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This gene encodes a member of the heat shock protein 90 family; these proteins are involved in signal transduction, protein folding and degradation and morphological evolution. This gene encodes the constitutive form of the cytosolic 90 kDa heat-shock protein and is thought to play a role in gastric apoptosis and inflammation. Alternative splicing results in multiple transcript variants. Pseudogenes have been identified on multiple chromosomes. [provided by RefSeq, Dec 2012]
[中文简述(自动翻译):]  该基因编码的热休克蛋白90家族中的一员;这些蛋白参与信号转导,蛋白质折叠和降解和形态演变。该基因编码的胞质90 kDa热休克蛋白的构形,并且被认为在胃癌细胞凋亡和炎症反应的作用。选择性剪接结果在多个抄本变形。假基因已被确定在多个染色体。 [由RefSeq的,2012年12月提供]
HSP90AB1基因(以及对应的蛋白质)的细胞分布位置:
HSP90AB1基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
HIV Infections | 0.120271442 | 2 | 0 | BeFree_CTD_human |
Prostatic Neoplasms | 0.12 | 1 | 0 | CTD_human |
Muscular Atrophy | 0.08 | 1 | 0 | RGD |
Pancreatitis | 0.08 | 1 | 0 | RGD |
Pulmonary Fibrosis | 0.08 | 1 | 0 | RGD |
leukemia | 0.00272435 | 1 | 0 | LHGDN |
Gastrointestinal Stromal Tumors | 0.00272435 | 1 | 0 | LHGDN |
Asthma | 0.002638474 | 2 | 0 | BeFree_GAD |
Malignant neoplasm of breast | 0.000814326 | 3 | 0 | BeFree |
Carcinogenesis | 0.000814326 | 3 | 0 | BeFree |
Breast Carcinoma | 0.000814326 | 3 | 0 | BeFree |
Multiple Myeloma | 0.000542884 | 2 | 0 | BeFree |
Malignant neoplasm of lung | 0.000542884 | 2 | 0 | BeFree |
Carcinoma of lung | 0.000542884 | 2 | 0 | BeFree |
Carcinoma, Papillary | 0.000271442 | 1 | 0 | BeFree |
Mental Depression | 0.000271442 | 1 | 0 | BeFree |
Depressive disorder | 0.000271442 | 1 | 0 | BeFree |
Leukemia, Myelocytic, Acute | 0.000271442 | 1 | 0 | BeFree |
Lupus Erythematosus, Systemic | 0.000271442 | 1 | 0 | BeFree |
Lymphatic Metastasis | 0.000271442 | 1 | 0 | BeFree |
Pituitary Diseases | 0.000271442 | 1 | 0 | BeFree |
Acute leukemia | 0.000271442 | 1 | 0 | BeFree |
Pancreatic carcinoma | 0.000271442 | 1 | 0 | BeFree |
Papillary thyroid carcinoma | 0.000271442 | 1 | 0 | BeFree |
Leukemogenesis | 0.000271442 | 1 | 0 | BeFree |
Glucocorticoid Receptor Deficiency | 0.000271442 | 1 | 0 | BeFree |
Philadelphia chromosome-positive acute lymphoblastic leukemia | 0.000271442 | 1 | 0 | BeFree |
Liver carcinoma | 0.000271442 | 1 | 0 | BeFree |
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