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This gene encodes a member of the interferon regulatory transcription factor (IRF) family. The encoded protein is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
[中文简述(自动翻译):]  该基因编码的干扰素调节转录因子(IRF)家族的一个成员。所编码的蛋白质是在非活性细胞质形式发现,在丝氨酸/苏氨酸磷酸化形成具有CREBBP的复合物。这种复杂转移到细胞核并激活干扰素α和β,以及其他干扰素诱导的基因的转录。编码多种亚型选择性剪接的转录物变体已经观察到这种基因。 [由RefSeq的,2011年11月提供]
IRF3基因(以及对应的蛋白质)的细胞分布位置:
IRF3基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Infection | 0.024519152 | 9 | 0 | LHGDN |
Virus Diseases | 0.009500466 | 35 | 0 | BeFree |
Lupus Erythematosus, Systemic | 0.006448592 | 5 | 0 | BeFree_GAD_LHGDN |
Hepatitis C, Chronic | 0.005005506 | 3 | 0 | BeFree_GAD |
Hepatitis C | 0.004538567 | 9 | 0 | BeFree_GAD |
Measles | 0.003267234 | 2 | 0 | BeFree_LHGDN |
Reoviridae Infections | 0.003267234 | 2 | 0 | BeFree_LHGDN |
Liver Cirrhosis | 0.002909916 | 3 | 0 | BeFree_GAD |
Lymphoma | 0.00272435 | 1 | 0 | LHGDN |
Rabies (disorder) | 0.00272435 | 1 | 0 | LHGDN |
Respiratory Syncytial Virus Infections | 0.002638474 | 2 | 0 | BeFree_GAD |
Malignant neoplasm of lung | 0.002638474 | 2 | 0 | BeFree_GAD |
Asthma | 0.002367032 | 1 | 0 | GAD |
Malignant neoplasm of urinary bladder | 0.002367032 | 1 | 0 | GAD |
Bronchiolitis, Viral | 0.002367032 | 1 | 0 | GAD |
Chronic Obstructive Airway Disease | 0.002367032 | 1 | 0 | GAD |
Neutropenia | 0.002367032 | 1 | 0 | GAD |
Thrombocytopenia | 0.002367032 | 1 | 0 | GAD |
Malignant neoplasm of esophagus | 0.002367032 | 1 | 0 | GAD |
Carcinoma in situ of uterine cervix | 0.002367032 | 1 | 1 | GAD |
HIV Infections | 0.001357209 | 5 | 0 | BeFree |
Herpes Simplex Infections | 0.001085767 | 4 | 0 | BeFree |
Vesicular Stomatitis | 0.001085767 | 4 | 0 | BeFree |
Influenza | 0.000814326 | 3 | 0 | BeFree |
melanoma | 0.000814326 | 3 | 0 | BeFree |
Non-Small Cell Lung Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Cytomegalovirus Infections | 0.000542884 | 2 | 0 | BeFree |
Fatty Liver | 0.000542884 | 2 | 0 | BeFree |
Kaposi Sarcoma | 0.000542884 | 2 | 0 | BeFree |
Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site | 0.000542884 | 2 | 0 | BeFree |
Carcinogenesis | 0.000542884 | 2 | 0 | BeFree |
West Nile viral infection | 0.000542884 | 2 | 0 | BeFree |
Cirrhosis | 0.000542884 | 2 | 0 | BeFree |
Liver carcinoma | 0.000542884 | 2 | 0 | BeFree |
Steatohepatitis | 0.000542884 | 2 | 0 | BeFree |
Rheumatoid Arthritis | 0.000271442 | 1 | 0 | BeFree |
Biliary Atresia | 0.000271442 | 1 | 0 | BeFree |
Malignant tumor of colon | 0.000271442 | 1 | 1 | BeFree |
Rectal Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Malignant tumor of cervix | 0.000271442 | 1 | 0 | BeFree |
Colorectal Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Eosinophilia | 0.000271442 | 1 | 0 | BeFree |
Glioma | 0.000271442 | 1 | 0 | BeFree |
Graft-vs-Host Disease | 0.000271442 | 1 | 0 | BeFree |
Hyperglycemia | 0.000271442 | 1 | 0 | BeFree |
Infection of kidney | 0.000271442 | 1 | 0 | BeFree |
Leukemia, Myelocytic, Acute | 0.000271442 | 1 | 0 | BeFree |
Lymphocytic Choriomeningitis | 0.000271442 | 1 | 0 | BeFree |
Malaria | 0.000271442 | 1 | 0 | BeFree |
Metabolic Diseases | 0.000271442 | 1 | 0 | BeFree |
Myocarditis | 0.000271442 | 1 | 0 | BeFree |
Neoplasm Metastasis | 0.000271442 | 1 | 0 | BeFree |
Obesity | 0.000271442 | 1 | 0 | BeFree |
Pyelonephritis | 0.000271442 | 1 | 0 | BeFree |
Retinal Degeneration | 0.000271442 | 1 | 0 | BeFree |
RNA Virus Infections | 0.000271442 | 1 | 0 | BeFree |
Schizophrenia | 0.000271442 | 1 | 0 | BeFree |
Cerebrovascular accident | 0.000271442 | 1 | 0 | BeFree |
Urinary tract infection | 0.000271442 | 1 | 0 | BeFree |
Non-arthropod borne lymphocytic choriomeningitis | 0.000271442 | 1 | 0 | BeFree |
Pancreatic carcinoma | 0.000271442 | 1 | 0 | BeFree |
Coronary Stenosis | 0.000271442 | 1 | 0 | BeFree |
Asymptomatic bacteriuria | 0.000271442 | 1 | 0 | BeFree |
Coinfection | 0.000271442 | 1 | 0 | BeFree |
Herpes encephalitis | 0.000271442 | 1 | 0 | BeFree |
Cervix carcinoma | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of pancreas | 0.000271442 | 1 | 0 | BeFree |
Acute pyelonephritis | 0.000271442 | 1 | 0 | BeFree |
Malignant Glioma | 0.000271442 | 1 | 0 | BeFree |
Colon Carcinoma | 0.000271442 | 1 | 1 | BeFree |
Severe Acute Respiratory Syndrome | 0.000271442 | 1 | 0 | BeFree |
Sarcoma | 0.000271442 | 1 | 0 | BeFree |
Eosinophilic disorder | 0.000271442 | 1 | 0 | BeFree |
Sendai virus infection | 0.000271442 | 1 | 0 | BeFree |
Colorectal Cancer | 0.000271442 | 1 | 0 | BeFree |
Disorder characterized by eosinophilia | 0.000271442 | 1 | 0 | BeFree |
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