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This gene encodes a subunit of the heterodimeric cytokine interleukin 23 (IL23). IL23 is composed of this protein and the p40 subunit of interleukin 12 (IL12B). The receptor of IL23 is formed by the beta 1 subunit of IL12 (IL12RB1) and an IL23 specific subunit, IL23R. Both IL23 and IL12 can activate the transcription activator STAT4, and stimulate the production of interferon-gamma (IFNG). In contrast to IL12, which acts mainly on naive CD4(+) T cells, IL23 preferentially acts on memory CD4(+) T cells. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  该基因编码的异源二聚体细胞因子白介素23(IL23)的一个亚基。 IL23是由这种蛋白和白细胞介素12(IL12B)的p40亚单位。 IL23的受体被IL??12(IL12RB1)和IL23特定亚单位,IL23R的beta 1亚基形成。无论IL23和IL12能激活转录激活STAT4,并刺激生产干扰素-γ(IFNG)的。相反,IL12,它主要作用于幼稚的CD4(+)T细胞,IL23优先作用于记忆性CD4 + T细胞。 [由RefSeq的,2008年7月提供]
IL23A基因(以及对应的蛋白质)的细胞分布位置:
IL23A基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Psoriasis | 0.138858973 | 44 | 1 | BeFree_CTD_human_GAD_LHGDN |
Rheumatoid Arthritis | 0.129520329 | 18 | 0 | BeFree_CTD_human_LHGDN |
Inflammation | 0.010897401 | 4 | 0 | LHGDN |
Autoimmune Diseases | 0.007881746 | 19 | 0 | BeFree_LHGDN |
Arthritis, Psoriatic | 0.007077352 | 8 | 2 | BeFree_LHGDN |
Inflammatory Bowel Diseases | 0.00706742 | 17 | 0 | BeFree_LHGDN |
Embryonal Carcinoma | 0.007057489 | 26 | 0 | BeFree |
Multiple Sclerosis | 0.005710211 | 11 | 0 | BeFree_LHGDN |
Crohn Disease | 0.004353001 | 6 | 0 | BeFree_LHGDN |
Lupus Erythematosus, Systemic | 0.004353001 | 7 | 0 | BeFree_LHGDN |
Behcet Syndrome | 0.00408156 | 5 | 0 | BeFree_LHGDN |
Mycosis Fungoides | 0.002995792 | 1 | 0 | BeFree_LHGDN |
Sezary Syndrome | 0.002995792 | 1 | 0 | BeFree_LHGDN |
Uveitis | 0.002995792 | 1 | 0 | BeFree_LHGDN |
Anemia | 0.00272435 | 1 | 0 | LHGDN |
Bronchiolitis Obliterans | 0.00272435 | 1 | 0 | LHGDN |
Sjogren's Syndrome | 0.00272435 | 1 | 0 | LHGDN |
Infection | 0.00272435 | 1 | 0 | LHGDN |
Ankylosing spondylitis | 0.002714419 | 10 | 0 | BeFree |
Hepatitis C | 0.002638474 | 2 | 0 | BeFree_GAD |
Experimental Autoimmune Encephalomyelitis | 0.002442977 | 9 | 0 | BeFree |
Adult T-Cell Lymphoma/Leukemia | 0.002171535 | 8 | 0 | BeFree |
Ulcerative Colitis | 0.001900093 | 7 | 0 | BeFree |
Colorectal Carcinoma | 0.001900093 | 7 | 0 | BeFree |
Arthritis | 0.001357209 | 5 | 0 | BeFree |
Neoplasm Metastasis | 0.001357209 | 5 | 0 | BeFree |
Degenerative polyarthritis | 0.001357209 | 5 | 0 | BeFree |
Colorectal Cancer | 0.001357209 | 5 | 0 | BeFree |
Dermatitis | 0.001085767 | 4 | 0 | BeFree |
Tuberculosis | 0.001085767 | 4 | 0 | BeFree |
Virus Diseases | 0.001085767 | 4 | 0 | BeFree |
Tumor Progression | 0.001085767 | 4 | 0 | BeFree |
bone destruction | 0.001085767 | 4 | 0 | BeFree |
Carcinogenesis | 0.001085767 | 4 | 0 | BeFree |
Asthma | 0.000814326 | 3 | 0 | BeFree |
Colitis | 0.000814326 | 3 | 0 | BeFree |
Dermatitis, Atopic | 0.000814326 | 3 | 0 | BeFree |
Diabetes Mellitus, Insulin-Dependent | 0.000814326 | 3 | 0 | BeFree |
Eczema | 0.000814326 | 3 | 0 | BeFree |
Graves Disease | 0.000814326 | 3 | 0 | BeFree |
Mycoses | 0.000814326 | 3 | 0 | BeFree |
Dermatologic disorders | 0.000814326 | 3 | 0 | BeFree |
Teratocarcinoma | 0.000814326 | 3 | 0 | BeFree |
Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site | 0.000814326 | 3 | 0 | BeFree |
Lupus Erythematosus | 0.000814326 | 3 | 0 | BeFree |
Malignant tumor of cervix | 0.000542884 | 2 | 0 | BeFree |
Hepatitis B | 0.000542884 | 2 | 0 | BeFree |
Leukemia, T-Cell | 0.000542884 | 2 | 0 | BeFree |
Lupus Vulgaris | 0.000542884 | 2 | 0 | BeFree |
Lupus Erythematosus, Discoid | 0.000542884 | 2 | 0 | BeFree |
Malignant neoplasm of stomach | 0.000542884 | 2 | 0 | BeFree |
melanoma | 0.000542884 | 2 | 0 | BeFree |
Mitral Valve Stenosis | 0.000542884 | 2 | 0 | BeFree |
Multiple Myeloma | 0.000542884 | 2 | 0 | BeFree |
Ovarian Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Pneumonia | 0.000542884 | 2 | 0 | BeFree |
Salmonella infections | 0.000542884 | 2 | 0 | BeFree |
Systemic Scleroderma | 0.000542884 | 2 | 0 | BeFree |
Severe Combined Immunodeficiency | 0.000542884 | 2 | 0 | BeFree |
Acute leukemia | 0.000542884 | 2 | 0 | BeFree |
Psoriasis vulgaris | 0.000542884 | 2 | 0 | BeFree |
Epithelial hyperplasia of skin | 0.000542884 | 2 | 0 | BeFree |
Cervix carcinoma | 0.000542884 | 2 | 0 | BeFree |
Hepatitis B, Chronic | 0.000542884 | 2 | 0 | BeFree |
Stomach Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Helicobacter pylori infection | 0.000542884 | 2 | 1 | BeFree |
Arthritis, Collagen-Induced | 0.000542884 | 2 | 0 | BeFree |
Malignant neoplasm of ovary | 0.000542884 | 2 | 0 | BeFree |
Inflammatory disorder | 0.000542884 | 2 | 0 | BeFree |
Precursor B-cell lymphoblastic leukemia | 0.000542884 | 2 | 0 | BeFree |
Adenoma | 0.000271442 | 1 | 0 | BeFree |
Extrinsic allergic alveolitis | 0.000271442 | 1 | 0 | BeFree |
Amyotrophic Lateral Sclerosis | 0.000271442 | 1 | 0 | BeFree |
Bacterial Infections | 0.000271442 | 1 | 0 | BeFree |
Non-Small Cell Lung Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Celiac Disease | 0.000271442 | 1 | 0 | BeFree |
Cholangitis | 0.000271442 | 1 | 0 | BeFree |
Primary biliary cirrhosis | 0.000271442 | 1 | 0 | BeFree |
Demyelinating Diseases | 0.000271442 | 1 | 0 | BeFree |
Diabetes | 0.000271442 | 1 | 0 | BeFree |
Diabetes Mellitus | 0.000271442 | 1 | 0 | BeFree |
Diabetes Mellitus, Non-Insulin-Dependent | 0.000271442 | 1 | 0 | BeFree |
Dwarfism | 0.000271442 | 1 | 0 | BeFree |
Bacterial Endocarditis | 0.000271442 | 1 | 0 | BeFree |
Erythema Nodosum | 0.000271442 | 1 | 0 | BeFree |
Glioma | 0.000271442 | 1 | 0 | BeFree |
Guillain-Barre Syndrome | 0.000271442 | 1 | 0 | BeFree |
Influenza | 0.000271442 | 1 | 0 | BeFree |
Kidney Diseases | 0.000271442 | 1 | 0 | BeFree |
Liver Cirrhosis | 0.000271442 | 1 | 0 | BeFree |
Chronic Obstructive Airway Disease | 0.000271442 | 1 | 0 | BeFree |
Lupus Nephritis | 0.000271442 | 1 | 0 | BeFree |
Lymphoma, Follicular | 0.000271442 | 1 | 0 | BeFree |
Malaria | 0.000271442 | 1 | 0 | BeFree |
Mucocutaneous Lymph Node Syndrome | 0.000271442 | 1 | 0 | BeFree |
Nephritis | 0.000271442 | 1 | 0 | BeFree |
Neuritis, Autoimmune, Experimental | 0.000271442 | 1 | 0 | BeFree |
Obesity | 0.000271442 | 1 | 0 | BeFree |
Parakeratosis | 0.000271442 | 1 | 0 | BeFree |
Pheochromocytoma | 0.000271442 | 1 | 0 | BeFree |
Retinoblastoma | 0.000271442 | 1 | 0 | BeFree |
Septicemia | 0.000271442 | 1 | 0 | BeFree |
Superinfection | 0.000271442 | 1 | 0 | BeFree |
Tuberculosis, Pulmonary | 0.000271442 | 1 | 0 | BeFree |
Uveomeningoencephalitic Syndrome | 0.000271442 | 1 | 0 | BeFree |
Diffuse Large B-Cell Lymphoma | 0.000271442 | 1 | 0 | BeFree |
Chronic gastritis | 0.000271442 | 1 | 1 | BeFree |
Joint swelling | 0.000271442 | 1 | 0 | BeFree |
Pustular psoriasis | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of mouth | 0.000271442 | 1 | 0 | BeFree |
Secondary malignant neoplasm of lung | 0.000271442 | 1 | 0 | BeFree |
Malnutrition | 0.000271442 | 1 | 0 | BeFree |
Ganglioglioma | 0.000271442 | 1 | 0 | BeFree |
Lip and Oral Cavity Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Gallbladder Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Pancreatic carcinoma | 0.000271442 | 1 | 0 | BeFree |
Colitis, Collagenous | 0.000271442 | 1 | 0 | BeFree |
Hereditary pancreatitis | 0.000271442 | 1 | 0 | BeFree |
Fibrosis, Liver | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of lung | 0.000271442 | 1 | 0 | BeFree |
Parasitemia | 0.000271442 | 1 | 0 | BeFree |
Sepsis | 0.000271442 | 1 | 0 | BeFree |
Psoriasiform eczema | 0.000271442 | 1 | 0 | BeFree |
Chronic arthritis | 0.000271442 | 1 | 0 | BeFree |
Thyroid associated opthalmopathies | 0.000271442 | 1 | 0 | BeFree |
Juvenile Myelomonocytic Leukemia | 0.000271442 | 1 | 0 | BeFree |
Human T-cell lymphotrophic virus, type I [HTLV-I] | 0.000271442 | 1 | 0 | BeFree |
Hematologic Neoplasms | 0.000271442 | 1 | 0 | BeFree |
Immune thrombocytopenic purpura | 0.000271442 | 1 | 0 | BeFree |
Leukocyte adhesion deficiency type 1 | 0.000271442 | 1 | 0 | BeFree |
Colitis, Lymphocytic | 0.000271442 | 1 | 0 | BeFree |
Chronic small plaque psoriasis | 0.000271442 | 1 | 0 | BeFree |
Primary antiphospholipid syndrome | 0.000271442 | 1 | 0 | BeFree |
Neuropathy | 0.000271442 | 1 | 0 | BeFree |
Pneumonia due to Klebsiella pneumoniae | 0.000271442 | 1 | 0 | BeFree |
Neurodegenerative Disorders | 0.000271442 | 1 | 0 | BeFree |
Auricular swelling | 0.000271442 | 1 | 0 | BeFree |
Squamous cell carcinoma of mouth | 0.000271442 | 1 | 0 | BeFree |
Costello syndrome (disorder) | 0.000271442 | 1 | 0 | BeFree |
Hashimoto Disease | 0.000271442 | 1 | 0 | BeFree |
Carcinoma of lung | 0.000271442 | 1 | 0 | BeFree |
Secondary malignant neoplasm of lymph node | 0.000271442 | 1 | 0 | BeFree |
Carcinoma of bladder | 0.000271442 | 1 | 0 | BeFree |
gastritis h pylori | 0.000271442 | 1 | 0 | BeFree |
Idiopathic Inflammatory Myopathies | 0.000271442 | 1 | 0 | BeFree |
neurological disability | 0.000271442 | 1 | 0 | BeFree |
Infectious disease of lung | 0.000271442 | 1 | 0 | BeFree |
Nosocomial pneumonia | 0.000271442 | 1 | 0 | BeFree |
Spondylarthritis | 0.000271442 | 1 | 0 | BeFree |
Spondylarthropathies | 0.000271442 | 1 | 0 | BeFree |
Infective endocarditis | 0.000271442 | 1 | 0 | BeFree |
Latent Tuberculosis | 0.000271442 | 1 | 0 | BeFree |
Severe Sepsis | 0.000271442 | 1 | 0 | BeFree |
Liver carcinoma | 0.000271442 | 1 | 0 | BeFree |
Extramedullary Hematopoiesis (disorder) | 0.000271442 | 1 | 0 | BeFree |
Acute-On-Chronic Liver Failure | 0.000271442 | 1 | 0 | BeFree |
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