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The protein encoded by this gene is a member of the interleukin 1 receptor family and is similar to the interleukin 1 accessory proteins. It is most closely related to interleukin 1 receptor accessory protein-like 2 (IL1RAPL2). This gene and IL1RAPL2 are located at a region on chromosome X that is associated with X-linked non-syndromic mental retardation. Deletions and mutations in this gene were found in patients with mental retardation. This gene is expressed at a high level in post-natal brain structures involved in the hippocampal memory system, which suggests a specialized role in the physiological processes underlying memory and learning abilities. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  由该基因编码的蛋白质是白细胞介素1受体家族的成员,并且是类似于白介素1辅助蛋白。它是最密切相关的白细胞介素1受体辅助蛋白样2(IL1RAPL2)。此基因和IL1RAPL2位于一个与X连锁非综合征精神发育迟滞相关X染色体上的区域。缺失和突变,该基因在患者的智力低下被发现了。该基因在参与海马记忆系统,这表明在生理过程的基本记忆和学习能力的专业作用,产后的大脑结构的高层表示。 [由RefSeq的,2008年7月提供]
IL1RAPL1基因(以及对应的蛋白质)的细胞分布位置:
IL1RAPL1基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Mental Retardation, X-Linked | 0.124895885 | 9 | 0 | BeFree_CTD_human_LHGDN |
| Autistic Disorder | 0.124267125 | 8 | 1 | BeFree_CTD_human_GAD |
| Cardiovascular Diseases | 0.12 | 1 | 1 | GWASCAT |
| Child Development Disorders, Pervasive | 0.12 | 1 | 0 | CTD_human |
| melanoma | 0.12 | 1 | 0 | CTD_human |
| Atkin syndrome | 0.12 | 0 | 0 | CTD_human |
| Brain Neoplasms | 0.002995792 | 1 | 0 | BeFree_LHGDN |
| Mental Retardation | 0.002442977 | 9 | 0 | BeFree |
| Chorioamnionitis | 0.002367032 | 1 | 0 | GAD |
| Fetal Membranes, Premature Rupture | 0.002367032 | 1 | 0 | GAD |
| Premature Obstetric Labor | 0.002367032 | 1 | 0 | GAD |
| Pre-Eclampsia | 0.002367032 | 1 | 0 | GAD |
| Schizophrenia | 0.002367032 | 1 | 0 | GAD |
| Premature Birth | 0.002367032 | 1 | 0 | GAD |
| Infection of amniotic sac and membranes, unspecified, unspecified trimester, not applicable or unspecified | 0.002367032 | 1 | 0 | GAD |
| Autism Spectrum Disorders | 0.000814326 | 3 | 1 | BeFree |
| Intellectual Disability | 0.000814326 | 3 | 0 | BeFree |
| Dysmorphic features | 0.000542884 | 2 | 0 | BeFree |
| Epilepsy | 0.000271442 | 1 | 0 | BeFree |
| Atrial Septal Defects | 0.000271442 | 1 | 0 | BeFree |
| Mild Mental Retardation | 0.000271442 | 1 | 0 | BeFree |
| Drop Attack | 0.000271442 | 1 | 0 | BeFree |
| CHROMOSOME Xp21 DELETION SYNDROME | 0.000271442 | 1 | 0 | BeFree |
| High-functioning autism | 0.000271442 | 1 | 0 | BeFree |
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