LCAT(lecithin-cholesterol acyltransferase)

基因简称(symbol)
    [HGNC]     [GeneCards]     [NCBI]
基因种类(locus group)
同源简称(alias symbol)
基因家族代码(gene_family_id)
    [HGNC]     [GenScript]
omim代码
entrez码
    [Vega]
vega基因码
ensembl基因码
    [Ensembl]
基因家族(gene family)
refseq数据库代号

更多...

基因种类(locus_type)
基因名称状态(status)
location_sortable
同源基因名称(alias name)
基因名称批准使用时间(date_approved_reserved)
基因简称更名时间(date_symbol_changed)
基因名称更名时间(date_name_changed)
更新时间(date_modified)
ucsc码
ena
ccds数据码
uniprot数据码
pubmed代码
mgd码
rgd码
生命科学数据库(lsdb)
更新时间(date modified)
cosmic
mirbase
基因曾用简称(prev symbol)
基因曾用名称(prev name)
homeodb
cosmic
snornabase
bioparadigms slc
orphanet
假基因信息(pseudogeneorg)
horde id
merops
imgt
iuphar
kznf基因类别
mamit-trnadb
cd
LncRNA数据库
酶代码
中间纤维数据库

收起

16q22.1
基因染色体位置图

This gene encodes the extracellular cholesterol esterifying enzyme, lecithin-cholesterol acyltransferase. The esterification of cholesterol is required for cholesterol transport. Mutations in this gene have been found to cause fish-eye disease as well as LCAT deficiency. [provided by RefSeq, Jul 2008]

[中文简述(自动翻译):]  该基因编码细胞外胆固醇酯化酶,卵磷脂胆固醇酰基转移酶。胆甾醇的酯化是必需的胆固醇运输。已发现该基因的突变导致鱼眼疾病以及LCAT缺乏。 [由RefSeq的,2008年7月提供]

LCAT基因的碱基序列:[NCBI]
LCAT基因的碱基突变:           显示全部snp
rs5922       rs5923       rs5924       rs1109166       rs4783549       rs4986970       rs11649537       rs11860115       rs11860141       rs11865016       rs12930987       rs13306495       rs13306496       rs13336998       rs13339667       rs17240371       rs17240378       rs17240392       rs17240399       rs17240406       rs17240413       rs17246744       rs17246751       rs17246758       rs17287327       rs17287334       rs17287341       rs17287348       rs17287355       rs17287362       rs17287369       rs17334103       rs17334110       rs17334117       rs17334145       rs17851876       rs28362524      
rs28940887       rs28940888       rs28942087       rs35673026       rs57506973       rs58381604       rs71382026       rs75550544       rs76074266       rs77679343       rs78870340       rs79374857       rs112195343       rs112401891       rs113136822       rs114275966       rs115102600       rs115439823       rs115688157       rs117817502       rs121908050       rs121908053       rs121908055       rs138321531       rs138462767       rs138943456       rs139146229       rs139261972       rs139360066       rs139453193       rs139909751       rs140068549       rs140531124       rs140576021       rs141357740       rs141453215       rs141835809       rs142487305       rs142644491       rs142683701       rs142875839       rs143128684       rs143251079       rs143698987       rs144075659       rs144922262       rs145126045       rs145159954       rs145509604       rs146659875       rs146713633       rs147412644       rs148089827       rs148126312       rs148439192       rs149389101       rs149726108       rs149991087       rs150430598       rs150617520       rs150816071       rs151178077       rs151310261       rs181411507       rs181421626       rs183282169       rs183693878       rs184992085       rs186045807       rs186174583       rs186409655       rs188692478       rs189323062       rs190331531       rs190617587       rs190807031       rs191551764       rs192807567       rs199560940       rs199573675       rs199711526       rs199717050       rs200102579       rs200147028       rs200160814       rs200225997       rs200317296       rs200354362       rs200506753       rs200596923       rs200823385       rs200840812       rs201081877       rs201117928       rs201218685       rs201495441       rs201542401       rs201555196       rs201649886       rs201917848       rs202010908       rs202017590       rs202035096       rs202180445       rs368097111       rs368492194       rs368571969       rs368689576       rs368772013       rs368831110       rs368847573       rs369427961       rs369910597       rs370196197       rs370257150       rs370589276       rs370595857       rs370602125       rs370803551       rs371031661       rs371253580       rs371357042       rs371391885       rs371542133       rs371551788       rs371888241       rs372394190       rs372699306       rs372780210       rs373093291       rs373288862       rs373290700       rs373370689       rs373601852       rs374200833       rs374675891       rs374775259       rs375105889       rs375227660       rs375566915       rs375573115       rs375627758       rs375740669       rs375862950       rs376080205       rs376197615       rs376276085       rs376685971       rs376817946       rs376973514       rs377335865       rs377728465       rs387906300       rs527645619       rs528244488       rs528284585       rs528939325       rs529402495       rs529528559       rs529994211       rs530658583       rs531087317       rs531369915       rs531821701       rs532898663       rs533238681       rs533815658       rs535283352       rs535764529       rs536601442       rs536761007       rs536801218       rs536961870       rs537040908       rs537955526       rs538047729       rs538148718       rs538162406       rs539020220       rs539116470       rs539179619       rs539248957       rs539363823       rs539925492       rs540334482       rs540814896       rs541024057       rs541484780       rs542206315       rs542318327       rs543515388       rs544632850       rs545182216       rs545457354       rs547430722       rs548113376       rs548263392       rs548584891       rs548638716       rs548743635       rs549831425       rs549941664       rs551419692       rs552068341       rs552105513       rs553192355       rs553707733       rs554132257       rs554574849       rs554910269       rs555058794       rs556480808       rs557373640       rs557673633       rs558243044       rs558320445       rs558657897       rs559025650       rs559100013       rs560140762       rs560548730       rs560646794       rs561845884       rs562803017       rs562966066       rs563077409       rs563968122       rs564157777       rs564268756       rs565455304       rs565694574       rs565740980       rs565798397       rs566231328       rs566469303       rs566944733       rs567134810       rs567249023       rs568021904       rs568147394       rs568288823       rs569248567       rs569282330       rs569405393       rs569522567       rs570434119       rs570849714       rs571028358       rs571509168       rs571513147       rs571554519       rs572225766       rs573439826       rs573472077       rs573698084       rs574650706       rs574776972       rs574854090       rs574942398       rs575990770       rs576008009       rs576077469       rs576994918       rs577337465       rs577863126       rs578020886       rs745320775       rs745488236       rs745493426       rs745585150       rs745639568       rs745833816       rs745892596       rs745923808       rs746113543       rs746148175       rs746240716       rs746263148       rs746342275       rs746440021       rs746464266       rs746487870       rs746801669       rs746841325       rs746912634       rs746914190       rs747000513       rs747027216       rs747059558       rs747079698       rs747293039       rs747316322       rs747319020       rs747530363       rs747571951       rs747769382       rs747810420       rs747882779       rs747911692       rs747921050       rs748065325       rs748067442       rs748160261       rs748189948       rs748348260       rs748370146       rs748424205       rs748427834       rs748994180       rs749029864       rs749155027       rs749186904       rs749308496       rs749328561       rs749331155       rs749500309       rs749574144       rs749594094       rs749825308       rs749900838       rs750086555       rs750100966       rs750103024       rs750264643       rs750376700       rs750495285       rs750551944       rs750602465       rs750626808       rs750655768       rs750847878       rs750866858       rs751070629       rs751105814       rs751222702       rs751256574       rs751266611       rs751274627       rs751362394       rs751480378       rs751636804       rs751707443       rs751757278       rs751777248       rs751874916       rs752045089       rs752061471       rs752088142       rs752258528       rs752387253       rs752428799       rs752443204       rs752452971       rs752637398       rs752777338       rs752851075       rs752871592       rs752957190       rs753019718       rs753021814       rs753143565       rs753459850       rs753534549       rs753579128       rs753759978       rs753838845       rs753873629       rs753929002       rs754003281       rs754109587       rs754128014       rs754163626       rs754278588       rs754295538       rs754357525       rs754380900       rs754549614       rs754636828       rs754797387       rs754922066       rs754950818       rs754974345       rs755096081       rs755112469       rs755138978       rs755270091       rs755292532       rs755320531       rs755679499       rs755897598       rs755912546       rs755919528       rs756001584       rs756044262       rs756113909       rs756252212       rs756268656       rs756365811       rs756435228       rs756457746       rs756625482       rs756696850       rs756818645       rs756828645       rs756835069       rs756903007       rs757068054       rs757094557       rs757228770       rs757270498       rs757293362       rs757555528       rs757597375       rs757647301       rs757787133       rs757939300       rs757975246       rs758036935       rs758209228       rs758210027       rs758221629       rs758245988       rs758459792       rs758596309       rs758750980       rs758937067       rs759027102       rs759077717       rs759216171       rs759236895       rs759423563       rs759510870       rs759715011       rs759917018       rs760004708       rs760044185       rs760085300       rs760136119       rs760219781       rs760296361       rs760380606       rs760441751       rs760480927       rs760647579       rs760682057       rs760768147       rs760768263       rs761019137       rs761032474       rs761065754       rs761143750       rs761272947       rs761312598       rs761397844       rs761443799       rs761593618       rs761601767       rs761720102       rs761864380       rs761884788       rs761902457       rs761906433       rs761999436       rs762182522       rs762202276       rs762281391       rs762296109       rs762304561       rs762306207       rs762477305       rs762600330       rs762741789       rs762886846       rs762929082       rs763018899       rs763035411       rs763120754       rs763148775       rs763214858       rs763241601       rs763361272       rs763366383       rs763487318       rs763505015       rs763589763       rs763769067       rs763857844       rs763920584       rs764199690       rs764315783       rs764415370       rs764430797       rs764513108       rs764548177       rs764625130       rs764737339       rs764782649       rs765009339       rs765059218       rs765119491       rs765146704       rs765225093       rs765334906       rs765388664       rs765518132       rs765520037       rs765630619       rs765667638       rs765713306       rs765753563       rs765864029       rs765953894       rs766461585       rs766545437       rs766583672       rs766622412       rs766633659       rs766641667       rs766843261       rs766908533       rs766917505       rs767110676       rs767125608       rs767217400       rs767380015       rs767508071       rs767628388       rs767716010       rs767741284       rs767963075       rs768017317       rs768148804       rs768299969       rs768345191       rs768470128       rs768543789       rs768693498       rs768708739       rs769045467       rs769051533       rs769067928       rs769259508       rs769347348       rs769383972       rs769452608       rs769485083       rs769580071       rs769638337       rs769728907       rs769746004       rs769863980       rs769919260       rs770211536       rs770281333       rs770299772       rs770356071       rs770404485       rs770469492       rs770531138       rs770577233       rs770644164       rs770863885       rs770914271       rs770997562       rs771041790       rs771059474       rs771082638       rs771389340       rs771393323       rs771517943       rs771555409       rs771607670       rs771717628       rs771761885       rs771988174       rs772004544       rs772109225       rs772138220       rs772234006       rs772313264       rs772316037       rs772409846       rs772490066       rs772733016       rs772746466       rs772762775       rs772821038       rs773180994       rs773303978       rs773366689       rs773456584       rs773582166       rs773756772       rs773888164       rs773925060       rs774093711       rs774145773       rs774291859       rs774333955       rs774340092       rs774374510       rs774377825       rs774458778       rs774532159       rs774574304       rs774662407       rs774934690       rs775025813       rs775267705       rs775278757       rs775304390       rs775380488       rs775396226       rs775419267       rs775504919       rs775764410       rs775781016       rs775968521       rs775986587       rs776035233       rs776058654       rs776070516       rs776158865       rs776536104       rs776635378       rs776734391       rs776737218       rs776987249       rs777035916       rs777090583       rs777181724       rs777185677       rs777417745       rs777463756       rs777476768       rs777491211       rs777505967       rs777603323       rs777685450       rs777706452       rs777796548       rs777885783       rs777956526       rs778004063       rs778059407       rs778090728       rs778180616       rs778410873       rs778556604       rs778651468       rs778658721       rs778938401       rs779028305       rs779051062       rs779114194       rs779137613       rs779203902       rs779223831       rs779338042       rs779419276       rs779627553       rs779716218       rs779771052       rs780122016       rs780245509       rs780357216       rs780438132       rs780478467       rs780635568       rs780637081       rs780824776       rs780826348       rs780886752       rs780912694       rs781120479       rs781208598       rs781377284       rs781490680       rs781502087       rs781502281       rs781573103       rs781771397      

LCAT基因在不同组织中的表达:    [UniProt]

基因在不同组织中的表达图
正向引物序列
正向引物Tm值
反向引物序列
反向引物Tm值
rank
CGATAACACCAGGGTTGTC
58
GAGTAGGTCTTGCCAAAGC
59
CTTCTTCACCATCTGGCTG
58
GTTGTAGACAACCCTGGTG
58
GGACCGCTTTATTGATGGC
59
GTGAGACCCTGTCTCTGAG
59
CTTCTTCACCATCTGGCTG
58
GTTGTAGACAACCCTGGTG
58
GCTTTATTGATGGCTTCATCTC
58
AGTAGGTGGTAGCTGTGTC
58
GCTTTATTGATGGCTTCATCTC
58
TAGGTGGTAGCTGTGTCAG
58
GACTTCTTCACCATCTGGCT
60
TAGACAACCCTGGTGTTATCG
60
CTGTGGAGTACCTGGACAG
59
ATTGTTGACCAGGTTCTGC
58
ACTTCTTCACCATCTGGCT
59
TAGACAACCCTGGTGTTATCG
60
GCTTTATTGATGGCTTCATCTC
58
CTCAGTGAAGCACATCCCT
59
      尚未收录相关数据

LCAT基因(以及对应的蛋白质)的细胞分布位置:

[UniProt]     [GenomeNet]

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 溶酶体
  • 内涵体
  • 细胞核
  • 细胞质
  • 液泡
  • 细胞膜
  • 细胞外基质
  • 内质网
  • 线粒体
  • 高尔基体
  • 细胞骨架

LCAT基因的本体(GO)信息:

GO库代码
对应的蛋白质
来源代码
GO:0006629
I3L0J6(UniProtKB)
IEA
GO:0008374
I3L0J6(UniProtKB)
IEA
GO:0016021
I3L0J6(UniProtKB)
IEA
GO:0006629
I3L1Q6(UniProtKB)
IEA
GO:0008374
I3L1Q6(UniProtKB)
IEA
GO:0006629
J3QKT0(UniProtKB)
IEA
GO:0008374
J3QKT0(UniProtKB)
IEA
GO:0006629
J3QSE5(UniProtKB)
IEA
GO:0008374
J3QSE5(UniProtKB)
IEA
GO:0004607
P04180(UniProtKB)
IDA
GO:0004607
P04180(UniProtKB)
NAS
GO:0004607
P04180(UniProtKB)
IDA
GO:0004607
P04180(UniProtKB)
IDA
GO:0004607
P04180(UniProtKB)
TAS
GO:0004623
P04180(UniProtKB)
IEA
GO:0005515
P04180(UniProtKB)
IPI
GO:0005576
P04180(UniProtKB)
TAS
GO:0005576
P04180(UniProtKB)
TAS
GO:0005576
P04180(UniProtKB)
TAS
GO:0005576
P04180(UniProtKB)
TAS
GO:0005576
P04180(UniProtKB)
TAS
GO:0005615
P04180(UniProtKB)
IDA
GO:0005615
P04180(UniProtKB)
IDA
GO:0005615
P04180(UniProtKB)
IDA
GO:0006644
P04180(UniProtKB)
IDA
GO:0006656
P04180(UniProtKB)
IDA
GO:0008203
P04180(UniProtKB)
IDA
GO:0008203
P04180(UniProtKB)
IDA
GO:0008203
P04180(UniProtKB)
IDA
GO:0030301
P04180(UniProtKB)
IDA
GO:0034186
P04180(UniProtKB)
IPI
GO:0034364
P04180(UniProtKB)
IDA
GO:0034372
P04180(UniProtKB)
IDA
GO:0034375
P04180(UniProtKB)
IDA
GO:0034375
P04180(UniProtKB)
IDA
GO:0034375
P04180(UniProtKB)
IDA
GO:0034375
P04180(UniProtKB)
IDA
GO:0034435
P04180(UniProtKB)
IDA
GO:0034435
P04180(UniProtKB)
IDA
GO:0034435
P04180(UniProtKB)
IDA
GO:0042157
P04180(UniProtKB)
TAS
GO:0042158
P04180(UniProtKB)
IEA
GO:0042632
P04180(UniProtKB)
IDA
GO:0043691
P04180(UniProtKB)
IDA
GO:0046470
P04180(UniProtKB)
IDA
GO:0046688
P04180(UniProtKB)
IEA
GO:0051384
P04180(UniProtKB)
IEA
GO:0070062
P04180(UniProtKB)
IDA
GO:0070062
P04180(UniProtKB)
IDA
GO:0090107
P04180(UniProtKB)
IEA
基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

可能调控LCAT基因的相关microRNA:     


通路基因列表
疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Lecithin Acyltransferase Deficiency 0.572420313 36 12 BeFree_CLINVAR_CTD_human_GAD_LHGDN_MGD_ORPHANET_UNIPROT
Fish-Eye Disease 0.446710102 21 5 BeFree_CLINVAR_GAD_MGD_ORPHANET_UNIPROT
Hyperlipidemia 0.085091382 3 0 GAD_LHGDN_RGD
Kidney Failure, Chronic 0.080542884 3 0 BeFree_RGD
Myocardial Infarction 0.08 1 0 RGD
Atherosclerosis 0.010801593 14 0 BeFree_GAD_LHGDN
Diabetes Mellitus, Non-Insulin-Dependent 0.007101096 3 0 GAD
Coronary Arteriosclerosis 0.005276948 3 0 BeFree_GAD
Dyslipidemias 0.005276948 4 0 BeFree_GAD
Hypoalphalipoproteinemias 0.004734064 2 0 GAD
Coronary Artery Disease 0.003267234 3 0 BeFree_LHGDN
Arteriosclerosis 0.002985861 11 0 BeFree
Coronary heart disease 0.002909916 3 0 BeFree_GAD
Cerebral Infarction 0.00272435 1 0 LHGDN
Lipid Metabolism Disorders 0.002638474 2 0 BeFree_GAD
Alzheimer's Disease 0.002367032 1 0 GAD
Malignant neoplasm of urinary bladder 0.002367032 1 0 GAD
Hypertriglyceridemia 0.002367032 1 0 GAD
Inflammation 0.002367032 1 0 GAD
Insulin Resistance 0.002367032 1 0 GAD
Chronic Obstructive Airway Disease 0.002367032 1 0 GAD
Malignant neoplasm of lung 0.002367032 1 0 GAD
Dementia 0.002367032 1 0 GAD
Hypertriglyceridemia result 0.002367032 1 0 GAD
Kidney Failure 0.000814326 3 0 BeFree
Cardiovascular Diseases 0.000542884 2 0 BeFree
Kidney Diseases 0.000542884 2 0 BeFree
Hyperlipoproteinemia Type I 0.000542884 2 0 BeFree
Obesity 0.000542884 2 0 BeFree
Cholesteryl Ester Transfer Protein Deficiency 0.000542884 2 0 BeFree
Hypoalphalipoproteinemia, Familial 0.000542884 2 0 BeFree
Hyperlipoproteinemias 0.000271442 1 0 BeFree
Liver diseases 0.000271442 1 0 BeFree
Inborn Errors of Metabolism 0.000271442 1 0 BeFree
Atherosclerosis of aorta 0.000271442 1 0 BeFree
Hdl Deficiency, Type 2 0.000271442 1 0 BeFree
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