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The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  的ITGB3蛋白质产物是整β链测试3整合素是一个α链和一个β链组成的积分细胞表面蛋白。一个给定的链条可能会导致不同的整合多个合作伙伴结合起来。整合素β3与血小板阿尔法防爆链一起找到。整是已知参与细胞粘附以及细胞表面介导的信号。 [由RefSeq的,2008年7月提供]
ITGB3基因(以及对应的蛋白质)的细胞分布位置:
ITGB3基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Thrombasthenia | 0.608217928 | 46 | 9 | BeFree_CLINVAR_CTD_human_GAD_LHGDN_MGD_ORPHANET_UNIPROT |
| Myocardial Infarction | 0.39304913 | 44 | 1 | BeFree_CLINVAR_CTD_human_GAD_LHGDN_RGD |
| Glanzmann Thrombasthenia, Autosomal Dominant | 0.32 | 1 | 1 | CLINVAR_MGD_UNIPROT |
| Cerebrovascular accident | 0.25330848 | 26 | 0 | BeFree_CTD_human_GAD_LHGDN_RGD |
| Acute Coronary Syndrome | 0.140193776 | 9 | 0 | BeFree_CTD_human_GAD_LHGDN |
| Autistic Disorder | 0.136816922 | 8 | 2 | BeFree_CTD_human_GAD_LHGDN |
| Prostatic Neoplasms | 0.136346101 | 7 | 0 | CTD_human_LHGDN |
| Thrombocytopenia | 0.130182764 | 5 | 0 | CTD_human_GAD_LHGDN |
| Neonatal Alloimmune Thrombocytopenia | 0.125091382 | 3 | 0 | CTD_human_GAD_LHGDN |
| Coronary Thrombosis | 0.124810009 | 11 | 0 | BeFree_CTD_human_GAD |
| Hemorrhage | 0.122367032 | 2 | 0 | CTD_human_GAD |
| Peripheral Neuropathy | 0.122367032 | 2 | 0 | CTD_human_GAD |
| Carotid Artery Thrombosis | 0.12 | 1 | 0 | CTD_human |
| Child Development Disorders, Pervasive | 0.12 | 1 | 0 | CTD_human |
| Gliosis | 0.12 | 1 | 0 | CTD_human |
| Posttransfusion purpura | 0.12 | 0 | 2 | CLINVAR |
| FRACTURE, HIP, SUSCEPTIBILITY TO (finding) | 0.12 | 0 | 1 | CLINVAR |
| Cerebral Hemorrhage | 0.12 | 1 | 0 | CTD_human |
| Transient Ischemic Attack | 0.082367032 | 2 | 0 | GAD_RGD |
| Arterial Occlusive Diseases | 0.08 | 1 | 0 | RGD |
| Pneumonia, Bacterial | 0.08 | 1 | 0 | RGD |
| Diabetes Mellitus, Experimental | 0.08 | 1 | 0 | RGD |
| Glomerulonephritis | 0.08 | 1 | 0 | RGD |
| Mammary Neoplasms, Experimental | 0.08 | 1 | 0 | RGD |
| Reperfusion Injury | 0.08 | 1 | 0 | RGD |
| Endotoxemia | 0.08 | 1 | 0 | RGD |
| Arthritis, Experimental | 0.08 | 1 | 0 | RGD |
| Thrombosis | 0.029476339 | 11 | 0 | GAD_LHGDN |
| Coronary Artery Disease | 0.029380531 | 19 | 0 | BeFree_GAD_LHGDN |
| Coronary Arteriosclerosis | 0.029294654 | 21 | 0 | BeFree_GAD |
| Cardiovascular Diseases | 0.027394561 | 16 | 2 | BeFree_GAD |
| Mammary Neoplasms | 0.022337686 | 10 | 0 | BeFree_LHGDN |
| Hypertensive disease | 0.019207698 | 8 | 2 | BeFree_GAD |
| Malignant neoplasm of breast | 0.016102285 | 10 | 0 | BeFree_GAD |
| Thrombophilia | 0.014473634 | 7 | 0 | BeFree_GAD |
| Brain Ischemia | 0.014202192 | 6 | 0 | GAD |
| Myocardial Ischemia | 0.014202192 | 6 | 0 | GAD |
| melanoma | 0.013893193 | 6 | 0 | BeFree_LHGDN |
| Atherosclerosis | 0.012378044 | 7 | 0 | BeFree_GAD |
| ASPIRIN RESISTANCE | 0.01183516 | 5 | 0 | GAD |
| Asthma | 0.011539974 | 6 | 1 | BeFree_GAD_LHGDN |
| Subarachnoid Hemorrhage | 0.01036833 | 3 | 0 | BeFree_GAD_LHGDN |
| Lymphoproliferative Disorders | 0.009468128 | 4 | 0 | GAD |
| Restenosis | 0.008458305 | 8 | 0 | BeFree_GAD |
| ovarian neoplasm | 0.008173051 | 3 | 0 | LHGDN |
| Ischemic stroke | 0.00764398 | 5 | 0 | BeFree_GAD |
| Neoplasm Metastasis | 0.007620235 | 10 | 0 | BeFree_LHGDN |
| Lupus Erythematosus, Systemic | 0.007458414 | 3 | 0 | GAD_LHGDN |
| Inflammation | 0.007101096 | 3 | 0 | GAD |
| Retinal vascular occlusion | 0.007101096 | 3 | 0 | GAD |
| Pregnancy loss | 0.007101096 | 3 | 0 | GAD |
| Coronary heart disease | 0.005895776 | 14 | 0 | BeFree_GAD |
| Immune thrombocytopenic purpura | 0.005720142 | 3 | 0 | BeFree_LHGDN |
| Malignant neoplasm of ovary | 0.00554839 | 3 | 0 | BeFree_GAD |
| Giant Cell Arteritis | 0.005362824 | 1 | 0 | BeFree_GAD_LHGDN |
| Diabetes Mellitus, Non-Insulin-Dependent | 0.005276948 | 4 | 0 | BeFree_GAD |
| Thromboembolism | 0.005276948 | 4 | 0 | BeFree_GAD |
| Malignant neoplasm of lung | 0.005276948 | 4 | 1 | BeFree_GAD |
| Spontaneous abortion | 0.005091382 | 2 | 0 | GAD_LHGDN |
| Hemorrhagic Fever with Renal Syndrome | 0.005091382 | 2 | 0 | GAD_LHGDN |
| Optic Neuritis | 0.005091382 | 1 | 0 | GAD_LHGDN |
| Abortion, Habitual | 0.004734064 | 2 | 0 | GAD |
| Anemia, Sickle Cell | 0.004734064 | 2 | 0 | GAD |
| Generalized atherosclerosis | 0.004734064 | 2 | 0 | GAD |
| Hemorrhagic Disorders | 0.004734064 | 2 | 0 | GAD |
| Female infertility | 0.004734064 | 2 | 0 | GAD |
| Kidney Failure, Chronic | 0.004734064 | 2 | 0 | GAD |
| Obesity | 0.004734064 | 2 | 0 | GAD |
| Pre-Eclampsia | 0.004734064 | 2 | 0 | GAD |
| Peripheral Vascular Diseases | 0.004734064 | 2 | 0 | GAD |
| Sudden Cardiac Death | 0.004734064 | 2 | 0 | GAD |
| Migraine Disorders | 0.004734064 | 2 | 0 | GAD |
| Fibrinogen Adverse Event | 0.004734064 | 2 | 0 | GAD |
| Venous Thromboembolism | 0.004734064 | 2 | 0 | GAD |
| Adenocarcinoma | 0.003538676 | 3 | 0 | BeFree_LHGDN |
| Arteriosclerosis | 0.002909916 | 3 | 0 | BeFree_GAD |
| Vascular Diseases | 0.002909916 | 3 | 0 | BeFree_GAD |
| Colorectal Cancer | 0.002909916 | 3 | 0 | BeFree_GAD |
| Aplastic Anemia | 0.00272435 | 1 | 0 | LHGDN |
| Angina, Unstable | 0.00272435 | 1 | 0 | LHGDN |
| Anoxia | 0.00272435 | 1 | 0 | LHGDN |
| Intracranial Arteriovenous Malformation | 0.00272435 | 1 | 0 | LHGDN |
| Chondrosarcoma | 0.00272435 | 1 | 0 | LHGDN |
| Endometriosis | 0.00272435 | 1 | 0 | LHGDN |
| Fever | 0.00272435 | 1 | 0 | LHGDN |
| Hodgkin Disease | 0.00272435 | 1 | 0 | LHGDN |
| Infarction | 0.00272435 | 1 | 0 | LHGDN |
| Lung Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
| Multiple Myeloma | 0.00272435 | 1 | 0 | LHGDN |
| Osteosarcoma | 0.00272435 | 1 | 0 | LHGDN |
| Bullous pemphigoid | 0.00272435 | 1 | 0 | LHGDN |
| Takayasu Arteritis | 0.00272435 | 1 | 0 | LHGDN |
| Blood Platelet Disorders | 0.002638474 | 2 | 0 | BeFree_GAD |
| Inflammatory Bowel Diseases | 0.002638474 | 2 | 1 | BeFree_GAD |
| Lymphoma, Non-Hodgkin | 0.002638474 | 1 | 0 | BeFree_GAD |
| Albuminuria | 0.002367032 | 1 | 0 | GAD |
| Amyotrophic Lateral Sclerosis | 0.002367032 | 1 | 0 | GAD |
| Angina Pectoris | 0.002367032 | 1 | 0 | GAD |
| Atrial Fibrillation | 0.002367032 | 1 | 0 | GAD |
| beta Thalassemia | 0.002367032 | 1 | 0 | GAD |
| Squamous cell carcinoma | 0.002367032 | 1 | 0 | GAD |
| Carotid Artery Diseases | 0.002367032 | 1 | 0 | GAD |
| Carotid Stenosis | 0.002367032 | 1 | 0 | GAD |
| Intracranial Aneurysm | 0.002367032 | 1 | 0 | GAD |
| Cerebral Palsy | 0.002367032 | 1 | 0 | GAD |
| Cerebrovascular Disorders | 0.002367032 | 1 | 0 | GAD |
| Chorioamnionitis | 0.002367032 | 1 | 0 | GAD |
| Colorectal Neoplasms | 0.002367032 | 1 | 0 | GAD |
| Hearing Loss, Sudden | 0.002367032 | 1 | 0 | GAD |
| Epistaxis | 0.002367032 | 1 | 0 | GAD |
| Fetal Membranes, Premature Rupture | 0.002367032 | 1 | 0 | GAD |
| Gastrointestinal Hemorrhage | 0.002367032 | 1 | 0 | GAD |
| Graft Occlusion, Vascular | 0.002367032 | 1 | 0 | GAD |
| Sensorineural Hearing Loss (disorder) | 0.002367032 | 1 | 0 | GAD |
| Heart Diseases | 0.002367032 | 1 | 0 | GAD |
| Hemolytic-Uremic Syndrome | 0.002367032 | 1 | 0 | GAD |
| Severe Dengue | 0.002367032 | 1 | 0 | GAD |
| Hepatitis C | 0.002367032 | 1 | 0 | GAD |
| Hyperlipidemia | 0.002367032 | 1 | 0 | GAD |
| Hypersensitivity | 0.002367032 | 1 | 0 | GAD |
| Iatrogenic Disease | 0.002367032 | 1 | 0 | GAD |
| Intermittent Claudication | 0.002367032 | 1 | 0 | GAD |
| Kidney Diseases | 0.002367032 | 1 | 0 | GAD |
| Premature Obstetric Labor | 0.002367032 | 1 | 0 | GAD |
| Mitral Valve Stenosis | 0.002367032 | 1 | 0 | GAD |
| Mouth Neoplasms | 0.002367032 | 1 | 0 | GAD |
| Peptic Ulcer | 0.002367032 | 1 | 0 | GAD |
| Polycystic Ovary Syndrome | 0.002367032 | 1 | 0 | GAD |
| Pregnancy Complications, Cardiovascular | 0.002367032 | 1 | 0 | GAD |
| Pregnancy Complications, Hematologic | 0.002367032 | 1 | 0 | GAD |
| Retinal Artery Occlusion | 0.002367032 | 1 | 0 | GAD |
| Retinal Vein Occlusion | 0.002367032 | 1 | 0 | GAD |
| Tobacco Use Disorder | 0.002367032 | 1 | 0 | GAD |
| Virilism | 0.002367032 | 1 | 0 | GAD |
| von Willebrand Disease | 0.002367032 | 1 | 0 | GAD |
| Helicobacter Infections | 0.002367032 | 1 | 0 | GAD |
| Antiphospholipid Syndrome | 0.002367032 | 1 | 0 | GAD |
| Premature Birth | 0.002367032 | 1 | 0 | GAD |
| Optic Neuropathy, Ischemic | 0.002367032 | 1 | 0 | GAD |
| Aneurysm, Ruptured | 0.002367032 | 1 | 0 | GAD |
| Dyslipidemias | 0.002367032 | 1 | 0 | GAD |
| Age related macular degeneration | 0.002367032 | 1 | 0 | GAD |
| Complications of Diabetes Mellitus | 0.002367032 | 1 | 0 | GAD |
| Malignant neoplasm of prostate | 0.002367032 | 1 | 0 | GAD |
| Brain hemorrhage | 0.002367032 | 1 | 0 | GAD |
| Hyperhomocysteinemia | 0.002367032 | 1 | 0 | GAD |
| Malignant neoplasm of kidney | 0.002367032 | 1 | 0 | GAD |
| Vaso-occlusive crisis | 0.002367032 | 1 | 0 | GAD |
| Intracranial Embolism | 0.002367032 | 1 | 0 | GAD |
| Intracranial Thrombosis | 0.002367032 | 1 | 0 | GAD |
| Embryo Loss | 0.002367032 | 1 | 0 | GAD |
| Blood Coagulation Disorders, Inherited | 0.002367032 | 1 | 0 | GAD |
| Systemic arterial pressure | 0.002367032 | 1 | 0 | GAD |
| Temporal Arteritis | 0.002367032 | 1 | 0 | GAD |
| Infection of amniotic sac and membranes, unspecified, unspecified trimester, not applicable or unspecified | 0.002367032 | 1 | 0 | GAD |
| Recurrent pregnancy loss | 0.002367032 | 1 | 0 | GAD |
| Stroke, Lacunar | 0.002367032 | 1 | 0 | GAD |
| Breast Carcinoma | 0.001900093 | 7 | 0 | BeFree |
| Acute myocardial infarction | 0.001628651 | 6 | 0 | BeFree |
| Thrombocytosis | 0.001085767 | 4 | 0 | BeFree |
| Colorectal Carcinoma | 0.000814326 | 3 | 0 | BeFree |
| Atrial Septal Defects | 0.000814326 | 3 | 0 | BeFree |
| leukemia | 0.000814326 | 3 | 0 | BeFree |
| Ovarian Carcinoma | 0.000814326 | 3 | 0 | BeFree |
| Alloimmunisation | 0.000814326 | 3 | 0 | BeFree |
| Alloimmune thrombocytopenia | 0.000814326 | 3 | 0 | BeFree |
| Non-Small Cell Lung Carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Diabetic Nephropathy | 0.000542884 | 2 | 0 | BeFree |
| HIV Infections | 0.000542884 | 2 | 0 | BeFree |
| Thrombocythemia, Essential | 0.000542884 | 2 | 0 | BeFree |
| Carcinoma of lung | 0.000542884 | 2 | 0 | BeFree |
| Secondary malignant neoplasm of lymph node | 0.000542884 | 2 | 0 | BeFree |
| Carotid Artery Plaque | 0.000542884 | 2 | 0 | BeFree |
| Autism Spectrum Disorders | 0.000542884 | 2 | 0 | BeFree |
| Neonatal alloimmune thrombocytopenia (NAIT) | 0.000542884 | 2 | 0 | BeFree |
| Rheumatoid Arthritis | 0.000271442 | 1 | 0 | BeFree |
| Mental disorders | 0.000271442 | 1 | 0 | BeFree |
| Behcet Syndrome | 0.000271442 | 1 | 0 | BeFree |
| Cleft Lip | 0.000271442 | 1 | 0 | BeFree |
| Crohn Disease | 0.000271442 | 1 | 0 | BeFree |
| Scleroderma | 0.000271442 | 1 | 0 | BeFree |
| Diabetes Mellitus, Insulin-Dependent | 0.000271442 | 1 | 0 | BeFree |
| Diabetic Retinopathy | 0.000271442 | 1 | 0 | BeFree |
| Bacterial Endocarditis | 0.000271442 | 1 | 0 | BeFree |
| Glioma | 0.000271442 | 1 | 0 | BeFree |
| Hypercholesterolemia, Familial | 0.000271442 | 1 | 0 | BeFree |
| Myeloid Leukemia, Chronic | 0.000271442 | 1 | 0 | BeFree |
| Preleukemia | 0.000271442 | 1 | 0 | BeFree |
| Kaposi Sarcoma | 0.000271442 | 1 | 0 | BeFree |
| Schizophrenia | 0.000271442 | 1 | 0 | BeFree |
| Systemic Scleroderma | 0.000271442 | 1 | 0 | BeFree |
| Varicosity | 0.000271442 | 1 | 0 | BeFree |
| Wiskott-Aldrich Syndrome | 0.000271442 | 1 | 0 | BeFree |
| B-Cell Lymphomas | 0.000271442 | 1 | 0 | BeFree |
| Lymphoma, Large-Cell, Follicular | 0.000271442 | 1 | 0 | BeFree |
| Severe Combined Immunodeficiency | 0.000271442 | 1 | 0 | BeFree |
| Deep Vein Thrombosis | 0.000271442 | 1 | 0 | BeFree |
| Deep thrombophlebitis | 0.000271442 | 1 | 0 | BeFree |
| Adenocarcinoma of lung (disorder) | 0.000271442 | 1 | 0 | BeFree |
| Old myocardial infarction | 0.000271442 | 1 | 0 | BeFree |
| Fibrillation | 0.000271442 | 1 | 0 | BeFree |
| Coronary Stenosis | 0.000271442 | 1 | 0 | BeFree |
| Autoimmune thrombocytopenia | 0.000271442 | 1 | 0 | BeFree |
| Coronary artery atheroma | 0.000271442 | 1 | 0 | BeFree |
| Cyanotic congenital heart disease | 0.000271442 | 1 | 0 | BeFree |
| Acute Undifferentiated Leukemia | 0.000271442 | 1 | 0 | BeFree |
| Impaired cognition | 0.000271442 | 1 | 0 | BeFree |
| Abdominal aortic atherosclerosis | 0.000271442 | 1 | 0 | BeFree |
| Exercise-induced angina | 0.000271442 | 1 | 1 | BeFree |
| Carcinogenesis | 0.000271442 | 1 | 0 | BeFree |
| Leukemogenesis | 0.000271442 | 1 | 0 | BeFree |
| Tumor Initiation | 0.000271442 | 1 | 0 | BeFree |
| cardiac event | 0.000271442 | 1 | 0 | BeFree |
| vascular disease occlusive | 0.000271442 | 1 | 0 | BeFree |
| Anterior Ischemic Optic Neuropathy | 0.000271442 | 1 | 0 | BeFree |
| latent infection | 0.000271442 | 1 | 0 | BeFree |
| First myocardial infarction | 0.000271442 | 1 | 0 | BeFree |
| Postoperative confusion | 0.000271442 | 1 | 0 | BeFree |
| Undifferentiated leukemia | 0.000271442 | 1 | 0 | BeFree |
| Infective endocarditis | 0.000271442 | 1 | 0 | BeFree |
| Brooke-Spiegler syndrome | 0.000271442 | 1 | 0 | BeFree |
| THROMBOCYTOPENIA 2 (disorder) | 0.000271442 | 1 | 0 | BeFree |
| Heparin induced thrombocytopenia (HIT) | 0.000271442 | 1 | 0 | BeFree |
| Ischemic Cerebrovascular Accident | 0.000271442 | 1 | 0 | BeFree |
| MYELODYSPLASTIC SYNDROME | 0.000271442 | 1 | 0 | BeFree |
| Triple Negative Breast Neoplasms | 0.000271442 | 1 | 0 | BeFree |
| Allergic disposition | 0.000271442 | 1 | 0 | BeFree |
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