KRT10基因详情-基因数据库-基因云馆

KRT10(keratin 10, type I)

基因简称(symbol)

KRT10 [HGNC] [GeneCards] [NCBI]

基因种类(locus group)

protein-coding gene

同源简称(alias symbol)

K10|CK10

基因家族代码(gene_family_id)

608 [HGNC] [GenScript]

omim代码

148080

entrez码

3858 [Vega]

vega基因码

OTTHUMG00000133368

ensembl基因码

ENSG00000186395 [Ensembl]

基因家族(gene family)

Keratins, type I

refseq数据库代号

NM_000421

更多...

基因种类(locus_type)

gene with protein product

基因名称状态(status)

Approved

location_sortable

17q21.2

同源基因名称(alias name)

cytokeratin 10|epidermolytic hyperkeratosis

基因名称批准使用时间(date_approved_reserved)

1988-08-12T00:00:00Z

基因简称更名时间(date_symbol_changed)

基因名称更名时间(date_name_changed)

2015-01-22T00:00:00Z

更新时间(date_modified)

2015-01-22T00:00:00Z

ucsc码

uc002hvi.3

ena

J04029

ccds数据码

CCDS11377

uniprot数据码

P13645

pubmed代码

2461420|16831889

mgd码

MGI:96685

rgd码

RGD:1359092

生命科学数据库(lsdb)

更新时间(date modified)

2015-01-22T00:00:00Z

cosmic

KRT10

mirbase

基因曾用简称(prev symbol)

KPP

基因曾用名称(prev name)

keratosis palmaris et plantaris|keratin 10

homeodb

cosmic

KRT10

snornabase

bioparadigms slc

orphanet

122891

假基因信息(pseudogeneorg)

horde id

merops

imgt

iuphar

kznf基因类别

mamit-trnadb

cd

LncRNA数据库

酶代码

中间纤维数据库

HGNC:6413

收起

17q21.2

This gene encodes a member of the type I (acidic) cytokeratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. Mutations in this gene are associated with epidermolytic hyperkeratosis. This gene is located within a cluster of keratin family members on chromosome 17q21. [provided by RefSeq, Jul 2008]

[中文简述(自动翻译):] 该基因编码的I型（酸性）细胞角蛋白家族，属于中间丝（IF）蛋白的超家族中的一员。角蛋白是形成中间丝杂聚结构蛋白。这些细丝，与肌动蛋白微丝和微管一起构成上皮细胞的细胞骨架。在这种基因突变与表皮角化过度有关。该基因位于角蛋白家族成员的染色体17q21上群集内。 [由RefSeq的，2008年7月提供]

OMIM数据库中对KRT10基因的介绍 Wikipedia数据库中对KRT10基因的介绍

KRT10基因的碱基序列：[NCBI]

KRT10基因的碱基突变：显示全部snp

rs12231 rs1132255 rs1132258 rs1132268 rs1132269 rs1132367 rs1799873 rs1799874 rs1799915 rs2071398 rs4261597 rs4621029 rs6503559 rs7209985 rs8067028 rs8082176 rs9892984 rs11312510 rs12945499 rs17855579 rs28411890 rs58075662 rs61434181 rs61735162 rs62065904 rs62065905 rs71371449 rs71371450 rs71371451 rs73299562 rs75734286 rs75823057 rs77919366 rs79174420 rs79843026 rs79992509 rs111323549

rs111410178 rs111849607 rs112000562 rs112217004 rs112290614 rs112695335 rs112752242 rs112791986 rs112906738 rs113166059 rs113279600 rs113334942 rs113365156 rs113384710 rs113525355 rs114467326 rs116709135 rs117588718 rs117610737 rs138435395 rs139270955 rs140096582 rs140697702 rs140700628 rs141152281 rs141187850 rs141720249 rs141784799 rs141815199 rs141830953 rs142018791 rs142050024 rs142158041 rs142767279 rs143780054 rs144095683 rs144109451 rs144138576 rs145111623 rs145243680 rs145403476 rs145899611 rs146342823 rs146835683 rs146855016 rs146957992 rs146976249 rs147104719 rs147592247 rs148693758 rs149215773 rs149227921 rs150048434 rs150098320 rs150918499 rs151143129 rs151149062 rs151162673 rs181194018 rs181269809 rs182927242 rs183337445 rs184159044 rs184568019 rs185266843 rs185732130 rs185790545 rs185881153 rs185895026 rs186759981 rs187553216 rs188100198 rs188362728 rs188372905 rs188908997 rs189169448 rs189586291 rs190783500 rs191791084 rs192311634 rs192465969 rs192578662 rs192587398 rs192800052 rs199646609 rs199745005 rs199785115 rs200060640 rs200062818 rs200118465 rs200239146 rs200507327 rs200517276 rs200567513 rs200665804 rs200971360 rs201089561 rs201135981 rs201343749 rs201389981 rs201624860 rs201647202 rs201691005 rs201879590 rs201994123 rs202036121 rs267607380 rs367672318 rs367709184 rs367939682 rs368170805 rs368264277 rs368573436 rs368594753 rs368733857 rs368784181 rs368893029 rs369473843 rs369810696 rs370667058 rs370815555 rs371456379 rs371503347 rs371654347 rs371774101 rs371899202 rs372028613 rs372303962 rs372427171 rs372792985 rs372831544 rs373213430 rs373319671 rs373366688 rs373397541 rs373723131 rs373769724 rs373917637 rs374581207 rs375113624 rs375567467 rs375594232 rs375696416 rs376170376 rs376239738 rs376607945 rs376693131 rs377364342 rs527842801 rs528425134 rs529849513 rs529995365 rs530472156 rs530741645 rs530944445 rs531054820 rs532309007 rs532545866 rs534188261 rs534749830 rs536665430 rs536668934 rs537841615 rs538043316 rs538065187 rs538605741 rs539015021 rs539247250 rs540117333 rs540168116 rs540205355 rs540685219 rs541227747 rs541291647 rs541836329 rs542004758 rs543145740 rs543248047 rs543603727 rs544234303 rs544264740 rs545018374 rs546219047 rs546231467 rs546321678 rs546629135 rs547362688 rs547425850 rs547525485 rs547613475 rs548092387 rs548436589 rs548605061 rs549666804 rs549812863 rs549985767 rs550666605 rs551982602 rs552043745 rs552556781 rs552810834 rs553559976 rs554064245 rs554253955 rs556262610 rs556457190 rs557636536 rs557698714 rs558183226 rs558246290 rs558502300 rs559532458 rs560446460 rs560685431 rs561061719 rs561817153 rs562513722 rs563178579 rs563358332 rs563736890 rs564032826 rs564497284 rs565227668 rs565597348 rs565829882 rs565976410 rs566350493 rs567149868 rs568073257 rs568147205 rs569431643 rs569546855 rs569617063 rs570136616 rs570191915 rs570343417 rs570853437 rs570963053 rs571388414 rs571434577 rs571608758 rs572920888 rs573079438 rs573355897 rs573629859 rs574022776 rs576125525 rs576416494 rs576538778 rs577758014 rs577796478 rs745531866 rs745725994 rs745745648 rs745768608 rs746037860 rs746054540 rs746058184 rs746128596 rs746654245 rs746687989 rs747004729 rs747156157 rs747183067 rs747237640 rs747376338 rs747431718 rs747435637 rs747484535 rs747571094 rs747712277 rs747720992 rs747769259 rs748048161 rs748075726 rs748078113 rs748149243 rs748192517 rs748362305 rs748417456 rs748530852 rs748594551 rs748627169 rs748865279 rs748913729 rs748918606 rs749208101 rs749379688 rs749432068 rs749495943 rs749719417 rs749819865 rs750006944 rs750039767 rs750064098 rs750064320 rs750113513 rs750260006 rs750311246 rs750366116 rs750559702 rs750666264 rs750858590 rs751078173 rs751102820 rs751126642 rs751181844 rs751362318 rs751529374 rs751727025 rs751780283 rs751835228 rs752306254 rs752448327 rs752483481 rs752531072 rs752590384 rs752767462 rs752817112 rs752869217 rs753188484 rs753205769 rs753364834 rs753489811 rs753547366 rs753614465 rs753787009 rs753928278 rs754010566 rs754238010 rs754280270 rs754359952 rs754396797 rs754439176 rs754626613 rs754741926 rs754922060 rs754935101 rs754958528 rs754993001 rs755227431 rs755259243 rs755416862 rs755466898 rs755521518 rs755521798 rs755819413 rs755924637 rs755977583 rs756038496 rs756224291 rs756574493 rs756625071 rs756695109 rs756736481 rs756915372 rs757008735 rs757069403 rs757177461 rs757275527 rs757582440 rs757729391 rs757830825 rs757865831 rs758141506 rs758227575 rs758342043 rs758343254 rs758631225 rs758685124 rs758784021 rs758930648 rs759183436 rs759192704 rs759199635 rs759260763 rs759357431 rs759536459 rs759776596 rs759827585 rs759837260 rs760129489 rs760198943 rs760366080 rs760452803 rs760637749 rs760695518 rs760787128 rs760840367 rs760989177 rs761111932 rs761352015 rs761476507 rs761534405 rs761554643 rs761726623 rs761803713 rs761851864 rs761920455 rs762259235 rs762305484 rs762441213 rs762441858 rs762627487 rs762648481 rs763011311 rs763058569 rs763439214 rs763494250 rs763533889 rs763714641 rs763846532 rs763920771 rs764225659 rs764282663 rs764312663 rs764382068 rs764477110 rs764653836 rs764717506 rs764984381 rs765046809 rs765099902 rs765197483 rs765311191 rs765348420 rs765383937 rs765546797 rs765598147 rs765796278 rs765945741 rs766199650 rs766349835 rs766514106 rs766622228 rs766683899 rs766701495 rs767039379 rs767159695 rs767238841 rs767261543 rs767314552 rs767360709 rs767721911 rs767778057 rs768003171 rs768219717 rs768279426 rs768355740 rs768461937 rs768689526 rs768808998 rs768815401 rs768864991 rs768920029 rs769026746 rs769078179 rs769111194 rs769261149 rs769296740 rs769473481 rs769857976 rs769997393 rs770154440 rs770286635 rs770303156 rs770483430 rs770522514 rs770578877 rs770636031 rs770653100 rs770918220 rs770992466 rs771197683 rs771360650 rs771559057 rs771610197 rs771762056 rs771884630 rs772058779 rs772155246 rs772222128 rs772258628 rs772573108 rs772718519 rs772769268 rs772784673 rs772848992 rs772976848 rs773096095 rs773329009 rs773382605 rs773438081 rs773482263 rs773713629 rs773800499 rs773883770 rs773935322 rs774132657 rs774566347 rs774570582 rs774571151 rs774619735 rs774624250 rs774876624 rs774891561 rs774945021 rs774951544 rs775004391 rs775054659 rs775107886 rs775234020 rs775260580 rs775514131 rs775704094 rs775815286 rs775868370 rs776041016 rs776096107 rs776191574 rs776242983 rs776266999 rs776373755 rs776653814 rs776722275 rs776853078 rs776973897 rs777026969 rs777113312 rs777365322 rs777412666 rs777413527 rs777440085 rs777680877 rs777754147 rs777924779 rs778175365 rs778310699 rs778345104 rs778362078 rs778429686 rs778591878 rs778841680 rs778883924 rs778920293 rs778939209 rs779021500 rs779327074 rs779416729 rs779464426 rs779633915 rs779748369 rs779973990 rs780031140 rs780082291 rs780085592 rs780087601 rs780181520 rs780337653 rs780363296 rs780472942 rs780490580 rs780819180 rs781123125 rs781203180 rs781225764 rs781280510 rs781330644 rs781484626 rs781635464 rs781659630 rs781705339

KRT10基因在不同组织中的表达： [UniProt]

正向引物序列

正向引物Tm值

反向引物序列

反向引物Tm值

rank

TGGCCTTGAAACAATCCCT

60

GGGCCTGAATCTGTGAGAG

60

CCTGGAGATGCAAATTGAGAG

59

CGAAGGTCTTTCATTTCCTCC

59

ACTGATAATGCCAACATCCT

57

CTCATTCTCATACTTCAGCCT

57

尚未收录相关数据

KRT10基因（以及对应的蛋白质）的细胞分布位置：

[UniProt] [GenomeNet]

溶酶体
内涵体
细胞核
细胞质
液泡
细胞膜
细胞外基质
内质网
线粒体
高尔基体
细胞骨架

KRT10基因的本体（GO）信息：

GO库代码

对应的蛋白质

来源代码

GO:0005615

P13645(UniProtKB)

IDA

GO:0005634

P13645(UniProtKB)

IDA

GO:0005737

P13645(UniProtKB)

IDA

GO:0005882

P13645(UniProtKB)

NAS

GO:0016020

P13645(UniProtKB)

IDA

GO:0030216

P13645(UniProtKB)

IEP

GO:0030280

P13645(UniProtKB)

NAS

GO:0070062

P13645(UniProtKB)

IDA

GO:0070062

P13645(UniProtKB)

IDA

GO:0070062

P13645(UniProtKB)

IDA

GO:0070062

P13645(UniProtKB)

IDA

序号	作用方式	资源库来源/分值	基因名称	基因名称

可能调控KRT10基因的相关microRNA：

hsa-miR-122

通路基因列表

疾病名称

关系值

NofPmids

NofSnps

来源

疾病名称	关系值	NofPmids	NofSnps	来源
Hyperkeratosis, Epidermolytic	0.496849259	45	10	BeFree_CLINVAR_CTD_human_LHGDN_ORPHANET_UNIPROT
Ichthyosis, Cyclic, with Epidermolytic Hyperkeratosis	0.360814326	3	1	BeFree_CTD_human_ORPHANET_UNIPROT
Congenital reticular ichthyosiform erythroderma	0.241085767	4	0	BeFree_CTD_human_ORPHANET
Squamous cell carcinoma	0.126263026	6	0	BeFree_CTD_human_LHGDN
Contact Dermatitis	0.12	1	0	CTD_human
Skin Neoplasms	0.12	1	0	CTD_human
Arsenic Poisoning	0.12	1	0	CTD_human
Erythrokeratoderma, Reticular	0.12	0	2	CLINVAR
Epidermolytic palmoplantar keratoderma of Vorner	0.008143256	30	2	BeFree
Lyme Disease	0.00272435	1	0	LHGDN
Teratoma	0.00272435	1	0	LHGDN
Liver carcinoma	0.00272435	1	0	LHGDN
Palmoplantar Keratosis	0.001628651	6	0	BeFree
Dermatologic disorders	0.001628651	6	1	BeFree
Hyperkeratosis	0.001357209	5	0	BeFree
Skin Diseases, Genetic	0.000814326	3	0	BeFree
Exfoliative dermatitis	0.000542884	2	0	BeFree
Epidermolysis Bullosa Simplex	0.000542884	2	0	BeFree
NEVUS, EPIDERMAL (disorder)	0.000542884	2	0	BeFree
Bloom Syndrome	0.000271442	1	0	BeFree
Dermoid Cyst	0.000271442	1	0	BeFree
Esophageal Neoplasms	0.000271442	1	0	BeFree
Ichthyoses	0.000271442	1	0	BeFree
Congenital ichthyosis	0.000271442	1	0	BeFree
Keratoderma, Palmoplantar, Diffuse	0.000271442	1	0	BeFree
Esophageal carcinoma	0.000271442	1	0	BeFree
Penile warts	0.000271442	1	0	BeFree
Malignant neoplasm of esophagus	0.000271442	1	0	BeFree
Carcinogenesis	0.000271442	1	0	BeFree
Spots on skin	0.000271442	1	0	BeFree