KRT1(keratin 1, type II) 转至新版数据库

基因基本信息

基因基本信息

基因简称(symbol)
    [HGNC]     [GeneCards]     [NCBI]
基因种类(locus group)
同源简称(alias symbol)
基因家族代码(gene_family_id)
    [HGNC]     [GenScript]
omim代码
entrez码
    [Vega]
vega基因码
ensembl基因码
    [Ensembl]
基因家族(gene family)
refseq数据库代号

更多...

基因种类(locus_type)
基因名称状态(status)
location_sortable
同源基因名称(alias name)
基因名称批准使用时间(date_approved_reserved)
基因简称更名时间(date_symbol_changed)
基因名称更名时间(date_name_changed)
更新时间(date_modified)
ucsc码
ena
ccds数据码
uniprot数据码
pubmed代码
mgd码
rgd码
生命科学数据库(lsdb)
更新时间(date modified)
cosmic
mirbase
基因曾用简称(prev symbol)
基因曾用名称(prev name)
homeodb
cosmic
snornabase
bioparadigms slc
orphanet
假基因信息(pseudogeneorg)
horde id
merops
imgt
iuphar
kznf基因类别
mamit-trnadb
cd
LncRNA数据库
酶代码
中间纤维数据库

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基因染色体位置

基因染色体位置

12q13.13
基因染色体位置图

基因简述

基因简述

The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the spinous and granular layers of the epidermis with family member KRT10 and mutations in these genes have been associated with bullous congenital ichthyosiform erythroderma. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008]

[中文简述(自动翻译):]  由该基因编码的蛋白质是角蛋白基因家族的一个成员。 II型角蛋白包括被布置成对简单和分层上皮组织分化过程中共同表达异型角蛋白链的碱性或中性的蛋白质。这种II型角蛋白是与家庭成员KRT10和在这些基因突变的表皮棘层和颗粒层中特异性表达已与大疱先天性鱼鳞癣红皮相关联。 II型角蛋白聚集在染色体12q12-Q13的一个区域。 [由RefSeq的，2008年7月提供]

OMIM数据库中对KRT1基因的介绍     Wikipedia数据库中对KRT1基因的介绍

基因序列

基因序列

KRT1基因的碱基序列：[NCBI]

基因突变

基因突变

KRT1基因的碱基突变：           显示全部snp
rs14024       rs584843       rs597685       rs626480       rs674860       rs698170       rs728147       rs828367       rs828368       rs863786       rs936958       rs1050872       rs1050886       rs1050890       rs1050893       rs1050895       rs1050897       rs2010060       rs2171585       rs2171586       rs2669584       rs2741152       rs2741153       rs2741154       rs2741155       rs2741158       rs2741159       rs2741160       rs2741161       rs3759191       rs3759192       rs3837476       rs7961891       rs11170231       rs11170232       rs12305986       rs12425650      
rs17678945       rs17679190       rs17735541       rs17735829       rs34154891       rs34787940       rs56895471       rs59044845       rs60359468       rs61218439       rs61392452       rs66514557       rs73094649       rs74093774       rs74354679       rs75007002       rs75711771       rs75948019       rs77077058       rs77522048       rs77846840       rs78169845       rs79068886       rs79527822       rs79693071       rs111295700       rs111597530       rs111907110       rs112275575       rs112384069       rs112525627       rs113126271       rs113804510       rs114835197       rs115068385       rs115742553       rs116444444       rs117108628       rs137920159       rs137978741       rs138041295       rs138409304       rs138983077       rs139277600       rs139428176       rs140098565       rs140169594       rs140449947       rs141127814       rs141641507       rs142164771       rs142451960       rs142474290       rs142759772       rs142781300       rs142821486       rs143756169       rs144520865       rs144758077       rs145112157       rs145256530       rs146117392       rs146155769       rs146169155       rs146820668       rs147251311       rs147622831       rs147682749       rs147840212       rs148193325       rs148526002       rs148588180       rs149108064       rs149269346       rs149429880       rs149480015       rs149638013       rs149984152       rs150082347       rs150503977       rs151245339       rs180746965       rs181130130       rs181343864       rs181516749       rs182359342       rs182817295       rs182891457       rs183980482       rs184313837       rs184532153       rs185032550       rs185897283       rs186129059       rs186487499       rs187528273       rs187779735       rs189087382       rs189913911       rs189943389       rs190219749       rs190720388       rs190774630       rs190928975       rs191774254       rs191805150       rs192210404       rs192365492       rs192498048       rs199852766       rs199877663       rs199898160       rs199947827       rs199972742       rs200190157       rs200254456       rs200353241       rs200685656       rs200891005       rs200891502       rs200896578       rs201036490       rs201069649       rs201494492       rs201544335       rs201550943       rs201584652       rs201712128       rs201825026       rs201850105       rs202088314       rs202173344       rs267603525       rs267607656       rs367576329       rs367758133       rs368096664       rs368177888       rs368400506       rs368821072       rs369049651       rs369321029       rs369324638       rs370206485       rs370239641       rs370368914       rs370545890       rs370799361       rs370833984       rs370990079       rs371104398       rs371124998       rs371171252       rs371428130       rs371554968       rs371657238       rs372121916       rs372123842       rs372130756       rs372686828       rs372937607       rs373243712       rs373780324       rs374006571       rs374523527       rs374560853       rs374690429       rs374728180       rs374949297       rs374968720       rs375014464       rs375264286       rs375276268       rs375387746       rs376101250       rs376128876       rs376915013       rs377070374       rs377220047       rs377282465       rs377333980       rs527241748       rs527639285       rs528193172       rs528256075       rs529168987       rs529661171       rs529735391       rs530214484       rs530276545       rs530511809       rs530556838       rs531100926       rs531102420       rs531290655       rs531638326       rs531710346       rs531824328       rs532003323       rs532426565       rs532702734       rs533834794       rs534574954       rs536080768       rs536609202       rs536619673       rs536680291       rs536813177       rs537744449       rs538148711       rs538206873       rs538989331       rs538998792       rs539036763       rs539061896       rs539275691       rs539890373       rs539952592       rs540130407       rs540680660       rs540699806       rs540805919       rs540928638       rs541520912       rs542030436       rs542318739       rs542753485       rs542892389       rs542953705       rs543042871       rs543421466       rs543980536       rs544960237       rs545202433       rs545263441       rs545434207       rs545498394       rs546400872       rs547067073       rs547130332       rs547181681       rs547305123       rs548041893       rs548660626       rs548892253       rs549279283       rs549754231       rs549917182       rs549932284       rs550597408       rs550879646       rs551140423       rs551202996       rs551449372       rs551552136       rs552006414       rs552526431       rs552723480       rs553082969       rs553332826       rs553384515       rs553419608       rs553480869       rs554536645       rs554592263       rs554748626       rs554811847       rs555069773       rs555119341       rs555326745       rs555469154       rs555530866       rs555945235       rs556122328       rs556128207       rs556541104       rs556838312       rs557077888       rs557388955       rs557452304       rs558912213       rs558974183       rs559652283       rs559722419       rs560312116       rs560662197       rs560870851       rs560913567       rs561467552       rs561530406       rs561592908       rs562141868       rs563399473       rs564135095       rs564926977       rs564946224       rs565272443       rs565475195       rs565545294       rs565822286       rs566881350       rs566942079       rs567003565       rs567761398       rs567789290       rs567992767       rs568325445       rs569095566       rs569308771       rs569689683       rs570230600       rs570384475       rs570553361       rs571583064       rs571892423       rs571925367       rs572078102       rs572191689       rs572335374       rs573098483       rs573159240       rs573222141       rs573283510       rs573933828       rs573966604       rs574029383       rs575075676       rs575349300       rs575585873       rs575648870       rs575886169       rs575995078       rs576064216       rs576453328       rs576516680       rs745549570       rs745632506       rs745702313       rs745740228       rs745830309       rs745848100       rs746219285       rs746307137       rs746382167       rs746484676       rs746682524       rs746754557       rs746888434       rs747087178       rs747243738       rs747494615       rs747645316       rs747734601       rs747854771       rs747876077       rs748024312       rs748112160       rs748334745       rs748601175       rs748636850       rs748686918       rs748720674       rs749001815       rs749171770       rs749274100       rs749289058       rs749418971       rs749444601       rs749532294       rs749594645       rs749643681       rs749682564       rs749815868       rs750015593       rs750190298       rs750248505       rs750509590       rs750715624       rs750757560       rs750849977       rs751076903       rs751155007       rs751192331       rs751354477       rs751420569       rs751464239       rs751653119       rs751665484       rs751753610       rs751974882       rs752065084       rs752219630       rs752221066       rs752232489       rs752372031       rs752462027       rs752595516       rs752789791       rs753373623       rs753562993       rs753630553       rs753826105       rs753842056       rs754021727       rs754081965       rs754206965       rs754534861       rs754534920       rs754622806       rs754745006       rs755016557       rs755073937       rs755152518       rs755336645       rs755344168       rs755394068       rs755551411       rs755676117       rs755745001       rs756115415       rs756384693       rs756514511       rs756537688       rs756729273       rs756735090       rs756819077       rs756948472       rs757184812       rs757213853       rs757414670       rs757417175       rs757500946       rs757504428       rs757513367       rs757610672       rs757702443       rs757838499       rs758035884       rs758099039       rs758101171       rs758313016       rs758512881       rs758514099       rs758594838       rs758763219       rs758984107       rs759092002       rs759212935       rs759244867       rs759299240       rs759299251       rs759330692       rs759518011       rs759524757       rs759961972       rs760448027       rs760475347       rs760503522       rs760517071       rs760593492       rs760639465       rs760922622       rs760938474       rs760991653       rs761013022       rs761110809       rs761180284       rs761181439       rs761294081       rs761306590       rs761466372       rs761779879       rs761859748       rs762063927       rs762098926       rs762165892       rs762323767       rs762340514       rs762401934       rs762455418       rs762734951       rs762826607       rs763002437       rs763093448       rs763145084       rs763280898       rs763309701       rs763445742       rs763489367       rs763533681       rs763592514       rs763609085       rs763965680       rs764305315       rs764459131       rs764558253       rs764560436       rs764742435       rs765045184       rs765055643       rs765150249       rs765291884       rs765344887       rs765379773       rs765624943       rs765714875       rs765732197       rs765750895       rs765763232       rs766125642       rs766205230       rs766223854       rs766275736       rs766385141       rs766418051       rs766678229       rs766766361       rs766783845       rs767331118       rs767414946       rs767422677       rs767422813       rs767433585       rs767510621       rs767646106       rs767794650       rs767824181       rs767857580       rs767920462       rs768162992       rs768234041       rs768678330       rs768678476       rs768738084       rs768764062       rs768853475       rs769218372       rs769301639       rs769349684       rs769462370       rs769587823       rs769822663       rs769826994       rs769968882       rs770355673       rs770383461       rs770635994       rs770778354       rs770868243       rs770919748       rs770940768       rs770965582       rs771032423       rs771157757       rs771245668       rs771440593       rs771524812       rs771587972       rs771675813       rs771998586       rs772052644       rs772066457       rs772092407       rs772162914       rs772515524       rs772602258       rs772664250       rs772693654       rs772694214       rs772710102       rs772752175       rs772832274       rs773141462       rs773287323       rs773500895       rs773587262       rs773592554       rs773784621       rs773812331       rs773834793       rs773900596       rs773926929       rs774036297       rs774048256       rs774240159       rs774332167       rs774367908       rs774379558       rs774418013       rs774724076       rs774726631       rs774807927       rs774920090       rs775108154       rs775323304       rs775385103       rs775473105       rs775504383       rs775570636       rs775594296       rs775688638       rs775896673       rs775947461       rs775951137       rs775992378       rs776254130       rs776371326       rs776431293       rs776478134       rs776631213       rs776654873       rs776718757       rs776744794       rs776823744       rs777181498       rs777269569       rs777283221       rs777387816       rs777466645       rs777516621       rs777554472       rs777651240       rs777661087       rs777945905       rs778049681       rs778141439       rs778343077       rs778385632       rs778502873       rs778594975       rs779045977       rs779067226       rs779092761       rs779194639       rs779653224       rs779743242       rs779762831       rs780043647       rs780136225       rs780136294       rs780232553       rs780250140       rs780301845       rs780472245       rs780491184       rs780507238       rs780600291       rs780692791       rs780795028       rs780806002       rs780981259       rs780993280       rs781535448      

基因表达

基因表达

KRT1基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向引物Tm值
反向引物序列
反向引物Tm值
rank
ACAATGTCAAGAAGCAGATCTC
58
CATCCTTGAGGGCATTCTC
58
GACAATGTCAAGAAGCAGATCTC
59
ATCCTTGAGGGCATTCTCG
59
GAAATTTCTGAGCTGAATCGTG
58
CTGCAAGTTGGAGATCTGC
58

转录因子

转录因子

      尚未收录相关数据

基因本体信息

KRT1基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 溶酶体
  • 内涵体
  • 细胞核
  • 细胞质
  • 液泡
  • 细胞膜
  • 细胞外基质
  • 内质网
  • 线粒体
  • 高尔基体
  • 细胞骨架

KRT1基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0001867
P04264(UniProtKB)
IPI
GO:0001895
P04264(UniProtKB)
IEP
GO:0004872
P04264(UniProtKB)
NAS
GO:0005198
P04264(UniProtKB)
IEA
GO:0005515
P04264(UniProtKB)
IPI
GO:0005615
P04264(UniProtKB)
IDA
GO:0005615
P04264(UniProtKB)
IDA
GO:0005634
P04264(UniProtKB)
IDA
GO:0005856
P04264(UniProtKB)
TAS
GO:0005886
P04264(UniProtKB)
IEA
GO:0006979
P04264(UniProtKB)
NAS
GO:0016020
P04264(UniProtKB)
IDA
GO:0016020
P04264(UniProtKB)
IDA
GO:0030246
P04264(UniProtKB)
IPI
GO:0031012
P04264(UniProtKB)
IDA
GO:0042730
P04264(UniProtKB)
NAS
GO:0045095
P04264(UniProtKB)
IEA
GO:0045765
P04264(UniProtKB)
NAS
GO:0050728
P04264(UniProtKB)
IEA
GO:0061436
P04264(UniProtKB)
IEA
GO:0070062
P04264(UniProtKB)
IDA
GO:0070062
P04264(UniProtKB)
IDA
GO:0070062
P04264(UniProtKB)
IDA
GO:0070062
P04264(UniProtKB)
IDA
GO:0072562
P04264(UniProtKB)
IDA

基因相互作用关系

基因相互作用关系

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因相关microRNA

基因相关microRNA

可能调控KRT1基因的相关microRNA：     

基因通路图

基因通路图

基因的通路属性图
通路基因列表

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Hyperkeratosis, Epidermolytic 0.6527677 43 15 BeFree_CLINVAR_CTD_human_LHGDN_MGD_ORPHANET_RGD_UNIPROT
Ichthyosis, Cyclic, with Epidermolytic Hyperkeratosis 0.48 1 2 CLINVAR_CTD_human_ORPHANET_UNIPROT
Keratoderma, Palmoplantar, Epidermolytic 0.361900093 7 1 BeFree_CLINVAR_CTD_human_ORPHANET
PALMOPLANTAR KERATODERMA, NONEPIDERMOLYTIC 0.360271442 2 1 BeFree_CLINVAR_CTD_human_UNIPROT
Ichthyosis hystrix, Curth Macklin type 0.240271442 1 0 BeFree_CTD_human_ORPHANET
Epidermolytic palmoplantar keratoderma of Vorner 0.127057489 26 0 BeFree_ORPHANET
Skin Neoplasms 0.120542884 3 0 BeFree_CTD_human
Congenital reticular ichthyosiform erythroderma 0.120271442 1 0 BeFree_ORPHANET
Squamous cell carcinoma 0.12 1 0 CTD_human
Ichthyosis hystrix of Curth-Macklin 0.12 0 0 ORPHANET
Epidermolytic Hyperkeratosis, Late-Onset 0.12 0 0 CLINVAR
Keratosis palmoplantaris striata 1 0.12 0 0 CTD_human
Keratosis palmoplantaris striata 3 0.12 0 0 CTD_human
Epidermolytic palmoplantar keratoderma Vorner type 0.12 0 0 ORPHANET
Palmoplantar Keratosis 0.003257302 12 1 BeFree
Hyperkeratosis 0.001900093 7 0 BeFree
Keratoderma, Palmoplantar, Diffuse 0.000814326 3 1 BeFree
Ichthyosis Bullosa of Siemens 0.000814326 3 0 BeFree
Exfoliative dermatitis 0.000542884 2 0 BeFree
Keratoderma 0.000542884 2 0 BeFree
Dermatologic disorders 0.000542884 2 0 BeFree
Skin Diseases, Genetic 0.000542884 2 0 BeFree
Epidermolysis Bullosa Simplex 0.000542884 2 0 BeFree
Ichthyosis hystrix 0.000542884 2 1 BeFree
Skin Carcinogenesis 0.000542884 2 0 BeFree
Papilloma 0.000271442 1 0 BeFree
Cataract 0.000271442 1 0 BeFree
Epstein-Barr Virus Infections 0.000271442 1 0 BeFree
Pachyonychia Congenita 0.000271442 1 0 BeFree
Carcinoma breast stage IV 0.000271442 1 0 BeFree
NEVUS, EPIDERMAL (disorder) 0.000271442 1 0 BeFree
Epidermolysis bullosa simplex with mottled pigmentation 0.000271442 1 1 BeFree
Bilateral cataracts (disorder) 0.000271442 1 0 BeFree
ICHTHYOSIS EXFOLIATIVA 0.000271442 1 0 BeFree

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