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The protein encoded by this gene is a subunit of the interleukin 13 receptor. This subunit forms a receptor complex with IL4 receptor alpha, a subunit shared by IL13 and IL4 receptors. This subunit serves as a primary IL13-binding subunit of the IL13 receptor, and may also be a component of IL4 receptors. This protein has been shown to bind tyrosine kinase TYK2, and thus may mediate the signaling processes that lead to the activation of JAK1, STAT3 and STAT6 induced by IL13 and IL4. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  由该基因编码的蛋白质是白细胞介素13受体的一个亚基。这亚基形成具有IL4受体α,由IL13和IL4受体共享的亚基受体复合物。这个亚基作为IL13受体的初级IL13结合亚基,并且也可以是IL4受体的组分。这种蛋白已经显示出结合酪氨酸激酶TYK2,并且因此可能介导导致JAK1,STAT3和STAT6的由IL13和IL4诱导激活的信令进程。 [由RefSeq的,2008年7月提供]
IL13RA1基因(以及对应的蛋白质)的细胞分布位置:
IL13RA1基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| IGA Glomerulonephritis | 0.12 | 1 | 0 | CTD_human |
| Asthma | 0.012735362 | 6 | 0 | BeFree_GAD_LHGDN |
| Glioma | 0.003267234 | 3 | 0 | BeFree_LHGDN |
| Dermatitis, Atopic | 0.002995792 | 2 | 0 | BeFree_LHGDN |
| Psoriasis | 0.00272435 | 1 | 0 | LHGDN |
| Chronic Obstructive Airway Disease | 0.002638474 | 1 | 1 | BeFree_GAD |
| Bronchiolitis, Viral | 0.002367032 | 1 | 0 | GAD |
| Respiratory Syncytial Virus Infections | 0.002367032 | 1 | 0 | GAD |
| Colitis | 0.000271442 | 1 | 0 | BeFree |
| Eczema | 0.000271442 | 1 | 0 | BeFree |
| Leprosy | 0.000271442 | 1 | 0 | BeFree |
| Systemic Scleroderma | 0.000271442 | 1 | 0 | BeFree |
| Trachoma | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of testis | 0.000271442 | 1 | 0 | BeFree |
| Neurodegenerative Disorders | 0.000271442 | 1 | 0 | BeFree |
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