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The protein encoded by this gene is a subunit of the receptor for IL23A/IL23. This protein pairs with the receptor molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling. This protein associates constitutively with Janus kinase 2 (JAK2), and also binds to transcription activator STAT3 in a ligand-dependent manner. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  由该基因编码的蛋白质是受体IL23A / IL23的一个亚基。与受体分子IL12RB1 / IL12Rbeta1该蛋白质对,并且两者都需要对IL23A信令。这与Janus激酶2蛋白联营组成(JAK2),并且还结合转录激活STAT3以配体依赖性。 [由RefSeq的,2008年7月提供]
IL23R基因(以及对应的蛋白质)的细胞分布位置:
IL23R基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Crohn Disease | 0.370597435 | 101 | 24 | BeFree_CTD_human_GAD_GWASCAT_LHGDN |
Inflammatory Bowel Diseases | 0.340104897 | 66 | 10 | BeFree_CTD_human_GAD_GWASCAT_LHGDN |
Ulcerative Colitis | 0.326936272 | 59 | 31 | BeFree_CTD_human_GAD_GWASCAT_LHGDN |
Psoriasis | 0.310524988 | 45 | 7 | BeFree_CTD_human_GAD_GWASCAT_LHGDN |
Ankylosing spondylitis | 0.281172083 | 40 | 2 | BeFree_CTD_human_GAD_GWASCAT_LHGDN |
Inflammatory Bowel Disease 17 | 0.24 | 1 | 1 | CTD_human_UNIPROT |
Behcet Syndrome | 0.130358398 | 12 | 3 | BeFree_GAD_ORPHANET |
Uveomeningoencephalitic Syndrome | 0.123452799 | 4 | 3 | BeFree_GAD_GWASCAT |
Leprosy | 0.120814326 | 3 | 0 | BeFree_CTD_human |
Inflammatory dermatosis | 0.12 | 1 | 1 | GWASCAT |
Myasthenia Gravis, Autoimmune, Experimental | 0.08 | 1 | 0 | RGD |
Multiple Sclerosis | 0.015916719 | 7 | 0 | BeFree_GAD_LHGDN |
Arthritis, Psoriatic | 0.015721222 | 14 | 1 | BeFree_GAD_LHGDN |
Celiac Disease | 0.013635564 | 4 | 0 | BeFree_GAD_LHGDN |
Rheumatoid Arthritis | 0.012811307 | 12 | 3 | BeFree_GAD_LHGDN |
Lupus Erythematosus, Systemic | 0.008458305 | 5 | 0 | BeFree_GAD |
Chronic ulcerative colitis | 0.007101096 | 3 | 1 | GAD |
Autoimmune Diseases | 0.006514605 | 24 | 1 | BeFree |
Graft-vs-Host Disease | 0.005276948 | 3 | 0 | BeFree_GAD |
Thyroid associated opthalmopathies | 0.005276948 | 2 | 0 | BeFree_GAD |
Diabetes Mellitus, Insulin-Dependent | 0.005005506 | 2 | 0 | BeFree_GAD |
Diabetes Mellitus, Non-Insulin-Dependent | 0.005005506 | 3 | 0 | BeFree_GAD |
Autoimmune thyroiditis | 0.004734064 | 2 | 0 | GAD |
Graves Disease | 0.003452799 | 4 | 0 | BeFree_GAD |
Irritable Bowel Syndrome | 0.003181358 | 4 | 0 | BeFree_GAD |
Systemic Scleroderma | 0.002909916 | 2 | 0 | BeFree_GAD |
Hashimoto Disease | 0.002909916 | 3 | 0 | BeFree_GAD |
Barrett Esophagus | 0.00272435 | 1 | 0 | LHGDN |
Bone necrosis | 0.00272435 | 1 | 0 | LHGDN |
Thyroid Diseases | 0.00272435 | 1 | 0 | LHGDN |
Asthma | 0.002638474 | 2 | 0 | BeFree_GAD |
Cardiomyopathy, Dilated | 0.002638474 | 1 | 0 | BeFree_GAD |
Esophageal Achalasia | 0.002638474 | 1 | 0 | BeFree_GAD |
Pulmonary Hypertension | 0.002638474 | 1 | 0 | BeFree_GAD |
Myocardial Infarction | 0.002638474 | 1 | 0 | BeFree_GAD |
Hematologic Neoplasms | 0.002638474 | 2 | 0 | BeFree_GAD |
Malignant neoplasm of ovary | 0.002638474 | 1 | 0 | BeFree_GAD |
Sjogren's Syndrome | 0.002638474 | 1 | 0 | BeFree_GAD |
Coronary Artery Disease | 0.002638474 | 2 | 0 | BeFree_GAD |
Aplastic Anemia | 0.002367032 | 1 | 0 | GAD |
Bronchiolitis, Viral | 0.002367032 | 1 | 0 | GAD |
Femur Head Necrosis | 0.002367032 | 1 | 0 | GAD |
Fuchs Endothelial Dystrophy | 0.002367032 | 1 | 0 | GAD |
Growth Disorders | 0.002367032 | 1 | 0 | GAD |
Hypertensive disease | 0.002367032 | 1 | 0 | GAD |
Intestinal Fistula | 0.002367032 | 1 | 0 | GAD |
Intestinal Obstruction | 0.002367032 | 1 | 0 | GAD |
Animal Mammary Neoplasms | 0.002367032 | 1 | 0 | GAD |
Rectal Fistula | 0.002367032 | 1 | 0 | GAD |
Respiratory Syncytial Virus Infections | 0.002367032 | 1 | 0 | GAD |
Dermatologic disorders | 0.002367032 | 1 | 0 | GAD |
Stomach Neoplasms | 0.002367032 | 1 | 0 | GAD |
Tobacco Use Disorder | 0.002367032 | 1 | 0 | GAD |
Stenosis | 0.002367032 | 1 | 0 | GAD |
Mammary Neoplasms | 0.002367032 | 1 | 0 | GAD |
Colorectal Carcinoma | 0.001628651 | 6 | 1 | BeFree |
Colorectal Cancer | 0.001628651 | 6 | 1 | BeFree |
Carcinogenesis | 0.001357209 | 5 | 2 | BeFree |
Hepatitis B | 0.000814326 | 3 | 0 | BeFree |
Malignant neoplasm of stomach | 0.000814326 | 3 | 1 | BeFree |
Secondary malignant neoplasm of lymph node | 0.000814326 | 3 | 0 | BeFree |
Stomach Carcinoma | 0.000814326 | 3 | 1 | BeFree |
Acute GVH disease | 0.000814326 | 3 | 1 | BeFree |
Inflammatory disorder | 0.000814326 | 3 | 0 | BeFree |
Liver carcinoma | 0.000814326 | 3 | 0 | BeFree |
Arthritis | 0.000542884 | 2 | 0 | BeFree |
Malignant neoplasm of breast | 0.000542884 | 2 | 1 | BeFree |
Rectal Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Neoplasm Metastasis | 0.000542884 | 2 | 0 | BeFree |
Tuberculosis | 0.000542884 | 2 | 0 | BeFree |
Uveitis | 0.000542884 | 2 | 0 | BeFree |
Autoimmune thyroid disease | 0.000542884 | 2 | 0 | BeFree |
Psoriasis vulgaris | 0.000542884 | 2 | 0 | BeFree |
Breast Carcinoma | 0.000542884 | 2 | 1 | BeFree |
Spondylarthritis | 0.000542884 | 2 | 1 | BeFree |
Pediatric Crohn's disease | 0.000542884 | 2 | 1 | BeFree |
Alzheimer's Disease | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of urinary bladder | 0.000271442 | 1 | 0 | BeFree |
Malignant tumor of colon | 0.000271442 | 1 | 0 | BeFree |
Non-Small Cell Lung Carcinoma | 0.000271442 | 1 | 6 | BeFree |
Colitis | 0.000271442 | 1 | 0 | BeFree |
Colorectal Neoplasms | 0.000271442 | 1 | 0 | BeFree |
Dermatitis, Atopic | 0.000271442 | 1 | 0 | BeFree |
Scleroderma | 0.000271442 | 1 | 0 | BeFree |
Eczema | 0.000271442 | 1 | 0 | BeFree |
Experimental Autoimmune Encephalomyelitis | 0.000271442 | 1 | 0 | BeFree |
Esophageal Neoplasms | 0.000271442 | 1 | 0 | BeFree |
Gastritis | 0.000271442 | 1 | 0 | BeFree |
Immune System Diseases | 0.000271442 | 1 | 0 | BeFree |
Arthropathy | 0.000271442 | 1 | 1 | BeFree |
Leukemia, Myelocytic, Acute | 0.000271442 | 1 | 0 | BeFree |
Lyme Disease | 0.000271442 | 1 | 0 | BeFree |
Mycobacterium Infections | 0.000271442 | 1 | 0 | BeFree |
Paracoccidioidomycosis | 0.000271442 | 1 | 0 | BeFree |
Rectal Neoplasms | 0.000271442 | 1 | 2 | BeFree |
Salmonella infections | 0.000271442 | 1 | 0 | BeFree |
Schistosomiasis | 0.000271442 | 1 | 1 | BeFree |
Giant Cell Arteritis | 0.000271442 | 1 | 2 | BeFree |
Anterior uveitis | 0.000271442 | 1 | 0 | BeFree |
Acute leukemia | 0.000271442 | 1 | 0 | BeFree |
Squamous cell carcinoma of lung | 0.000271442 | 1 | 0 | BeFree |
Small cell carcinoma of lung | 0.000271442 | 1 | 0 | BeFree |
Adenocarcinoma of lung (disorder) | 0.000271442 | 1 | 0 | BeFree |
Esophageal carcinoma | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of mouth | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of nasopharynx | 0.000271442 | 1 | 0 | BeFree |
Lip and Oral Cavity Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Cancer of Nasopharynx | 0.000271442 | 1 | 0 | BeFree |
Carcinoma, Small Cell | 0.000271442 | 1 | 0 | BeFree |
Stenosis of intestine | 0.000271442 | 1 | 0 | BeFree |
Squamous cell carcinoma of esophagus | 0.000271442 | 1 | 0 | BeFree |
Transitional cell carcinoma of bladder | 0.000271442 | 1 | 0 | BeFree |
Solid tumour | 0.000271442 | 1 | 1 | BeFree |
Superficial ulcer | 0.000271442 | 1 | 1 | BeFree |
Primary immune deficiency disorder | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of esophagus | 0.000271442 | 1 | 0 | BeFree |
Sacroiliitis | 0.000271442 | 1 | 1 | BeFree |
Colon Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Carcinoma of bladder | 0.000271442 | 1 | 0 | BeFree |
Acute anterior uveitis | 0.000271442 | 1 | 0 | BeFree |
Cancer of Digestive System | 0.000271442 | 1 | 0 | BeFree |
Helicobacter pylori infection | 0.000271442 | 1 | 1 | BeFree |
Pancolitis | 0.000271442 | 1 | 2 | BeFree |
Enthesitis | 0.000271442 | 1 | 0 | BeFree |
Chronic inflammatory disorder | 0.000271442 | 1 | 1 | BeFree |
Precursor B-cell lymphoblastic leukemia | 0.000271442 | 1 | 0 | BeFree |
Adenoma of large intestine | 0.000271442 | 1 | 0 | BeFree |
Sporadic Breast Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Salivary Gland Pleomorphic Adenoma | 0.000271442 | 1 | 2 | BeFree |
Rectal Tumors | 0.000271442 | 1 | 2 | BeFree |
Non-Malignant Ascites Adverse Event | 0.000271442 | 1 | 0 | BeFree |
Immune Reconstitution Inflammatory Syndrome | 0.000271442 | 1 | 1 | BeFree |
Nasopharyngeal carcinoma | 0.000271442 | 1 | 0 | BeFree |
Juvenile arthritis | 0.000271442 | 1 | 0 | BeFree |
Juvenile rheumatoid arthritis | 0.000271442 | 1 | 0 | BeFree |
Juvenile psoriatic arthritis | 0.000271442 | 1 | 0 | BeFree |
Pulmonary Hypertension, Primary, 1, With Hereditary Hemorrhagic Telangiectasia | 0.000271442 | 1 | 0 | BeFree |
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