010977227 24 0 BeFree_GAD
Diabetes Mellitus, Insulin-Dependent 0.010086957 12 0 BeFree_GAD
Neoplasm Metastasis 0.00979177 18 0 BeFree_LHGDN
Cardiovascular Diseases 0.009705894 18 1 BeFree_GAD_LHGDN
Dyslipidemias 0.009444384 9 0 BeFree_GAD_LHGDN
Malignant neoplasm of prostate 0.009272631 10 0 BeFree_GAD
Schizophrenia 0.008815624 7 0 BeFree_GAD_LHGDN
Colorectal Cancer 0.008805692 15 1 BeFree_GAD
Lipodystrophy 0.008706003 14 0 BeFree_LHGDN
Liver carcinoma 0.008706003 12 0 BeFree_LHGDN
Diabetes 0.008414698 31 0 BeFree
Asthma 0.008358616 3 0 BeFree_GAD_LHGDN
Infection 0.008173051 3 0 LHGDN
Carcinogenesis 0.008143256 30 0 BeFree
Kidney Failure, Chronic 0.008087174 4 0 BeFree_GAD_LHGDN
Sleep Apnea, Obstructive 0.008001298 4 0 BeFree_GAD_LHGDN
Anoxia 0.007815732 3 0 GAD_LHGDN
Lymphoma 0.00764398 5 1 BeFree_GAD
Anorexia 0.00706742 17 0 BeFree_LHGDN
Coronary heart disease 0.006263026 5 0 BeFree_LHGDN
Metabolic Diseases 0.005981653 12 0 BeFree_LHGDN
Malignant neoplasm of lung 0.005819831 5 0 BeFree_GAD
Behcet Syndrome 0.005634266 3 0 BeFree_GAD_LHGDN
Kidney Diseases 0.005634266 3 0 BeFree_GAD_LHGDN
Chronic Obstructive Airway Disease 0.005634266 4 0 BeFree_GAD_LHGDN
Liver Cirrhosis 0.0054487 2 0 LHGDN
Nephrotic Syndrome 0.0054487 2 0 LHGDN
Stomach Neoplasms 0.0054487 2 0 LHGDN
Immune thrombocytopenic purpura 0.0054487 2 0 LHGDN
Degenerative polyarthritis 0.005438769 11 0 BeFree_LHGDN
Pituitary Diseases 0.005157396 19 0 BeFree
Pregnancy associated hypertension 0.005091382 2 0 GAD_LHGDN
Pregnancy in Diabetics 0.005005506 3 0 BeFree_GAD
body mass 0.004734064 2 0 GAD
Leukemia, Myelocytic, Acute 0.00408156 6 0 BeFree_LHGDN
Colorectal Carcinoma 0.004071628 15 1 BeFree
Coronary Artery Disease 0.003810118 5 0 BeFree_LHGDN
Rheumatoid Arthritis 0.003538676 4 1 BeFree_LHGDN
Choriocarcinoma 0.003538676 4 0 BeFree_LHGDN
Lupus Erythematosus, Systemic 0.003538676 4 0 BeFree_LHGDN
Mental Depression 0.003452799 4 0 BeFree_GAD
Adenocarcinoma 0.003267234 3 0 BeFree_LHGDN
Ulcerative Colitis 0.003267234 3 0 BeFree_LHGDN
HIV Infections 0.003267234 3 0 BeFree_LHGDN
Myoma 0.003267234 2 0 BeFree_LHGDN
Psoriasis 0.003267234 2 0 BeFree_LHGDN
Rett Syndrome 0.003267234 3 0 BeFree_LHGDN
Precursor Cell Lymphoblastic Leukemia Lymphoma 0.003267234 3 0 BeFree_LHGDN
Heart failure 0.003181358 4 0 BeFree_GAD
Liver diseases 0.003181358 4 0 BeFree_GAD
Lymphoma, Non-Hodgkin 0.003181358 4 0 BeFree_GAD
Arthritis 0.002995792 2 0 BeFree_LHGDN
Hypothyroidism 0.002995792 2 0 BeFree_LHGDN
Placental Insufficiency 0.002995792 1 0 BeFree_LHGDN
Ankylosing spondylitis 0.002995792 2 0 BeFree_LHGDN
Uremia 0.002995792 2 0 BeFree_LHGDN
Multiple Sclerosis, Relapsing-Remitting 0.002995792 2 0 BeFree_LHGDN
Major Depressive Disorder 0.002995792 2 0 BeFree_LHGDN
Arteriosclerosis 0.002985861 11 2 BeFree
Atherosclerosis 0.002985861 11 2 BeFree
Ovarian Diseases 0.002985861 11 0 BeFree
Multiple Sclerosis 0.002909916 3 0 BeFree_GAD
HELLP Syndrome 0.002909916 2 0 BeFree_GAD
Congenital adrenal hyperplasia 0.00272435 1 0 LHGDN
Angina, Unstable 0.00272435 1 0 LHGDN
Metabolic Bone Disorder 0.00272435 1 0 LHGDN
Cognition Disorders 0.00272435 1 0 LHGDN
Colorectal Neoplasms 0.00272435 1 0 LHGDN
Dysautonomia 0.00272435 1 0 LHGDN
Hyperplasia 0.00272435 1 0 LHGDN
Infertility 0.00272435 1 0 LHGDN
Biliary cirrhosis 0.00272435 1 0 LHGDN
Lung Neoplasms 0.00272435 1 0 LHGDN
Pregnancy Complications 0.00272435 1 0 LHGDN
Scoliosis, unspecified 0.00272435 1 0 LHGDN
Starvation 0.00272435 1 0 LHGDN
Thrombosis 0.00272435 1 0 LHGDN
Vascular Diseases 0.00272435 1 0 LHGDN
Venous Thrombosis 0.00272435 1 0 LHGDN
Ovarian Hyperstimulation Syndrome 0.00272435 1 0 LHGDN
Pancreatitis, Chronic 0.00272435 1 0 LHGDN
Aortic Aneurysm, Abdominal 0.00272435 1 0 LHGDN
Biliary calculi 0.00272435 1 0 LHGDN
Eclampsia 0.002714419 10 0 BeFree
Malignant neoplasm of urinary bladder 0.002638474 2 0 BeFree_GAD
Squamous cell carcinoma 0.002638474 2 0 BeFree_GAD
Churg-Strauss Syndrome 0.002638474 2 0 BeFree_GAD
Osteoarthritis, Knee 0.002638474 1 0 BeFree_GAD
Malignant tumor of colon 0.002442977 9 0 BeFree
Colon Carcinoma 0.002442977 9 0 BeFree
Albuminuria 0.002367032 1 0 GAD
Amyotrophic Lateral Sclerosis 0.002367032 1 0 GAD
Chorioamnionitis 0.002367032 1 0 GAD
Endometrial Neoplasms 0.002367032 1 0 GAD
Fetal Membranes, Premature Rupture 0.002367032 1 0 GAD
Premature Obstetric Labor 0.002367032 1 0 GAD
Animal Mammary Neoplasms 0.002367032 1 0 GAD
Mouth Neoplasms 0.002367032 1 0 GAD
Pathologic Neovascularization 0.002367032 1 0 GAD
Pregnancy Complications, Cardiovascular 0.002367032 1 0 GAD
Uterine Neoplasms 0.002367032 1 0 GAD
Premature Birth 0.002367032 1 0 GAD
Malignant neoplasm of esophagus 0.002367032 1 0 GAD
Microsatellite Instability 0.002367032 1 0 GAD
Coronary Restenosis 0.002367032 1 0 GAD
Age at menarche 0.002367032 1 0 GAD
Weight Loss Adverse Event 0.002367032 1 0 GAD
Infection of amniotic sac and membranes, unspecified, unspecified trimester, not applicable or unspecified 0.002367032 1 0 GAD
Granulomatosis with polyangiitis 0.002367032 1 0 GAD
Hyperglycemia 0.002171535 8 0 BeFree
Liver neoplasms 0.002171535 8 0 BeFree
Tumor Progression 0.002171535 8 0 BeFree
Endometrial Carcinoma 0.002171535 8 0 BeFree
Prostate carcinoma 0.002171535 8 0 BeFree
Malignant neoplasm of endometrium 0.001900093 7 0 BeFree
Malignant neoplasm of stomach 0.001900093 7 0 BeFree
Prader-Willi Syndrome 0.001900093 7 0 BeFree
Essential Hypertension 0.001900093 7 0 BeFree
Malnutrition 0.001900093 7 0 BeFree
Stomach Carcinoma 0.001900093 7 0 BeFree
Uterine Corpus Cancer 0.001900093 7 0 BeFree
Congenital leptin deficiency 0.001900093 7 0 BeFree
Cachexia 0.001628651 6 0 BeFree
Hunger 0.001628651 6 0 BeFree
Secondary malignant neoplasm of lymph node 0.001628651 6 0 BeFree
Steatohepatitis 0.001628651 6 0 BeFree
Ovarian Carcinoma 0.001357209 5 0 BeFree
Pituitary Adenoma 0.001357209 5 0 BeFree
Impaired glucose tolerance 0.001357209 5 0 BeFree
Malignant neoplasm of ovary 0.001357209 5 0 BeFree
Adenoma 0.001085767 4 0 BeFree
Autoimmune Diseases 0.001085767 4 0 BeFree
Depressive disorder 0.001085767 4 0 BeFree
Eating Disorders 0.001085767 4 0 BeFree
Congestive heart failure 0.001085767 4 4 BeFree
Hepatitis C 0.001085767 4 0 BeFree
Immune System Diseases 0.001085767 4 0 BeFree
leukemia 0.001085767 4 0 BeFree
Familial generalized lipodystrophy 0.001085767 4 0 BeFree
Fibrosis, Liver 0.001085767 4 0 BeFree
Somatotropin deficiency 0.001085767 4 0 BeFree
Hypothalamic amenorrhea 0.001085767 4 0 BeFree
Hepatitis C, Chronic 0.001085767 4 0 BeFree
Carcinoma of lung 0.001085767 4 0 BeFree
Pediatric Obesity 0.001085767 4 0 BeFree
Nonalcoholic Steatohepatitis 0.001085767 4 0 BeFree
Coronary Arteriosclerosis 0.000814326 3 0 BeFree
Experimental Autoimmune Encephalomyelitis 0.000814326 3 0 BeFree
Klinefelter Syndrome 0.000814326 3 0 BeFree
Myeloid Leukemia, Chronic 0.000814326 3 0 BeFree
Acquired partial lipodystrophy 0.000814326 3 1 BeFree
Decrease in appetite 0.000814326 3 0 BeFree
Alcohol withdrawal syndrome 0.000814326 3 0 BeFree
Papillary thyroid carcinoma 0.000814326 3 0 BeFree
Adenocarcinoma Of Esophagus 0.000814326 3 0 BeFree
Obesity, Abdominal 0.000814326 3 0 BeFree
Thyroid associated opthalmopathies 0.000814326 3 0 BeFree
Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site 0.000814326 3 0 BeFree
Bardet-Biedl Syndrome 0.000814326 3 0 BeFree
Helicobacter pylori infection 0.000814326 3 0 BeFree
Xenograft Model 0.000814326 3 0 BeFree
Bulimia Nervosa 0.000814326 3 0 BeFree
Allergic rhinitis (disorder) 0.000814326 3 0 BeFree
Insulin resistance syndrome 0.000814326 3 0 BeFree
Adrenal Gland Neoplasms 0.000542884 2 0 BeFree
Bipolar Disorder 0.000542884 2 0 BeFree
Bulimia 0.000542884 2 0 BeFree
Down Syndrome 0.000542884 2 0 BeFree
Dwarfism 0.000542884 2 0 BeFree
Gastritis 0.000542884 2 0 BeFree
Glioblastoma 0.000542884 2 0 BeFree
Glioma 0.000542884 2 0 BeFree
Hydatidiform Mole 0.000542884 2 0 BeFree
Inflammatory Bowel Diseases 0.000542884 2 0 BeFree
insulinoma 0.000542884 2 0 BeFree
Ischemia 0.000542884 2 0 BeFree
Acute lymphocytic leukemia 0.000542884 2 0 BeFree
Lipoma 0.000542884 2 0 BeFree
Lymphoma, Follicular 0.000542884 2 0 BeFree
Narcolepsy 0.000542884 2 0 BeFree
Nasal Polyps 0.000542884 2 0 BeFree
Neuroblastoma 0.000542884 2 0 BeFree
Psychotic Disorders 0.000542884 2 1 BeFree
Kidney Failure 0.000542884 2 0 BeFree
Cerebrovascular accident 0.000542884 2 0 BeFree
Acute leukemia 0.000542884 2 1 BeFree
Depressive Symptoms 0.000542884 2 0 BeFree
Lip and Oral Cavity Carcinoma 0.000542884 2 1 BeFree
Congenital hypoplasia of adrenal gland 0.000542884 2 0 BeFree
Chronic schizophrenia 0.000542884 2 0 BeFree
Sore to touch 0.000542884 2 0 BeFree
Hypogonadotropic hypogonadism 0.000542884 2 0 BeFree
Familial partial lipodystrophy 0.000542884 2 0 BeFree
Liver and Intrahepatic Biliary Tract Carcinoma 0.000542884 2 0 BeFree
Restenosis 0.000542884 2 0 BeFree
Malignant neoplasm of liver 0.000542884 2 0 BeFree
Hematopoietic Neoplasms 0.000542884 2 0 BeFree
Epithelial ovarian cancer 0.000542884 2 0 BeFree
Central neuroblastoma 0.000542884 2 0 BeFree
Ductal Carcinoma 0.000542884 2 0 BeFree
Adenoma of large intestine 0.000542884 2 0 BeFree
Mammary Tumorigenesis 0.000542884 2 0 BeFree
Chronic Kidney Diseases 0.000542884 2 0 BeFree
androgen independent prostate cancer 0.000542884 2 0 BeFree
HYDATIDIFORM MOLE, RECURRENT, 1 0.000542884 2 0 BeFree
Lipomatosis, Multiple 0.000542884 2 0 BeFree
LEPTIN RECEPTOR DEFICIENCY 0.000542884 2 0 BeFree
Isolated somatotropin deficiency 0.000542884 2 0 BeFree
Adenolymphoma 0.000271442 1 0 BeFree
Alcoholic Intoxication, Chronic 0.000271442 1 0 BeFree
Anemia 0.000271442 1 0 BeFree
Anemia of chronic disease 0.000271442 1 0 BeFree
Aneurysm 0.000271442 1 0 BeFree
Anxiety Disorders 0.000271442 1 0 BeFree
Aortic Aneurysm 0.000271442 1 0 BeFree
Mental disorders 0.000271442 1 0 BeFree
Brain Neoplasms 0.000271442 1 0 BeFree
Non-Small Cell Lung Carcinoma 0.000271442 1 0 BeFree
Renal Cell Carcinoma 0.000271442 1 0 BeFree
Transient Ischemic Attack 0.000271442 1 0 BeFree
Cholera 0.000271442 1 0 BeFree
Cushing Syndrome 0.000271442 1 0 BeFree
Diabetic Nephropathy 0.000271442 1 0 BeFree
Diverticulitis 0.000271442 1 0 BeFree
Drug abuse 0.000271442 1 0 BeFree
Dysentery 0.000271442 1 0 BeFree
Endocrine System Diseases 0.000271442 1 0 BeFree
External exotoses 0.000271442 1 0 BeFree
Gastritis, Atrophic 0.000271442 1 0 BeFree
Heart Diseases 0.000271442 1 0 BeFree
Hemangioma 0.000271442 1 0 BeFree
Hepatitis 0.000271442 1 0 BeFree
Hepatitis A 0.000271442 1 0 BeFree
Hodgkin Disease 0.000271442 1 0 BeFree
Hyperlipidemia, Familial Combined 0.000271442 1 0 BeFree
Hyperparathyroidism 0.000271442 1 0 BeFree
Pulmonary Hypertension 0.000271442 1 0 BeFree
Hyperthyroidism 0.000271442 1 0 BeFree
Immunologic Deficiency Syndromes 0.000271442 1 0 BeFree
Influenza 0.000271442 1 0 BeFree
Lethargy 0.000271442 1 0 BeFree
Acute Erythroblastic Leukemia 0.000271442 1 0 BeFree
Leukemia, Lymphocytic, Acute, L1 0.000271442 1 2 BeFree
liposarcoma 0.000271442 1 0 BeFree
Lupus Nephritis 0.000271442 1 0 BeFree
Malabsorption Syndrome 0.000271442 1 0 BeFree
melanoma 0.000271442 1 0 BeFree
Premature Menopause 0.000271442 1 4 BeFree
Mixed Salivary Gland Tumor 0.000271442 1 0 BeFree
Multiple Myeloma 0.000271442 1 0 BeFree
Muscular Dystrophy 0.000271442 1 0 BeFree
Myocardial Infarction 0.000271442 1 0 BeFree
Myotonic Dystrophy 0.000271442 1 0 BeFree
Parotid Neoplasms 0.000271442 1 0 BeFree
Pituitary Neoplasms 0.000271442 1 0 BeFree
Adenomatous Polyposis Coli 0.000271442 1 0 BeFree
Precancerous Conditions 0.000271442 1 0 BeFree
Pyruvate Carboxylase Deficiency Disease 0.000271442 1 0 BeFree
Retinoblastoma 0.000271442 1 0 BeFree
Septicemia 0.000271442 1 0 BeFree
Sleep disturbances 0.000271442 1 0 BeFree
Stress, Psychological 0.000271442 1 0 BeFree
Thyroid Diseases 0.000271442 1 0 BeFree
Attention Deficit Disorder 0.000271442 1 0 BeFree
Uterine Fibroids 0.000271442 1 0 BeFree
B-Cell Lymphomas 0.000271442 1 0 BeFree
Diffuse Large B-Cell Lymphoma 0.000271442 1 0 BeFree
Lymphoma, Large-Cell, Follicular 0.000271442 1 0 BeFree
Severe Combined Immunodeficiency 0.000271442 1 0 BeFree
Burning sensation 0.000271442 1 0 BeFree
Alcohol abuse 0.000271442 1 0 BeFree
Disorder of pregnancy 0.000271442 1 0 BeFree
Arterial thrombosis 0.000271442 1 0 BeFree
Idiopathic pulmonary hypertension 0.000271442 1 0 BeFree
Malignant neoplasm of mouth 0.000271442 1 1 BeFree
Glomerulosclerosis (disorder) 0.000271442 1 0 BeFree
Liposarcoma, Pleomorphic 0.000271442 1 0 BeFree
Diabetic Foot 0.000271442 1 0 BeFree
Nose symptoms 0.000271442 1 0 BeFree
Congenital diaphragmatic hernia 0.000271442 1 0 BeFree
Liver mass 0.000271442 1 0 BeFree
Parathyroid Adenoma 0.000271442 1 0 BeFree
Congenital hypoplasia of lung 0.000271442 1 0 BeFree
Endometrioma 0.000271442 1 0 BeFree
Rabson-Mendenhall Syndrome 0.000271442 1 0 BeFree
Parathyroid hyperplasia 0.000271442 1 0 BeFree
Carcinoma breast stage IV 0.000271442 1 0 BeFree
Healing ulcer 0.000271442 1 0 BeFree
Senile Plaques 0.000271442 1 0 BeFree
Impaired cognition 0.000271442 1 0 BeFree
Aortic aneurysm without mention of rupture NOS 0.000271442 1 0 BeFree
Constitutional delay of growth and puberty 0.000271442 1 0 BeFree
Precocious Puberty, Central 0.000271442 1 0 BeFree
Growth Hormone-Secreting Pituitary Adenoma 0.000271442 1 0 BeFree
Chronic superficial gastritis 0.000271442 1 0 BeFree
Nonorganic psychosis 0.000271442 1 0 BeFree
Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site 0.000271442 1 0 BeFree
Chronic Kidney Insufficiency 0.000271442 1 0 BeFree
Congenital Myotonic Dystrophy 0.000271442 1 0 BeFree
Gastrointestinal symptom 0.000271442 1 0 BeFree
Klinefelter's syndrome - male with more than two X chromosomes 0.000271442 1 0 BeFree
Chronic active hepatitis 0.000271442 1 0 BeFree
Peritoneal Fibrosis 0.000271442 1 0 BeFree
Carotid Atherosclerosis 0.000271442 1 0 BeFree
Malignant neoplasm of gastrointestinal tract 0.000271442 1 0 BeFree
Diabetic peripheral neuropathy 0.000271442 1 0 BeFree
Malignant neoplasm of kidney 0.000271442 1 0 BeFree
Premenopausal breast cancer 0.000271442 1 0 BeFree
Hypothalamic Dysfunction Syndromes 0.000271442 1 0 BeFree
Narcolepsy-Cataplexy Syndrome 0.000271442 1 0 BeFree
Viral hepatitis, type G 0.000271442 1 0 BeFree
Sleep Disorders 0.000271442 1 0 BeFree
Invasive breast carcinoma 0.000271442 1 0 BeFree
Diabetic Cardiomyopathies 0.000271442 1 0 BeFree
Advanced cancer 0.000271442 1 0 BeFree
Acute Coronary Syndrome 0.000271442 1 0 BeFree
Gestational Trophoblastic Neoplasms 0.000271442 1 0 BeFree
Compensatory Hyperinsulinemia 0.000271442 1 1 BeFree
Attention deficit hyperactivity disorder 0.000271442 1 0 BeFree
Cardiovascular morbidity 0.000271442 1 0 BeFree
Sporadic Breast Carcinoma 0.000271442 1 0 BeFree
Epithelioma 0.000271442 1 0 BeFree
Renal carcinoma 0.000271442 1 0 BeFree
Secondary Peritonitis 0.000271442 1 0 BeFree
Diabetic foot ulcer 0.000271442 1 0 BeFree
Skin Carcinogenesis 0.000271442 1 0 BeFree
Neoplasms, Intracranial 0.000271442 1 0 BeFree
Glioblastoma Multiforme 0.000271442 1 0 BeFree
Familial Partial Lipodystrophy, Type 1 0.000271442 1 0 BeFree
Osteophyte 0.000271442 1 0 BeFree
Adiponectin Deficiency 0.000271442 1 0 BeFree
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis 0.000271442 1 0 BeFree
Obesity, Visceral 0.000271442 1 0 BeFree
Plaque, Amyloid 0.000271442 1 0 BeFree
Pulmonary arterial hypertension 0.000271442 1 0 BeFree
Diabetic Heart Disease 0.000271442 1 0 BeFree
dowling-degos disease 0.000271442 1 0 BeFree
Pulmonary Hypertension, Primary, 1, With Hereditary Hemorrhagic Telangiectasia 0.000271442 1 0 BeFree
Obesity in animals 0.000271442 1 0 BeFree
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