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This gene encodes indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan.[provided by RefSeq, Feb 2011]
[中文简述(自动翻译):]  这个基因编码吲哚胺2,3-双加氧酶(IDO) - 催化色氨酸分解代谢的第一个和限速步骤到N-甲酰犬尿氨酸血红素酶。这种酶作用于多个色氨酸底物,包括D-色氨酸,L-色氨酸,5-羟基色氨酸,色胺,和血清素。这种酶被认为在各种病理生理过程,例如抗微生物和抗肿瘤防御,神经病理学,免疫调节,以及抗氧化活性的作用。通过其在树突状细胞,单核细胞和巨噬细胞表达此酶由它的外周蜂窝必需氨基酸色氨酸catabolization调节T细胞的行为。[通过的RefSeq,2011年2月提供]
IDO1基因(以及对应的蛋白质)的细胞分布位置:
IDO1基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Mammary Neoplasms | 0.1254487 | 3 | 0 | CTD_human_LHGDN |
| Inflammation | 0.12272435 | 2 | 0 | CTD_human_LHGDN |
| Endometriosis | 0.120542884 | 3 | 0 | BeFree_CTD_human |
| Neoplasm Recurrence, Local | 0.12 | 1 | 0 | CTD_human |
| Neurodegenerative Disorders | 0.12 | 1 | 0 | CTD_human |
| Leukemia, Myelocytic, Acute | 0.008444493 | 4 | 0 | BeFree_LHGDN |
| Infection | 0.008173051 | 3 | 0 | LHGDN |
| Hepatitis C | 0.005362824 | 3 | 0 | BeFree_GAD_LHGDN |
| Multiple Sclerosis | 0.005091382 | 2 | 0 | GAD_LHGDN |
| Crohn Disease | 0.003267234 | 3 | 0 | BeFree_LHGDN |
| Liver carcinoma | 0.003267234 | 3 | 0 | BeFree_LHGDN |
| Ulcerative Colitis | 0.002995792 | 2 | 0 | BeFree_LHGDN |
| Hepatitis C, Chronic | 0.002995792 | 2 | 0 | BeFree_LHGDN |
| Boutonneuse Fever | 0.00272435 | 1 | 0 | LHGDN |
| Colorectal Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
| Lichen Planus | 0.00272435 | 1 | 0 | LHGDN |
| Biliary cirrhosis | 0.00272435 | 1 | 0 | LHGDN |
| Measles | 0.00272435 | 1 | 0 | LHGDN |
| Trophoblastic Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
| Alcoholic Intoxication, Chronic | 0.002367032 | 1 | 0 | GAD |
| Pre-Eclampsia | 0.002367032 | 1 | 0 | GAD |
| Malignant neoplasm of breast | 0.001357209 | 5 | 0 | BeFree |
| HIV Infections | 0.001357209 | 5 | 0 | BeFree |
| Breast Carcinoma | 0.001357209 | 5 | 0 | BeFree |
| Mental Depression | 0.000814326 | 3 | 0 | BeFree |
| Depressive disorder | 0.000814326 | 3 | 0 | BeFree |
| Autoimmune Diseases | 0.000542884 | 2 | 0 | BeFree |
| Renal Cell Carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Neoplasm Metastasis | 0.000542884 | 2 | 0 | BeFree |
| Ovarian Carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Cervical Intraepithelial Neoplasia | 0.000542884 | 2 | 0 | BeFree |
| Malignant neoplasm of ovary | 0.000542884 | 2 | 0 | BeFree |
| Rheumatoid Arthritis | 0.000271442 | 1 | 0 | BeFree |
| Candidiasis of vagina | 0.000271442 | 1 | 0 | BeFree |
| Malignant tumor of colon | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of thyroid | 0.000271442 | 1 | 0 | BeFree |
| Colitis | 0.000271442 | 1 | 0 | BeFree |
| Colorectal Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Eclampsia | 0.000271442 | 1 | 0 | BeFree |
| Herpes Simplex Infections | 0.000271442 | 1 | 0 | BeFree |
| Inflammatory Bowel Diseases | 0.000271442 | 1 | 0 | BeFree |
| Influenza | 0.000271442 | 1 | 0 | BeFree |
| Kidney Diseases | 0.000271442 | 1 | 0 | BeFree |
| Kidney Neoplasm | 0.000271442 | 1 | 0 | BeFree |
| Lung Neoplasms | 0.000271442 | 1 | 0 | BeFree |
| Lymphoma, Non-Hodgkin | 0.000271442 | 1 | 0 | BeFree |
| Malaria, Cerebral | 0.000271442 | 1 | 0 | BeFree |
| Nasal Polyps | 0.000271442 | 1 | 0 | BeFree |
| Kaposi Sarcoma | 0.000271442 | 1 | 0 | BeFree |
| Stress, Psychological | 0.000271442 | 1 | 0 | BeFree |
| Thyroid Neoplasm | 0.000271442 | 1 | 0 | BeFree |
| Tuberculosis | 0.000271442 | 1 | 0 | BeFree |
| Diffuse Large B-Cell Lymphoma | 0.000271442 | 1 | 0 | BeFree |
| Lymphoma, Large-Cell, Follicular | 0.000271442 | 1 | 0 | BeFree |
| Depressive Symptoms | 0.000271442 | 1 | 1 | BeFree |
| Chronic pain | 0.000271442 | 1 | 0 | BeFree |
| Uveal melanoma | 0.000271442 | 1 | 0 | BeFree |
| Anaplastic thyroid carcinoma | 0.000271442 | 1 | 0 | BeFree |
| ankle arthritis | 0.000271442 | 1 | 0 | BeFree |
| Interstitial fibrosis | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of lung | 0.000271442 | 1 | 0 | BeFree |
| Squamous cell carcinoma of esophagus | 0.000271442 | 1 | 0 | BeFree |
| Cervical intraepithelial neoplasia grade 2 | 0.000271442 | 1 | 0 | BeFree |
| Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site | 0.000271442 | 1 | 0 | BeFree |
| Thyroid carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Carcinogenesis | 0.000271442 | 1 | 0 | BeFree |
| Carcinoma of lung | 0.000271442 | 1 | 0 | BeFree |
| Secondary malignant neoplasm of lymph node | 0.000271442 | 1 | 0 | BeFree |
| Colon Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Candidiasis, Vulvovaginal | 0.000271442 | 1 | 0 | BeFree |
| Primary infection NOS | 0.000271442 | 1 | 0 | BeFree |
| Arthritis, Collagen-Induced | 0.000271442 | 1 | 0 | BeFree |
| Gastric infection | 0.000271442 | 1 | 0 | BeFree |
| Renal carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Neuropathogenesis | 0.000271442 | 1 | 0 | BeFree |
| Tumor Immunity | 0.000271442 | 1 | 0 | BeFree |
| Colorectal Cancer | 0.000271442 | 1 | 0 | BeFree |
| Benign Prostatic Hyperplasia | 0.000271442 | 1 | 0 | BeFree |
| Clear-cell metastatic renal cell carcinoma | 0.000271442 | 1 | 0 | BeFree |
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