LDHA(lactate dehydrogenase A) 转至新版数据库

基因简称(symbol)
    [HGNC]     [GeneCards]     [NCBI]
基因种类(locus group)
同源简称(alias symbol)
基因家族代码(gene_family_id)
    [HGNC]     [GenScript]
omim代码
entrez码
    [Vega]
vega基因码
ensembl基因码
    [Ensembl]
基因家族(gene family)
refseq数据库代号

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基因种类(locus_type)
基因名称状态(status)
location_sortable
同源基因名称(alias name)
基因名称批准使用时间(date_approved_reserved)
基因简称更名时间(date_symbol_changed)
基因名称更名时间(date_name_changed)
更新时间(date_modified)
ucsc码
ena
ccds数据码
uniprot数据码
pubmed代码
mgd码
rgd码
生命科学数据库(lsdb)
更新时间(date modified)
cosmic
mirbase
基因曾用简称(prev symbol)
基因曾用名称(prev name)
homeodb
cosmic
snornabase
bioparadigms slc
orphanet
假基因信息(pseudogeneorg)
horde id
merops
imgt
iuphar
kznf基因类别
mamit-trnadb
cd
LncRNA数据库
酶代码
中间纤维数据库

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11p15.1
基因染色体位置图

The protein encoded by this gene catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. The protein is found predominantly in muscle tissue and belongs to the lactate dehydrogenase family. Mutations in this gene have been linked to exertional myoglobinuria. Multiple transcript variants encoding different isoforms have been found for this gene. The human genome contains several non-transcribed pseudogenes of this gene. [provided by RefSeq, Sep 2008]

[中文简述(自动翻译):]  由该基因编码的蛋白质催化L-乳酸和NAD的为丙酮酸和NADH在无氧糖酵解的最后步骤的转换。该蛋白在肌肉组织中主要发现,属于乳酸脱氢酶家族。在这个基因的突变已与劳力肌红蛋白尿。已发现该基因编码不同亚型的多个抄本变形。人类基因组中包含该基因的几种非转录假基因。 [由RefSeq的,2008年9月提供]

LDHA基因的碱基序列:[NCBI]
LDHA基因的碱基突变:           显示全部snp
rs4687       rs4820       rs6498       rs14789       rs14790       rs1830425       rs1830426       rs1881716       rs1969562       rs1969563       rs1969564       rs1969565       rs2249631       rs2403278       rs2403279       rs2896526       rs3758680       rs3758681       rs3758682       rs3758683       rs3781641       rs4274186       rs4757650       rs4757651       rs4757652       rs4757653       rs5790035       rs6486423       rs6486424       rs6486425       rs7101840       rs7107861       rs7111748       rs7117399       rs7120485       rs7121244       rs7128549      
rs7130990       rs7932887       rs7947664       rs10554414       rs10562494       rs10766475       rs10766476       rs10832928       rs10832929       rs10832930       rs10832931       rs10832932       rs10832933       rs11024641       rs11024642       rs11024643       rs11024644       rs11024645       rs11383902       rs11553866       rs11553870       rs11601409       rs11601413       rs12221941       rs12274651       rs12278153       rs12284013       rs12293161       rs12576300       rs12578098       rs12790695       rs12804008       rs16935411       rs16935413       rs34305721       rs34692667       rs34740438       rs35006409       rs35254161       rs35292478       rs35341031       rs35609290       rs35873857       rs35960334       rs55770432       rs56104473       rs56261949       rs56345574       rs59294421       rs59853257       rs61752915       rs61884347       rs71047592       rs71047593       rs72868528       rs72868529       rs72868542       rs73434676       rs73434696       rs74449461       rs74660044       rs75469962       rs76024205       rs76655193       rs76818137       rs77594770       rs78123102       rs78250273       rs78311521       rs78311829       rs78762081       rs79282833       rs79288565       rs79367445       rs80339187       rs111461382       rs111585790       rs111598561       rs112255990       rs112627800       rs113183346       rs113183823       rs113277870       rs113340412       rs113520635       rs113639646       rs113731380       rs113789185       rs113881147       rs113983010       rs114901827       rs114921759       rs116498671       rs116707169       rs116817482       rs116841148       rs117435911       rs117731905       rs117978027       rs118012729       rs118185287       rs137996815       rs138120080       rs138352370       rs138482276       rs138820183       rs139369990       rs140027721       rs140090654       rs140121364       rs140155918       rs140239987       rs140320099       rs140935722       rs141158742       rs141278780       rs141858909       rs142168109       rs142215176       rs143206293       rs143493256       rs143728814       rs144317385       rs144435718       rs144496208       rs144507081       rs144745697       rs144856598       rs144943684       rs145064957       rs145118034       rs145142186       rs145343940       rs145506651       rs145530692       rs145662285       rs145889467       rs146351449       rs146848160       rs147174554       rs147520495       rs147553361       rs147563417       rs148186234       rs148555833       rs148774730       rs148821053       rs149047877       rs149588992       rs149686758       rs149790112       rs150371912       rs150740870       rs150743964       rs150985861       rs151135658       rs180833316       rs180853582       rs181049567       rs181384746       rs181597439       rs181853217       rs181959934       rs181971767       rs182335994       rs182577287       rs182677003       rs182873744       rs183105832       rs183136048       rs183661907       rs183893673       rs184074326       rs184854190       rs184898539       rs184970314       rs185328272       rs185736805       rs186181952       rs186462007       rs186542748       rs186843316       rs186905110       rs187005834       rs187251030       rs187328595       rs187464585       rs187467694       rs188029324       rs188222782       rs188276581       rs188524538       rs188565096       rs189053762       rs189063205       rs189233414       rs189345660       rs189786479       rs190132212       rs190552648       rs190643188       rs190921109       rs191602457       rs191747797       rs191748190       rs191763215       rs192015489       rs192351379       rs192533550       rs192588330       rs193012490       rs193106891       rs193282587       rs199521486       rs199525449       rs199653952       rs199659698       rs199722017       rs199859192       rs199901539       rs199918200       rs200019907       rs200075826       rs200079157       rs200081533       rs200093825       rs200096279       rs200133108       rs200172020       rs200198118       rs200251957       rs200256380       rs200267888       rs200268273       rs200332813       rs200383424       rs200384555       rs200436948       rs200441639       rs200443451       rs200480390       rs200483406       rs200519855       rs200566403       rs200586792       rs200669604       rs200718851       rs200724597       rs200725917       rs200772587       rs200774396       rs200791480       rs200810272       rs200916427       rs200971093       rs201008031       rs201140577       rs201227737       rs201252408       rs201254300       rs201261563       rs201287644       rs201323060       rs201367554       rs201372985       rs201419761       rs201460924       rs201530363       rs201534782       rs201713804       rs201933139       rs201937009       rs201958008       rs202048658       rs202095684       rs202101193       rs202160072       rs202202736       rs367553288       rs368105451       rs368815124       rs369245773       rs369570558       rs370086375       rs370097085       rs370174954       rs370193389       rs370781767       rs371068167       rs373130532       rs373534867       rs373689485       rs374547891       rs374953657       rs375721617       rs375803679       rs376156863       rs376918699       rs377156358       rs377516196       rs377663876       rs398015444       rs527401531       rs527509184       rs527511756       rs527604704       rs528111002       rs528532705       rs529132703       rs529720188       rs529950677       rs530067594       rs530092785       rs530100236       rs530144337       rs530325291       rs531131470       rs531163484       rs531252092       rs531562656       rs531563027       rs531589202       rs531834907       rs532654296       rs532942664       rs533049105       rs533066527       rs533386547       rs533687086       rs533734216       rs533858321       rs534033811       rs534381501       rs534756275       rs534857270       rs535091533       rs535171320       rs535478266       rs535493067       rs535684320       rs535700069       rs535745632       rs536024861       rs536029468       rs536046167       rs536085659       rs536365228       rs536516161       rs537487381       rs537767321       rs537881880       rs537881978       rs538035362       rs538097303       rs538097791       rs538352453       rs538419135       rs538423002       rs538903350       rs539116880       rs539171552       rs539537614       rs539880956       rs539885724       rs540088276       rs540144696       rs540201461       rs540234566       rs540241819       rs540327602       rs540381987       rs540487347       rs540512717       rs540909495       rs541117974       rs541200892       rs541259055       rs541831561       rs541861048       rs541882226       rs542070033       rs542162368       rs542186612       rs542249170       rs542603354       rs542849128       rs543272480       rs543384332       rs543821382       rs543910236       rs544177684       rs544199332       rs544381154       rs544501453       rs544869809       rs545166605       rs545834753       rs545857705       rs545879201       rs546081732       rs546188687       rs546196460       rs546346576       rs546578577       rs546963323       rs546982372       rs547252181       rs547674559       rs547677559       rs547974367       rs548075959       rs548239270       rs549112311       rs549596609       rs549662459       rs549767576       rs550000014       rs550132273       rs550561090       rs550823219       rs551119059       rs551357743       rs551364364       rs551535785       rs552003093       rs552095516       rs552140004       rs552534884       rs553153615       rs553797118       rs553862163       rs554064872       rs554151815       rs554281525       rs554474286       rs554478784       rs554613809       rs554879531       rs554882083       rs555158602       rs555244300       rs555556403       rs555787413       rs556218672       rs556270063       rs556330123       rs556340704       rs556356941       rs556468670       rs556537577       rs556608607       rs556694767       rs556698774       rs556882708       rs557288314       rs557864797       rs558157548       rs558682059       rs558750359       rs558820257       rs558872434       rs559240574       rs560074622       rs560240535       rs560301354       rs560554983       rs560569858       rs560891872       rs561245685       rs561466372       rs561665039       rs561688509       rs561877719       rs561993066       rs562052619       rs562494262       rs562600057       rs562694907       rs562844566       rs562870908       rs562916892       rs563041570       rs563227227       rs563826730       rs563888216       rs564285762       rs564615873       rs564856089       rs564960172       rs565286637       rs565426382       rs565513653       rs565780118       rs565818682       rs566358920       rs566653337       rs566770146       rs567063880       rs567331912       rs567523918       rs567926833       rs567932160       rs568149362       rs568216745       rs568337886       rs568734702       rs568990515       rs569026251       rs569391045       rs569503377       rs570034363       rs570215180       rs570428172       rs570599699       rs570678917       rs570736990       rs570755425       rs570815637       rs570843552       rs571307277       rs571402347       rs571414644       rs571812319       rs572046429       rs572530918       rs572832929       rs572870525       rs572973253       rs573007050       rs573087248       rs573132736       rs573184134       rs573220908       rs574018612       rs574575191       rs574634909       rs574658360       rs574763904       rs574899342       rs575080426       rs575178047       rs575450430       rs576616180       rs576795028       rs576857474       rs576872855       rs577005356       rs577114710       rs577120545       rs577348693       rs577365164       rs745396682       rs745571742       rs745669796       rs745820834       rs745967472       rs746544029       rs746629321       rs746719151       rs746791147       rs746810321       rs746981573       rs747155581       rs747445517       rs747612023       rs747680577       rs747740938       rs748167423       rs748436361       rs748472471       rs748478809       rs748483881       rs748572565       rs748856517       rs749119901       rs749220974       rs749248612       rs749493960       rs750043828       rs750319408       rs750672775       rs750754695       rs751021921       rs751461543       rs751792408       rs751878211       rs751881685       rs752156024       rs752558359       rs752750333       rs752788996       rs753173739       rs753218262       rs753250935       rs753500347       rs753594094       rs753669409       rs753690566       rs753778781       rs753917384       rs753956888       rs754064594       rs754131832       rs754331527       rs754439498       rs754765640       rs754768150       rs755438993       rs755472354       rs755718918       rs756045998       rs756225293       rs756227406       rs756599511       rs756838417       rs757310036       rs757429462       rs757736035       rs757942016       rs758175888       rs758268446       rs758355826       rs758645316       rs758692078       rs758710600       rs758823920       rs758877938       rs759205592       rs759661874       rs759821060       rs759838023       rs759849879       rs760132196       rs760172008       rs760507886       rs760781166       rs761154271       rs761363157       rs761485593       rs761698693       rs761740106       rs761781727       rs761824195       rs761982670       rs762356273       rs762580567       rs762657047       rs762680971       rs762686295       rs762771019       rs763068850       rs763125061       rs763264028       rs763270838       rs763532378       rs763532603       rs763665163       rs763715344       rs763771927       rs764045758       rs764142811       rs764211566       rs764398695       rs764597107       rs764796100       rs764906662       rs764991833       rs765088560       rs765134847       rs765180823       rs765211774       rs765303765       rs765584184       rs765760101       rs765937866       rs766136084       rs766535492       rs766641807       rs766720385       rs766837091       rs766915377       rs766960326       rs767123470       rs767261269       rs767828446       rs767892699       rs767946655       rs768277742       rs768335491       rs768402299       rs768444502       rs768715402       rs768761936       rs768832981       rs769055089       rs769562236       rs769677845       rs769816031       rs769861412       rs770066988       rs770770614       rs770829264       rs771136276       rs771190916       rs771684587       rs771712815       rs772003722       rs772238965       rs772774301       rs772778240       rs772791680       rs772882630       rs773366936       rs773454769       rs773547533       rs773810823       rs773897712       rs773917634       rs773945378       rs774039198       rs774128810       rs774569446       rs774677714       rs774686615       rs775161485       rs775447569       rs775537428       rs775823378       rs775825471       rs776023375       rs776461335       rs776562957       rs776579959       rs776605053       rs776649952       rs776953904       rs777160159       rs777419564       rs777517739       rs777690501       rs777800299       rs777884699       rs777893906       rs777988373       rs778468175       rs778574836       rs778685360       rs778931531       rs779023149       rs779123718       rs779176970       rs779515052       rs779623625       rs779709683       rs779893062       rs780014361       rs780360946       rs780459495       rs780548812       rs780840340       rs781123152       rs781132218       rs781235880       rs781321565       rs781574480       rs781676694      

LDHA基因在不同组织中的表达:    [UniProt]

基因在不同组织中的表达图
正向引物序列
正向引物Tm值
反向引物序列
反向引物Tm值
rank
TCTTAATGAAGGACTTGGCAG
58
ATGTTGGAGATCCATCATCTC
57
AATTTGGTCCAGCGTAACG
59
GTAGGTCAAGATATCCACTGGA
59
CCATGATTAAGGGTCTTTACGG
59
CTGAGATTCCATTCTGTCCCA
60
TGTCTTGAACTCCTGACCT
58
TTCATCTGCCAAGTCATCTG
58
CCATGATTAAGGGTCTTTACGG
59
CTGAGATTCCATTCTGTCCCA
60
TCTTAATGAAGGACTTGGCAG
58
ATGTTGGAGATCCATCATCTC
57
ATTCCGGATCTCATTGCCA
59
AAAGGAATCGGGAATGCAC
58
GATTCCGGATCTCATTGCC
58
AAAGGAATCGGGAATGCAC
58
TCTTAATGAAGGACTTGGCAG
58
ATGTTGGAGATCCATCATCTC
57
TAACTGCAAACTCCAAGCT
57
TAGGTCAAGATATCCACTGGA
58
      尚未收录相关数据

LDHA基因(以及对应的蛋白质)的细胞分布位置:

[UniProt]     [GenomeNet]

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 溶酶体
  • 内涵体
  • 细胞核
  • 细胞质
  • 液泡
  • 细胞膜
  • 细胞外基质
  • 内质网
  • 线粒体
  • 高尔基体
  • 细胞骨架

LDHA基因的本体(GO)信息:

GO库代码
对应的蛋白质
来源代码
GO:0016021
F5GWW2(UniProtKB)
IEA
GO:0016616
F5GWW2(UniProtKB)
IEA
GO:0019752
F5GWW2(UniProtKB)
IEA
GO:0055114
F5GWW2(UniProtKB)
IEA
GO:0016021
F5GXC7(UniProtKB)
IEA
GO:0016616
F5GXC7(UniProtKB)
IEA
GO:0019752
F5GXC7(UniProtKB)
IEA
GO:0055114
F5GXC7(UniProtKB)
IEA
GO:0016616
F5GXH2(UniProtKB)
IEA
GO:0019752
F5GXH2(UniProtKB)
IEA
GO:0055114
F5GXH2(UniProtKB)
IEA
GO:0016021
F5GXU1(UniProtKB)
IEA
GO:0016616
F5GXU1(UniProtKB)
IEA
GO:0019752
F5GXU1(UniProtKB)
IEA
GO:0055114
F5GXU1(UniProtKB)
IEA
GO:0016616
F5GXY2(UniProtKB)
IEA
GO:0019752
F5GXY2(UniProtKB)
IEA
GO:0055114
F5GXY2(UniProtKB)
IEA
GO:0016616
F5GYU2(UniProtKB)
IEA
GO:0019752
F5GYU2(UniProtKB)
IEA
GO:0055114
F5GYU2(UniProtKB)
IEA
GO:0016616
F5GZQ4(UniProtKB)
IEA
GO:0019752
F5GZQ4(UniProtKB)
IEA
GO:0055114
F5GZQ4(UniProtKB)
IEA
GO:0016616
F5H5J4(UniProtKB)
IEA
GO:0019752
F5H5J4(UniProtKB)
IEA
GO:0055114
F5H5J4(UniProtKB)
IEA
GO:0016616
F5H6W8(UniProtKB)
IEA
GO:0019752
F5H6W8(UniProtKB)
IEA
GO:0055114
F5H6W8(UniProtKB)
IEA
GO:0016021
F5H8H6(UniProtKB)
IEA
GO:0016616
F5H8H6(UniProtKB)
IEA
GO:0019752
F5H8H6(UniProtKB)
IEA
GO:0055114
F5H8H6(UniProtKB)
IEA
GO:0001666
P00338(UniProtKB)
IEA
GO:0004459
P00338(UniProtKB)
EXP
GO:0004459
P00338(UniProtKB)
NAS
GO:0004459
P00338(UniProtKB)
EXP
GO:0005515
P00338(UniProtKB)
IPI
GO:0005515
P00338(UniProtKB)
IPI
GO:0005515
P00338(UniProtKB)
IPI
GO:0005634
P00338(UniProtKB)
IDA
GO:0005829
P00338(UniProtKB)
TAS
GO:0005829
P00338(UniProtKB)
TAS
GO:0006089
P00338(UniProtKB)
IEA
GO:0006090
P00338(UniProtKB)
TAS
GO:0006096
P00338(UniProtKB)
NAS
GO:0007584
P00338(UniProtKB)
IEA
GO:0009749
P00338(UniProtKB)
IEA
GO:0016020
P00338(UniProtKB)
IDA
GO:0019674
P00338(UniProtKB)
IEA
GO:0019900
P00338(UniProtKB)
IEA
GO:0021762
P00338(UniProtKB)
IEP
GO:0042493
P00338(UniProtKB)
IEA
GO:0042542
P00338(UniProtKB)
IEA
GO:0042802
P00338(UniProtKB)
IEA
GO:0043065
P00338(UniProtKB)
IEA
GO:0043627
P00338(UniProtKB)
IEA
GO:0048569
P00338(UniProtKB)
IEA
GO:0051287
P00338(UniProtKB)
IEA
GO:0051591
P00338(UniProtKB)
IEA
GO:0055114
P00338(UniProtKB)
IEA
GO:0070062
P00338(UniProtKB)
IDA
GO:0070062
P00338(UniProtKB)
IDA
GO:0070062
P00338(UniProtKB)
IDA
GO:0070062
P00338(UniProtKB)
IDA
GO:0070062
P00338(UniProtKB)
IDA
基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

可能调控LDHA基因的相关microRNA:     


通路基因列表
疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Lactate dehydrogenase deficiency type A 0.24 0 0 CTD_human_ORPHANET
Myocardial Infarction 0.12 1 0 CTD_human
Myoglobinuria 0.12 1 0 CTD_human
Cardiomyopathies 0.12 1 0 CTD_human
Hyperglycemia 0.08 1 0 RGD
Neoplasms, Experimental 0.08 1 0 RGD
Lymphoma 0.002995792 2 0 BeFree_LHGDN
Adenocarcinoma 0.00272435 1 0 LHGDN
Primary Myelofibrosis 0.00272435 1 0 LHGDN
Lung Neoplasms 0.00272435 1 0 LHGDN
Peptic Ulcer 0.00272435 1 0 LHGDN
Pleural effusion disorder 0.00272435 1 0 LHGDN
Thrombocythemia, Essential 0.00272435 1 0 LHGDN
Myocardial Ischemia 0.00272435 1 0 LHGDN
Panic Disorder 0.002638474 1 0 BeFree_GAD
Narcolepsy 0.002367032 1 0 GAD
Malignant neoplasm of breast 0.001357209 5 0 BeFree
Pancreatic carcinoma 0.001357209 5 0 BeFree
Malignant neoplasm of pancreas 0.001357209 5 0 BeFree
Carcinogenesis 0.001357209 5 0 BeFree
Breast Carcinoma 0.001357209 5 0 BeFree
Tumor Progression 0.001085767 4 0 BeFree
Colon Carcinoma 0.001085767 4 0 BeFree
Malignant neoplasm of stomach 0.000814326 3 0 BeFree
Multiple Myeloma 0.000814326 3 0 BeFree
Stomach Carcinoma 0.000814326 3 0 BeFree
Malignant tumor of colon 0.000542884 2 0 BeFree
Chondrosarcoma 0.000542884 2 0 BeFree
Diabetes Mellitus, Non-Insulin-Dependent 0.000542884 2 0 BeFree
Glioma 0.000542884 2 0 BeFree
Neoplasm Metastasis 0.000542884 2 0 BeFree
Pancreatic Neoplasm 0.000542884 2 0 BeFree
Malignant neoplasm of prostate 0.000542884 2 0 BeFree
Prostate carcinoma 0.000542884 2 0 BeFree
Mammary Neoplasms 0.000542884 2 0 BeFree
Liver carcinoma 0.000542884 2 0 BeFree
Autoimmune Diseases 0.000271442 1 0 BeFree
Malignant neoplasm of thyroid 0.000271442 1 0 BeFree
Cardiomyopathy, Dilated 0.000271442 1 0 BeFree
Eclampsia 0.000271442 1 0 BeFree
Glioblastoma 0.000271442 1 0 BeFree
Goiter 0.000271442 1 0 BeFree
Mitral Valve Insufficiency 0.000271442 1 0 BeFree
Myopathy 0.000271442 1 0 BeFree
Neuroblastoma 0.000271442 1 0 BeFree
Ovarian Carcinoma 0.000271442 1 0 BeFree
Retinoblastoma 0.000271442 1 0 BeFree
Rhabdomyosarcoma 0.000271442 1 0 BeFree
Metastatic malignant neoplasm to brain 0.000271442 1 0 BeFree
Anaplastic thyroid carcinoma 0.000271442 1 0 BeFree
Papillary thyroid carcinoma 0.000271442 1 0 BeFree
Malignant neoplasm of lung 0.000271442 1 0 BeFree
Carcinoma breast stage IV 0.000271442 1 0 BeFree
Squamous cell carcinoma of esophagus 0.000271442 1 0 BeFree
Conventional (Clear Cell) Renal Cell Carcinoma 0.000271442 1 0 BeFree
Impaired exercise tolerance 0.000271442 1 0 BeFree
Thyroid carcinoma 0.000271442 1 0 BeFree
Carcinoma of lung 0.000271442 1 0 BeFree
Secondary malignant neoplasm of lymph node 0.000271442 1 0 BeFree
Central neuroblastoma 0.000271442 1 0 BeFree
Malignant neoplasm of kidney 0.000271442 1 0 BeFree
Malignant neoplasm of ovary 0.000271442 1 0 BeFree
Squamous cell carcinoma of the head and neck 0.000271442 1 0 BeFree
Renal carcinoma 0.000271442 1 0 BeFree
tumor vasculature 0.000271442 1 0 BeFree
Benign Prostatic Hyperplasia 0.000271442 1 0 BeFree
Non-Neoplastic Disorder 0.000271442 1 0 BeFree
Malformations of Cortical Development, Group II 0.000271442 1 0 BeFree
PANIC DISORDER 1 0.000271442 1 0 BeFree
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