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The protein encoded by this gene is a helix-loop-helix (HLH) protein that can form heterodimers with members of the basic HLH family of transcription factors. The encoded protein has no DNA binding activity and therefore can inhibit the DNA binding and transcriptional activation ability of basic HLH proteins with which it interacts. This protein may play a role in cell growth, senescence, and differentiation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  由该基因编码的蛋白质是可以形成具有基本HLH家族转录因子的成员的异源二聚体螺旋 - 环 - 螺旋(HLH)蛋白。所编码的蛋白质不具有DNA结合活性,因此,可以抑制DNA结合和与它相互作用基本HLH蛋白的转录激活的能力。这种蛋白可能参与细胞生长,衰老和分化的作用。已发现该基因编码不同亚型的两个转录变异体。 [由RefSeq的,2008年7月提供]
ID1基因(以及对应的蛋白质)的细胞分布位置:
ID1基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Diabetes Mellitus, Experimental | 0.12 | 1 | 0 | CTD_human |
Diabetes Mellitus, Non-Insulin-Dependent | 0.12 | 1 | 0 | CTD_human |
Mammary Neoplasms, Experimental | 0.12 | 1 | 0 | CTD_human |
Myocardial Ischemia | 0.12 | 1 | 0 | CTD_human |
Pulmonary Hypertension | 0.080271442 | 2 | 0 | BeFree_RGD |
Cholestasis | 0.08 | 1 | 0 | RGD |
Prostatic Neoplasms | 0.016346101 | 6 | 0 | LHGDN |
Mammary Neoplasms | 0.013621751 | 5 | 0 | LHGDN |
Thyroid Neoplasm | 0.008444493 | 4 | 0 | BeFree_LHGDN |
melanoma | 0.007077352 | 6 | 0 | BeFree_LHGDN |
Neoplasm Metastasis | 0.00680591 | 7 | 0 | BeFree_LHGDN |
Squamous cell carcinoma | 0.005720142 | 3 | 0 | BeFree_LHGDN |
Colorectal Neoplasms | 0.0054487 | 2 | 0 | LHGDN |
leukemia | 0.003267234 | 2 | 0 | BeFree_LHGDN |
Psoriasis | 0.002995792 | 1 | 0 | BeFree_LHGDN |
Bladder Neoplasm | 0.00272435 | 1 | 0 | LHGDN |
Uterine Cervical Neoplasm | 0.00272435 | 1 | 0 | LHGDN |
Esophageal Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
Hypertensive disease | 0.00272435 | 1 | 0 | LHGDN |
Acute Promyelocytic Leukemia | 0.00272435 | 1 | 0 | LHGDN |
Pancreatic Neoplasm | 0.00272435 | 1 | 0 | LHGDN |
Rett Syndrome | 0.00272435 | 1 | 0 | LHGDN |
Kaposi Sarcoma | 0.00272435 | 1 | 0 | LHGDN |
Stomach Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
Malignant neoplasm of prostate | 0.002442977 | 9 | 0 | BeFree |
Prostate carcinoma | 0.002442977 | 9 | 0 | BeFree |
Malignant neoplasm of breast | 0.001628651 | 6 | 0 | BeFree |
Carcinogenesis | 0.001628651 | 6 | 0 | BeFree |
Breast Carcinoma | 0.001628651 | 6 | 0 | BeFree |
Non-Small Cell Lung Carcinoma | 0.001085767 | 4 | 0 | BeFree |
Malignant neoplasm of thyroid | 0.000814326 | 3 | 0 | BeFree |
Adenoid Cystic Carcinoma | 0.000814326 | 3 | 0 | BeFree |
Thyroid carcinoma | 0.000814326 | 3 | 0 | BeFree |
Adenocarcinoma | 0.000542884 | 2 | 0 | BeFree |
Malignant neoplasm of urinary bladder | 0.000542884 | 2 | 0 | BeFree |
Glioma | 0.000542884 | 2 | 0 | BeFree |
Ovarian Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Adenocarcinoma of lung (disorder) | 0.000542884 | 2 | 0 | BeFree |
Cervix carcinoma | 0.000542884 | 2 | 0 | BeFree |
Carcinoma of lung | 0.000542884 | 2 | 0 | BeFree |
Carcinoma of bladder | 0.000542884 | 2 | 0 | BeFree |
Malignant neoplasm of ovary | 0.000542884 | 2 | 0 | BeFree |
Anaplasia | 0.000271442 | 1 | 0 | BeFree |
Malignant tumor of cervix | 0.000271442 | 1 | 0 | BeFree |
Graves Disease | 0.000271442 | 1 | 0 | BeFree |
Kidney Diseases | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of stomach | 0.000271442 | 1 | 0 | BeFree |
Multiple Myeloma | 0.000271442 | 1 | 0 | BeFree |
Pulmonary Fibrosis | 0.000271442 | 1 | 0 | BeFree |
Ureteral obstruction | 0.000271442 | 1 | 0 | BeFree |
Obstructive nephropathy | 0.000271442 | 1 | 0 | BeFree |
Secondary malignant neoplasm of lung | 0.000271442 | 1 | 0 | BeFree |
Tumor Progression | 0.000271442 | 1 | 0 | BeFree |
Pancreatic carcinoma | 0.000271442 | 1 | 0 | BeFree |
Medullary carcinoma of thyroid | 0.000271442 | 1 | 0 | BeFree |
Papillary thyroid carcinoma | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of lung | 0.000271442 | 1 | 0 | BeFree |
Carcinoma breast stage IV | 0.000271442 | 1 | 0 | BeFree |
Adenocarcinoma of pancreas | 0.000271442 | 1 | 0 | BeFree |
Squamous intraepithelial lesion | 0.000271442 | 1 | 0 | BeFree |
High-Grade Squamous Intraepithelial Lesions | 0.000271442 | 1 | 0 | BeFree |
Multinodular goiter | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of pancreas | 0.000271442 | 1 | 0 | BeFree |
Leukemogenesis | 0.000271442 | 1 | 0 | BeFree |
Secondary malignant neoplasm of lymph node | 0.000271442 | 1 | 0 | BeFree |
Stomach Carcinoma | 0.000271442 | 1 | 0 | BeFree |
ovarian neoplasm | 0.000271442 | 1 | 0 | BeFree |
Ductal Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Non-small cell carcinoma | 0.000271442 | 1 | 0 | BeFree |
Low Grade Squamous Intraepithelial Neoplasia | 0.000271442 | 1 | 0 | BeFree |
Tumor Angiogenesis | 0.000271442 | 1 | 0 | BeFree |
Xenograft Model | 0.000271442 | 1 | 0 | BeFree |
androgen independent prostate cancer | 0.000271442 | 1 | 0 | BeFree |
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