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The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is constitutively and abundantly expressed by all leucocytes and may be the most important ligand for LFA-1 in the initiation of the immune response. It functions not only as an adhesion molecule, but also as a potent signalling molecule. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  由该基因编码的蛋白质是细胞间粘附分子(ICAM)家族的一个成员。所有的ICAM蛋白质是I型跨膜糖蛋白,含有2-9免疫球蛋白样C2型结构域,以及结合到白细胞粘附LFA-1的蛋白质。这种蛋白是组成型和所有白细胞中大量表达,可能是对于LFA-1的免疫反应的开始时的最重要的配位体。它的功能不仅是作为一种粘附分子,也可作为有效的信号分子。 [由RefSeq的,2008年7月提供]
ICAM3基因(以及对应的蛋白质)的细胞分布位置:
ICAM3基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Biliary cirrhosis | 0.12 | 1 | 0 | CTD_human |
HIV Infections | 0.002985861 | 11 | 0 | BeFree |
Mycosis Fungoides | 0.00272435 | 1 | 0 | LHGDN |
Rheumatoid Arthritis | 0.002638474 | 2 | 0 | BeFree_GAD |
Hepatitis C | 0.002638474 | 2 | 0 | BeFree_GAD |
Severe Acute Respiratory Syndrome | 0.002638474 | 2 | 0 | BeFree_GAD |
Tuberculosis | 0.000542884 | 2 | 0 | BeFree |
Malignant tumor of cervix | 0.000271442 | 1 | 0 | BeFree |
Esophageal Neoplasms | 0.000271442 | 1 | 0 | BeFree |
Lymphoma | 0.000271442 | 1 | 0 | BeFree |
Multiple Myeloma | 0.000271442 | 1 | 0 | BeFree |
Degenerative polyarthritis | 0.000271442 | 1 | 0 | BeFree |
Esophageal carcinoma | 0.000271442 | 1 | 0 | BeFree |
Cervix carcinoma | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of esophagus | 0.000271442 | 1 | 0 | BeFree |
Stromal Neoplasm | 0.000271442 | 1 | 0 | BeFree |
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