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The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants have been described. A related pseudogene has been identified on chromosome 17. [provided by RefSeq, May 2014]
[中文简述(自动翻译):]  由该基因编码的蛋白质是由许多细胞因子,包括白细胞介素6(IL6)共享一个信号转换器,睫状神经营养因子(CNTF),白血病抑制因子(LIF),和制瘤素M(OSM)。该蛋白质作为细胞因子受体复合物的一部分。这种蛋白质的活化依赖于细胞因子的与其受体的结合。 vIL6,有关IL6和由卡波西肉瘤相关疱疹病毒编码的蛋白,可以绕过白细胞介素6受体(IL6R)和直接激活该蛋白质。在小鼠中敲除的研究表明,该基因在调节细胞凋亡的关键作用。可变剪接转录物变体已有描述。一个相关的假基因已被确定在[由RefSeq的,2014年5月提供] 17号染色??体
IL6ST基因(以及对应的蛋白质)的细胞分布位置:
IL6ST基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Rheumatoid Arthritis | 0.204538567 | 9 | 2 | BeFree_CTD_human_GAD_MGD |
| Pneumonia | 0.122995792 | 3 | 0 | BeFree_CTD_human_LHGDN |
| Colorectal Neoplasms | 0.12 | 1 | 0 | CTD_human |
| Hypersensitivity | 0.12 | 1 | 0 | CTD_human |
| Animal Mammary Neoplasms | 0.12 | 1 | 0 | CTD_human |
| Mammary Neoplasms, Experimental | 0.12 | 1 | 0 | CTD_human |
| Reperfusion Injury | 0.12 | 1 | 0 | CTD_human |
| Myocardial Ischemia | 0.12 | 1 | 0 | CTD_human |
| Infarction, Middle Cerebral Artery | 0.12 | 1 | 0 | CTD_human |
| ovarian neoplasm | 0.12 | 1 | 0 | CTD_human |
| Stomach Carcinoma | 0.081628651 | 6 | 0 | BeFree_MGD |
| Liver carcinoma | 0.081357209 | 6 | 0 | BeFree_RGD |
| Brain Ischemia | 0.08 | 1 | 0 | RGD |
| Hypertriglyceridemia | 0.08 | 1 | 0 | RGD |
| Pituitary Neoplasms | 0.08 | 1 | 0 | RGD |
| Seizures | 0.08 | 1 | 0 | RGD |
| Status Epilepticus | 0.08 | 1 | 0 | RGD |
| Multiple Myeloma | 0.007991366 | 13 | 0 | BeFree_GAD |
| Heart failure | 0.00408156 | 5 | 0 | BeFree_LHGDN |
| Stomach Neoplasms | 0.003810118 | 5 | 0 | BeFree_LHGDN |
| Hepatocellular Adenoma | 0.003810118 | 4 | 0 | BeFree_LHGDN |
| Myocardial Infarction | 0.003452799 | 4 | 0 | BeFree_GAD |
| melanoma | 0.003267234 | 3 | 0 | BeFree_LHGDN |
| Obesity | 0.003181358 | 3 | 0 | BeFree_GAD |
| Malignant neoplasm of ovary | 0.003181358 | 4 | 0 | BeFree_GAD |
| Adenocarcinoma | 0.002995792 | 2 | 0 | BeFree_LHGDN |
| Atherosclerosis | 0.002995792 | 2 | 0 | BeFree_LHGDN |
| Liver diseases | 0.002995792 | 1 | 0 | BeFree_LHGDN |
| Periodontitis | 0.002909916 | 3 | 0 | BeFree_GAD |
| Squamous cell carcinoma | 0.00272435 | 1 | 0 | LHGDN |
| Encephalitis | 0.00272435 | 1 | 0 | LHGDN |
| Fibrosis | 0.00272435 | 1 | 0 | LHGDN |
| Glioma | 0.00272435 | 1 | 0 | LHGDN |
| Infertility | 0.00272435 | 1 | 0 | LHGDN |
| Plasmacytoma | 0.00272435 | 1 | 0 | LHGDN |
| Pre-Eclampsia | 0.00272435 | 1 | 0 | LHGDN |
| Uveitis | 0.00272435 | 1 | 0 | LHGDN |
| Idiopathic Pulmonary Fibrosis | 0.00272435 | 1 | 0 | LHGDN |
| Hyperandrogenism | 0.002638474 | 1 | 0 | BeFree_GAD |
| Metabolic Syndrome X | 0.002638474 | 1 | 0 | BeFree_GAD |
| Coronary heart disease | 0.002367032 | 1 | 0 | GAD |
| Hypertensive disease | 0.002367032 | 1 | 0 | GAD |
| Chronic Lymphocytic Leukemia | 0.002367032 | 1 | 0 | GAD |
| Malignant neoplasm of breast | 0.001900093 | 7 | 0 | BeFree |
| Carcinogenesis | 0.001900093 | 7 | 0 | BeFree |
| Breast Carcinoma | 0.001900093 | 7 | 0 | BeFree |
| Malignant neoplasm of stomach | 0.001628651 | 6 | 0 | BeFree |
| Congestive heart failure | 0.001357209 | 5 | 0 | BeFree |
| Leukemia, Myelocytic, Acute | 0.001085767 | 4 | 0 | BeFree |
| Ovarian Carcinoma | 0.001085767 | 4 | 0 | BeFree |
| HIV Infections | 0.000814326 | 3 | 0 | BeFree |
| Inflammatory Bowel Diseases | 0.000814326 | 3 | 0 | BeFree |
| leukemia | 0.000814326 | 3 | 0 | BeFree |
| Liver neoplasms | 0.000814326 | 3 | 0 | BeFree |
| Experimental Autoimmune Encephalomyelitis | 0.000542884 | 2 | 0 | BeFree |
| Gastritis | 0.000542884 | 2 | 0 | BeFree |
| Acute lymphocytic leukemia | 0.000542884 | 2 | 0 | BeFree |
| Pituitary Adenoma | 0.000542884 | 2 | 0 | BeFree |
| Pituitary Diseases | 0.000542884 | 2 | 0 | BeFree |
| Systemic Scleroderma | 0.000542884 | 2 | 0 | BeFree |
| Tumor Progression | 0.000542884 | 2 | 0 | BeFree |
| Malignant neoplasm of lung | 0.000542884 | 2 | 0 | BeFree |
| Chronic Periodontitis | 0.000542884 | 2 | 0 | BeFree |
| Carcinoma of lung | 0.000542884 | 2 | 0 | BeFree |
| Precursor Cell Lymphoblastic Leukemia Lymphoma | 0.000542884 | 2 | 0 | BeFree |
| Adenoma | 0.000271442 | 1 | 0 | BeFree |
| Alzheimer's Disease | 0.000271442 | 1 | 0 | BeFree |
| Arthritis | 0.000271442 | 1 | 0 | BeFree |
| Arthritis, Psoriatic | 0.000271442 | 1 | 0 | BeFree |
| Autoimmune Diseases | 0.000271442 | 1 | 0 | BeFree |
| Melanoma, B16 | 0.000271442 | 1 | 0 | BeFree |
| Benign Ovarian Neoplasm | 0.000271442 | 1 | 0 | BeFree |
| Bile Duct Diseases | 0.000271442 | 1 | 0 | BeFree |
| Brain Neoplasms | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of endometrium | 0.000271442 | 1 | 0 | BeFree |
| Cardiomyopathy, Dilated | 0.000271442 | 1 | 0 | BeFree |
| Colitis | 0.000271442 | 1 | 0 | BeFree |
| Diabetes Mellitus, Non-Insulin-Dependent | 0.000271442 | 1 | 0 | BeFree |
| Arthropathy | 0.000271442 | 1 | 0 | BeFree |
| Lung Neoplasms | 0.000271442 | 1 | 0 | BeFree |
| Medulloblastoma | 0.000271442 | 1 | 0 | BeFree |
| Monoclonal Gammopathy of Undetermined Significance | 0.000271442 | 1 | 0 | BeFree |
| Neoplasm Metastasis | 0.000271442 | 1 | 0 | BeFree |
| Degenerative polyarthritis | 0.000271442 | 1 | 0 | BeFree |
| Peripheral Neuropathy | 0.000271442 | 1 | 0 | BeFree |
| Prolactinoma | 0.000271442 | 1 | 0 | BeFree |
| Pulmonary Emphysema | 0.000271442 | 1 | 0 | BeFree |
| Kaposi Sarcoma | 0.000271442 | 1 | 0 | BeFree |
| Thrombocythemia, Essential | 0.000271442 | 1 | 0 | BeFree |
| Virus Diseases | 0.000271442 | 1 | 0 | BeFree |
| Toxoplasmosis, Cerebral | 0.000271442 | 1 | 0 | BeFree |
| Acute leukemia | 0.000271442 | 1 | 0 | BeFree |
| Gastric adenoma | 0.000271442 | 1 | 0 | BeFree |
| Cholangiocarcinoma | 0.000271442 | 1 | 0 | BeFree |
| Pancreatic carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Female Pseudohermaphroditism | 0.000271442 | 1 | 0 | BeFree |
| Cervix carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse | 0.000271442 | 1 | 0 | BeFree |
| Dissection of aorta | 0.000271442 | 1 | 0 | BeFree |
| Endometrial Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Prostate carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Sarcoma | 0.000271442 | 1 | 0 | BeFree |
| Primary Effusion Lymphoma | 0.000271442 | 1 | 0 | BeFree |
| Mammary Neoplasms | 0.000271442 | 1 | 0 | BeFree |
| Ovarian Clear Cell Adenocarcinoma | 0.000271442 | 1 | 0 | BeFree |
| Tumor-Associated Vasculature | 0.000271442 | 1 | 0 | BeFree |
| Tumor Expansion | 0.000271442 | 1 | 0 | BeFree |
| Uterine Corpus Cancer | 0.000271442 | 1 | 0 | BeFree |
| Inflammatory Hepatocellular Adenoma | 0.000271442 | 1 | 0 | BeFree |
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