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This gene encodes the alpha 1 subunit of integrin receptors. This protein heterodimerizes with the beta 1 subunit to form a cell-surface receptor for collagen and laminin. The heterodimeric receptor is involved in cell-cell adhesion and may play a role in inflammation and fibrosis. The alpha 1 subunit contains an inserted (I) von Willebrand factor type I domain which is thought to be involved in collagen binding. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):] 该基因编码整合素受体的α1亚单位。这种蛋白质与测试1亚基杂二以形成胶原蛋白和层粘连蛋白的细胞表面受体。异源二聚体受体是参与细胞 - 细胞粘附和在炎症和纤维化中起一定作用。阿尔法1亚基包含插入(Ⅰ)血管性血友病因子I型这被认为是参与胶原结合结构域。 [由RefSeq的,2008年7月提供]
ITGA1基因(以及对应的蛋白质)的细胞分布位置:
ITGA1基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Gliosis | 0.12 | 1 | 0 | CTD_human |
Pulmonary function (finding) | 0.12 | 1 | 1 | GWASCAT |
Hyperalgesia | 0.08 | 2 | 0 | RGD |
Osteoporosis | 0.003538676 | 3 | 0 | BeFree_LHGDN |
Rheumatoid Arthritis | 0.003267234 | 3 | 0 | BeFree_LHGDN |
Colonic Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
Inflammation | 0.00272435 | 1 | 0 | LHGDN |
Multiple Sclerosis | 0.00272435 | 1 | 0 | LHGDN |
Neoplasm Metastasis | 0.00272435 | 1 | 0 | LHGDN |
Pancreatic Neoplasm | 0.00272435 | 1 | 0 | LHGDN |
Phimosis | 0.00272435 | 1 | 0 | LHGDN |
Diabetes Mellitus, Non-Insulin-Dependent | 0.002638474 | 2 | 0 | BeFree_GAD |
Liver diseases | 0.002367032 | 1 | 0 | GAD |
Gilles de la Tourette syndrome | 0.002367032 | 1 | 0 | GAD |
Attention deficit hyperactivity disorder | 0.002367032 | 1 | 0 | GAD |
Arthritis, Psoriatic | 0.000271442 | 1 | 0 | BeFree |
Colitis | 0.000271442 | 1 | 0 | BeFree |
Diabetic Nephropathy | 0.000271442 | 1 | 0 | BeFree |
Fatty Liver | 0.000271442 | 1 | 0 | BeFree |
Fibrosis, Liver | 0.000271442 | 1 | 0 | BeFree |
Alveolitis | 0.000271442 | 1 | 0 | BeFree |
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