HSPA1B(heat shock 70kDa protein 1B)

基因基本信息

基因基本信息

基因简称(symbol)
    [HGNC]     [GeneCards]     [NCBI]
基因种类(locus group)
同源简称(alias symbol)
基因家族代码(gene_family_id)
    [HGNC]     [GenScript]
omim代码
entrez码
    [Vega]
vega基因码
ensembl基因码
    [Ensembl]
基因家族(gene family)
refseq数据库代号

更多...

基因种类(locus_type)
基因名称状态(status)
location_sortable
同源基因名称(alias name)
基因名称批准使用时间(date_approved_reserved)
基因简称更名时间(date_symbol_changed)
基因名称更名时间(date_name_changed)
更新时间(date_modified)
ucsc码
ena
ccds数据码
uniprot数据码
pubmed代码
mgd码
rgd码
生命科学数据库(lsdb)
更新时间(date modified)
cosmic
mirbase
基因曾用简称(prev symbol)
基因曾用名称(prev name)
homeodb
cosmic
snornabase
bioparadigms slc
orphanet
假基因信息(pseudogeneorg)
horde id
merops
imgt
iuphar
kznf基因类别
mamit-trnadb
cd
LncRNA数据库
酶代码
中间纤维数据库

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基因染色体位置

基因染色体位置

6p21.3
基因染色体位置图

基因简述

基因简述

This intronless gene encodes a 70kDa heat shock protein which is a member of the heat shock protein 70 family. In conjuction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. It is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode similar proteins. [provided by RefSeq, Jul 2008]

[中文简述(自动翻译):]  此内含子基因编码的70kDa的热休克蛋白，其是热休克蛋白70家族的一个成员。与其它热休克蛋白一起选择，该蛋白质稳定抗聚集现有蛋白并介导在细胞质和细胞器新近翻译的蛋白质的折叠。它还通过与富含AU的元件RNA结合蛋白1基因位于主要组织相容性复合物III类区域的相互作用参与泛素 - 蛋白酶体途径，在一个集群与编码相似的蛋白质两个密切相关的基因。 [由RefSeq的，2008年7月提供]

OMIM数据库中对HSPA1B基因的介绍     Wikipedia数据库中对HSPA1B基因的介绍

基因序列

基因序列

HSPA1B基因的碱基序列：[NCBI]

基因突变

基因突变

HSPA1B基因的碱基突变：           显示全部snp
rs483638       rs539689       rs668558       rs1061623       rs2607017       rs2607018       rs2763979       rs3036297       rs6457452       rs7740730       rs7771177       rs9281590       rs11576012       rs11576013       rs11576014       rs11576015       rs11576016       rs11576017       rs13217108       rs17201199       rs17207559       rs17207580       rs34004874       rs34396430       rs34467149       rs34562565       rs34614836       rs34620275       rs34964264       rs34979718       rs35175000       rs35294112       rs35440917       rs35592410       rs35682610       rs35925297       rs35987121      
rs41312317       rs41312321       rs41312325       rs56280220       rs74600001       rs111862534       rs112132061       rs113094932       rs113775903       rs139873915       rs141193881       rs141231210       rs144223778       rs144929896       rs146946127       rs148310376       rs149254838       rs150176783       rs181732231       rs183185175       rs183394334       rs184495811       rs184693879       rs185921924       rs187587622       rs188087094       rs188186019       rs189005016       rs190885585       rs191304598       rs192701057       rs192750481       rs199562339       rs199901440       rs200083915       rs200684519       rs201449275       rs202014917       rs368738599       rs368848050       rs368877313       rs369266199       rs370054194       rs370072638       rs371573539       rs371838772       rs372841582       rs373056566       rs374210554       rs375533667       rs376092958       rs376368028       rs376637337       rs377206432       rs527649107       rs531028875       rs531333961       rs531755319       rs532676974       rs534221374       rs536439406       rs536575449       rs536871049       rs537576552       rs538280104       rs538434578       rs538567442       rs539242276       rs540226539       rs541068717       rs541674586       rs543036200       rs543835198       rs543996309       rs544819831       rs545199327       rs545616480       rs547116736       rs547650914       rs548009367       rs548389331       rs548638667       rs549377450       rs549401286       rs549822168       rs552875580       rs553121630       rs553797882       rs554925829       rs555739484       rs556001598       rs557519600       rs558798778       rs558961889       rs560641010       rs562367974       rs562456233       rs564834394       rs565305638       rs565430409       rs565973902       rs566144133       rs566295595       rs567032880       rs569833184       rs571971681       rs572178551       rs572251092       rs572902650       rs573265664       rs573575265       rs573636247       rs575390053       rs576580373       rs577308881       rs745490027       rs746496379       rs746788169       rs746836242       rs746894565       rs747141351       rs747582192       rs747850923       rs748037871       rs748251058       rs748823567       rs748909553       rs749173984       rs749346414       rs749422919       rs749633572       rs749692628       rs749927695       rs750303526       rs750593341       rs750633019       rs750832171       rs751110817       rs751134129       rs751251143       rs751472418       rs751937726       rs752223953       rs752412486       rs752573957       rs752859730       rs753177806       rs753195932       rs753327404       rs753657142       rs753666542       rs753754688       rs753985209       rs754390828       rs754714469       rs754888705       rs755035742       rs755400987       rs755609565       rs756378544       rs756527041       rs756621240       rs756701710       rs756954789       rs757031783       rs757264447       rs757789364       rs757798817       rs757955844       rs758120764       rs758371188       rs758818926       rs759080482       rs759379347       rs759497056       rs759701257       rs760183365       rs760195475       rs760744554       rs760804114       rs761021592       rs761040214       rs761595780       rs761612232       rs761981698       rs762089786       rs762334116       rs762552163       rs762557780       rs762753580       rs763102430       rs763607709       rs763791273       rs764669178       rs764758902       rs765352761       rs765767334       rs765900539       rs766033315       rs766389413       rs766480317       rs766556300       rs767507834       rs767647495       rs767884583       rs768215193       rs768546865       rs768845731       rs768978676       rs769068842       rs769641569       rs769989552       rs770115420       rs770554335       rs770698112       rs770756887       rs770854663       rs771217973       rs771303814       rs771564612       rs771788373       rs772210736       rs772599435       rs772700750       rs772883162       rs773305827       rs773576501       rs773664824       rs774173847       rs774259708       rs774614444       rs774752880       rs774866724       rs775184193       rs775184395       rs775498735       rs775815798       rs776149449       rs776168134       rs776661762       rs776865756       rs777027173       rs777213027       rs777553598       rs777583348       rs777680801       rs778151524       rs778239250       rs778424336       rs778536964       rs779265498       rs779841385       rs779945701       rs780061260       rs780607464       rs780625528       rs780987498       rs781183404       rs781660688      

基因表达

基因表达

HSPA1B基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向引物Tm值
反向引物序列
反向引物Tm值
rank
CAAGGCCAACAAGATCACC
59
CTCGATCTCCTCCTTGCTC
59
AGTGTCAAGAGGTCATCTCG
59
TCAAACTCGTCCTTCTCGG
60
GAGACCAAGGCATTCTACC
58
TCTCCTTCATCTTGGTCAGC
60

转录因子

转录因子

      尚未收录相关数据

基因本体信息

HSPA1B基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 溶酶体
  • 内涵体
  • 细胞核
  • 细胞质
  • 液泡
  • 细胞膜
  • 细胞外基质
  • 内质网
  • 线粒体
  • 高尔基体
  • 细胞骨架

HSPA1B基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0005524
A0A0G2JIW1(UniProtKB)
IEA
GO:0001618
P0DMV9(UniProtKB)
IEA
GO:0001664
P0DMV9(UniProtKB)
IDA
GO:0005102
P0DMV9(UniProtKB)
IPI
GO:0005515
P0DMV9(UniProtKB)
IPI
GO:0005515
P0DMV9(UniProtKB)
IPI
GO:0005524
P0DMV9(UniProtKB)
IDA
GO:0005654
P0DMV9(UniProtKB)
TAS
GO:0005654
P0DMV9(UniProtKB)
TAS
GO:0005654
P0DMV9(UniProtKB)
TAS
GO:0005654
P0DMV9(UniProtKB)
TAS
GO:0005654
P0DMV9(UniProtKB)
TAS
GO:0005654
P0DMV9(UniProtKB)
TAS
GO:0005654
P0DMV9(UniProtKB)
TAS
GO:0005654
P0DMV9(UniProtKB)
TAS
GO:0005737
P0DMV9(UniProtKB)
IDA
GO:0005814
P0DMV9(UniProtKB)
IDA
GO:0005829
P0DMV9(UniProtKB)
IDA
GO:0005829
P0DMV9(UniProtKB)
TAS
GO:0005829
P0DMV9(UniProtKB)
TAS
GO:0005829
P0DMV9(UniProtKB)
TAS
GO:0005829
P0DMV9(UniProtKB)
TAS
GO:0005925
P0DMV9(UniProtKB)
IDA
GO:0010628
P0DMV9(UniProtKB)
IMP
GO:0016234
P0DMV9(UniProtKB)
IDA
GO:0016887
P0DMV9(UniProtKB)
IDA
GO:0019899
P0DMV9(UniProtKB)
IPI
GO:0031072
P0DMV9(UniProtKB)
IPI
GO:0031072
P0DMV9(UniProtKB)
IPI
GO:0031072
P0DMV9(UniProtKB)
IPI
GO:0031072
P0DMV9(UniProtKB)
IPI
GO:0031072
P0DMV9(UniProtKB)
IPI
GO:0031072
P0DMV9(UniProtKB)
IPI
GO:0031072
P0DMV9(UniProtKB)
IPI
GO:0031072
P0DMV9(UniProtKB)
IPI
GO:0031072
P0DMV9(UniProtKB)
IPI
GO:0031072
P0DMV9(UniProtKB)
IPI
GO:0031072
P0DMV9(UniProtKB)
IPI
GO:0031072
P0DMV9(UniProtKB)
IPI
GO:0031396
P0DMV9(UniProtKB)
IDA
GO:0031397
P0DMV9(UniProtKB)
IDA
GO:0031625
P0DMV9(UniProtKB)
IPI
GO:0031625
P0DMV9(UniProtKB)
IPI
GO:0032757
P0DMV9(UniProtKB)
IMP
GO:0034599
P0DMV9(UniProtKB)
TAS
GO:0034605
P0DMV9(UniProtKB)
IDA
GO:0042026
P0DMV9(UniProtKB)
IDA
GO:0042026
P0DMV9(UniProtKB)
IDA
GO:0042623
P0DMV9(UniProtKB)
IDA
GO:0042826
P0DMV9(UniProtKB)
IPI
GO:0044183
P0DMV9(UniProtKB)
IDA
GO:0046034
P0DMV9(UniProtKB)
IDA
GO:0046718
P0DMV9(UniProtKB)
IEA
GO:0048471
P0DMV9(UniProtKB)
IDA
GO:0050821
P0DMV9(UniProtKB)
TAS
GO:0050821
P0DMV9(UniProtKB)
IMP
GO:0051082
P0DMV9(UniProtKB)
NAS
GO:0051082
P0DMV9(UniProtKB)
IDA
GO:0051092
P0DMV9(UniProtKB)
IMP
GO:0055131
P0DMV9(UniProtKB)
IPI
GO:0060548
P0DMV9(UniProtKB)
IDA
GO:0060548
P0DMV9(UniProtKB)
IMP
GO:0070370
P0DMV9(UniProtKB)
IMP
GO:0070434
P0DMV9(UniProtKB)
IMP
GO:0072562
P0DMV9(UniProtKB)
IDA
GO:0090084
P0DMV9(UniProtKB)
IDA
GO:0090084
P0DMV9(UniProtKB)
IDA
GO:1900034
P0DMV9(UniProtKB)
TAS
GO:1900034
P0DMV9(UniProtKB)
TAS
GO:1903265
P0DMV9(UniProtKB)
IMP
GO:2001240
P0DMV9(UniProtKB)
IMP
GO:0010941
P0DMV9(UniProtKB)
IMP
GO:0000151
P0DMV9(UniProtKB)
IDA

基因相互作用关系

基因相互作用关系

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因相关microRNA

基因相关microRNA

可能调控HSPA1B基因的相关microRNA：      显示全部miRNA

基因通路图

基因通路图

基因的通路属性图
通路基因列表

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Dermatologic disorders 0.122367032 2 0 CTD_human_GAD
Atherosclerosis 0.120542884 2 0 BeFree_CTD_human
Muscular Dystrophy, Facioscapulohumeral 0.12 1 0 CTD_human
Arsenic Poisoning 0.12 1 0 CTD_human
Carcinoma, Pancreatic Ductal 0.12 1 0 CTD_human
Mammary Neoplasms 0.12 1 0 CTD_human
Graft-vs-Host Disease 0.08 1 0 RGD
Reperfusion Injury 0.08 1 0 RGD
Crohn Disease 0.014621642 5 0 BeFree_GAD_LHGDN
Diabetes Mellitus, Non-Insulin-Dependent 0.008544182 5 0 BeFree_GAD_LHGDN
Lupus Erythematosus, Systemic 0.008458305 6 1 BeFree_GAD
Schizophrenia 0.008458305 6 0 BeFree_GAD
Inflammation 0.007101096 3 0 GAD
Premature Birth 0.007101096 3 0 GAD
Obesity 0.005819831 4 0 BeFree_GAD
Diabetes Mellitus, Insulin-Dependent 0.00554839 4 1 BeFree_GAD
Pancreatitis 0.005362824 1 0 BeFree_GAD_LHGDN
Pancreatitis, Alcoholic 0.005362824 1 0 BeFree_GAD_LHGDN
Stomach Neoplasms 0.005091382 1 0 GAD_LHGDN
Sepsis 0.005005506 3 0 BeFree_GAD
Liver carcinoma 0.003452799 4 0 BeFree_GAD
Autoimmune Diseases 0.003181358 4 0 BeFree_GAD
Malignant neoplasm of stomach 0.003181358 3 0 BeFree_GAD
Ulcerative Colitis 0.002995792 1 0 BeFree_LHGDN
Urinary tract infection 0.002909916 2 0 BeFree_GAD
Malignant neoplasm of lung 0.002909916 2 0 BeFree_GAD
Major Depressive Disorder 0.002909916 2 0 BeFree_GAD
Nasopharyngeal carcinoma 0.002909916 2 0 BeFree_GAD
Anoxia 0.00272435 1 0 LHGDN
pathologic fistula 0.00272435 1 0 LHGDN
leukemia 0.002638474 2 0 BeFree_GAD
Diabetic Foot 0.002638474 1 0 BeFree_GAD
Ischemic stroke 0.002638474 1 0 BeFree_GAD
Spondylarthropathies 0.002638474 1 0 BeFree_GAD
Spontaneous abortion 0.002367032 1 0 GAD
Alzheimer's Disease 0.002367032 1 0 GAD
Connective Tissue Diseases 0.002367032 1 0 GAD
Fetal Diseases 0.002367032 1 0 GAD
Heart failure 0.002367032 1 0 GAD
Hypertensive disease 0.002367032 1 0 GAD
Hypothyroidism 0.002367032 1 0 GAD
Liver neoplasms 0.002367032 1 0 GAD
Musculoskeletal Diseases 0.002367032 1 0 GAD
Osteoporosis 0.002367032 1 0 GAD
Parkinson Disease 0.002367032 1 0 GAD
Pre-Eclampsia 0.002367032 1 0 GAD
Pregnancy Complications, Hematologic 0.002367032 1 0 GAD
Puerperal Disorders 0.002367032 1 0 GAD
Pulmonary Edema 0.002367032 1 0 GAD
Septic Shock 0.002367032 1 0 GAD
Streptococcal Infections 0.002367032 1 0 GAD
Acute mountain sickness 0.002367032 1 0 GAD
Cancer of Nasopharynx 0.002367032 1 0 GAD
Ventricular Dysfunction, Left 0.002367032 1 0 GAD
Restenosis 0.002367032 1 0 GAD
Hepatitis B, Chronic 0.002367032 1 0 GAD
Hepatitis C, Chronic 0.002367032 1 0 GAD
High altitude illness 0.002367032 1 0 GAD
Infection 0.002367032 1 0 GAD
Glioblastoma 0.001628651 6 0 BeFree
Acute pancreatitis 0.001085767 4 0 BeFree
Malignant neoplasm of breast 0.001085767 4 0 BeFree
Coronary heart disease 0.001085767 4 0 BeFree
Duodenal Ulcer 0.001085767 4 0 BeFree
Ischemia 0.001085767 4 0 BeFree
Neoplasm Metastasis 0.001085767 4 0 BeFree
Breast Carcinoma 0.001085767 4 0 BeFree
Stomach Carcinoma 0.001085767 4 0 BeFree
Coronary Artery Disease 0.001085767 4 0 BeFree
Malignant neoplasm of urinary bladder 0.000814326 3 0 BeFree
Celiac Disease 0.000814326 3 0 BeFree
Coronary Arteriosclerosis 0.000814326 3 0 BeFree
Diabetes 0.000814326 3 0 BeFree
Diabetes Mellitus 0.000814326 3 0 BeFree
Glioma 0.000814326 3 0 BeFree
Malignant neoplasm of prostate 0.000814326 3 0 BeFree
Prostate carcinoma 0.000814326 3 0 BeFree
Carcinoma of bladder 0.000814326 3 0 BeFree
Agranulocytosis 0.000542884 2 0 BeFree
Arteriosclerosis 0.000542884 2 0 BeFree
Non-Small Cell Lung Carcinoma 0.000542884 2 1 BeFree
Renal Cell Carcinoma 0.000542884 2 0 BeFree
Cardiovascular Diseases 0.000542884 2 0 BeFree
Carotid Stenosis 0.000542884 2 0 BeFree
Inflammatory Bowel Diseases 0.000542884 2 0 BeFree
Kidney Failure, Acute 0.000542884 2 0 BeFree
Multiple Myeloma 0.000542884 2 0 BeFree
Multiple Sclerosis 0.000542884 2 0 BeFree
Sarcoidosis 0.000542884 2 0 BeFree
Ankylosing spondylitis 0.000542884 2 0 BeFree
Unipolar Depression 0.000542884 2 0 BeFree
Pancreatitis, Chronic 0.000542884 2 0 BeFree
Small cell carcinoma of lung 0.000542884 2 0 BeFree
Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site 0.000542884 2 0 BeFree
Neurodegenerative Disorders 0.000542884 2 0 BeFree
Carcinoma of lung 0.000542884 2 0 BeFree
Cerebral Ischemia 0.000542884 2 0 BeFree
Cancer Cell Growth 0.000542884 2 0 BeFree
Chronic Kidney Diseases 0.000542884 2 0 BeFree
Anxiety Disorders 0.000271442 1 0 BeFree
Rheumatoid Arthritis 0.000271442 1 0 BeFree
Cerebral Infarction 0.000271442 1 0 BeFree
Transient Ischemic Attack 0.000271442 1 0 BeFree
Dementia, Vascular 0.000271442 1 0 BeFree
Fibrosarcoma 0.000271442 1 0 BeFree
Graves Disease 0.000271442 1 0 BeFree
Congestive heart failure 0.000271442 1 0 BeFree
Hepatitis, Chronic 0.000271442 1 0 BeFree
Immune System Diseases 0.000271442 1 0 BeFree
Male infertility 0.000271442 1 0 BeFree
Fibroid Tumor 0.000271442 1 0 BeFree
Leishmaniasis, Visceral 0.000271442 1 0 BeFree
Lymphoma 0.000271442 1 0 BeFree
Single major depressive episode 0.000271442 1 0 BeFree
Malaria 0.000271442 1 0 BeFree
Measles 0.000271442 1 0 BeFree
melanoma 0.000271442 1 0 BeFree
Metabolic Diseases 0.000271442 1 0 BeFree
Mitral Valve Stenosis 0.000271442 1 0 BeFree
Mumps 0.000271442 1 0 BeFree
Neuroblastoma 0.000271442 1 0 BeFree
Pneumonia 0.000271442 1 0 BeFree
Pretibial myxedema 0.000271442 1 0 BeFree
Kidney Failure 0.000271442 1 0 BeFree
Respiratory Distress Syndrome, Newborn 0.000271442 1 0 BeFree
Respiratory Distress Syndrome, Adult 0.000271442 1 0 BeFree
Paranoid Schizophrenia 0.000271442 1 0 BeFree
Age-related cataract 0.000271442 1 0 BeFree
Cerebrovascular accident 0.000271442 1 0 BeFree
Uterine Fibroids 0.000271442 1 0 BeFree
Uveitis 0.000271442 1 0 BeFree
Vascular Diseases 0.000271442 1 0 BeFree
Vitiligo 0.000271442 1 0 BeFree
Foot Ulcer 0.000271442 1 0 BeFree
Essential Hypertension 0.000271442 1 0 BeFree
Cataract 0.000271442 1 0 BeFree
Malignant neoplasm of brain 0.000271442 1 0 BeFree
Hypopigmentation disorder 0.000271442 1 0 BeFree
Autoimmune thyroid disease 0.000271442 1 0 BeFree
Ki-1+ Anaplastic Large Cell Lymphoma 0.000271442 1 0 BeFree
Zinc deficiency 0.000271442 1 0 BeFree
Recurrent urinary tract infection 0.000271442 1 0 BeFree
Chronic heart failure 0.000271442 1 0 BeFree
Carotid artery occlusion 0.000271442 1 0 BeFree
Carcinoma breast stage IV 0.000271442 1 0 BeFree
Very Low Birth Weight 0.000271442 1 0 BeFree
Anaplastic astrocytoma 0.000271442 1 0 BeFree
Thyroid associated opthalmopathies 0.000271442 1 0 BeFree
Enterocutaneous Fistula 0.000271442 1 0 BeFree
Carcinogenesis 0.000271442 1 0 BeFree
Community acquired pneumonia 0.000271442 1 0 BeFree
Central neuroblastoma 0.000271442 1 0 BeFree
Tauopathies 0.000271442 1 0 BeFree
Tumor Immunity 0.000271442 1 0 BeFree
Non-Malignant Ascites Adverse Event 0.000271442 1 0 BeFree
Renal Insufficiency 0.000271442 1 0 BeFree
Glioblastoma Multiforme 0.000271442 1 0 BeFree
Severe Sepsis 0.000271442 1 0 BeFree
VITILIGO-ASSOCIATED MULTIPLE AUTOIMMUNE DISEASE SUSCEPTIBILITY 1 (finding) 0.000271442 1 0 BeFree
Ischemic Cerebrovascular Accident 0.000271442 1 0 BeFree

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