更多...
收起
Conventional kinesin is a tetrameric molecule composed of two heavy chains and two light chains, and transports various cargos along microtubules toward their plus ends. The heavy chains provide the motor activity, while the light chains bind to various cargos. This gene encodes a member of the kinesin light chain family. It associates with kinesin heavy chain through an N-terminal domain, and six tetratricopeptide repeat (TPR) motifs are thought to be involved in binding of cargos such as vesicles, mitochondria, and the Golgi complex. Thus, kinesin light chains function as adapter molecules and not motors per se. Although previously named "kinesin 2", this gene is not a member of the kinesin-2 / kinesin heavy chain subfamily of kinesin motor proteins. Extensive alternative splicing produces isoforms with different C-termini that are proposed to bind to different cargos; however, the full-length nature and/or biological validity of most of these variants have not been determined. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  常规驱动蛋白是两条重链和两条轻链组成的四聚体分子,并且沿着朝着自己加上端部的微管运输各种货物。重链提供运动活动,而轻链结合到各种货物。该基因编码的驱动蛋白轻链家族的一个成员。它与驱动蛋白重链相关联,通过一个N-末端结构域,和六个三十四肽重复(TPR)基序被认为是参与货物如囊泡,线粒体和高尔基复合体的结合。因此,驱动蛋白轻链作为接头分子,而不是发动机本身。虽然以前命名为“驱动蛋白2”,该基因并不是驱动蛋白2驱动蛋白马达蛋白/驱动蛋白重链亚家族的一个成员。广泛的选择性剪接产生与提出结合不同货物不同的C末端同种型;然而,全长性质和/或生物学有效性大多数这些变体尚未确定。 [由RefSeq的,2008年7月提供]
KLC1基因(以及对应的蛋白质)的细胞分布位置:
KLC1基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Hypertensive disease | 0.007101096 | 3 | 0 | GAD |
Leukoaraiosis | 0.007101096 | 3 | 0 | GAD |
Alzheimer's Disease | 0.006263026 | 5 | 1 | BeFree_LHGDN |
Cataract | 0.002909916 | 3 | 1 | BeFree_GAD |
Multiple Sclerosis | 0.00272435 | 1 | 0 | LHGDN |
Cognition Disorders | 0.002367032 | 1 | 0 | GAD |
melanoma | 0.002367032 | 1 | 0 | GAD |
Skin Neoplasms | 0.002367032 | 1 | 0 | GAD |
Cerebrovascular accident | 0.002367032 | 1 | 0 | GAD |
Impaired cognition | 0.002367032 | 1 | 0 | GAD |
Multiple Sclerosis, Relapsing-Remitting | 0.002367032 | 1 | 0 | GAD |
Hypoxia-Ischemia, Brain | 0.002367032 | 1 | 0 | GAD |
Age-related cataract | 0.000814326 | 3 | 0 | BeFree |
Cortical cataract | 0.000271442 | 1 | 0 | BeFree |
Bilateral cataracts (disorder) | 0.000271442 | 1 | 1 | BeFree |
忘记密码? 点击找回密码.
扫一扫右方二维码,关注微信订阅号,实时查看信息,关注医学生物学动态。