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Kynureninase is a pyridoxal-5'-phosphate (pyridoxal-P) dependent enzyme that catalyzes the cleavage of L-kynurenine and L-3-hydroxykynurenine into anthranilic and 3-hydroxyanthranilic acids, respectively. Kynureninase is involved in the biosynthesis of NAD cofactors from tryptophan through the kynurenine pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010]
[中文简述(自动翻译):]  Kynureninase是吡哆醛-5‘-磷酸(吡哆醛-P)依赖的,其分别催化的L-犬尿氨酸和L-3- hydroxykynurenine的裂解成邻氨基和3-羟基-2-氨基酸,酶。 Kynureninase参与NAD辅因子的从色氨酸通过犬尿氨酸路径的生物合成。选择性剪接结果在多个抄本变形。 [由RefSeq的,2010年11月提供]
KYNU基因(以及对应的蛋白质)的细胞分布位置:
KYNU基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Hydroxykynureninuria | 0.480271442 | 1 | 1 | BeFree_CLINVAR_CTD_human_ORPHANET_UNIPROT |
IGA Glomerulonephritis | 0.12 | 1 | 0 | CTD_human |
Inflammation | 0.12 | 1 | 0 | CTD_human |
Neurodegenerative Disorders | 0.12 | 1 | 0 | CTD_human |
Hypertensive disease | 0.002367032 | 1 | 0 | GAD |
Tobacco Use Disorder | 0.002367032 | 1 | 0 | GAD |
Essential Hypertension | 0.000271442 | 1 | 0 | BeFree |
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