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This gene encodes indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan.[provided by RefSeq, Feb 2011]
[中文简述(自动翻译):]  这个基因编码吲哚胺2,3-双加氧酶(IDO) - 催化色氨酸分解代谢的第一个和限速步骤到N-甲酰犬尿氨酸血红素酶。这种酶作用于多个色氨酸底物,包括D-色氨酸,L-色氨酸,5-羟基色氨酸,色胺,和血清素。这种酶被认为在各种病理生理过程,例如抗微生物和抗肿瘤防御,神经病理学,免疫调节,以及抗氧化活性的作用。通过其在树突状细胞,单核细胞和巨噬细胞表达此酶由它的外周蜂窝必需氨基酸色氨酸catabolization调节T细胞的行为。[通过的RefSeq,2011年2月提供]
IDO1基因(以及对应的蛋白质)的细胞分布位置:
IDO1基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Mammary Neoplasms | 0.1254487 | 3 | 0 | CTD_human_LHGDN |
Inflammation | 0.12272435 | 2 | 0 | CTD_human_LHGDN |
Endometriosis | 0.120542884 | 3 | 0 | BeFree_CTD_human |
Neoplasm Recurrence, Local | 0.12 | 1 | 0 | CTD_human |
Neurodegenerative Disorders | 0.12 | 1 | 0 | CTD_human |
Leukemia, Myelocytic, Acute | 0.008444493 | 4 | 0 | BeFree_LHGDN |
Infection | 0.008173051 | 3 | 0 | LHGDN |
Hepatitis C | 0.005362824 | 3 | 0 | BeFree_GAD_LHGDN |
Multiple Sclerosis | 0.005091382 | 2 | 0 | GAD_LHGDN |
Crohn Disease | 0.003267234 | 3 | 0 | BeFree_LHGDN |
Liver carcinoma | 0.003267234 | 3 | 0 | BeFree_LHGDN |
Ulcerative Colitis | 0.002995792 | 2 | 0 | BeFree_LHGDN |
Hepatitis C, Chronic | 0.002995792 | 2 | 0 | BeFree_LHGDN |
Boutonneuse Fever | 0.00272435 | 1 | 0 | LHGDN |
Colorectal Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
Lichen Planus | 0.00272435 | 1 | 0 | LHGDN |
Biliary cirrhosis | 0.00272435 | 1 | 0 | LHGDN |
Measles | 0.00272435 | 1 | 0 | LHGDN |
Trophoblastic Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
Alcoholic Intoxication, Chronic | 0.002367032 | 1 | 0 | GAD |
Pre-Eclampsia | 0.002367032 | 1 | 0 | GAD |
Malignant neoplasm of breast | 0.001357209 | 5 | 0 | BeFree |
HIV Infections | 0.001357209 | 5 | 0 | BeFree |
Breast Carcinoma | 0.001357209 | 5 | 0 | BeFree |
Mental Depression | 0.000814326 | 3 | 0 | BeFree |
Depressive disorder | 0.000814326 | 3 | 0 | BeFree |
Autoimmune Diseases | 0.000542884 | 2 | 0 | BeFree |
Renal Cell Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Neoplasm Metastasis | 0.000542884 | 2 | 0 | BeFree |
Ovarian Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Cervical Intraepithelial Neoplasia | 0.000542884 | 2 | 0 | BeFree |
Malignant neoplasm of ovary | 0.000542884 | 2 | 0 | BeFree |
Rheumatoid Arthritis | 0.000271442 | 1 | 0 | BeFree |
Candidiasis of vagina | 0.000271442 | 1 | 0 | BeFree |
Malignant tumor of colon | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of thyroid | 0.000271442 | 1 | 0 | BeFree |
Colitis | 0.000271442 | 1 | 0 | BeFree |
Colorectal Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Eclampsia | 0.000271442 | 1 | 0 | BeFree |
Herpes Simplex Infections | 0.000271442 | 1 | 0 | BeFree |
Inflammatory Bowel Diseases | 0.000271442 | 1 | 0 | BeFree |
Influenza | 0.000271442 | 1 | 0 | BeFree |
Kidney Diseases | 0.000271442 | 1 | 0 | BeFree |
Kidney Neoplasm | 0.000271442 | 1 | 0 | BeFree |
Lung Neoplasms | 0.000271442 | 1 | 0 | BeFree |
Lymphoma, Non-Hodgkin | 0.000271442 | 1 | 0 | BeFree |
Malaria, Cerebral | 0.000271442 | 1 | 0 | BeFree |
Nasal Polyps | 0.000271442 | 1 | 0 | BeFree |
Kaposi Sarcoma | 0.000271442 | 1 | 0 | BeFree |
Stress, Psychological | 0.000271442 | 1 | 0 | BeFree |
Thyroid Neoplasm | 0.000271442 | 1 | 0 | BeFree |
Tuberculosis | 0.000271442 | 1 | 0 | BeFree |
Diffuse Large B-Cell Lymphoma | 0.000271442 | 1 | 0 | BeFree |
Lymphoma, Large-Cell, Follicular | 0.000271442 | 1 | 0 | BeFree |
Depressive Symptoms | 0.000271442 | 1 | 1 | BeFree |
Chronic pain | 0.000271442 | 1 | 0 | BeFree |
Uveal melanoma | 0.000271442 | 1 | 0 | BeFree |
Anaplastic thyroid carcinoma | 0.000271442 | 1 | 0 | BeFree |
ankle arthritis | 0.000271442 | 1 | 0 | BeFree |
Interstitial fibrosis | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of lung | 0.000271442 | 1 | 0 | BeFree |
Squamous cell carcinoma of esophagus | 0.000271442 | 1 | 0 | BeFree |
Cervical intraepithelial neoplasia grade 2 | 0.000271442 | 1 | 0 | BeFree |
Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site | 0.000271442 | 1 | 0 | BeFree |
Thyroid carcinoma | 0.000271442 | 1 | 0 | BeFree |
Carcinogenesis | 0.000271442 | 1 | 0 | BeFree |
Carcinoma of lung | 0.000271442 | 1 | 0 | BeFree |
Secondary malignant neoplasm of lymph node | 0.000271442 | 1 | 0 | BeFree |
Colon Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Candidiasis, Vulvovaginal | 0.000271442 | 1 | 0 | BeFree |
Primary infection NOS | 0.000271442 | 1 | 0 | BeFree |
Arthritis, Collagen-Induced | 0.000271442 | 1 | 0 | BeFree |
Gastric infection | 0.000271442 | 1 | 0 | BeFree |
Renal carcinoma | 0.000271442 | 1 | 0 | BeFree |
Neuropathogenesis | 0.000271442 | 1 | 0 | BeFree |
Tumor Immunity | 0.000271442 | 1 | 0 | BeFree |
Colorectal Cancer | 0.000271442 | 1 | 0 | BeFree |
Benign Prostatic Hyperplasia | 0.000271442 | 1 | 0 | BeFree |
Clear-cell metastatic renal cell carcinoma | 0.000271442 | 1 | 0 | BeFree |
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