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This gene encodes a transcription factor belonging to a family of proteins that share homology with the high mobility group protein-1. The protein encoded by this gene can bind to a functionally important site in the T-cell receptor-alpha enhancer, thereby conferring maximal enhancer activity. This transcription factor is involved in the Wnt signaling pathway, and it may function in hair cell differentiation and follicle morphogenesis. Mutations in this gene have been found in somatic sebaceous tumors. This gene has also been linked to other cancers, including androgen-independent prostate cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
[中文简述(自动翻译):]  这个基因编码属于一个家族,与高迁移率族蛋白1具有同源性的蛋白质的转录因子。由该基因编码的蛋白质可以结合到在T细胞受体-α增强剂的功能上重要的网站,从而赋予极大增强子活性。此转录因子参与Wnt信号通路,并且它可以在毛细胞分化和毛囊形态的作用。这个基因的突变体中的皮脂腺瘤被发现。这种基因也被链接到其它的癌症,包括雄激素依赖性前列腺癌。选择性剪接结果在多个抄本变形。 [由RefSeq的,2009年10月提供]
LEF1基因(以及对应的蛋白质)的细胞分布位置:
LEF1基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Chronic Lymphocytic Leukemia | 0.241900093 | 8 | 1 | BeFree_CTD_human_GWASCAT |
Colonic Neoplasms | 0.122995792 | 3 | 0 | BeFree_CTD_human_LHGDN |
Sebaceous Gland Neoplasms | 0.12272435 | 1 | 0 | CTD_human_LHGDN |
leukemia | 0.003810118 | 4 | 0 | BeFree_LHGDN |
Mammary Neoplasms | 0.003267234 | 3 | 0 | BeFree_LHGDN |
Malignant tumor of colon | 0.003257302 | 12 | 0 | BeFree |
Colon Carcinoma | 0.003257302 | 12 | 0 | BeFree |
Neutropenia | 0.002995792 | 2 | 0 | BeFree_LHGDN |
T-Cell Lymphoma | 0.002995792 | 1 | 0 | BeFree_LHGDN |
Peripheral T-Cell Lymphoma | 0.002995792 | 1 | 0 | BeFree_LHGDN |
Colorectal Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
Cholangiocarcinoma | 0.00272435 | 1 | 0 | LHGDN |
Carcinogenesis | 0.002714419 | 10 | 0 | BeFree |
Alcoholic Intoxication, Chronic | 0.002367032 | 1 | 0 | GAD |
Mental Depression | 0.002367032 | 1 | 0 | GAD |
Congenital Heart Defects | 0.002367032 | 1 | 0 | GAD |
Lupus Erythematosus, Systemic | 0.002367032 | 1 | 1 | GAD |
Congenital neutropenia | 0.001900093 | 7 | 0 | BeFree |
Severe congenital neutropenia | 0.001900093 | 7 | 0 | BeFree |
Malignant neoplasm of breast | 0.001628651 | 6 | 0 | BeFree |
Colorectal Carcinoma | 0.001628651 | 6 | 0 | BeFree |
melanoma | 0.001628651 | 6 | 0 | BeFree |
Acute lymphocytic leukemia | 0.001357209 | 5 | 0 | BeFree |
Neoplasm Metastasis | 0.001357209 | 5 | 0 | BeFree |
Adenomatous Polyposis Coli | 0.001357209 | 5 | 0 | BeFree |
Breast Carcinoma | 0.001357209 | 5 | 0 | BeFree |
Colorectal Cancer | 0.001357209 | 5 | 0 | BeFree |
Leukemia, Myelocytic, Acute | 0.001085767 | 4 | 0 | BeFree |
Lymphoma | 0.001085767 | 4 | 0 | BeFree |
Malignant neoplasm of prostate | 0.001085767 | 4 | 0 | BeFree |
Prostate carcinoma | 0.001085767 | 4 | 0 | BeFree |
Precursor Cell Lymphoblastic Leukemia Lymphoma | 0.001085767 | 4 | 0 | BeFree |
Leukemogenesis | 0.000814326 | 3 | 0 | BeFree |
Malignant neoplasm of endometrium | 0.000542884 | 2 | 0 | BeFree |
Lymphoid leukemia | 0.000542884 | 2 | 0 | BeFree |
Myeloid Leukemia, Chronic | 0.000542884 | 2 | 0 | BeFree |
Osteosarcoma | 0.000542884 | 2 | 0 | BeFree |
Precancerous Conditions | 0.000542884 | 2 | 0 | BeFree |
Christ-Siemens-Touraine syndrome | 0.000542884 | 2 | 0 | BeFree |
Endometrial Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Osteosarcoma of bone | 0.000542884 | 2 | 0 | BeFree |
Precursor B-cell lymphoblastic leukemia | 0.000542884 | 2 | 0 | BeFree |
Uterine Corpus Cancer | 0.000542884 | 2 | 0 | BeFree |
Liver carcinoma | 0.000542884 | 2 | 0 | BeFree |
Adenocarcinoma | 0.000271442 | 1 | 0 | BeFree |
Primary Myelofibrosis | 0.000271442 | 1 | 0 | BeFree |
Melanoma, B16 | 0.000271442 | 1 | 0 | BeFree |
Epilepsy, Temporal Lobe | 0.000271442 | 1 | 0 | BeFree |
Glioblastoma | 0.000271442 | 1 | 0 | BeFree |
Hepatitis A | 0.000271442 | 1 | 0 | BeFree |
Hepatitis B | 0.000271442 | 1 | 0 | BeFree |
Angioimmunoblastic Lymphadenopathy | 0.000271442 | 1 | 0 | BeFree |
Immunologic Deficiency Syndromes | 0.000271442 | 1 | 0 | BeFree |
Intestinal Neoplasms | 0.000271442 | 1 | 0 | BeFree |
Acute Promyelocytic Leukemia | 0.000271442 | 1 | 0 | BeFree |
Leukopenia | 0.000271442 | 1 | 0 | BeFree |
Lymphocytosis | 0.000271442 | 1 | 0 | BeFree |
Lymphoma, Follicular | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of stomach | 0.000271442 | 1 | 0 | BeFree |
Diffuse Large B-Cell Lymphoma | 0.000271442 | 1 | 0 | BeFree |
Acute leukemia | 0.000271442 | 1 | 0 | BeFree |
Tumor Progression | 0.000271442 | 1 | 0 | BeFree |
Pancreatic carcinoma | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of lung | 0.000271442 | 1 | 0 | BeFree |
Mucosa-Associated Lymphoid Tissue Lymphoma | 0.000271442 | 1 | 0 | BeFree |
Gastric Adenocarcinoma | 0.000271442 | 1 | 0 | BeFree |
adult acute promyelocytic leukemia (M3) | 0.000271442 | 1 | 0 | BeFree |
Adenocarcinoma of pancreas | 0.000271442 | 1 | 0 | BeFree |
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse | 0.000271442 | 1 | 0 | BeFree |
Multiple malignancy | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of pancreas | 0.000271442 | 1 | 0 | BeFree |
Disseminated Malignant Neoplasm | 0.000271442 | 1 | 0 | BeFree |
Hematopoietic Neoplasms | 0.000271442 | 1 | 0 | BeFree |
Hematologic Neoplasms | 0.000271442 | 1 | 0 | BeFree |
Secondary malignant neoplasm of liver | 0.000271442 | 1 | 0 | BeFree |
Biliary stricture | 0.000271442 | 1 | 0 | BeFree |
Carcinoma of lung | 0.000271442 | 1 | 0 | BeFree |
Stomach Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Adult Acute Lymphocytic Leukemia | 0.000271442 | 1 | 0 | BeFree |
Cleft Lip with or without Cleft Palate | 0.000271442 | 1 | 0 | BeFree |
Philadelphia chromosome positive | 0.000271442 | 1 | 0 | BeFree |
Mucinous Neoplasm | 0.000271442 | 1 | 0 | BeFree |
Pancreatic Ductal Adenocarcinoma | 0.000271442 | 1 | 0 | BeFree |
Marginal Zone B-Cell Lymphoma | 0.000271442 | 1 | 0 | BeFree |
Epithelioma | 0.000271442 | 1 | 0 | BeFree |
Benign melanocytic nevus | 0.000271442 | 1 | 0 | BeFree |
Pancreatic Intraductal Papillary-Mucinous Neoplasm | 0.000271442 | 1 | 0 | BeFree |
Pancreatic Mucinous-Cystic Neoplasm | 0.000271442 | 1 | 0 | BeFree |
Tumor Angiogenesis | 0.000271442 | 1 | 0 | BeFree |
Lymphoepithelioid lymphoma (clinical) | 0.000271442 | 1 | 0 | BeFree |
Glioblastoma Multiforme | 0.000271442 | 1 | 0 | BeFree |
androgen independent prostate cancer | 0.000271442 | 1 | 0 | BeFree |
B Acute Lymphoblastic Leukemia with t(9;22)(q34;q11.2); BCR-ABL1 | 0.000271442 | 1 | 0 | BeFree |
Idiopathic Pulmonary Fibrosis | 0.000271442 | 1 | 0 | BeFree |
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma | 0.000271442 | 1 | 0 | BeFree |
Cytogenetically normal acute myeloid leukemia | 0.000271442 | 1 | 0 | BeFree |
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