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This gene encodes an intracellular tyrosine kinase expressed in T-cells. The protein contains both SH2 and SH3 domains which are often found in intracellular kinases. It is thought to play a role in T-cell proliferation and differentiation. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  该基因编码在T细胞中表达的细胞内酪氨酸激酶。蛋白质含有这往往是在细胞内激酶发现两个SH2和SH3结构域。它被认为在T细胞增殖和分化的作用。 [由RefSeq的,2008年7月提供]
ITK基因(以及对应的蛋白质)的细胞分布位置:
ITK基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Lymphoproliferative Syndrome, Ebv-Associated, Autosomal, 1 | 0.24 | 0 | 3 | CLINVAR_CTD_human |
Bipolar Disorder | 0.12 | 1 | 1 | GWASCAT |
IGA Glomerulonephritis | 0.12 | 1 | 0 | CTD_human |
LYMPHOPROLIFERATIVE SYNDROME 1 | 0.12 | 1 | 1 | UNIPROT |
Neoplasm Metastasis | 0.013572094 | 50 | 0 | BeFree |
Breast Carcinoma | 0.010043349 | 37 | 0 | BeFree |
Malignant neoplasm of breast | 0.009771907 | 36 | 0 | BeFree |
Asthma | 0.003267234 | 3 | 0 | BeFree_LHGDN |
Colorectal Carcinoma | 0.003257302 | 12 | 0 | BeFree |
Liver carcinoma | 0.003257302 | 12 | 0 | BeFree |
Tumor Progression | 0.002985861 | 11 | 0 | BeFree |
Colorectal Cancer | 0.002985861 | 11 | 0 | BeFree |
HIV Infections | 0.00272435 | 1 | 0 | LHGDN |
Malignant neoplasm of prostate | 0.002714419 | 10 | 0 | BeFree |
Prostate carcinoma | 0.002714419 | 10 | 0 | BeFree |
Malignant neoplasm of stomach | 0.002442977 | 9 | 0 | BeFree |
Pancreatic carcinoma | 0.002442977 | 9 | 0 | BeFree |
Malignant neoplasm of lung | 0.002442977 | 9 | 0 | BeFree |
Malignant neoplasm of pancreas | 0.002442977 | 9 | 0 | BeFree |
Carcinoma of lung | 0.002442977 | 9 | 0 | BeFree |
Stomach Carcinoma | 0.002442977 | 9 | 0 | BeFree |
As If Personality | 0.002367032 | 1 | 1 | GAD |
Body Weight Changes | 0.002367032 | 1 | 1 | GAD |
Hay fever | 0.002367032 | 1 | 0 | GAD |
Atopy | 0.002367032 | 1 | 0 | GAD |
Dermatitis and eczema | 0.002367032 | 1 | 0 | GAD |
Peripheral T-Cell Lymphoma | 0.001900093 | 7 | 0 | BeFree |
Carcinogenesis | 0.001900093 | 7 | 0 | BeFree |
Malignant tumor of colon | 0.001628651 | 6 | 0 | BeFree |
Non-Small Cell Lung Carcinoma | 0.001628651 | 6 | 0 | BeFree |
Endometrial Carcinoma | 0.001628651 | 6 | 0 | BeFree |
Colon Carcinoma | 0.001628651 | 6 | 0 | BeFree |
Lymphoproliferative Disorders | 0.001357209 | 5 | 0 | BeFree |
Pancreatic Ductal Adenocarcinoma | 0.001357209 | 5 | 0 | BeFree |
Malignant neoplasm of endometrium | 0.001085767 | 4 | 0 | BeFree |
melanoma | 0.001085767 | 4 | 0 | BeFree |
Ovarian Carcinoma | 0.001085767 | 4 | 0 | BeFree |
Renal fibrosis | 0.001085767 | 4 | 0 | BeFree |
Secondary malignant neoplasm of liver | 0.001085767 | 4 | 0 | BeFree |
Malignant neoplasm of ovary | 0.001085767 | 4 | 0 | BeFree |
Uterine Corpus Cancer | 0.001085767 | 4 | 0 | BeFree |
Adenocarcinoma | 0.000814326 | 3 | 0 | BeFree |
Glioma | 0.000814326 | 3 | 0 | BeFree |
Immunologic Deficiency Syndromes | 0.000814326 | 3 | 0 | BeFree |
Epstein-Barr Virus Infections | 0.000814326 | 3 | 0 | BeFree |
Secondary malignant neoplasm of lung | 0.000814326 | 3 | 0 | BeFree |
Carcinoma breast stage IV | 0.000814326 | 3 | 0 | BeFree |
Idiopathic Pulmonary Fibrosis | 0.000814326 | 3 | 0 | BeFree |
Malignant neoplasm of urinary bladder | 0.000542884 | 2 | 0 | BeFree |
Malignant neoplasm of thyroid | 0.000542884 | 2 | 0 | BeFree |
Renal Cell Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Squamous cell carcinoma | 0.000542884 | 2 | 0 | BeFree |
Eczema | 0.000542884 | 2 | 0 | BeFree |
Esophageal Neoplasms | 0.000542884 | 2 | 0 | BeFree |
Angioimmunoblastic Lymphadenopathy | 0.000542884 | 2 | 0 | BeFree |
Lymphohistiocytosis, Hemophagocytic | 0.000542884 | 2 | 0 | BeFree |
Lymphoma | 0.000542884 | 2 | 0 | BeFree |
Adenocarcinoma of lung (disorder) | 0.000542884 | 2 | 0 | BeFree |
Esophageal carcinoma | 0.000542884 | 2 | 0 | BeFree |
Fibrosis, Liver | 0.000542884 | 2 | 0 | BeFree |
Squamous cell carcinoma of esophagus | 0.000542884 | 2 | 0 | BeFree |
Malignant neoplasm of esophagus | 0.000542884 | 2 | 0 | BeFree |
X-Linked Lymphoproliferative Disorder | 0.000542884 | 2 | 0 | BeFree |
Thyroid carcinoma | 0.000542884 | 2 | 0 | BeFree |
Epithelial ovarian cancer | 0.000542884 | 2 | 0 | BeFree |
Carcinoma of bladder | 0.000542884 | 2 | 0 | BeFree |
Mammary Neoplasms | 0.000542884 | 2 | 0 | BeFree |
Nasopharyngeal carcinoma | 0.000542884 | 2 | 0 | BeFree |
Triple Negative Breast Neoplasms | 0.000542884 | 2 | 0 | BeFree |
Astrocytoma | 0.000271442 | 1 | 0 | BeFree |
Noninfiltrating Intraductal Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Carcinosarcoma | 0.000271442 | 1 | 0 | BeFree |
Malignant tumor of cervix | 0.000271442 | 1 | 0 | BeFree |
Colonic Neoplasms | 0.000271442 | 1 | 0 | BeFree |
Colorectal Neoplasms | 0.000271442 | 1 | 0 | BeFree |
Phyllodes Tumor | 0.000271442 | 1 | 0 | BeFree |
Fanconi Anemia | 0.000271442 | 1 | 0 | BeFree |
Glioblastoma | 0.000271442 | 1 | 0 | BeFree |
Keloid | 0.000271442 | 1 | 0 | BeFree |
Hairy Cell Leukemia | 0.000271442 | 1 | 0 | BeFree |
Liver neoplasms | 0.000271442 | 1 | 0 | BeFree |
Myocarditis | 0.000271442 | 1 | 0 | BeFree |
Obsessive-Compulsive Disorder | 0.000271442 | 1 | 0 | BeFree |
Osteochondritis Dissecans | 0.000271442 | 1 | 0 | BeFree |
Osteosarcoma | 0.000271442 | 1 | 0 | BeFree |
Pancreatic Neoplasm | 0.000271442 | 1 | 0 | BeFree |
Pheochromocytoma | 0.000271442 | 1 | 0 | BeFree |
Pituitary Adenoma | 0.000271442 | 1 | 0 | BeFree |
Pituitary Neoplasms | 0.000271442 | 1 | 0 | BeFree |
Pleural effusion disorder | 0.000271442 | 1 | 0 | BeFree |
Prostatic Neoplasms | 0.000271442 | 1 | 0 | BeFree |
Protein Deficiency | 0.000271442 | 1 | 0 | BeFree |
Sarcoidosis | 0.000271442 | 1 | 0 | BeFree |
Spontaneous pneumothorax | 0.000271442 | 1 | 0 | BeFree |
Squamous cell carcinoma of lung | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of nasopharynx | 0.000271442 | 1 | 0 | BeFree |
Secondary malignant neoplasm of bone | 0.000271442 | 1 | 0 | BeFree |
Ki-1+ Anaplastic Large Cell Lymphoma | 0.000271442 | 1 | 0 | BeFree |
Hepatoblastoma | 0.000271442 | 1 | 0 | BeFree |
childhood Hodgkin's lymphoma | 0.000271442 | 1 | 0 | BeFree |
Renal interstitial fibrosis | 0.000271442 | 1 | 0 | BeFree |
Cancer of Nasopharynx | 0.000271442 | 1 | 0 | BeFree |
Congenital absence of lung | 0.000271442 | 1 | 0 | BeFree |
Isovaleryl-CoA dehydrogenase deficiency | 0.000271442 | 1 | 0 | BeFree |
Spastic syndrome | 0.000271442 | 1 | 0 | BeFree |
Viral myocarditis | 0.000271442 | 1 | 0 | BeFree |
Cancer of Head and Neck | 0.000271442 | 1 | 0 | BeFree |
Cervical Squamous Cell Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Squamous cell carcinoma of oropharynx | 0.000271442 | 1 | 0 | BeFree |
Cervix carcinoma | 0.000271442 | 1 | 0 | BeFree |
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse | 0.000271442 | 1 | 0 | BeFree |
Intrahepatic Cholangiocarcinoma | 0.000271442 | 1 | 0 | BeFree |
Multiple malignancy | 0.000271442 | 1 | 0 | BeFree |
Non-alcoholic Fatty Liver Disease | 0.000271442 | 1 | 0 | BeFree |
Squamous cell carcinoma of skin | 0.000271442 | 1 | 0 | BeFree |
Osteosarcoma of bone | 0.000271442 | 1 | 0 | BeFree |
Leukemogenesis | 0.000271442 | 1 | 0 | BeFree |
Secondary malignant neoplasm of lymph node | 0.000271442 | 1 | 0 | BeFree |
Biliary Tract Cancer | 0.000271442 | 1 | 0 | BeFree |
Malignant Pleural Mesothelioma | 0.000271442 | 1 | 0 | BeFree |
Invasive breast carcinoma | 0.000271442 | 1 | 0 | BeFree |
Metastatic Prostate Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Ductal Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Anaplastic large cell lymphoma, ALK negative | 0.000271442 | 1 | 0 | BeFree |
Classical Hodgkin's Lymphoma | 0.000271442 | 1 | 0 | BeFree |
Posterior capsule opacification | 0.000271442 | 1 | 0 | BeFree |
Tumor Angiogenesis | 0.000271442 | 1 | 0 | BeFree |
Benign Prostatic Hyperplasia | 0.000271442 | 1 | 0 | BeFree |
FANCONI ANEMIA, COMPLEMENTATION GROUP A (disorder) | 0.000271442 | 1 | 0 | BeFree |
Basal-Like Breast Carcinoma | 0.000271442 | 1 | 0 | BeFree |
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