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This gene encodes a cytokine receptor that specifically binds interleukin 15 (IL15) with high affinity. The receptors of IL15 and IL2 share two subunits, IL2R beta and IL2R gamma. This forms the basis of many overlapping biological activities of IL15 and IL2. The protein encoded by this gene is structurally related to IL2R alpha, an additional IL2-specific alpha subunit necessary for high affinity IL2 binding. Unlike IL2RA, IL15RA is capable of binding IL15 with high affinity independent of other subunits, which suggests distinct roles between IL15 and IL2. This receptor is reported to enhance cell proliferation and expression of apoptosis inhibitor BCL2L1/BCL2-XL and BCL2. Multiple alternatively spliced transcript variants of this gene have been reported.[provided by RefSeq, Apr 2010]
[中文简述(自动翻译):]  该基因编码特异性地以高亲和力结合白介素15(IL-15)细胞因子受体。 IL15和IL2的受体共享两个亚基,IL2Rβ和伽玛IL2R。这形成的IL15和IL2的许多重叠生物活动的基础。由该基因编码的蛋白质在结构上与IL2Rα,必需的高亲和力IL2结合一个附加的特定的IL2-α亚基。不像IL2RA,IL15RA能够以高亲和力独立于其他亚基,这表明IL15和IL2之间不同的作用结合IL15。这种受体报道,增强细胞增殖和凋亡的抑制剂BCL2L1 / BCL2-XL和BCL2的表达。据报道这种基因的多选择性剪接转录变异体。[由RefSeq的,2010年4月提供]
IL15RA基因(以及对应的蛋白质)的细胞分布位置:
IL15RA基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Malignant neoplasm of lung | 0.004734064 | 2 | 0 | GAD |
| Obesity | 0.002909916 | 2 | 0 | BeFree_GAD |
| B-Cell Lymphomas | 0.00272435 | 1 | 0 | LHGDN |
| Asthma | 0.002367032 | 1 | 0 | GAD |
| Malignant neoplasm of urinary bladder | 0.002367032 | 1 | 0 | GAD |
| Bronchiolitis, Viral | 0.002367032 | 1 | 0 | GAD |
| Graft-vs-Host Disease | 0.002367032 | 1 | 0 | GAD |
| Hyperparathyroidism, Secondary | 0.002367032 | 1 | 0 | GAD |
| Inflammation | 0.002367032 | 1 | 1 | GAD |
| Chronic Obstructive Airway Disease | 0.002367032 | 1 | 0 | GAD |
| Neoplasm Recurrence, Local | 0.002367032 | 1 | 0 | GAD |
| Respiratory Syncytial Virus Infections | 0.002367032 | 1 | 0 | GAD |
| Diffuse Large B-Cell Lymphoma | 0.002367032 | 1 | 0 | GAD |
| Hematologic Neoplasms | 0.002367032 | 1 | 0 | GAD |
| body mass | 0.002367032 | 1 | 0 | GAD |
| Metabolic Syndrome X | 0.002367032 | 1 | 0 | GAD |
| Adenocarcinoma | 0.000271442 | 1 | 1 | BeFree |
| Malignant neoplasm of breast | 0.000271442 | 1 | 5 | BeFree |
| Ulcerative Colitis | 0.000271442 | 1 | 0 | BeFree |
| Coronary Arteriosclerosis | 0.000271442 | 1 | 0 | BeFree |
| Coronary heart disease | 0.000271442 | 1 | 0 | BeFree |
| Dermatitis | 0.000271442 | 1 | 0 | BeFree |
| Eosinophilia | 0.000271442 | 1 | 0 | BeFree |
| Inflammatory Bowel Diseases | 0.000271442 | 1 | 0 | BeFree |
| leukemia | 0.000271442 | 1 | 0 | BeFree |
| Leukemia, T-Cell | 0.000271442 | 1 | 0 | BeFree |
| Psoriasis | 0.000271442 | 1 | 0 | BeFree |
| Dermatologic disorders | 0.000271442 | 1 | 0 | BeFree |
| Eosinophilic esophagitis | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of prostate | 0.000271442 | 1 | 0 | BeFree |
| Secondary malignant neoplasm of liver | 0.000271442 | 1 | 0 | BeFree |
| Hepatitis C, Chronic | 0.000271442 | 1 | 0 | BeFree |
| Prostate carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Breast Carcinoma | 0.000271442 | 1 | 5 | BeFree |
| Colon Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Eosinophilic disorder | 0.000271442 | 1 | 0 | BeFree |
| Disorder characterized by eosinophilia | 0.000271442 | 1 | 0 | BeFree |
| T-lymphocyte deficiency | 0.000271442 | 1 | 0 | BeFree |
| OSSIFICATION OF THE POSTERIOR LONGITUDINAL LIGAMENT OF SPINE | 0.000271442 | 1 | 0 | BeFree |
| T-Cell Large Granular Lymphocyte Leukemia | 0.000271442 | 1 | 0 | BeFree |
| Coronary Artery Disease | 0.000271442 | 1 | 0 | BeFree |
| Triple Negative Breast Neoplasms | 0.000271442 | 1 | 0 | BeFree |
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