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This gene encodes a protein with a kinase-like domain and four ankyrin-like repeats. The encoded protein associates at the cell membrane with the cytoplasmic domain of beta integrins, where it regulates integrin-mediated signal transduction. Activity of this protein is important in the epithelial to mesenchymal transition, and over-expression of this gene is implicated in tumor growth and metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]
[中文简述(自动翻译):]  该基因编码具有激酶样结构域和四个锚蛋白样重复蛋白。编码的蛋白质相关联的细胞膜与β-整合的胞质域,在那里它调节整合素介导的信号转导。该蛋白质的活性在上皮至间质转变重要的,并且过表达该基因在肿瘤生长和转移的牵连。选择性剪接结果在多个抄本变形。 [由RefSeq的,2013年6月提供]
ILK基因(以及对应的蛋白质)的细胞分布位置:
ILK基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Transient Ischemic Attack | 0.12 | 1 | 0 | CTD_human |
| Colonic Polyps | 0.12 | 1 | 0 | CTD_human |
| Epilepsy | 0.12 | 1 | 0 | CTD_human |
| Liver Cirrhosis, Experimental | 0.12 | 1 | 0 | CTD_human |
| Cocaine-Related Disorders | 0.12 | 2 | 0 | CTD_human |
| ovarian neoplasm | 0.010897401 | 4 | 0 | LHGDN |
| melanoma | 0.00680591 | 7 | 0 | BeFree_LHGDN |
| Neoplasm Metastasis | 0.004885954 | 18 | 0 | BeFree |
| Carcinogenesis | 0.003800186 | 14 | 0 | BeFree |
| Glioma | 0.003538676 | 4 | 0 | BeFree_LHGDN |
| Renal Cell Carcinoma | 0.003267234 | 2 | 0 | BeFree_LHGDN |
| Coronary Artery Disease | 0.002995792 | 1 | 0 | BeFree_LHGDN |
| Anoxia | 0.00272435 | 1 | 0 | LHGDN |
| Colonic Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
| Lung Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
| Pancreatic Neoplasm | 0.00272435 | 1 | 0 | LHGDN |
| Malignant neoplasm of breast | 0.002714419 | 10 | 0 | BeFree |
| Ovarian Carcinoma | 0.002714419 | 10 | 0 | BeFree |
| Tumor Progression | 0.002714419 | 10 | 0 | BeFree |
| Breast Carcinoma | 0.002442977 | 9 | 0 | BeFree |
| Malignant neoplasm of ovary | 0.002442977 | 9 | 0 | BeFree |
| Malignant neoplasm of prostate | 0.002171535 | 8 | 0 | BeFree |
| Prostate carcinoma | 0.002171535 | 8 | 0 | BeFree |
| Colorectal Carcinoma | 0.001628651 | 6 | 0 | BeFree |
| Stomach Carcinoma | 0.001628651 | 6 | 0 | BeFree |
| Malignant neoplasm of urinary bladder | 0.001357209 | 5 | 0 | BeFree |
| Carcinoma of bladder | 0.001357209 | 5 | 0 | BeFree |
| Colorectal Cancer | 0.001357209 | 5 | 0 | BeFree |
| Glioblastoma | 0.001085767 | 4 | 0 | BeFree |
| Epithelial ovarian cancer | 0.001085767 | 4 | 0 | BeFree |
| Non-Small Cell Lung Carcinoma | 0.000814326 | 3 | 0 | BeFree |
| Malignant neoplasm of stomach | 0.000814326 | 3 | 0 | BeFree |
| Rhabdomyosarcoma | 0.000814326 | 3 | 0 | BeFree |
| Adenocarcinoma | 0.000542884 | 2 | 0 | BeFree |
| Astrocytoma | 0.000542884 | 2 | 0 | BeFree |
| Colitis | 0.000542884 | 2 | 0 | BeFree |
| Eclampsia | 0.000542884 | 2 | 0 | BeFree |
| Heart Diseases | 0.000542884 | 2 | 0 | BeFree |
| Kidney Diseases | 0.000542884 | 2 | 0 | BeFree |
| leukemia | 0.000542884 | 2 | 0 | BeFree |
| Adenomatous Polyposis Coli | 0.000542884 | 2 | 0 | BeFree |
| Retinoblastoma | 0.000542884 | 2 | 0 | BeFree |
| Solid tumour | 0.000542884 | 2 | 0 | BeFree |
| Adenocarcinoma of pancreas | 0.000542884 | 2 | 0 | BeFree |
| Carcinoma of lung | 0.000542884 | 2 | 0 | BeFree |
| Secondary malignant neoplasm of lymph node | 0.000542884 | 2 | 0 | BeFree |
| Cardiomyopathies | 0.000542884 | 2 | 0 | BeFree |
| Sarcoma | 0.000542884 | 2 | 0 | BeFree |
| Mammary Neoplasms | 0.000542884 | 2 | 0 | BeFree |
| Liver carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Brain Neoplasms | 0.000271442 | 1 | 0 | BeFree |
| Adenocarcinoma of prostate | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of thyroid | 0.000271442 | 1 | 0 | BeFree |
| Cardiomyopathy, Dilated | 0.000271442 | 1 | 0 | BeFree |
| Diabetes Mellitus, Non-Insulin-Dependent | 0.000271442 | 1 | 0 | BeFree |
| Heart failure | 0.000271442 | 1 | 0 | BeFree |
| Congestive heart failure | 0.000271442 | 1 | 0 | BeFree |
| Ischemia | 0.000271442 | 1 | 0 | BeFree |
| Kidney Failure, Chronic | 0.000271442 | 1 | 0 | BeFree |
| Leukemia, Myelocytic, Acute | 0.000271442 | 1 | 0 | BeFree |
| Multiple Myeloma | 0.000271442 | 1 | 0 | BeFree |
| Myocarditis | 0.000271442 | 1 | 0 | BeFree |
| Osteosarcoma | 0.000271442 | 1 | 0 | BeFree |
| polyps | 0.000271442 | 1 | 0 | BeFree |
| Prostatic Neoplasms | 0.000271442 | 1 | 0 | BeFree |
| Tongue Neoplasms | 0.000271442 | 1 | 0 | BeFree |
| Virus Diseases | 0.000271442 | 1 | 0 | BeFree |
| Severe Combined Immunodeficiency | 0.000271442 | 1 | 0 | BeFree |
| Obstructive nephropathy | 0.000271442 | 1 | 0 | BeFree |
| Renal fibrosis | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of tongue | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of gallbladder | 0.000271442 | 1 | 0 | BeFree |
| Adenosquamous carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Alveolar rhabdomyosarcoma | 0.000271442 | 1 | 0 | BeFree |
| Rhabdomyosarcoma, Embryonal | 0.000271442 | 1 | 0 | BeFree |
| Renal interstitial fibrosis | 0.000271442 | 1 | 0 | BeFree |
| Anaplastic thyroid carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Proliferative vitreoretinopathy | 0.000271442 | 1 | 0 | BeFree |
| Carcinoma breast stage IV | 0.000271442 | 1 | 0 | BeFree |
| Gallbladder adenocarcinoma | 0.000271442 | 1 | 0 | BeFree |
| Multiple polyps | 0.000271442 | 1 | 0 | BeFree |
| Disseminated Malignant Neoplasm | 0.000271442 | 1 | 0 | BeFree |
| Chronic Kidney Insufficiency | 0.000271442 | 1 | 0 | BeFree |
| Thyroid carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Tongue Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Osteosarcoma of bone | 0.000271442 | 1 | 0 | BeFree |
| vascular ischemia | 0.000271442 | 1 | 0 | BeFree |
| Colon Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Basal Cell Cancer | 0.000271442 | 1 | 0 | BeFree |
| Intraepithelial Neoplasia | 0.000271442 | 1 | 0 | BeFree |
| Pancreatic intraepithelial neoplasia | 0.000271442 | 1 | 0 | BeFree |
| Hepatocarcinogenesis | 0.000271442 | 1 | 0 | BeFree |
| Chronic Kidney Diseases | 0.000271442 | 1 | 0 | BeFree |
| Non-Neoplastic Disorder | 0.000271442 | 1 | 0 | BeFree |
| Experimental Organism Basal Cell Carcinoma | 0.000271442 | 1 | 0 | BeFree |
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