KIR2DL5A基因详情-基因数据库-基因云馆

KIR2DL5A(killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5A) 转至新版数据库

基因简称(symbol)

KIR2DL5A [HGNC] [GeneCards] [NCBI]

基因种类(locus group)

protein-coding gene

同源简称(alias symbol)

KIR2DL5.1|KIR2DL5|CD158F

基因家族代码(gene_family_id)

471|594|620 [HGNC] [GenScript]

omim代码

605305

entrez码

57292 [Vega]

vega基因码

OTTHUMG00000151665

ensembl基因码

[Ensembl]

基因家族(gene family)

CD molecules|Immunoglobulin-like domain containing|Killer cell immunoglobulin-like receptors

refseq数据库代号

NM_020535

更多...

基因种类(locus_type)

gene with protein product

基因名称状态(status)

Approved

location_sortable

19q13.4 alternate reference locus

同源基因名称(alias name)

基因名称批准使用时间(date_approved_reserved)

2005-06-03T00:00:00Z

基因简称更名时间(date_symbol_changed)

基因名称更名时间(date_name_changed)

更新时间(date_modified)

2014-01-23T00:00:00Z

ucsc码

uc032kym.1

ena

AF217485|GL949747

ccds数据码

uniprot数据码

Q8N109

pubmed代码

11086080|12185535

mgd码

rgd码

生命科学数据库(lsdb)

IPD-KIR Database|http://www.ebi.ac.uk/ipd/kir/

更新时间(date modified)

2014-01-23T00:00:00Z

cosmic

mirbase

基因曾用简称(prev symbol)

基因曾用名称(prev name)

homeodb

cosmic

snornabase

bioparadigms slc

orphanet

假基因信息(pseudogeneorg)

horde id

merops

I43.951

imgt

iuphar

kznf基因类别

mamit-trnadb

cd

CD158F

LncRNA数据库

酶代码

中间纤维数据库

收起

19q13.4 alternate reference locus

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008]

[中文简述(自动翻译):] 杀伤细胞免疫球蛋白样受体（的KIRs）是通过自然杀伤细胞和T细胞亚群表达跨膜糖蛋白。的KIR基因多态和高度同源的并且它们中的1兆白细胞受体复合物（LRC）内染色体19q13.4群集找到。的KIR基因簇的基因含量的单倍型的不同而不同，虽然有几个“框架”的基因在所有的单倍型（KIR3DL3，KIR3DP1，KIR3DL4，KIR3DL2）找到。的KIR蛋白由细胞外免疫球蛋白结构域（2D或3D）的数目和由划分他们是否具有长（L）或短（S） - 胞质域。与长的胞质域的KIR蛋白质在配体经由一个基于免疫受体酪氨酸的抑制基序（ITIM）结合转导抑制性信号，同时与短胞质域KIR蛋白缺乏ITIM基序，而是与TYRO蛋白酪氨酸激酶关联结合蛋白转导激活信号。数KIR蛋白配体是HLA I类分子的子集;因而，KIR蛋白被认为在免疫应答的调节中发挥着重要作用。 [由RefSeq的，2008年7月提供]

OMIM数据库中对KIR2DL5A基因的介绍 Wikipedia数据库中对KIR2DL5A基因的介绍

KIR2DL5A基因的碱基序列：[NCBI]

KIR2DL5A基因的碱基突变：显示全部snp

rs1130476 rs1130476 rs1535401 rs1535403 rs1885390 rs1885392 rs1969728 rs2740454 rs2740454 rs2916049 rs2916049 rs2916051 rs2916051 rs4563149 rs4563149 rs4575639 rs4575639 rs4806452 rs4806452 rs4806453 rs4806453 rs4806582 rs4806582 rs7258328 rs10423866 rs10423866 rs11667722 rs11667722 rs11667798 rs11667798 rs11667799 rs11667799 rs11672006 rs11672006 rs11672012 rs11672012 rs11672015

rs12150998 rs12150998 rs12151085 rs12151085 rs12151256 rs12151256 rs34177062 rs57119480 rs57119480 rs57653681 rs57653681 rs59091355 rs59091355 rs72489148 rs72489148 rs72489149 rs72489149 rs72489150 rs72489150 rs72489151 rs72489151 rs72629106 rs72629106 rs72629108 rs72629108 rs72629112 rs72629112 rs76346436 rs76346436 rs76535269 rs76535269 rs78368843 rs78732506 rs78732506 rs79291747 rs79291747 rs79486747 rs79486747 rs111647590 rs111647590 rs111713875 rs111713875 rs111755630 rs111755630 rs111922136 rs111922136 rs112323185 rs112323185 rs113018226 rs113018226 rs113156656 rs113156656 rs113195465 rs113195465 rs113238685 rs113238685 rs113410873 rs113410873 rs113538222 rs113538222 rs113564309 rs113564309 rs113719221 rs113719221 rs114229817 rs114229817 rs114765601 rs114765601 rs115033907 rs115033907 rs115534037 rs115534037 rs115685960 rs115685960 rs116483083 rs116483083 rs117127282 rs117127282 rs138066671 rs138066671 rs138598976 rs138598976 rs138612309 rs138612309 rs140204499 rs140204499 rs140613562 rs140613562 rs141679531 rs141679531 rs142283222 rs142283222 rs142759353 rs142759353 rs143540072 rs143540072 rs143722061 rs143722061 rs143857200 rs143857200 rs145671038 rs145671038 rs146790627 rs146790627 rs148069625 rs148069625 rs150360867 rs150360867 rs150737349 rs150737349 rs181940988 rs181940988 rs182161130 rs182161130 rs183312055 rs183312055 rs183336952 rs183336952 rs184639014 rs184639014 rs184893808 rs184893808 rs184926304 rs184926304 rs185372370 rs185372370 rs187922737 rs187922737 rs188034092 rs188034092 rs189425914 rs189425914 rs191053718 rs192077351 rs192077351 rs192557160 rs192557160 rs199731517 rs199731517 rs200268048 rs200268048 rs200781151 rs200781151 rs200900052 rs200900052 rs200910211 rs200910211 rs201336361 rs201336361 rs202026478 rs202026478 rs367797656 rs367797656 rs368267928 rs368267928 rs368679255 rs368679255 rs369380566 rs369380566 rs369930679 rs369930679 rs370647152 rs370647152 rs373049393 rs373354248 rs373563121 rs374020062 rs374020062 rs374252476 rs374252476 rs374653077 rs374653077 rs374945085 rs374945085 rs376833149 rs376833149 rs377436958 rs377436958 rs527514677 rs527514677 rs527769268 rs527769268 rs528516832 rs528516832 rs529712789 rs529712789 rs534208975 rs534208975 rs535240928 rs535240928 rs535582047 rs535582047 rs535803720 rs535803720 rs536113602 rs536113602 rs537645286 rs537645286 rs537918657 rs537918657 rs538050539 rs538050539 rs538837589 rs539448556 rs539709858 rs540543522 rs542078510 rs542416520 rs543142924 rs543243558 rs543854707 rs543941750 rs545807659 rs546114928 rs546528252 rs546575539 rs547436522 rs549759361 rs549805577 rs549880349 rs550684189 rs550889396 rs552117477 rs552382547 rs553728656 rs554653060 rs555915421 rs556458634 rs558830629 rs560221972 rs561886860 rs562183505 rs562517255 rs562788444 rs563642913 rs563675304 rs563906081 rs565586867 rs566233322 rs567875212 rs569638295 rs569986373 rs570317342 rs570642901 rs571725392 rs572004572 rs574029457 rs575946275 rs576242109 rs576866994 rs577011317 rs577439081 rs746720874 rs749636490 rs749829868 rs750525542 rs751710186 rs751897976 rs755311493 rs759324605 rs759538677 rs760097108 rs761417664 rs762838503 rs764023174 rs770036658 rs775628308 rs776234530 rs778128803 rs780333840 rs781385412

KIR2DL5A基因在不同组织中的表达： [UniProt]

正向引物序列

正向引物Tm值

反向引物序列

反向引物Tm值

rank

尚未收录相关数据

KIR2DL5A基因（以及对应的蛋白质）的细胞分布位置：

[UniProt] [GenomeNet]

溶酶体
内涵体
细胞核
细胞质
液泡
细胞膜
细胞外基质
内质网
线粒体
高尔基体
细胞骨架

KIR2DL5A基因的本体（GO）信息：

GO库代码

对应的蛋白质

来源代码

GO:0016021

B0L652(UniProtKB)

IEA

GO:0005886

Q8N109(UniProtKB)

IEA

GO:0016021

Q8N109(UniProtKB)

IEA

序号	作用方式	资源库来源/分值	基因名称	基因名称

可能调控KIR2DL5A基因的相关microRNA：

通路基因列表

疾病名称

关系值

NofPmids

NofSnps

来源

疾病名称	关系值	NofPmids	NofSnps	来源
Ankylosing spondylitis	0.011368221	9	0	BeFree_GAD
Diabetes Mellitus, Insulin-Dependent	0.010825337	9	0	BeFree_GAD
HIV Infections	0.009001189	10	0	BeFree_GAD
Lupus Erythematosus, Systemic	0.008458305	6	0	BeFree_GAD
Psoriasis	0.00827274	5	0	BeFree_GAD_LHGDN
leukemia	0.00764398	4	0	BeFree_GAD
Hepatitis C, Chronic	0.007101096	3	0	GAD
Graft-vs-Host Disease	0.006091273	7	0	BeFree_GAD
Leukemia, Myelocytic, Acute	0.005819831	6	0	BeFree_GAD
Multiple Sclerosis	0.00554839	5	0	BeFree_GAD
Autoimmune Diseases	0.005005506	3	0	BeFree_GAD
Uveomeningoencephalitic Syndrome	0.005005506	2	0	BeFree_GAD
Spontaneous abortion	0.004734064	2	0	GAD
Hepatitis B, Chronic	0.004734064	2	0	GAD
Pregnancy loss	0.004734064	2	0	GAD
Myeloid Leukemia, Chronic	0.003181358	4	0	BeFree_GAD
Behcet Syndrome	0.002909916	3	0	BeFree_GAD
Cytomegalovirus Infections	0.002909916	3	0	BeFree_GAD
Tropical Spastic Paraparesis	0.002638474	1	0	BeFree_GAD
Familial Mediterranean Fever	0.002638474	1	0	BeFree_GAD
Acute GVH disease	0.002638474	2	0	BeFree_GAD
Recurrent respiratory papillomatosis	0.002638474	1	0	BeFree_GAD
Precursor Cell Lymphoblastic Leukemia Lymphoma	0.002638474	2	0	BeFree_GAD
Liver carcinoma	0.002638474	2	0	BeFree_GAD
Abortion, Habitual	0.002367032	1	0	GAD
Equine Infectious Anemia	0.002367032	1	0	GAD
Gastritis	0.002367032	1	0	GAD
Graves Disease	0.002367032	1	0	GAD
Hepatitis C	0.002367032	1	0	GAD
Leprosy	0.002367032	1	0	GAD
Leptospirosis	0.002367032	1	0	GAD
Myeloid Leukemia	0.002367032	1	0	GAD
Liver Cirrhosis	0.002367032	1	0	GAD
Liver neoplasms	0.002367032	1	0	GAD
Lymphocytosis	0.002367032	1	0	GAD
Lymphoma, Non-Hodgkin	0.002367032	1	0	GAD
Neoplasm Recurrence, Local	0.002367032	1	0	GAD
Degenerative polyarthritis	0.002367032	1	0	GAD
Postoperative Complications	0.002367032	1	0	GAD
Hemorrhagic Fever, Ebola	0.002367032	1	0	GAD
Leukemia, Large Granular Lymphocytic	0.002367032	1	0	GAD
Arthritis, Psoriatic	0.001357209	5	0	BeFree
Rheumatoid Arthritis	0.001357209	5	0	BeFree
Lymphoma	0.000814326	3	0	BeFree
Malaria	0.000814326	3	0	BeFree
Psoriasis vulgaris	0.000814326	3	0	BeFree
Celiac Disease	0.000542884	2	0	BeFree
Endometriosis	0.000542884	2	0	BeFree
Hepatitis B	0.000542884	2	0	BeFree
Systemic Scleroderma	0.000542884	2	0	BeFree
Tuberculosis	0.000542884	2	0	BeFree
Tuberculosis, Pulmonary	0.000542884	2	0	BeFree
Aplastic Anemia	0.000271442	1	0	BeFree
Diabetes Mellitus, Non-Insulin-Dependent	0.000271442	1	0	BeFree
Leprosy, Lepromatous	0.000271442	1	0	BeFree
Acute lymphocytic leukemia	0.000271442	1	0	BeFree
Obesity	0.000271442	1	0	BeFree
Virus Diseases	0.000271442	1	0	BeFree
Age related macular degeneration	0.000271442	1	0	BeFree
Neoplasm, Residual	0.000271442	1	0	BeFree
Superficial ulcer	0.000271442	1	0	BeFree
Idiopathic bronchiectasis	0.000271442	1	0	BeFree
Microscopic Polyangiitis	0.000271442	1	0	BeFree
Chronic Chagas' disease	0.000271442	1	0	BeFree
Leukaemia recurrent	0.000271442	1	0	BeFree
Colorectal cancer metastatic	0.000271442	1	0	BeFree
MULTICYSTIC RENAL DYSPLASIA, BILATERAL	0.000271442	1	0	BeFree
Bone Marrow failure syndromes	0.000271442	1	0	BeFree