LEFTY2基因详情-基因数据库-基因云馆

LEFTY2(left-right determination factor 2) 转至新版数据库

基因简称(symbol)

LEFTY2 [HGNC] [GeneCards] [NCBI]

基因种类(locus group)

protein-coding gene

同源简称(alias symbol)

LEFTA|LEFTYA

基因家族代码(gene_family_id)

[HGNC] [GenScript]

omim代码

601877

entrez码

7044 [Vega]

vega基因码

OTTHUMG00000037441

ensembl基因码

ENSG00000143768 [Ensembl]

基因家族(gene family)

refseq数据库代号

NM_003240

更多...

基因种类(locus_type)

gene with protein product

基因名称状态(status)

Approved

location_sortable

01q42.1

同源基因名称(alias name)

transforming growth factor, beta-4 (endometrial bleeding-associated factor; LEFTY A)

基因名称批准使用时间(date_approved_reserved)

1998-01-20T00:00:00Z

基因简称更名时间(date_symbol_changed)

2004-11-17T00:00:00Z

基因名称更名时间(date_name_changed)

2004-11-17T00:00:00Z

更新时间(date_modified)

2014-11-18T00:00:00Z

ucsc码

uc001hpt.2

ena

U81523

ccds数据码

CCDS1549|CCDS53479

uniprot数据码

O00292

pubmed代码

9153275

mgd码

MGI:2443573

rgd码

生命科学数据库(lsdb)

更新时间(date modified)

2014-11-18T00:00:00Z

cosmic

LEFTY2

mirbase

基因曾用简称(prev symbol)

TGFB4|EBAF

基因曾用名称(prev name)

endometrial bleeding associated factor (left-right determination, factor A; transforming growth factor beta superfamily)

homeodb

cosmic

LEFTY2

snornabase

bioparadigms slc

orphanet

168165

假基因信息(pseudogeneorg)

horde id

merops

imgt

iuphar

kznf基因类别

mamit-trnadb

cd

LncRNA数据库

酶代码

中间纤维数据库

收起

1q42.1

This gene encodes a member of the TGF-beta family of proteins. The encoded protein is secreted and plays a role in left-right asymmetry determination of organ systems during development. The protein may also play a role in endometrial bleeding. Mutations in this gene have been associated with left-right axis malformations, particularly in the heart and lungs. Some types of infertility have been associated with dysregulated expression of this gene in the endometrium. Alternative processing of this protein can yield three different products. This gene is closely linked to both a related family member and a related pseudogene. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2010]

[中文简述(自动翻译):] 此基因编码的TGF-β蛋白质家族的一个成员。所编码的蛋白质被分泌和发育过程中起着器官系统的左右不对称判定的作用。蛋白质也可起到的子宫内膜出血的作用。该基因突变与左，右轴畸形，特别是在心脏和肺部。某些类型的不育症已与该基因在子宫内膜的失调表达相关。这种蛋白质的代替处理可产生三种不同的产品。该基因是密切相关的这两个相关的家庭成员和相关的假。这个基因的交替拼接产生在多个转录变体。 [由RefSeq的，2010年2月提供]

OMIM数据库中对LEFTY2基因的介绍 Wikipedia数据库中对LEFTY2基因的介绍

LEFTY2基因的碱基序列：[NCBI]

LEFTY2基因的碱基突变：显示全部snp

rs12356 rs366439 rs428237 rs429477 rs429638 rs2273405 rs2295418 rs2295419 rs3007716 rs3753673 rs3753674 rs3753675 rs6662343 rs6697182 rs34986398 rs35245900 rs60825997 rs60846830 rs61731738 rs61731739 rs72470466 rs72755000 rs73131854 rs74578461 rs76698712 rs78074131 rs79421472 rs80180076 rs111742680 rs111974101 rs112610798 rs113071219 rs113541075 rs113571019 rs113770088 rs113777882 rs113957628

rs114492272 rs115510690 rs116099119 rs116381907 rs116385193 rs116581490 rs117906464 rs121909126 rs138096911 rs138576556 rs138605434 rs139968909 rs141162559 rs141625209 rs141634208 rs141642787 rs141678077 rs141680926 rs142150655 rs142782703 rs142795303 rs143245498 rs143444872 rs143844031 rs144148432 rs145827598 rs146772130 rs146882318 rs147414512 rs147502906 rs148338301 rs149969900 rs149996855 rs151034245 rs151047822 rs180700937 rs181269950 rs181651384 rs182178707 rs182741459 rs183196107 rs183780099 rs184091696 rs184362301 rs185173714 rs185436719 rs185998523 rs186788139 rs186992827 rs187312912 rs187585547 rs188018347 rs188858500 rs189053707 rs189653868 rs189977303 rs190467530 rs190589289 rs191411721 rs191981298 rs192164472 rs192266728 rs192727866 rs199559277 rs199979438 rs200062073 rs200062470 rs201183637 rs201705891 rs201859285 rs201860418 rs202147285 rs367895949 rs369323060 rs370194491 rs370284916 rs370436460 rs370508860 rs372128132 rs372720820 rs372862888 rs373002929 rs373198678 rs373309083 rs373445281 rs373949523 rs374435067 rs374563637 rs375073116 rs375414329 rs375598455 rs375696864 rs375716923 rs376374473 rs376643564 rs376918921 rs377275269 rs377316618 rs377391875 rs397691660 rs527299436 rs527428985 rs527865192 rs528312955 rs528315107 rs528452113 rs528805493 rs528937301 rs529670955 rs529950916 rs530184482 rs530716247 rs530793276 rs530830676 rs531192669 rs531221567 rs532528469 rs533583687 rs534340873 rs534898434 rs534914442 rs536023695 rs536066973 rs536871035 rs537645193 rs538416875 rs538500104 rs539025487 rs539447360 rs540267721 rs540392243 rs540584507 rs540688755 rs540728004 rs543240181 rs543472211 rs543686098 rs544275209 rs544362133 rs545519108 rs545578943 rs545713844 rs545926431 rs546151739 rs547922000 rs548655695 rs548918152 rs549616551 rs549685564 rs551111678 rs552112643 rs552474765 rs552614398 rs552634573 rs553503161 rs553661464 rs553967177 rs554256494 rs555390725 rs555560102 rs555615913 rs555775721 rs556064294 rs556472392 rs556638667 rs556908009 rs557432880 rs557736484 rs558838000 rs558881096 rs559042318 rs559715148 rs559861319 rs559994823 rs560779304 rs560788822 rs561486852 rs562376865 rs563150340 rs563590002 rs563642515 rs564180251 rs564233601 rs564349792 rs564625026 rs565668518 rs565730616 rs566071534 rs566504205 rs567148710 rs567288581 rs568635265 rs568936165 rs568973467 rs569751677 rs569986361 rs570110577 rs570682991 rs571136849 rs571767420 rs571804276 rs572817616 rs573132257 rs573938421 rs574003288 rs575206068 rs575338007 rs576461272 rs576554454 rs576573709 rs577405086 rs578075749 rs745421883 rs745493924 rs745610854 rs745793434 rs745994230 rs746343846 rs746371252 rs746398866 rs746650132 rs746743976 rs746976495 rs747238507 rs747265709 rs747461806 rs747632190 rs747778361 rs747992499 rs747997771 rs748059986 rs748117464 rs748390892 rs748448462 rs748750049 rs748850344 rs748929616 rs748980948 rs749178002 rs749195036 rs749208940 rs749235622 rs749262393 rs749311293 rs749823804 rs749827440 rs750002080 rs750092527 rs750344975 rs750351248 rs750627964 rs750632817 rs750982897 rs751004252 rs751191995 rs751192279 rs751234553 rs751370455 rs751791088 rs751847686 rs751976627 rs752128236 rs752319954 rs752369410 rs752695210 rs752703165 rs752934263 rs753158598 rs753170242 rs753274618 rs753352075 rs753735677 rs753756795 rs753978139 rs754114719 rs754322874 rs754774141 rs754829216 rs754829336 rs754975161 rs755012264 rs755035521 rs755280651 rs755305700 rs755576793 rs755626167 rs755657173 rs755874511 rs755899491 rs755946624 rs756005459 rs756126244 rs756179691 rs756300208 rs756463179 rs756552745 rs756579092 rs756716142 rs756750444 rs756772734 rs756910990 rs757277425 rs757289077 rs757490152 rs757654185 rs757705399 rs757892012 rs758041150 rs758215895 rs758482003 rs758807163 rs758883303 rs758918698 rs758966612 rs759360443 rs759411284 rs759630184 rs760148371 rs760312451 rs760365254 rs760746645 rs760840457 rs760940615 rs761074083 rs761287888 rs761522854 rs761983180 rs762009053 rs762309017 rs762361835 rs762406763 rs762458221 rs762606282 rs762760884 rs762810472 rs762837520 rs763081514 rs763209209 rs763928668 rs763980050 rs764196664 rs764447513 rs764464047 rs764560817 rs764757236 rs764833469 rs764976878 rs765065148 rs765106644 rs765196454 rs765855832 rs766266655 rs766277265 rs766372322 rs766634188 rs767003638 rs767055046 rs767091541 rs767324990 rs767473429 rs767526690 rs767847665 rs767953560 rs767979825 rs768006517 rs768253651 rs768306743 rs768357169 rs768796043 rs768799650 rs768979334 rs769164420 rs769210186 rs769834771 rs769963460 rs770118660 rs770360266 rs770500519 rs770687570 rs770779514 rs771018721 rs771500688 rs771776125 rs771827330 rs771829074 rs772058370 rs772171590 rs772252890 rs772445393 rs772813596 rs772887173 rs773043525 rs773224522 rs773314691 rs773437742 rs773491129 rs773558297 rs773816996 rs773961866 rs774073478 rs774109979 rs775122326 rs775287256 rs775509163 rs775526350 rs775761211 rs775888896 rs776013943 rs776106315 rs776142871 rs776356781 rs776602814 rs776674785 rs776905640 rs776907343 rs776960459 rs776993619 rs777013502 rs777116464 rs777139964 rs777195213 rs777331120 rs777571178 rs777635848 rs777688820 rs777814051 rs778193587 rs778447375 rs778654147 rs778815939 rs778849241 rs778867386 rs778889075 rs778939309 rs779092914 rs779197128 rs779245889 rs779333460 rs779338069 rs779701223 rs779806325 rs780037300 rs780082623 rs780129261 rs780132877 rs780491006 rs780669060 rs780843858 rs781615840 rs781692281

LEFTY2基因在不同组织中的表达： [UniProt]

正向引物序列

正向引物Tm值

反向引物序列

反向引物Tm值

rank

CTCAGGGACTATGGAGCTC

59

AATGTACATCTCCTGGCGG

60

CAGGGACTATGGAGCTCAG

59

CAATGTACATCTCCTGGCG

58

CAGGGACTATGGAGCTCAG

59

AATGTACATCTCCTGGCGG

60

尚未收录相关数据

LEFTY2基因（以及对应的蛋白质）的细胞分布位置：

[UniProt] [GenomeNet]

溶酶体
内涵体
细胞核
细胞质
液泡
细胞膜
细胞外基质
内质网
线粒体
高尔基体
细胞骨架

LEFTY2基因的本体（GO）信息：

GO库代码

对应的蛋白质

来源代码

GO:0005160

A0A087X1L7(UniProtKB)

IEA

GO:0005576

A0A087X1L7(UniProtKB)

IEA

GO:0008083

A0A087X1L7(UniProtKB)

IEA

GO:0016049

A0A087X1L7(UniProtKB)

IEA

GO:0002576

O00292(UniProtKB)

TAS

GO:0005125

O00292(UniProtKB)

IBA

GO:0005160

O00292(UniProtKB)

IBA

GO:0005576

O00292(UniProtKB)

TAS

GO:0005615

O00292(UniProtKB)

IBA

GO:0007179

O00292(UniProtKB)

TAS

GO:0007275

O00292(UniProtKB)

IEA

GO:0008083

O00292(UniProtKB)

IEA

GO:0010862

O00292(UniProtKB)

IBA

GO:0016049

O00292(UniProtKB)

IEA

GO:0031012

O00292(UniProtKB)

IDA

GO:0031093

O00292(UniProtKB)

TAS

GO:0042981

O00292(UniProtKB)

IBA

GO:0043408

O00292(UniProtKB)

IBA

GO:0048468

O00292(UniProtKB)

IBA

GO:0060395

O00292(UniProtKB)

IBA

序号	作用方式	资源库来源/分值	基因名称	基因名称

可能调控LEFTY2基因的相关microRNA：

hsa-miR-302a hsa-miR-302d

通路基因列表

疾病名称

关系值

NofPmids

NofSnps

来源

疾病名称	关系值	NofPmids	NofSnps	来源
Situs ambiguus	0.12	0	0	ORPHANET
Situs ambiguous	0.12	0	0	ORPHANET
Left-Right Axis Malformations	0.12	0	2	CLINVAR
Heterotaxy Syndrome	0.12	1	0	CTD_human
Adenocarcinoma	0.000271442	1	0	BeFree
Coronary heart disease	0.000271442	1	1	BeFree
Patent ductus arteriosus	0.000271442	1	0	BeFree
Endometriosis	0.000271442	1	0	BeFree
Embryonal Carcinoma	0.000271442	1	0	BeFree