更多...
收起
IRF1 encodes interferon regulatory factor 1, a member of the interferon regulatory transcription factor (IRF) family. IRF1 serves as an activator of interferons alpha and beta transcription, and in mouse it has been shown to be required for double-stranded RNA induction of these genes. IRF1 also functions as a transcription activator of genes induced by interferons alpha, beta, and gamma. Further, IRF1 has been shown to play roles in regulating apoptosis and tumor-suppressoion. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  IRF1编码干扰素调节因子1,干扰素调节转录因子(IRF)家族的一个成员。 IRF1作为干扰素α和β的转录的活化剂,并在小鼠它已被证明是所需的这些基因的双链RNA诱导。 IRF1还用作由干扰素α,β,和γ诱导的基因的转录激活剂。此外,IRF1已被证明在调节细胞凋亡和肿瘤suppressoion发挥作用。 [由RefSeq的,2008年7月提供]
IRF1基因(以及对应的蛋白质)的细胞分布位置:
IRF1基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Stomach Neoplasms | 0.240271442 | 1 | 1 | BeFree_CLINVAR_CTD_human |
Stomach Carcinoma | 0.121085767 | 5 | 0 | BeFree_UNIPROT |
5q-syndrome | 0.120271442 | 1 | 0 | BeFree_CTD_human |
Non-Small Cell Lung Carcinoma | 0.12 | 0 | 1 | CLINVAR |
Lung Neoplasms | 0.12 | 0 | 0 | CTD_human |
Cerebrovascular accident | 0.12 | 1 | 0 | CTD_human |
Myocardial Ischemia | 0.12 | 1 | 0 | CTD_human |
Respiratory Syncytial Virus Infections | 0.085005506 | 4 | 0 | BeFree_GAD_RGD |
Allergic Conjunctivitis | 0.08 | 1 | 0 | RGD |
Endometrial Neoplasms | 0.08 | 1 | 0 | RGD |
Lung diseases | 0.08 | 1 | 0 | RGD |
Reperfusion Injury | 0.08 | 1 | 0 | RGD |
Ureteral obstruction | 0.08 | 1 | 0 | RGD |
Infection | 0.013621751 | 5 | 0 | LHGDN |
Mammary Neoplasms | 0.011168843 | 5 | 0 | BeFree_LHGDN |
Asthma | 0.010553895 | 7 | 0 | BeFree_GAD |
Tuberculosis | 0.009172942 | 7 | 0 | BeFree_GAD_LHGDN |
Hepatitis C, Chronic | 0.008815624 | 7 | 0 | BeFree_GAD_LHGDN |
Celiac Disease | 0.008358616 | 3 | 0 | BeFree_GAD_LHGDN |
Hepatitis C | 0.008358616 | 3 | 0 | BeFree_GAD_LHGDN |
Multiple Sclerosis | 0.005905708 | 4 | 0 | BeFree_GAD_LHGDN |
Behcet Syndrome | 0.005362824 | 1 | 0 | BeFree_GAD_LHGDN |
Juvenile arthritis | 0.005276948 | 3 | 0 | BeFree_GAD |
Malaria, Falciparum | 0.005005506 | 2 | 0 | BeFree_GAD |
Bronchiolitis, Viral | 0.004734064 | 2 | 0 | GAD |
Fibrinogen Adverse Event | 0.004734064 | 2 | 3 | GAD |
Cervix carcinoma | 0.003995683 | 6 | 0 | BeFree_GAD |
Malaria | 0.003267234 | 3 | 0 | BeFree_LHGDN |
Crohn Disease | 0.003181358 | 4 | 0 | BeFree_GAD |
MYELODYSPLASTIC SYNDROME | 0.002995792 | 2 | 0 | BeFree_LHGDN |
Bladder Neoplasm | 0.00272435 | 1 | 0 | LHGDN |
Inflammation | 0.00272435 | 1 | 0 | LHGDN |
Carcinoma, Endometrioid | 0.00272435 | 1 | 0 | LHGDN |
Graves Disease | 0.002638474 | 1 | 0 | BeFree_GAD |
Hepatitis B | 0.002638474 | 1 | 0 | BeFree_GAD |
Bronchial Hyperreactivity | 0.002638474 | 2 | 0 | BeFree_GAD |
Hepatitis B, Chronic | 0.002638474 | 2 | 0 | BeFree_GAD |
Leukemia, Myelocytic, Acute | 0.002442977 | 9 | 0 | BeFree |
Arthritis | 0.002367032 | 1 | 0 | GAD |
Malignant neoplasm of urinary bladder | 0.002367032 | 1 | 0 | GAD |
Graft-vs-Host Disease | 0.002367032 | 1 | 0 | GAD |
Hypersensitivity | 0.002367032 | 1 | 0 | GAD |
Immediate hypersensitivity | 0.002367032 | 1 | 0 | GAD |
Chronic Obstructive Airway Disease | 0.002367032 | 1 | 0 | GAD |
Thrombosis | 0.002367032 | 1 | 0 | GAD |
Viremia | 0.002367032 | 1 | 0 | GAD |
Malignant neoplasm of lung | 0.002367032 | 1 | 0 | GAD |
HIV Infections | 0.002171535 | 8 | 0 | BeFree |
Malignant neoplasm of breast | 0.001900093 | 7 | 0 | BeFree |
leukemia | 0.001628651 | 6 | 0 | BeFree |
Carcinogenesis | 0.001628651 | 6 | 0 | BeFree |
Breast Carcinoma | 0.001628651 | 6 | 0 | BeFree |
Liver carcinoma | 0.001628651 | 6 | 0 | BeFree |
Malignant tumor of cervix | 0.001357209 | 5 | 0 | BeFree |
Malignant neoplasm of stomach | 0.001357209 | 5 | 0 | BeFree |
Myelodysplasia | 0.001357209 | 5 | 0 | BeFree |
Virus Diseases | 0.001357209 | 5 | 0 | BeFree |
Squamous cell carcinoma | 0.001085767 | 4 | 0 | BeFree |
melanoma | 0.001085767 | 4 | 0 | BeFree |
Ovarian Carcinoma | 0.001085767 | 4 | 0 | BeFree |
Preleukemia | 0.001085767 | 4 | 0 | BeFree |
Renal Cell Carcinoma | 0.000814326 | 3 | 0 | BeFree |
Myeloid Leukemia | 0.000814326 | 3 | 0 | BeFree |
Liver neoplasms | 0.000814326 | 3 | 0 | BeFree |
Degenerative polyarthritis | 0.000814326 | 3 | 0 | BeFree |
Arteriosclerosis | 0.000542884 | 2 | 0 | BeFree |
Rheumatoid Arthritis | 0.000542884 | 2 | 0 | BeFree |
Atherosclerosis | 0.000542884 | 2 | 0 | BeFree |
Myeloid Leukemia, Chronic | 0.000542884 | 2 | 0 | BeFree |
Lupus Erythematosus, Systemic | 0.000542884 | 2 | 0 | BeFree |
Multiple Myeloma | 0.000542884 | 2 | 0 | BeFree |
Neoplasm Metastasis | 0.000542884 | 2 | 0 | BeFree |
Neuroblastoma | 0.000542884 | 2 | 0 | BeFree |
Subacute Sclerosing Panencephalitis | 0.000542884 | 2 | 0 | BeFree |
Acute leukemia | 0.000542884 | 2 | 0 | BeFree |
Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site | 0.000542884 | 2 | 0 | BeFree |
Epithelial ovarian cancer | 0.000542884 | 2 | 0 | BeFree |
Central neuroblastoma | 0.000542884 | 2 | 0 | BeFree |
Malignant neoplasm of ovary | 0.000542884 | 2 | 0 | BeFree |
Juvenile rheumatoid arthritis | 0.000542884 | 2 | 0 | BeFree |
Ataxia Telangiectasia | 0.000271442 | 1 | 0 | BeFree |
Malignant tumor of colon | 0.000271442 | 1 | 0 | BeFree |
Noninfiltrating Intraductal Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Cardiomyopathy, Dilated | 0.000271442 | 1 | 0 | BeFree |
Colitis | 0.000271442 | 1 | 0 | BeFree |
Ulcerative Colitis | 0.000271442 | 1 | 0 | BeFree |
Colorectal Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Down Syndrome | 0.000271442 | 1 | 0 | BeFree |
Gingival Diseases | 0.000271442 | 1 | 0 | BeFree |
Heart failure | 0.000271442 | 1 | 0 | BeFree |
Congestive heart failure | 0.000271442 | 1 | 0 | BeFree |
Inflammatory Bowel Diseases | 0.000271442 | 1 | 0 | BeFree |
Ischemia | 0.000271442 | 1 | 0 | BeFree |
Acute lymphocytic leukemia | 0.000271442 | 1 | 0 | BeFree |
Leukemia, Myeloid, Chronic-Phase | 0.000271442 | 1 | 0 | BeFree |
Acute Promyelocytic Leukemia | 0.000271442 | 1 | 0 | BeFree |
Lipoma | 0.000271442 | 1 | 0 | BeFree |
Medulloblastoma | 0.000271442 | 1 | 0 | BeFree |
Mitral Valve Stenosis | 0.000271442 | 1 | 0 | BeFree |
Myocarditis | 0.000271442 | 1 | 0 | BeFree |
Periodontal Diseases | 0.000271442 | 1 | 0 | BeFree |
Adenomatous Polyposis Coli | 0.000271442 | 1 | 0 | BeFree |
Psoriasis | 0.000271442 | 1 | 0 | BeFree |
Skin Neoplasms | 0.000271442 | 1 | 0 | BeFree |
Smallpox | 0.000271442 | 1 | 0 | BeFree |
Diffuse Large B-Cell Lymphoma | 0.000271442 | 1 | 0 | BeFree |
Synovial Cyst | 0.000271442 | 1 | 0 | BeFree |
Allergic asthma | 0.000271442 | 1 | 0 | BeFree |
Sotos' syndrome | 0.000271442 | 1 | 0 | BeFree |
Pancreatic carcinoma | 0.000271442 | 1 | 0 | BeFree |
Muscular Dystrophy, Facioscapulohumeral | 0.000271442 | 1 | 0 | BeFree |
Testicular embryonal carcinoma | 0.000271442 | 1 | 0 | BeFree |
Childhood asthma | 0.000271442 | 1 | 0 | BeFree |
Miller Dieker syndrome | 0.000271442 | 1 | 0 | BeFree |
Gastric Adenocarcinoma | 0.000271442 | 1 | 0 | BeFree |
Liver and Intrahepatic Biliary Tract Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Adenocarcinoma Of Esophagus | 0.000271442 | 1 | 0 | BeFree |
Solid tumour | 0.000271442 | 1 | 0 | BeFree |
Leber Congenital Amaurosis | 0.000271442 | 1 | 0 | BeFree |
Ventricular hypertrophy | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of liver | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of pancreas | 0.000271442 | 1 | 0 | BeFree |
Juvenile Myelomonocytic Leukemia | 0.000271442 | 1 | 0 | BeFree |
Hematopoietic Neoplasms | 0.000271442 | 1 | 0 | BeFree |
Metabolic Syndrome X | 0.000271442 | 1 | 0 | BeFree |
Leukemogenesis | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of gastrointestinal tract | 0.000271442 | 1 | 0 | BeFree |
Colon Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Invasive breast carcinoma | 0.000271442 | 1 | 0 | BeFree |
Endothelial dysfunction | 0.000271442 | 1 | 0 | BeFree |
Metastatic Prostate Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Acute Coronary Syndrome | 0.000271442 | 1 | 0 | BeFree |
West Nile viral infection | 0.000271442 | 1 | 0 | BeFree |
Invasive Ductal Breast Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Primary HIV infection | 0.000271442 | 1 | 0 | BeFree |
Myxoid cyst | 0.000271442 | 1 | 0 | BeFree |
Myelodysplastic Syndrome with Isolated del(5q) | 0.000271442 | 1 | 0 | BeFree |
Acute Myeloid Leukemia Arising from Previous Myelodysplastic Syndrome | 0.000271442 | 1 | 0 | BeFree |
Atypical Ductal Breast Hyperplasia | 0.000271442 | 1 | 0 | BeFree |
Sporadic Breast Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Vascular lesions | 0.000271442 | 1 | 0 | BeFree |
Cardiomyopathy, Familial Idiopathic | 0.000271442 | 1 | 0 | BeFree |
Colorectal Cancer | 0.000271442 | 1 | 0 | BeFree |
Chromosome 5, trisomy 5q | 0.000271442 | 1 | 0 | BeFree |
Precursor Cell Lymphoblastic Leukemia Lymphoma | 0.000271442 | 1 | 0 | BeFree |
Lipomatosis, Multiple | 0.000271442 | 1 | 0 | BeFree |
Allergic disposition | 0.000271442 | 1 | 0 | BeFree |
Experimental Organism Basal Cell Carcinoma | 0.000271442 | 1 | 0 | BeFree |
忘记密码? 点击找回密码.
扫一扫右方二维码,关注微信订阅号,实时查看信息,关注医学生物学动态。