IL23A(interleukin 23, alpha subunit p19)

基因简称(symbol)
    [HGNC]     [GeneCards]     [NCBI]
基因种类(locus group)
同源简称(alias symbol)
基因家族代码(gene_family_id)
    [HGNC]     [GenScript]
omim代码
entrez码
    [Vega]
vega基因码
ensembl基因码
    [Ensembl]
基因家族(gene family)
refseq数据库代号

更多...

基因种类(locus_type)
基因名称状态(status)
location_sortable
同源基因名称(alias name)
基因名称批准使用时间(date_approved_reserved)
基因简称更名时间(date_symbol_changed)
基因名称更名时间(date_name_changed)
更新时间(date_modified)
ucsc码
ena
ccds数据码
uniprot数据码
pubmed代码
mgd码
rgd码
生命科学数据库(lsdb)
更新时间(date modified)
cosmic
mirbase
基因曾用简称(prev symbol)
基因曾用名称(prev name)
homeodb
cosmic
snornabase
bioparadigms slc
orphanet
假基因信息(pseudogeneorg)
horde id
merops
imgt
iuphar
kznf基因类别
mamit-trnadb
cd
LncRNA数据库
酶代码
中间纤维数据库

收起

12q13.13
基因染色体位置图

This gene encodes a subunit of the heterodimeric cytokine interleukin 23 (IL23). IL23 is composed of this protein and the p40 subunit of interleukin 12 (IL12B). The receptor of IL23 is formed by the beta 1 subunit of IL12 (IL12RB1) and an IL23 specific subunit, IL23R. Both IL23 and IL12 can activate the transcription activator STAT4, and stimulate the production of interferon-gamma (IFNG). In contrast to IL12, which acts mainly on naive CD4(+) T cells, IL23 preferentially acts on memory CD4(+) T cells. [provided by RefSeq, Jul 2008]

[中文简述(自动翻译):]  该基因编码的异源二聚体细胞因子白介素23(IL23)的一个亚基。 IL23是由这种蛋白和白细胞介素12(IL12B)的p40亚单位。 IL23的受体被IL??12(IL12RB1)和IL23特定亚单位,IL23R的beta 1亚基形成。无论IL23和IL12能激活转录激活STAT4,并刺激生产干扰素-γ(IFNG)的。相反,IL12,它主要作用于幼稚的CD4(+)T细胞,IL23优先作用于记忆性CD4 + T细胞。 [由RefSeq的,2008年7月提供]

IL23A基因的碱基序列:[NCBI]
IL23A基因的碱基突变:           显示全部snp
rs2371494       rs2643626       rs4759208       rs11171805       rs11171806       rs11358218       rs11465741       rs11465742       rs11465743       rs11465744       rs11465745       rs11465746       rs11558139       rs11575254       rs11575255       rs11575256       rs11835054       rs12424096       rs34174579       rs35157967       rs59094153       rs59401840       rs61937687       rs61937688       rs73131077       rs74496027       rs75754909       rs76145103       rs77443896       rs78379207       rs78441936       rs79101914       rs79383676       rs79813541       rs79824801       rs80317430       rs111326153      
rs111932562       rs112188779       rs112327018       rs112513307       rs112818220       rs113045514       rs113129337       rs113688058       rs117084460       rs117392962       rs117642816       rs138486926       rs138569905       rs139158997       rs140686122       rs141408331       rs141473706       rs142059416       rs142401046       rs142811781       rs142837313       rs144051240       rs144463048       rs145233794       rs145861334       rs146415250       rs146998334       rs147076355       rs148563949       rs148648899       rs149675638       rs150119995       rs150940553       rs151144365       rs180825144       rs181087214       rs181446540       rs181839333       rs183405127       rs183630861       rs183653596       rs184644194       rs184784332       rs185032444       rs185160968       rs185400182       rs186505267       rs186860869       rs187679814       rs188218929       rs188263235       rs189216033       rs189419122       rs189574242       rs191377199       rs191450873       rs191452087       rs192921271       rs193014535       rs199537910       rs199575492       rs199760416       rs199897292       rs200257493       rs200277617       rs200585151       rs200708303       rs200730200       rs201125188       rs201143212       rs201179769       rs201309092       rs201540723       rs201704660       rs201710057       rs201789768       rs201902467       rs201916567       rs201997002       rs202124814       rs202171087       rs202189915       rs367895145       rs369938169       rs370367860       rs370833575       rs371831505       rs372470337       rs374109535       rs376972183       rs527777656       rs527786553       rs528154932       rs528196468       rs528458208       rs529178304       rs529213396       rs530330892       rs531212956       rs532737891       rs532822856       rs533056078       rs533070996       rs533127924       rs533235352       rs534283393       rs534368009       rs534485715       rs534652194       rs534791691       rs534897610       rs535541370       rs535603776       rs535785985       rs536322507       rs536611753       rs536809649       rs537400697       rs537462244       rs539663492       rs539849804       rs540360762       rs540961764       rs541219743       rs542032939       rs542055109       rs542151206       rs542480865       rs542758401       rs542790001       rs543068160       rs543346133       rs544024496       rs544351539       rs545089056       rs545167417       rs545177853       rs546465101       rs546590675       rs546785338       rs547016231       rs547357322       rs547780096       rs547790667       rs547801153       rs549320913       rs550525306       rs550556858       rs550567332       rs550755421       rs550864112       rs551672438       rs551688276       rs551945192       rs552285708       rs552966362       rs553156394       rs553268856       rs553488277       rs553804944       rs554985099       rs555046135       rs555051601       rs555443294       rs555997075       rs556188136       rs557064333       rs557140087       rs557455914       rs557787120       rs557931580       rs558403577       rs558475931       rs558745983       rs558912994       rs559755303       rs560015579       rs560075491       rs560344536       rs560970561       rs561193106       rs561334546       rs561721221       rs561784555       rs561915529       rs562519989       rs562534975       rs562580985       rs562720160       rs562986322       rs564633747       rs565376157       rs566874682       rs567086421       rs568173265       rs568235540       rs569022999       rs569133387       rs569188675       rs569471722       rs570550074       rs570590337       rs570852821       rs570853871       rs572237485       rs572378321       rs573398645       rs573453301       rs573608909       rs574694546       rs575880845       rs575919125       rs577276591       rs577337426       rs745330561       rs745769997       rs746078083       rs746186697       rs746480092       rs746727343       rs746997179       rs747018963       rs747492997       rs747841636       rs747905636       rs748125861       rs748430183       rs748666789       rs749044232       rs749208260       rs749346594       rs749541680       rs750048704       rs750245537       rs750410589       rs750548351       rs750574285       rs751022009       rs751297662       rs751697693       rs751865187       rs751964308       rs752194855       rs752286546       rs752995341       rs753089266       rs753323186       rs753335993       rs753888175       rs753906462       rs754186812       rs754421582       rs754983389       rs755181383       rs755630983       rs755787916       rs756303469       rs756637304       rs756835874       rs757860674       rs758017950       rs758098526       rs758481963       rs758617831       rs759123582       rs759334436       rs759571948       rs759787713       rs760096090       rs760141378       rs760262754       rs760422784       rs760584414       rs760965618       rs761634870       rs761726950       rs761747136       rs762044893       rs762107047       rs762122707       rs762680319       rs762696858       rs763062396       rs763208935       rs763344669       rs763671246       rs763880976       rs764415400       rs764509184       rs764893192       rs764910608       rs765038229       rs765659551       rs765681910       rs766147397       rs766167780       rs766514214       rs766545393       rs766637414       rs766861824       rs766907063       rs767279694       rs767367536       rs767388265       rs767584027       rs767745568       rs767894389       rs768368070       rs768455912       rs768621346       rs768673852       rs768859348       rs768984725       rs769235407       rs769687309       rs769785954       rs769827596       rs769999061       rs770167229       rs770199764       rs770328461       rs770394285       rs770482196       rs770791043       rs770842854       rs771223487       rs771313436       rs771674797       rs772029422       rs772189173       rs772379441       rs772567614       rs772794641       rs772993973       rs773268328       rs773710976       rs774022773       rs774093079       rs774312153       rs774443373       rs774488262       rs774511668       rs774799160       rs775327956       rs775454249       rs775570129       rs775611540       rs776021749       rs776113700       rs776419342       rs776538904       rs776666056       rs776876825       rs777038608       rs777608040       rs777842019       rs778289311       rs778300397       rs778563353       rs778776361       rs779071647       rs779231443       rs779330106       rs779438939       rs779602288       rs780010806       rs781117953       rs781334550       rs781750652       rs869040067      

IL23A基因在不同组织中的表达:    [UniProt]

基因在不同组织中的表达图
正向引物序列
正向引物Tm值
反向引物序列
反向引物Tm值
rank
AGAAAGGCTCCCAGAATGG
59
CAAGCAGAACTGACTGTTGTC
60
GACACATGGATCTAAGAGAAGAG
58
TGACTGTTGTCCCTGAGTC
59
ATTACGTCTAGGGCTCCCA
60
GTCTCTTCATCTCCCTCTTCTC
60
TGGGACACATGGATCTAAGAG
59
GACTGTTGTCCCTGAGTCC
60
AGAGACTACAAATGATGTTCCC
58
TTGCAAGCAGAACTGACTG
58
AATTACGTCTAGGGCTCCC
59
GTCTCTTCATCTCCCTCTTCTC
60
TGGGACACATGGATCTAAGAG
59
TGACTGTTGTCCCTGAGTC
59
AATTACGTCTAGGGCTCCC
59
TCTCTTCATCTCCCTCTTCTC
58
TTAGAAAGGCTCCCAGAATGG
60
CAAGCAGAACTGACTGTTGTC
60
TAGAAAGGCTCCCAGAATGG
59
CAAGCAGAACTGACTGTTGTC
60
      尚未收录相关数据

IL23A基因(以及对应的蛋白质)的细胞分布位置:

[UniProt]     [GenomeNet]

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 溶酶体
  • 内涵体
  • 细胞核
  • 细胞质
  • 液泡
  • 细胞膜
  • 细胞外基质
  • 内质网
  • 线粒体
  • 高尔基体
  • 细胞骨架

IL23A基因的本体(GO)信息:

GO库代码
对应的蛋白质
来源代码
GO:0001916
Q9NPF7(UniProtKB)
ISS
GO:0002230
Q9NPF7(UniProtKB)
ISS
GO:0002230
Q9NPF7(UniProtKB)
IDA
GO:0002827
Q9NPF7(UniProtKB)
ISS
GO:0002827
Q9NPF7(UniProtKB)
IDA
GO:0002827
Q9NPF7(UniProtKB)
TAS
GO:0002827
Q9NPF7(UniProtKB)
NAS
GO:0005125
Q9NPF7(UniProtKB)
IEA
GO:0005515
Q9NPF7(UniProtKB)
IPI
GO:0005515
Q9NPF7(UniProtKB)
IPI
GO:0005515
Q9NPF7(UniProtKB)
IPI
GO:0005515
Q9NPF7(UniProtKB)
IPI
GO:0005576
Q9NPF7(UniProtKB)
TAS
GO:0006954
Q9NPF7(UniProtKB)
IEA
GO:0010535
Q9NPF7(UniProtKB)
IDA
GO:0032693
Q9NPF7(UniProtKB)
IMP
GO:0032725
Q9NPF7(UniProtKB)
IDA
GO:0032729
Q9NPF7(UniProtKB)
IDA
GO:0032729
Q9NPF7(UniProtKB)
IDA
GO:0032729
Q9NPF7(UniProtKB)
TAS
GO:0032729
Q9NPF7(UniProtKB)
IDA
GO:0032733
Q9NPF7(UniProtKB)
IDA
GO:0032733
Q9NPF7(UniProtKB)
TAS
GO:0032735
Q9NPF7(UniProtKB)
IDA
GO:0032740
Q9NPF7(UniProtKB)
IDA
GO:0032740
Q9NPF7(UniProtKB)
IDA
GO:0032740
Q9NPF7(UniProtKB)
IDA
GO:0032760
Q9NPF7(UniProtKB)
IMP
GO:0032816
Q9NPF7(UniProtKB)
IC
GO:0032819
Q9NPF7(UniProtKB)
IDA
GO:0034105
Q9NPF7(UniProtKB)
IC
GO:0042098
Q9NPF7(UniProtKB)
IEA
GO:0042102
Q9NPF7(UniProtKB)
IDA
GO:0042104
Q9NPF7(UniProtKB)
IDA
GO:0042346
Q9NPF7(UniProtKB)
TAS
GO:0042510
Q9NPF7(UniProtKB)
IDA
GO:0042517
Q9NPF7(UniProtKB)
IDA
GO:0042517
Q9NPF7(UniProtKB)
IDA
GO:0042520
Q9NPF7(UniProtKB)
IDA
GO:0042520
Q9NPF7(UniProtKB)
IDA
GO:0042520
Q9NPF7(UniProtKB)
IDA
GO:0042523
Q9NPF7(UniProtKB)
IDA
GO:0043382
Q9NPF7(UniProtKB)
ISS
GO:0045087
Q9NPF7(UniProtKB)
IEA
GO:0045672
Q9NPF7(UniProtKB)
IDA
GO:0045944
Q9NPF7(UniProtKB)
IEA
GO:0048771
Q9NPF7(UniProtKB)
IEA
GO:0050729
Q9NPF7(UniProtKB)
IC
GO:0050829
Q9NPF7(UniProtKB)
IDA
GO:0050829
Q9NPF7(UniProtKB)
IDA
GO:0051135
Q9NPF7(UniProtKB)
IDA
GO:0051135
Q9NPF7(UniProtKB)
IC
GO:0051142
Q9NPF7(UniProtKB)
IDA
GO:0051607
Q9NPF7(UniProtKB)
IEA
GO:0070743
Q9NPF7(UniProtKB)
IDA
GO:0090023
Q9NPF7(UniProtKB)
IEA
GO:2000318
Q9NPF7(UniProtKB)
ISS
GO:2000330
Q9NPF7(UniProtKB)
ISS
GO:2000330
Q9NPF7(UniProtKB)
IBA
GO:0045519
Q9NPF7(UniProtKB)
IDA
基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

可能调控IL23A基因的相关microRNA:     


通路基因列表
疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Psoriasis 0.138858973 44 1 BeFree_CTD_human_GAD_LHGDN
Rheumatoid Arthritis 0.129520329 18 0 BeFree_CTD_human_LHGDN
Inflammation 0.010897401 4 0 LHGDN
Autoimmune Diseases 0.007881746 19 0 BeFree_LHGDN
Arthritis, Psoriatic 0.007077352 8 2 BeFree_LHGDN
Inflammatory Bowel Diseases 0.00706742 17 0 BeFree_LHGDN
Embryonal Carcinoma 0.007057489 26 0 BeFree
Multiple Sclerosis 0.005710211 11 0 BeFree_LHGDN
Crohn Disease 0.004353001 6 0 BeFree_LHGDN
Lupus Erythematosus, Systemic 0.004353001 7 0 BeFree_LHGDN
Behcet Syndrome 0.00408156 5 0 BeFree_LHGDN
Mycosis Fungoides 0.002995792 1 0 BeFree_LHGDN
Sezary Syndrome 0.002995792 1 0 BeFree_LHGDN
Uveitis 0.002995792 1 0 BeFree_LHGDN
Anemia 0.00272435 1 0 LHGDN
Bronchiolitis Obliterans 0.00272435 1 0 LHGDN
Sjogren's Syndrome 0.00272435 1 0 LHGDN
Infection 0.00272435 1 0 LHGDN
Ankylosing spondylitis 0.002714419 10 0 BeFree
Hepatitis C 0.002638474 2 0 BeFree_GAD
Experimental Autoimmune Encephalomyelitis 0.002442977 9 0 BeFree
Adult T-Cell Lymphoma/Leukemia 0.002171535 8 0 BeFree
Ulcerative Colitis 0.001900093 7 0 BeFree
Colorectal Carcinoma 0.001900093 7 0 BeFree
Arthritis 0.001357209 5 0 BeFree
Neoplasm Metastasis 0.001357209 5 0 BeFree
Degenerative polyarthritis 0.001357209 5 0 BeFree
Colorectal Cancer 0.001357209 5 0 BeFree
Dermatitis 0.001085767 4 0 BeFree
Tuberculosis 0.001085767 4 0 BeFree
Virus Diseases 0.001085767 4 0 BeFree
Tumor Progression 0.001085767 4 0 BeFree
bone destruction 0.001085767 4 0 BeFree
Carcinogenesis 0.001085767 4 0 BeFree
Asthma 0.000814326 3 0 BeFree
Colitis 0.000814326 3 0 BeFree
Dermatitis, Atopic 0.000814326 3 0 BeFree
Diabetes Mellitus, Insulin-Dependent 0.000814326 3 0 BeFree
Eczema 0.000814326 3 0 BeFree
Graves Disease 0.000814326 3 0 BeFree
Mycoses 0.000814326 3 0 BeFree
Dermatologic disorders 0.000814326 3 0 BeFree
Teratocarcinoma 0.000814326 3 0 BeFree
Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site 0.000814326 3 0 BeFree
Lupus Erythematosus 0.000814326 3 0 BeFree
Malignant tumor of cervix 0.000542884 2 0 BeFree
Hepatitis B 0.000542884 2 0 BeFree
Leukemia, T-Cell 0.000542884 2 0 BeFree
Lupus Vulgaris 0.000542884 2 0 BeFree
Lupus Erythematosus, Discoid 0.000542884 2 0 BeFree
Malignant neoplasm of stomach 0.000542884 2 0 BeFree
melanoma 0.000542884 2 0 BeFree
Mitral Valve Stenosis 0.000542884 2 0 BeFree
Multiple Myeloma 0.000542884 2 0 BeFree
Ovarian Carcinoma 0.000542884 2 0 BeFree
Pneumonia 0.000542884 2 0 BeFree
Salmonella infections 0.000542884 2 0 BeFree
Systemic Scleroderma 0.000542884 2 0 BeFree
Severe Combined Immunodeficiency 0.000542884 2 0 BeFree
Acute leukemia 0.000542884 2 0 BeFree
Psoriasis vulgaris 0.000542884 2 0 BeFree
Epithelial hyperplasia of skin 0.000542884 2 0 BeFree
Cervix carcinoma 0.000542884 2 0 BeFree
Hepatitis B, Chronic 0.000542884 2 0 BeFree
Stomach Carcinoma 0.000542884 2 0 BeFree
Helicobacter pylori infection 0.000542884 2 1 BeFree
Arthritis, Collagen-Induced 0.000542884 2 0 BeFree
Malignant neoplasm of ovary 0.000542884 2 0 BeFree
Inflammatory disorder 0.000542884 2 0 BeFree
Precursor B-cell lymphoblastic leukemia 0.000542884 2 0 BeFree
Adenoma 0.000271442 1 0 BeFree
Extrinsic allergic alveolitis 0.000271442 1 0 BeFree
Amyotrophic Lateral Sclerosis 0.000271442 1 0 BeFree
Bacterial Infections 0.000271442 1 0 BeFree
Non-Small Cell Lung Carcinoma 0.000271442 1 0 BeFree
Celiac Disease 0.000271442 1 0 BeFree
Cholangitis 0.000271442 1 0 BeFree
Primary biliary cirrhosis 0.000271442 1 0 BeFree
Demyelinating Diseases 0.000271442 1 0 BeFree
Diabetes 0.000271442 1 0 BeFree
Diabetes Mellitus 0.000271442 1 0 BeFree
Diabetes Mellitus, Non-Insulin-Dependent 0.000271442 1 0 BeFree
Dwarfism 0.000271442 1 0 BeFree
Bacterial Endocarditis 0.000271442 1 0 BeFree
Erythema Nodosum 0.000271442 1 0 BeFree
Glioma 0.000271442 1 0 BeFree
Guillain-Barre Syndrome 0.000271442 1 0 BeFree
Influenza 0.000271442 1 0 BeFree
Kidney Diseases 0.000271442 1 0 BeFree
Liver Cirrhosis 0.000271442 1 0 BeFree
Chronic Obstructive Airway Disease 0.000271442 1 0 BeFree
Lupus Nephritis 0.000271442 1 0 BeFree
Lymphoma, Follicular 0.000271442 1 0 BeFree
Malaria 0.000271442 1 0 BeFree
Mucocutaneous Lymph Node Syndrome 0.000271442 1 0 BeFree
Nephritis 0.000271442 1 0 BeFree
Neuritis, Autoimmune, Experimental 0.000271442 1 0 BeFree
Obesity 0.000271442 1 0 BeFree
Parakeratosis 0.000271442 1 0 BeFree
Pheochromocytoma 0.000271442 1 0 BeFree
Retinoblastoma 0.000271442 1 0 BeFree
Septicemia 0.000271442 1 0 BeFree
Superinfection 0.000271442 1 0 BeFree
Tuberculosis, Pulmonary 0.000271442 1 0 BeFree
Uveomeningoencephalitic Syndrome 0.000271442 1 0 BeFree
Diffuse Large B-Cell Lymphoma 0.000271442 1 0 BeFree
Chronic gastritis 0.000271442 1 1 BeFree
Joint swelling 0.000271442 1 0 BeFree
Pustular psoriasis 0.000271442 1 0 BeFree
Malignant neoplasm of mouth 0.000271442 1 0 BeFree
Secondary malignant neoplasm of lung 0.000271442 1 0 BeFree
Malnutrition 0.000271442 1 0 BeFree
Ganglioglioma 0.000271442 1 0 BeFree
Lip and Oral Cavity Carcinoma 0.000271442 1 0 BeFree
Gallbladder Carcinoma 0.000271442 1 0 BeFree
Pancreatic carcinoma 0.000271442 1 0 BeFree
Colitis, Collagenous 0.000271442 1 0 BeFree
Hereditary pancreatitis 0.000271442 1 0 BeFree
Fibrosis, Liver 0.000271442 1 0 BeFree
Malignant neoplasm of lung 0.000271442 1 0 BeFree
Parasitemia 0.000271442 1 0 BeFree
Sepsis 0.000271442 1 0 BeFree
Psoriasiform eczema 0.000271442 1 0 BeFree
Chronic arthritis 0.000271442 1 0 BeFree
Thyroid associated opthalmopathies 0.000271442 1 0 BeFree
Juvenile Myelomonocytic Leukemia 0.000271442 1 0 BeFree
Human T-cell lymphotrophic virus, type I [HTLV-I] 0.000271442 1 0 BeFree
Hematologic Neoplasms 0.000271442 1 0 BeFree
Immune thrombocytopenic purpura 0.000271442 1 0 BeFree
Leukocyte adhesion deficiency type 1 0.000271442 1 0 BeFree
Colitis, Lymphocytic 0.000271442 1 0 BeFree
Chronic small plaque psoriasis 0.000271442 1 0 BeFree
Primary antiphospholipid syndrome 0.000271442 1 0 BeFree
Neuropathy 0.000271442 1 0 BeFree
Pneumonia due to Klebsiella pneumoniae 0.000271442 1 0 BeFree
Neurodegenerative Disorders 0.000271442 1 0 BeFree
Auricular swelling 0.000271442 1 0 BeFree
Squamous cell carcinoma of mouth 0.000271442 1 0 BeFree
Costello syndrome (disorder) 0.000271442 1 0 BeFree
Hashimoto Disease 0.000271442 1 0 BeFree
Carcinoma of lung 0.000271442 1 0 BeFree
Secondary malignant neoplasm of lymph node 0.000271442 1 0 BeFree
Carcinoma of bladder 0.000271442 1 0 BeFree
gastritis h pylori 0.000271442 1 0 BeFree
Idiopathic Inflammatory Myopathies 0.000271442 1 0 BeFree
neurological disability 0.000271442 1 0 BeFree
Infectious disease of lung 0.000271442 1 0 BeFree
Nosocomial pneumonia 0.000271442 1 0 BeFree
Spondylarthritis 0.000271442 1 0 BeFree
Spondylarthropathies 0.000271442 1 0 BeFree
Infective endocarditis 0.000271442 1 0 BeFree
Latent Tuberculosis 0.000271442 1 0 BeFree
Severe Sepsis 0.000271442 1 0 BeFree
Liver carcinoma 0.000271442 1 0 BeFree
Extramedullary Hematopoiesis (disorder) 0.000271442 1 0 BeFree
Acute-On-Chronic Liver Failure 0.000271442 1 0 BeFree
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