LAT(linker for activation of T cells) 转至新版数据库

基因基本信息

基因基本信息

基因简称(symbol)
    [HGNC]     [GeneCards]     [NCBI]
基因种类(locus group)
同源简称(alias symbol)
基因家族代码(gene_family_id)
    [HGNC]     [GenScript]
omim代码
entrez码
    [Vega]
vega基因码
ensembl基因码
    [Ensembl]
基因家族(gene family)
refseq数据库代号

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基因种类(locus_type)
基因名称状态(status)
location_sortable
同源基因名称(alias name)
基因名称批准使用时间(date_approved_reserved)
基因简称更名时间(date_symbol_changed)
基因名称更名时间(date_name_changed)
更新时间(date_modified)
ucsc码
ena
ccds数据码
uniprot数据码
pubmed代码
mgd码
rgd码
生命科学数据库(lsdb)
更新时间(date modified)
cosmic
mirbase
基因曾用简称(prev symbol)
基因曾用名称(prev name)
homeodb
cosmic
snornabase
bioparadigms slc
orphanet
假基因信息(pseudogeneorg)
horde id
merops
imgt
iuphar
kznf基因类别
mamit-trnadb
cd
LncRNA数据库
酶代码
中间纤维数据库

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基因染色体位置

基因染色体位置

16q13
基因染色体位置图

基因简述

基因简述

The protein encoded by this gene is phosphorylated by ZAP-70/Syk protein tyrosine kinases following activation of the T-cell antigen receptor (TCR) signal transduction pathway. This transmembrane protein localizes to lipid rafts and acts as a docking site for SH2 domain-containing proteins. Upon phosphorylation, this protein recruits multiple adaptor proteins and downstream signaling molecules into multimolecular signaling complexes located near the site of TCR engagement. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

[中文简述(自动翻译):]  由该基因编码的蛋白质由ZAP-70的磷酸化/下列T细胞抗原受体（TCR）信号转导通路的激活Syk的蛋白酪氨酸激酶。这跨膜蛋白定位于脂筏，并作为一个停靠站点为含SH2结构域的蛋白。磷酸化后，这种蛋白新兵多适配器蛋白质和下游信号分子到位于TCR订婚的地点附近多分子信号复合。在多个转录剪接变异体导致编码不同亚型。 [由RefSeq的，2008年7月提供]

OMIM数据库中对LAT基因的介绍     Wikipedia数据库中对LAT基因的介绍

基因序列

基因序列

LAT基因的碱基序列：[NCBI]

基因突变

基因突变

LAT基因的碱基突变：           显示全部snp
rs7140       rs1131543       rs1802141       rs4788114       rs4788115       rs7202093       rs8062374       rs9929088       rs11859822       rs11862178       rs34282488       rs41280846       rs41280848       rs41280852       rs41292396       rs41301797       rs55945024       rs56058140       rs56154572       rs56197241       rs71387635       rs73535859       rs73535863       rs74014834       rs74014835       rs74369679       rs77460148       rs77760721       rs111329935       rs111709895       rs112565938       rs112681246       rs112964111       rs113165798       rs115596085       rs115616784       rs116848701      
rs117382857       rs118086285       rs138166678       rs138285628       rs138506930       rs138690406       rs139118570       rs139165953       rs139206035       rs139374736       rs139864999       rs139975852       rs140236840       rs140327086       rs140761317       rs140899124       rs141085007       rs141916698       rs142722234       rs143269723       rs143322433       rs143348117       rs143360117       rs143508152       rs144215223       rs144257249       rs144866787       rs144911297       rs145500741       rs145503991       rs145586651       rs145698858       rs146679097       rs146742435       rs146777044       rs147113499       rs147527167       rs148292832       rs148603133       rs148817437       rs148875869       rs149558811       rs149585476       rs149610167       rs149899237       rs149935445       rs149999622       rs150322036       rs150635404       rs150747516       rs150961285       rs181365946       rs181949767       rs181978775       rs182067462       rs182255709       rs182816098       rs183459740       rs184918944       rs185073400       rs185437814       rs186127841       rs186644726       rs186738344       rs186783312       rs187943429       rs188166694       rs188350465       rs188613201       rs189266054       rs189604733       rs189806388       rs189885588       rs190031582       rs192616031       rs192673446       rs192694353       rs193155488       rs199561184       rs199659388       rs199695694       rs199717512       rs199764231       rs199917933       rs200047353       rs200070316       rs200095367       rs200183698       rs200196031       rs200258693       rs200951110       rs200982471       rs201009782       rs201110056       rs201354349       rs201445944       rs201490940       rs201588794       rs201680708       rs201698210       rs201744028       rs201886731       rs201900870       rs202104103       rs367578258       rs367681802       rs367684485       rs367825225       rs367956473       rs368314043       rs368322414       rs368363818       rs368424638       rs368906014       rs368910284       rs369094656       rs369135566       rs369317401       rs369369314       rs369564255       rs369963623       rs370294498       rs370326654       rs370343624       rs370513940       rs370561029       rs370734464       rs371061969       rs371112474       rs371271382       rs371758736       rs371979988       rs372388377       rs372588861       rs372595985       rs372606392       rs372684773       rs372754605       rs372836843       rs372848518       rs372858431       rs373283173       rs373418202       rs373796041       rs373895074       rs373946823       rs374150900       rs374340826       rs374507740       rs374673653       rs375000927       rs375039365       rs375042443       rs375448402       rs375713159       rs375777872       rs375804327       rs376181529       rs376374033       rs376620943       rs376696716       rs377393523       rs377594928       rs527291763       rs527351075       rs527888341       rs527957466       rs528707660       rs529643994       rs529706681       rs530160099       rs530219359       rs530922450       rs531463376       rs532534583       rs532612675       rs533907477       rs534313859       rs535156699       rs535225629       rs535296748       rs535320374       rs535376435       rs535435400       rs535516530       rs535980414       rs536309173       rs536430907       rs537565741       rs537634076       rs537661777       rs537701725       rs537763411       rs537991877       rs538095912       rs538192669       rs538626974       rs538679978       rs538922741       rs539448014       rs539884129       rs540815534       rs541318743       rs541766243       rs541818150       rs541879892       rs542002275       rs542964252       rs543635052       rs544037733       rs544129068       rs544386172       rs544631964       rs544913468       rs545915891       rs546066720       rs546424474       rs546540805       rs547125942       rs547955350       rs548189189       rs548257810       rs548318274       rs548480155       rs549673621       rs549676154       rs549994584       rs550212603       rs550517396       rs551122221       rs551987214       rs552153925       rs552188855       rs552374969       rs552598727       rs552721001       rs553020688       rs553724434       rs553972309       rs554136740       rs554170512       rs554778571       rs554839726       rs555904248       rs555965537       rs556109451       rs556171017       rs556712421       rs557090670       rs557421465       rs557963747       rs558560447       rs558682145       rs558867911       rs559618769       rs560078317       rs560203035       rs560328333       rs561226162       rs561281542       rs561446498       rs561506107       rs562425023       rs562491820       rs562637469       rs562774019       rs563371211       rs564023629       rs564142476       rs564540512       rs564656761       rs565170127       rs566486534       rs566548790       rs566598862       rs566613285       rs566800943       rs566862499       rs568054979       rs568346859       rs568797681       rs568913374       rs569132973       rs570584285       rs570638324       rs570648955       rs571691147       rs572112079       rs572530726       rs573080487       rs573142710       rs573204072       rs574286659       rs574346270       rs574430942       rs575520196       rs576530173       rs576634276       rs577174147       rs577605066       rs745402667       rs745543579       rs745697231       rs745697368       rs745803209       rs745919635       rs745992930       rs746082940       rs746180846       rs746270286       rs746277119       rs746284233       rs746374454       rs746397826       rs746680129       rs746739617       rs746890598       rs747058489       rs747217398       rs747292175       rs747381905       rs747425519       rs747563842       rs747700060       rs747789529       rs747938876       rs748026823       rs748164763       rs748192459       rs748199503       rs748200927       rs748205194       rs748297241       rs748416446       rs748478144       rs748565962       rs748653729       rs748746757       rs748834760       rs748983223       rs749468155       rs749589604       rs749739177       rs749776309       rs749822295       rs749827158       rs749929744       rs749965686       rs750017815       rs750192929       rs750234365       rs750273574       rs750395084       rs750458427       rs750585579       rs750677281       rs750776330       rs750866342       rs750939577       rs751029944       rs751174435       rs751292818       rs751514242       rs751592501       rs751838570       rs751932833       rs751983098       rs752059672       rs752067260       rs752157482       rs752247158       rs752295381       rs752401268       rs752495360       rs752514234       rs752700016       rs752980559       rs753063338       rs753116139       rs753133124       rs753325233       rs753338456       rs753417205       rs753460582       rs753643173       rs753688067       rs753688145       rs753785101       rs754014715       rs754100918       rs754122326       rs754124065       rs754266171       rs754296935       rs754490583       rs754495701       rs754913650       rs754929840       rs754968255       rs754994693       rs755082804       rs755118992       rs755150157       rs755239709       rs755475291       rs755492698       rs755569515       rs755580342       rs755773671       rs755796646       rs756012730       rs756153037       rs756210979       rs756231325       rs756465051       rs756489699       rs756667596       rs756695444       rs756713309       rs756791074       rs756908098       rs756999794       rs757120430       rs757179508       rs757208563       rs757376717       rs757390248       rs757583630       rs757637846       rs757759156       rs757783223       rs757871413       rs758041286       rs758183666       rs758241866       rs758477625       rs758691872       rs758961386       rs759046674       rs759048740       rs759054406       rs759136751       rs759261962       rs759351836       rs759479849       rs759494087       rs759530239       rs759731250       rs759793490       rs759856408       rs759946355       rs760086078       rs760258056       rs760280178       rs760284754       rs760307159       rs760482047       rs760484259       rs760570104       rs760707201       rs760777156       rs760865296       rs760937191       rs761044704       rs761079956       rs761326854       rs761347703       rs761360134       rs761430686       rs761564318       rs761652439       rs761802878       rs761916378       rs762024259       rs762037718       rs762366434       rs762609185       rs762752952       rs762786347       rs762937546       rs762993390       rs763087170       rs763178827       rs763233534       rs763238779       rs763504939       rs763513365       rs763554523       rs763569525       rs763741555       rs763746133       rs763749687       rs763846844       rs763885383       rs763961559       rs763979282       rs764064908       rs764092491       rs764217769       rs764340292       rs764355544       rs764430069       rs764459449       rs764545334       rs764639285       rs764876352       rs765002501       rs765011819       rs765025305       rs765075145       rs765114982       rs765124156       rs765425662       rs765515636       rs765603999       rs765665378       rs765914772       rs766000975       rs766076040       rs766184578       rs766185217       rs766273200       rs766296448       rs766318180       rs766664039       rs766744385       rs766751965       rs766834134       rs766921963       rs767053389       rs767237358       rs767283907       rs767284445       rs767321097       rs767404662       rs767496296       rs767569710       rs767585820       rs767624264       rs767629651       rs767638751       rs767671603       rs767864621       rs767874913       rs768142595       rs768249345       rs768337088       rs768339475       rs768699762       rs768758578       rs768840011       rs768840374       rs768930245       rs769144660       rs769236559       rs769309598       rs769326237       rs769485203       rs769638291       rs769778459       rs769998028       rs770019079       rs770063032       rs770232897       rs770318081       rs770406128       rs770491878       rs770547833       rs770552343       rs770635685       rs770664577       rs770851628       rs770972382       rs771062314       rs771097316       rs771452648       rs771484935       rs771534253       rs771623836       rs771718245       rs771802250       rs772048600       rs772109038       rs772202808       rs772286326       rs772317897       rs772496335       rs772511444       rs772598185       rs772826609       rs772874528       rs772876855       rs773144841       rs773311118       rs773312505       rs773355607       rs773400965       rs773485849       rs773544697       rs773761427       rs773818567       rs773970127       rs774041984       rs774065817       rs774114219       rs774458860       rs774472206       rs774515405       rs774578428       rs774640143       rs774671847       rs774928083       rs775047643       rs775119978       rs775209924       rs775228902       rs775238350       rs775328558       rs775332145       rs775515583       rs775587482       rs775621384       rs775627172       rs775631702       rs775720799       rs775773084       rs775798838       rs776004267       rs776066960       rs776379318       rs776437042       rs776545121       rs776771216       rs776829469       rs776829556       rs776857551       rs776863646       rs777222878       rs777258133       rs777259938       rs777307963       rs777346159       rs777395936       rs777429025       rs777699822       rs777710737       rs777798581       rs778017891       rs778279821       rs778357838       rs778358757       rs778655191       rs778842314       rs778932306       rs779141735       rs779308938       rs779309559       rs779326526       rs779409087       rs779495290       rs779537109       rs779585597       rs779625131       rs779791055       rs780068029       rs780099847       rs780191848       rs780249785       rs780318800       rs780431310       rs780470001       rs780532784       rs780566473       rs780620380       rs780677002       rs780679331       rs780767031       rs780952040       rs781119598       rs781160519       rs781180363       rs781239865       rs781243388       rs781410769       rs781501862       rs781614203       rs781688554       rs781772315       rs41280846       rs182816098      

基因表达

基因表达

LAT基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向引物Tm值
反向引物序列
反向引物Tm值
rank
TACGAGAATCTGCAGGAGC
59
CTGGTTCCAGGACAGACTC
59
AGATTACGAGAATCTGCAGGAG
60
CTGGTTCCAGGACAGACTC
59
GATTACGAGAATCTGCAGGAG
58
CTGGTTCCAGGACAGACTC
59
GATTCTGATGGTGCCAACAG
59
GTCGTCCTCATCCTCATCC
59
ATTCTGATGGTGCCAACAG
58
TGATAGTCGTCCTCATCCTC
58
CCATGTTGATGGCACTGTG
60
CCTTGGATACAAACTATCTGAGGA
60

转录因子

转录因子

      尚未收录相关数据

基因本体信息

LAT基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 溶酶体
  • 内涵体
  • 细胞核
  • 细胞质
  • 液泡
  • 细胞膜
  • 细胞外基质
  • 内质网
  • 线粒体
  • 高尔基体
  • 细胞骨架

LAT基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0007165
C7C5T5(UniProtKB)
IEA
GO:0016020
C7C5T5(UniProtKB)
IEA
GO:0007165
H3BQD8(UniProtKB)
IEA
GO:0016020
H3BQD8(UniProtKB)
IEA
GO:0000165
O43561(UniProtKB)
TAS
GO:0001772
O43561(UniProtKB)
IDA
GO:0002250
O43561(UniProtKB)
IEA
GO:0002260
O43561(UniProtKB)
IEA
GO:0005070
O43561(UniProtKB)
IDA
GO:0005088
O43561(UniProtKB)
TAS
GO:0005515
O43561(UniProtKB)
IPI
GO:0005515
O43561(UniProtKB)
IPI
GO:0005515
O43561(UniProtKB)
IPI
GO:0005515
O43561(UniProtKB)
IPI
GO:0005515
O43561(UniProtKB)
IPI
GO:0005515
O43561(UniProtKB)
IPI
GO:0005515
O43561(UniProtKB)
IPI
GO:0005515
O43561(UniProtKB)
IPI
GO:0005515
O43561(UniProtKB)
IPI
GO:0005515
O43561(UniProtKB)
IPI
GO:0005515
O43561(UniProtKB)
IPI
GO:0005515
O43561(UniProtKB)
IPI
GO:0005515
O43561(UniProtKB)
IPI
GO:0005515
O43561(UniProtKB)
IPI
GO:0005515
O43561(UniProtKB)
IPI
GO:0005515
O43561(UniProtKB)
IPI
GO:0005515
O43561(UniProtKB)
IPI
GO:0005515
O43561(UniProtKB)
IPI
GO:0005886
O43561(UniProtKB)
TAS
GO:0005886
O43561(UniProtKB)
TAS
GO:0005886
O43561(UniProtKB)
TAS
GO:0005886
O43561(UniProtKB)
TAS
GO:0005886
O43561(UniProtKB)
TAS
GO:0005886
O43561(UniProtKB)
TAS
GO:0005886
O43561(UniProtKB)
TAS
GO:0005886
O43561(UniProtKB)
TAS
GO:0005886
O43561(UniProtKB)
TAS
GO:0005886
O43561(UniProtKB)
TAS
GO:0005886
O43561(UniProtKB)
TAS
GO:0005886
O43561(UniProtKB)
TAS
GO:0005886
O43561(UniProtKB)
TAS
GO:0005886
O43561(UniProtKB)
TAS
GO:0005886
O43561(UniProtKB)
TAS
GO:0005886
O43561(UniProtKB)
TAS
GO:0005886
O43561(UniProtKB)
TAS
GO:0005886
O43561(UniProtKB)
TAS
GO:0005886
O43561(UniProtKB)
TAS
GO:0005886
O43561(UniProtKB)
TAS
GO:0005886
O43561(UniProtKB)
TAS
GO:0005886
O43561(UniProtKB)
TAS
GO:0005886
O43561(UniProtKB)
TAS
GO:0005886
O43561(UniProtKB)
TAS
GO:0005886
O43561(UniProtKB)
TAS
GO:0005886
O43561(UniProtKB)
TAS
GO:0005886
O43561(UniProtKB)
TAS
GO:0005886
O43561(UniProtKB)
TAS
GO:0005886
O43561(UniProtKB)
TAS
GO:0005886
O43561(UniProtKB)
TAS
GO:0005886
O43561(UniProtKB)
TAS
GO:0005886
O43561(UniProtKB)
TAS
GO:0005886
O43561(UniProtKB)
TAS
GO:0005886
O43561(UniProtKB)
TAS
GO:0005911
O43561(UniProtKB)
IEA
GO:0006954
O43561(UniProtKB)
IEA
GO:0006955
O43561(UniProtKB)
IDA
GO:0007229
O43561(UniProtKB)
IDA
GO:0007265
O43561(UniProtKB)
IMP
GO:0008180
O43561(UniProtKB)
ISS
GO:0009967
O43561(UniProtKB)
IEA
GO:0010467
O43561(UniProtKB)
IEA
GO:0016021
O43561(UniProtKB)
IDA
GO:0019722
O43561(UniProtKB)
IMP
GO:0019901
O43561(UniProtKB)
IPI
GO:0030168
O43561(UniProtKB)
TAS
GO:0035556
O43561(UniProtKB)
IDA
GO:0038095
O43561(UniProtKB)
TAS
GO:0042110
O43561(UniProtKB)
TAS
GO:0042629
O43561(UniProtKB)
IEA
GO:0043303
O43561(UniProtKB)
IEA
GO:0043547
O43561(UniProtKB)
IEA
GO:0045121
O43561(UniProtKB)
TAS
GO:0045860
O43561(UniProtKB)
IEP
GO:0050852
O43561(UniProtKB)
TAS
GO:0050863
O43561(UniProtKB)
IMP

基因相互作用关系

基因相互作用关系

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因相关microRNA

基因相关microRNA

可能调控LAT基因的相关microRNA：     

基因通路图

基因通路图

基因的通路属性图
通路基因列表

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Liver diseases 0.12 1 0 CTD_human
Neurotoxicity Syndromes 0.12 1 0 CTD_human
AMYOTROPHIC LATERAL SCLEROSIS 1 0.12 1 0 CTD_human
Herpes Simplex Infections 0.004885954 18 0 BeFree
Lupus Erythematosus, Systemic 0.002995792 1 0 BeFree_LHGDN
Intolerance to protein 0.001085767 4 0 BeFree
Non-Small Cell Lung Carcinoma 0.000814326 3 0 BeFree
Glioblastoma 0.000814326 3 0 BeFree
Cystinuria 0.000542884 2 0 BeFree
Lymphoproliferative Disorders 0.000542884 2 0 BeFree
Malignant neoplasm of prostate 0.000542884 2 0 BeFree
Prostate carcinoma 0.000542884 2 0 BeFree
Asthma 0.000271442 1 0 BeFree
Brain Diseases 0.000271442 1 0 BeFree
Renal Cell Carcinoma 0.000271442 1 0 BeFree
Squamous cell carcinoma 0.000271442 1 0 BeFree
Carcinoma, Transitional Cell 0.000271442 1 0 BeFree
Keratitis, Herpetic 0.000271442 1 0 BeFree
HIV Infections 0.000271442 1 0 BeFree
Lung Neoplasms 0.000271442 1 0 BeFree
melanoma 0.000271442 1 1 BeFree
Neoplasm Metastasis 0.000271442 1 0 BeFree
Phenylketonurias 0.000271442 1 0 BeFree
Adenocarcinoma of lung (disorder) 0.000271442 1 0 BeFree
Allergic asthma 0.000271442 1 0 BeFree
Tumor Progression 0.000271442 1 0 BeFree
Cholangiocarcinoma 0.000271442 1 0 BeFree
Conventional (Clear Cell) Renal Cell Carcinoma 0.000271442 1 0 BeFree
Malignant Glioma 0.000271442 1 0 BeFree
Bile duct carcinoma 0.000271442 1 0 BeFree
Classical phenylketonuria 0.000271442 1 0 BeFree
Hyperphenylalaninaemia 0.000271442 1 0 BeFree
latent infection 0.000271442 1 0 BeFree
Squamous cell carcinoma of the head and neck 0.000271442 1 0 BeFree
Bile duct adenocarcinoma 0.000271442 1 0 BeFree
Severe Aplastic Anemia 0.000271442 1 0 BeFree
Clear-cell metastatic renal cell carcinoma 0.000271442 1 0 BeFree

基因相关文献

基因相关文献

基因相关服务

基因相关服务

基因评论

基因评论

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