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The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  的ITGB3蛋白质产物是整β链测试3整合素是一个α链和一个β链组成的积分细胞表面蛋白。一个给定的链条可能会导致不同的整合多个合作伙伴结合起来。整合素β3与血小板阿尔法防爆链一起找到。整是已知参与细胞粘附以及细胞表面介导的信号。 [由RefSeq的,2008年7月提供]
ITGB3基因(以及对应的蛋白质)的细胞分布位置:
ITGB3基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Thrombasthenia | 0.608217928 | 46 | 9 | BeFree_CLINVAR_CTD_human_GAD_LHGDN_MGD_ORPHANET_UNIPROT |
Myocardial Infarction | 0.39304913 | 44 | 1 | BeFree_CLINVAR_CTD_human_GAD_LHGDN_RGD |
Glanzmann Thrombasthenia, Autosomal Dominant | 0.32 | 1 | 1 | CLINVAR_MGD_UNIPROT |
Cerebrovascular accident | 0.25330848 | 26 | 0 | BeFree_CTD_human_GAD_LHGDN_RGD |
Acute Coronary Syndrome | 0.140193776 | 9 | 0 | BeFree_CTD_human_GAD_LHGDN |
Autistic Disorder | 0.136816922 | 8 | 2 | BeFree_CTD_human_GAD_LHGDN |
Prostatic Neoplasms | 0.136346101 | 7 | 0 | CTD_human_LHGDN |
Thrombocytopenia | 0.130182764 | 5 | 0 | CTD_human_GAD_LHGDN |
Neonatal Alloimmune Thrombocytopenia | 0.125091382 | 3 | 0 | CTD_human_GAD_LHGDN |
Coronary Thrombosis | 0.124810009 | 11 | 0 | BeFree_CTD_human_GAD |
Hemorrhage | 0.122367032 | 2 | 0 | CTD_human_GAD |
Peripheral Neuropathy | 0.122367032 | 2 | 0 | CTD_human_GAD |
Carotid Artery Thrombosis | 0.12 | 1 | 0 | CTD_human |
Child Development Disorders, Pervasive | 0.12 | 1 | 0 | CTD_human |
Gliosis | 0.12 | 1 | 0 | CTD_human |
Posttransfusion purpura | 0.12 | 0 | 2 | CLINVAR |
FRACTURE, HIP, SUSCEPTIBILITY TO (finding) | 0.12 | 0 | 1 | CLINVAR |
Cerebral Hemorrhage | 0.12 | 1 | 0 | CTD_human |
Transient Ischemic Attack | 0.082367032 | 2 | 0 | GAD_RGD |
Arterial Occlusive Diseases | 0.08 | 1 | 0 | RGD |
Pneumonia, Bacterial | 0.08 | 1 | 0 | RGD |
Diabetes Mellitus, Experimental | 0.08 | 1 | 0 | RGD |
Glomerulonephritis | 0.08 | 1 | 0 | RGD |
Mammary Neoplasms, Experimental | 0.08 | 1 | 0 | RGD |
Reperfusion Injury | 0.08 | 1 | 0 | RGD |
Endotoxemia | 0.08 | 1 | 0 | RGD |
Arthritis, Experimental | 0.08 | 1 | 0 | RGD |
Thrombosis | 0.029476339 | 11 | 0 | GAD_LHGDN |
Coronary Artery Disease | 0.029380531 | 19 | 0 | BeFree_GAD_LHGDN |
Coronary Arteriosclerosis | 0.029294654 | 21 | 0 | BeFree_GAD |
Cardiovascular Diseases | 0.027394561 | 16 | 2 | BeFree_GAD |
Mammary Neoplasms | 0.022337686 | 10 | 0 | BeFree_LHGDN |
Hypertensive disease | 0.019207698 | 8 | 2 | BeFree_GAD |
Malignant neoplasm of breast | 0.016102285 | 10 | 0 | BeFree_GAD |
Thrombophilia | 0.014473634 | 7 | 0 | BeFree_GAD |
Brain Ischemia | 0.014202192 | 6 | 0 | GAD |
Myocardial Ischemia | 0.014202192 | 6 | 0 | GAD |
melanoma | 0.013893193 | 6 | 0 | BeFree_LHGDN |
Atherosclerosis | 0.012378044 | 7 | 0 | BeFree_GAD |
ASPIRIN RESISTANCE | 0.01183516 | 5 | 0 | GAD |
Asthma | 0.011539974 | 6 | 1 | BeFree_GAD_LHGDN |
Subarachnoid Hemorrhage | 0.01036833 | 3 | 0 | BeFree_GAD_LHGDN |
Lymphoproliferative Disorders | 0.009468128 | 4 | 0 | GAD |
Restenosis | 0.008458305 | 8 | 0 | BeFree_GAD |
ovarian neoplasm | 0.008173051 | 3 | 0 | LHGDN |
Ischemic stroke | 0.00764398 | 5 | 0 | BeFree_GAD |
Neoplasm Metastasis | 0.007620235 | 10 | 0 | BeFree_LHGDN |
Lupus Erythematosus, Systemic | 0.007458414 | 3 | 0 | GAD_LHGDN |
Inflammation | 0.007101096 | 3 | 0 | GAD |
Retinal vascular occlusion | 0.007101096 | 3 | 0 | GAD |
Pregnancy loss | 0.007101096 | 3 | 0 | GAD |
Coronary heart disease | 0.005895776 | 14 | 0 | BeFree_GAD |
Immune thrombocytopenic purpura | 0.005720142 | 3 | 0 | BeFree_LHGDN |
Malignant neoplasm of ovary | 0.00554839 | 3 | 0 | BeFree_GAD |
Giant Cell Arteritis | 0.005362824 | 1 | 0 | BeFree_GAD_LHGDN |
Diabetes Mellitus, Non-Insulin-Dependent | 0.005276948 | 4 | 0 | BeFree_GAD |
Thromboembolism | 0.005276948 | 4 | 0 | BeFree_GAD |
Malignant neoplasm of lung | 0.005276948 | 4 | 1 | BeFree_GAD |
Spontaneous abortion | 0.005091382 | 2 | 0 | GAD_LHGDN |
Hemorrhagic Fever with Renal Syndrome | 0.005091382 | 2 | 0 | GAD_LHGDN |
Optic Neuritis | 0.005091382 | 1 | 0 | GAD_LHGDN |
Abortion, Habitual | 0.004734064 | 2 | 0 | GAD |
Anemia, Sickle Cell | 0.004734064 | 2 | 0 | GAD |
Generalized atherosclerosis | 0.004734064 | 2 | 0 | GAD |
Hemorrhagic Disorders | 0.004734064 | 2 | 0 | GAD |
Female infertility | 0.004734064 | 2 | 0 | GAD |
Kidney Failure, Chronic | 0.004734064 | 2 | 0 | GAD |
Obesity | 0.004734064 | 2 | 0 | GAD |
Pre-Eclampsia | 0.004734064 | 2 | 0 | GAD |
Peripheral Vascular Diseases | 0.004734064 | 2 | 0 | GAD |
Sudden Cardiac Death | 0.004734064 | 2 | 0 | GAD |
Migraine Disorders | 0.004734064 | 2 | 0 | GAD |
Fibrinogen Adverse Event | 0.004734064 | 2 | 0 | GAD |
Venous Thromboembolism | 0.004734064 | 2 | 0 | GAD |
Adenocarcinoma | 0.003538676 | 3 | 0 | BeFree_LHGDN |
Arteriosclerosis | 0.002909916 | 3 | 0 | BeFree_GAD |
Vascular Diseases | 0.002909916 | 3 | 0 | BeFree_GAD |
Colorectal Cancer | 0.002909916 | 3 | 0 | BeFree_GAD |
Aplastic Anemia | 0.00272435 | 1 | 0 | LHGDN |
Angina, Unstable | 0.00272435 | 1 | 0 | LHGDN |
Anoxia | 0.00272435 | 1 | 0 | LHGDN |
Intracranial Arteriovenous Malformation | 0.00272435 | 1 | 0 | LHGDN |
Chondrosarcoma | 0.00272435 | 1 | 0 | LHGDN |
Endometriosis | 0.00272435 | 1 | 0 | LHGDN |
Fever | 0.00272435 | 1 | 0 | LHGDN |
Hodgkin Disease | 0.00272435 | 1 | 0 | LHGDN |
Infarction | 0.00272435 | 1 | 0 | LHGDN |
Lung Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
Multiple Myeloma | 0.00272435 | 1 | 0 | LHGDN |
Osteosarcoma | 0.00272435 | 1 | 0 | LHGDN |
Bullous pemphigoid | 0.00272435 | 1 | 0 | LHGDN |
Takayasu Arteritis | 0.00272435 | 1 | 0 | LHGDN |
Blood Platelet Disorders | 0.002638474 | 2 | 0 | BeFree_GAD |
Inflammatory Bowel Diseases | 0.002638474 | 2 | 1 | BeFree_GAD |
Lymphoma, Non-Hodgkin | 0.002638474 | 1 | 0 | BeFree_GAD |
Albuminuria | 0.002367032 | 1 | 0 | GAD |
Amyotrophic Lateral Sclerosis | 0.002367032 | 1 | 0 | GAD |
Angina Pectoris | 0.002367032 | 1 | 0 | GAD |
Atrial Fibrillation | 0.002367032 | 1 | 0 | GAD |
beta Thalassemia | 0.002367032 | 1 | 0 | GAD |
Squamous cell carcinoma | 0.002367032 | 1 | 0 | GAD |
Carotid Artery Diseases | 0.002367032 | 1 | 0 | GAD |
Carotid Stenosis | 0.002367032 | 1 | 0 | GAD |
Intracranial Aneurysm | 0.002367032 | 1 | 0 | GAD |
Cerebral Palsy | 0.002367032 | 1 | 0 | GAD |
Cerebrovascular Disorders | 0.002367032 | 1 | 0 | GAD |
Chorioamnionitis | 0.002367032 | 1 | 0 | GAD |
Colorectal Neoplasms | 0.002367032 | 1 | 0 | GAD |
Hearing Loss, Sudden | 0.002367032 | 1 | 0 | GAD |
Epistaxis | 0.002367032 | 1 | 0 | GAD |
Fetal Membranes, Premature Rupture | 0.002367032 | 1 | 0 | GAD |
Gastrointestinal Hemorrhage | 0.002367032 | 1 | 0 | GAD |
Graft Occlusion, Vascular | 0.002367032 | 1 | 0 | GAD |
Sensorineural Hearing Loss (disorder) | 0.002367032 | 1 | 0 | GAD |
Heart Diseases | 0.002367032 | 1 | 0 | GAD |
Hemolytic-Uremic Syndrome | 0.002367032 | 1 | 0 | GAD |
Severe Dengue | 0.002367032 | 1 | 0 | GAD |
Hepatitis C | 0.002367032 | 1 | 0 | GAD |
Hyperlipidemia | 0.002367032 | 1 | 0 | GAD |
Hypersensitivity | 0.002367032 | 1 | 0 | GAD |
Iatrogenic Disease | 0.002367032 | 1 | 0 | GAD |
Intermittent Claudication | 0.002367032 | 1 | 0 | GAD |
Kidney Diseases | 0.002367032 | 1 | 0 | GAD |
Premature Obstetric Labor | 0.002367032 | 1 | 0 | GAD |
Mitral Valve Stenosis | 0.002367032 | 1 | 0 | GAD |
Mouth Neoplasms | 0.002367032 | 1 | 0 | GAD |
Peptic Ulcer | 0.002367032 | 1 | 0 | GAD |
Polycystic Ovary Syndrome | 0.002367032 | 1 | 0 | GAD |
Pregnancy Complications, Cardiovascular | 0.002367032 | 1 | 0 | GAD |
Pregnancy Complications, Hematologic | 0.002367032 | 1 | 0 | GAD |
Retinal Artery Occlusion | 0.002367032 | 1 | 0 | GAD |
Retinal Vein Occlusion | 0.002367032 | 1 | 0 | GAD |
Tobacco Use Disorder | 0.002367032 | 1 | 0 | GAD |
Virilism | 0.002367032 | 1 | 0 | GAD |
von Willebrand Disease | 0.002367032 | 1 | 0 | GAD |
Helicobacter Infections | 0.002367032 | 1 | 0 | GAD |
Antiphospholipid Syndrome | 0.002367032 | 1 | 0 | GAD |
Premature Birth | 0.002367032 | 1 | 0 | GAD |
Optic Neuropathy, Ischemic | 0.002367032 | 1 | 0 | GAD |
Aneurysm, Ruptured | 0.002367032 | 1 | 0 | GAD |
Dyslipidemias | 0.002367032 | 1 | 0 | GAD |
Age related macular degeneration | 0.002367032 | 1 | 0 | GAD |
Complications of Diabetes Mellitus | 0.002367032 | 1 | 0 | GAD |
Malignant neoplasm of prostate | 0.002367032 | 1 | 0 | GAD |
Brain hemorrhage | 0.002367032 | 1 | 0 | GAD |
Hyperhomocysteinemia | 0.002367032 | 1 | 0 | GAD |
Malignant neoplasm of kidney | 0.002367032 | 1 | 0 | GAD |
Vaso-occlusive crisis | 0.002367032 | 1 | 0 | GAD |
Intracranial Embolism | 0.002367032 | 1 | 0 | GAD |
Intracranial Thrombosis | 0.002367032 | 1 | 0 | GAD |
Embryo Loss | 0.002367032 | 1 | 0 | GAD |
Blood Coagulation Disorders, Inherited | 0.002367032 | 1 | 0 | GAD |
Systemic arterial pressure | 0.002367032 | 1 | 0 | GAD |
Temporal Arteritis | 0.002367032 | 1 | 0 | GAD |
Infection of amniotic sac and membranes, unspecified, unspecified trimester, not applicable or unspecified | 0.002367032 | 1 | 0 | GAD |
Recurrent pregnancy loss | 0.002367032 | 1 | 0 | GAD |
Stroke, Lacunar | 0.002367032 | 1 | 0 | GAD |
Breast Carcinoma | 0.001900093 | 7 | 0 | BeFree |
Acute myocardial infarction | 0.001628651 | 6 | 0 | BeFree |
Thrombocytosis | 0.001085767 | 4 | 0 | BeFree |
Colorectal Carcinoma | 0.000814326 | 3 | 0 | BeFree |
Atrial Septal Defects | 0.000814326 | 3 | 0 | BeFree |
leukemia | 0.000814326 | 3 | 0 | BeFree |
Ovarian Carcinoma | 0.000814326 | 3 | 0 | BeFree |
Alloimmunisation | 0.000814326 | 3 | 0 | BeFree |
Alloimmune thrombocytopenia | 0.000814326 | 3 | 0 | BeFree |
Non-Small Cell Lung Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Diabetic Nephropathy | 0.000542884 | 2 | 0 | BeFree |
HIV Infections | 0.000542884 | 2 | 0 | BeFree |
Thrombocythemia, Essential | 0.000542884 | 2 | 0 | BeFree |
Carcinoma of lung | 0.000542884 | 2 | 0 | BeFree |
Secondary malignant neoplasm of lymph node | 0.000542884 | 2 | 0 | BeFree |
Carotid Artery Plaque | 0.000542884 | 2 | 0 | BeFree |
Autism Spectrum Disorders | 0.000542884 | 2 | 0 | BeFree |
Neonatal alloimmune thrombocytopenia (NAIT) | 0.000542884 | 2 | 0 | BeFree |
Rheumatoid Arthritis | 0.000271442 | 1 | 0 | BeFree |
Mental disorders | 0.000271442 | 1 | 0 | BeFree |
Behcet Syndrome | 0.000271442 | 1 | 0 | BeFree |
Cleft Lip | 0.000271442 | 1 | 0 | BeFree |
Crohn Disease | 0.000271442 | 1 | 0 | BeFree |
Scleroderma | 0.000271442 | 1 | 0 | BeFree |
Diabetes Mellitus, Insulin-Dependent | 0.000271442 | 1 | 0 | BeFree |
Diabetic Retinopathy | 0.000271442 | 1 | 0 | BeFree |
Bacterial Endocarditis | 0.000271442 | 1 | 0 | BeFree |
Glioma | 0.000271442 | 1 | 0 | BeFree |
Hypercholesterolemia, Familial | 0.000271442 | 1 | 0 | BeFree |
Myeloid Leukemia, Chronic | 0.000271442 | 1 | 0 | BeFree |
Preleukemia | 0.000271442 | 1 | 0 | BeFree |
Kaposi Sarcoma | 0.000271442 | 1 | 0 | BeFree |
Schizophrenia | 0.000271442 | 1 | 0 | BeFree |
Systemic Scleroderma | 0.000271442 | 1 | 0 | BeFree |
Varicosity | 0.000271442 | 1 | 0 | BeFree |
Wiskott-Aldrich Syndrome | 0.000271442 | 1 | 0 | BeFree |
B-Cell Lymphomas | 0.000271442 | 1 | 0 | BeFree |
Lymphoma, Large-Cell, Follicular | 0.000271442 | 1 | 0 | BeFree |
Severe Combined Immunodeficiency | 0.000271442 | 1 | 0 | BeFree |
Deep Vein Thrombosis | 0.000271442 | 1 | 0 | BeFree |
Deep thrombophlebitis | 0.000271442 | 1 | 0 | BeFree |
Adenocarcinoma of lung (disorder) | 0.000271442 | 1 | 0 | BeFree |
Old myocardial infarction | 0.000271442 | 1 | 0 | BeFree |
Fibrillation | 0.000271442 | 1 | 0 | BeFree |
Coronary Stenosis | 0.000271442 | 1 | 0 | BeFree |
Autoimmune thrombocytopenia | 0.000271442 | 1 | 0 | BeFree |
Coronary artery atheroma | 0.000271442 | 1 | 0 | BeFree |
Cyanotic congenital heart disease | 0.000271442 | 1 | 0 | BeFree |
Acute Undifferentiated Leukemia | 0.000271442 | 1 | 0 | BeFree |
Impaired cognition | 0.000271442 | 1 | 0 | BeFree |
Abdominal aortic atherosclerosis | 0.000271442 | 1 | 0 | BeFree |
Exercise-induced angina | 0.000271442 | 1 | 1 | BeFree |
Carcinogenesis | 0.000271442 | 1 | 0 | BeFree |
Leukemogenesis | 0.000271442 | 1 | 0 | BeFree |
Tumor Initiation | 0.000271442 | 1 | 0 | BeFree |
cardiac event | 0.000271442 | 1 | 0 | BeFree |
vascular disease occlusive | 0.000271442 | 1 | 0 | BeFree |
Anterior Ischemic Optic Neuropathy | 0.000271442 | 1 | 0 | BeFree |
latent infection | 0.000271442 | 1 | 0 | BeFree |
First myocardial infarction | 0.000271442 | 1 | 0 | BeFree |
Postoperative confusion | 0.000271442 | 1 | 0 | BeFree |
Undifferentiated leukemia | 0.000271442 | 1 | 0 | BeFree |
Infective endocarditis | 0.000271442 | 1 | 0 | BeFree |
Brooke-Spiegler syndrome | 0.000271442 | 1 | 0 | BeFree |
THROMBOCYTOPENIA 2 (disorder) | 0.000271442 | 1 | 0 | BeFree |
Heparin induced thrombocytopenia (HIT) | 0.000271442 | 1 | 0 | BeFree |
Ischemic Cerebrovascular Accident | 0.000271442 | 1 | 0 | BeFree |
MYELODYSPLASTIC SYNDROME | 0.000271442 | 1 | 0 | BeFree |
Triple Negative Breast Neoplasms | 0.000271442 | 1 | 0 | BeFree |
Allergic disposition | 0.000271442 | 1 | 0 | BeFree |
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