HRG(histidine-rich glycoprotein) 转至新版数据库

基因基本信息

基因基本信息

基因简称(symbol)
    [HGNC]     [GeneCards]     [NCBI]
基因种类(locus group)
同源简称(alias symbol)
基因家族代码(gene_family_id)
    [HGNC]     [GenScript]
omim代码
entrez码
    [Vega]
vega基因码
ensembl基因码
    [Ensembl]
基因家族(gene family)
refseq数据库代号

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基因种类(locus_type)
基因名称状态(status)
location_sortable
同源基因名称(alias name)
基因名称批准使用时间(date_approved_reserved)
基因简称更名时间(date_symbol_changed)
基因名称更名时间(date_name_changed)
更新时间(date_modified)
ucsc码
ena
ccds数据码
uniprot数据码
pubmed代码
mgd码
rgd码
生命科学数据库(lsdb)
更新时间(date modified)
cosmic
mirbase
基因曾用简称(prev symbol)
基因曾用名称(prev name)
homeodb
cosmic
snornabase
bioparadigms slc
orphanet
假基因信息(pseudogeneorg)
horde id
merops
imgt
iuphar
kznf基因类别
mamit-trnadb
cd
LncRNA数据库
酶代码
中间纤维数据库

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基因染色体位置

基因染色体位置

3q27
基因染色体位置图

基因简述

基因简述

This histidine-rich glycoprotein contains two cystatin-like domains and is located in plasma and platelets. The physiological function has not been determined but it is known that the protein binds heme, dyes and divalent metal ions. The encoded protein also has a peptide that displays antimicrobial activity against C. albicans, E. coli, S. aureus, P. aeruginosa, and E. faecalis. It can inhibit rosette formation and interacts with heparin, thrombospondin and plasminogen. Two of the protein's effects, the inhibition of fibrinolysis and the reduction of inhibition of coagulation, indicate a potential prothrombotic effect. Mutations in this gene lead to thrombophilia due to abnormal histidine-rich glycoprotein levels. [provided by RefSeq, Nov 2014]

[中文简述(自动翻译):]  本富组氨酸糖蛋白含有两个半胱氨酸蛋白酶抑制剂样结构域和位于血浆和血小板。的生理功能尚未确定，但已知的是该蛋白结合血红素，染料和二价金属离子。所编码的蛋白质也具有显示抗微生物活性对白色念珠菌，大肠杆菌，金黄色葡萄球菌，绿脓杆菌，和粪肠球菌的肽。它可以抑制花环形成和肝素，血小板和纤维蛋白溶酶原相互作用。的蛋白质的作用的两个，纤维蛋白溶解的抑制和抑制凝血的减少，表明潜在的血栓效果。突变这个基因导致血栓形成，由于异常富含组氨酸的糖蛋白的水平。 [由RefSeq的，2014年11月提供]

OMIM数据库中对HRG基因的介绍     Wikipedia数据库中对HRG基因的介绍

基因序列

基因序列

HRG基因的碱基序列：[NCBI]

基因突变

基因突变

HRG基因的碱基突变：           显示全部snp
rs9898       rs10770       rs1042445       rs1042464       rs1126720       rs2228243       rs2229331       rs2276804       rs2378122       rs2555515       rs3733008       rs3733009       rs3733012       rs3890864       rs4516605       rs4549264       rs5855108       rs6444154       rs6765529       rs6781684       rs6796477       rs6808232       rs7426947       rs7428891       rs7429092       rs7614709       rs7617554       rs7621525       rs7622283       rs7625980       rs7626301       rs7629680       rs7643298       rs7644164       rs9814369       rs9814412       rs9848336      
rs9866126       rs10706995       rs11316946       rs11707899       rs11708008       rs11708856       rs11711923       rs11721235       rs12493926       rs16860974       rs16860992       rs16861004       rs34359202       rs55759544       rs55763243       rs56248425       rs56376528       rs57545180       rs59123177       rs60531302       rs60693099       rs61374531       rs66707192       rs67635656       rs71164598       rs72625026       rs72625027       rs73061469       rs73061473       rs73886010       rs73886011       rs73886012       rs73886013       rs73886014       rs74456956       rs74630096       rs74896442       rs75305175       rs75388420       rs75650463       rs76093304       rs76316326       rs76449467       rs77998515       rs78140870       rs78598469       rs78789232       rs78904050       rs78954048       rs79773833       rs80205675       rs111439697       rs111484368       rs111495611       rs111646867       rs111789521       rs111910825       rs112158450       rs112220357       rs112594124       rs112623561       rs112861431       rs112968733       rs113195010       rs113337232       rs113342286       rs113360670       rs113404574       rs113444154       rs113553006       rs113656453       rs114054207       rs114203701       rs114232169       rs114478925       rs114559013       rs114601045       rs114636749       rs114643371       rs114895145       rs114920990       rs114932239       rs115043810       rs115116898       rs115242562       rs115351495       rs115361509       rs115486333       rs115642881       rs115668102       rs115707463       rs115767711       rs115876426       rs116004251       rs116112861       rs116297009       rs116321075       rs116801720       rs116805977       rs117049790       rs117849730       rs137943864       rs137953854       rs138024376       rs138389406       rs138559947       rs138603183       rs139353175       rs139380005       rs139387319       rs139458490       rs139706088       rs139747236       rs139869156       rs139987539       rs140010651       rs140187296       rs140228181       rs140336956       rs140916341       rs141193891       rs141306838       rs141595547       rs142020162       rs142229429       rs142313098       rs142367763       rs142394055       rs142981587       rs143012421       rs143118011       rs143179773       rs143193705       rs143855375       rs143856310       rs144260335       rs144288090       rs144501228       rs144721553       rs144723131       rs145162969       rs145334098       rs145344471       rs145379172       rs145399945       rs145482557       rs145523957       rs145791512       rs145843676       rs146112406       rs146147437       rs146233280       rs146244921       rs146265787       rs146676859       rs146771057       rs147236076       rs147447873       rs147458440       rs147479927       rs147602189       rs147897059       rs147904913       rs147915320       rs148146926       rs148277485       rs148327062       rs148593044       rs148714053       rs148716747       rs148766267       rs148829642       rs149027620       rs149355864       rs149387425       rs149578094       rs149629327       rs149828975       rs149945842       rs149992908       rs150089820       rs150143388       rs150270280       rs150522400       rs150963946       rs151028119       rs151331549       rs180979343       rs181208139       rs181431796       rs181443813       rs181447663       rs181651805       rs181805828       rs182028325       rs182043248       rs182388263       rs182489272       rs182934021       rs182990380       rs183341869       rs183667558       rs183766451       rs184189660       rs184191434       rs184209379       rs184430670       rs184629077       rs184685307       rs185199342       rs185417744       rs185493097       rs186017000       rs186238444       rs186257490       rs186553879       rs186636512       rs187308748       rs187428541       rs187523083       rs187526626       rs188322703       rs188324894       rs188519467       rs188760222       rs189141402       rs189409134       rs189693375       rs189944576       rs189965304       rs190007945       rs190187342       rs190627763       rs191043713       rs191055793       rs191178143       rs191554701       rs191703250       rs191845843       rs192096861       rs192413186       rs192606674       rs192655177       rs193063661       rs193295280       rs199501331       rs199706826       rs200206741       rs200424943       rs200607708       rs200759110       rs200979058       rs201032457       rs201145692       rs201145740       rs201151195       rs201187538       rs201213205       rs201250387       rs201338810       rs201357157       rs201491218       rs201536659       rs201961723       rs201966999       rs202122126       rs202136038       rs367683269       rs367921433       rs368159274       rs368320527       rs368739467       rs368934357       rs369028946       rs369636205       rs370027832       rs370193084       rs370234178       rs370685538       rs370815203       rs371179842       rs371455626       rs371609513       rs371964213       rs372521158       rs372615230       rs372674732       rs372950323       rs373408646       rs373809711       rs374361865       rs374411791       rs374455873       rs374829693       rs374949611       rs374953969       rs375471719       rs375554577       rs376409380       rs376552502       rs377098713       rs377175129       rs397688789       rs527478835       rs527841138       rs528186513       rs528308679       rs528609678       rs528634250       rs529036933       rs529099432       rs529128238       rs529521530       rs529833599       rs530076545       rs530257805       rs530951711       rs531070851       rs531222511       rs531283507       rs531288743       rs531410754       rs531473946       rs531864806       rs532268092       rs532557716       rs532561136       rs532575331       rs532701957       rs532786190       rs532899005       rs532917206       rs532979438       rs533382486       rs533455246       rs533506620       rs533523120       rs533637172       rs533697991       rs533726958       rs533898020       rs534262435       rs534295025       rs534479195       rs534557947       rs534946504       rs535047500       rs535181933       rs535781538       rs536025317       rs536025361       rs536160199       rs536722586       rs537814592       rs537919147       rs537992920       rs538187884       rs538668763       rs538743980       rs539003389       rs539066651       rs539167874       rs539503824       rs539629653       rs539727354       rs539916877       rs539930881       rs539988258       rs539997802       rs540057160       rs540318463       rs540709644       rs540768012       rs541000493       rs541131560       rs541230233       rs541320156       rs542500565       rs542534129       rs542546602       rs542772765       rs542843896       rs542909651       rs543579189       rs543724255       rs543747513       rs543972958       rs544562657       rs544777133       rs545351312       rs545477098       rs546277332       rs546828327       rs546887554       rs546889719       rs547256889       rs547502476       rs547504311       rs547526147       rs547590702       rs547761599       rs547797761       rs547882409       rs547970567       rs548102367       rs548697507       rs548728577       rs548993708       rs549251793       rs549281734       rs549585033       rs549619021       rs549908659       rs550059701       rs550192770       rs550998333       rs551171065       rs551260829       rs551316086       rs551392788       rs551740332       rs551977524       rs552124195       rs552701238       rs552715651       rs552737339       rs553616785       rs553668698       rs553802172       rs553975597       rs554837476       rs554861968       rs554924439       rs555125371       rs555401176       rs555456270       rs555773694       rs556595700       rs556971866       rs557357031       rs557381498       rs557760488       rs557786665       rs558063394       rs558409115       rs558852361       rs558914618       rs559066666       rs559149511       rs559563477       rs559683887       rs559753514       rs559877443       rs559894347       rs559957776       rs560363308       rs560743010       rs560940381       rs561048677       rs561777249       rs562170199       rs562605149       rs563237107       rs563660037       rs563789029       rs563790141       rs563933562       rs564030727       rs564132624       rs564539491       rs564851330       rs564911651       rs564939895       rs565128560       rs566455036       rs566590437       rs566866240       rs566934674       rs567052692       rs567195359       rs567331294       rs567982699       rs568227924       rs568234704       rs568502311       rs568572870       rs568668981       rs568683045       rs568718197       rs569054106       rs569055146       rs569341002       rs569474115       rs569876794       rs570676621       rs570787037       rs570838985       rs570972604       rs571239478       rs571258551       rs571301721       rs571329728       rs571544193       rs571572582       rs571615991       rs572473896       rs572572526       rs573184929       rs573283597       rs573515372       rs573962212       rs573967684       rs574485843       rs574908224       rs575023544       rs575119883       rs575726398       rs575898901       rs576037874       rs576180472       rs576310588       rs576432525       rs576718474       rs576788944       rs576930921       rs577240897       rs577371988       rs577376647       rs745361026       rs745452620       rs745552398       rs745625307       rs745726964       rs745798416       rs745904040       rs745975225       rs746180617       rs746278114       rs746388274       rs746401858       rs746561677       rs746976585       rs747359973       rs747499895       rs747568177       rs747738334       rs747765775       rs747925894       rs748041340       rs748061967       rs748240389       rs748474167       rs748551861       rs748559861       rs748697267       rs748893541       rs749072675       rs749360035       rs749407623       rs749449930       rs749515984       rs749626630       rs749714513       rs749764451       rs749811893       rs749884290       rs750006098       rs750074783       rs750086510       rs750119859       rs750226957       rs750425071       rs750560387       rs750833379       rs751218381       rs751314384       rs751709501       rs751854162       rs752048802       rs752191157       rs752208032       rs752541692       rs752645882       rs752842701       rs752950785       rs753145931       rs753363055       rs753404560       rs753448977       rs753655695       rs753801232       rs753892398       rs754182457       rs754766654       rs754842733       rs754929624       rs755269813       rs755394941       rs755451982       rs755507439       rs755537724       rs755545501       rs755648825       rs755741611       rs755963528       rs755982098       rs756235870       rs756344310       rs756429024       rs756430124       rs756432163       rs756590274       rs756643944       rs756902681       rs756994316       rs757216451       rs757317814       rs757366154       rs757562628       rs757723153       rs757811061       rs757892920       rs757926632       rs758064884       rs758205128       rs758500061       rs758658307       rs759038007       rs759068192       rs759267044       rs759294339       rs759554349       rs759656714       rs759743764       rs759745752       rs759956884       rs760522629       rs760809921       rs760870073       rs760886196       rs760899920       rs761079419       rs761120958       rs761378787       rs761465011       rs761490620       rs761661444       rs761684924       rs761749686       rs761776963       rs761839729       rs761884753       rs762019364       rs762433108       rs762602188       rs762693717       rs762967594       rs762985026       rs763164439       rs763271513       rs763664098       rs763697219       rs763883442       rs763891541       rs764085453       rs764400190       rs764549526       rs764616505       rs764819702       rs765067014       rs765126145       rs765537265       rs765983445       rs766376795       rs766385491       rs766544209       rs766569834       rs766938336       rs767043667       rs767119637       rs767306247       rs767378755       rs767523702       rs767715787       rs767918352       rs767977047       rs768017107       rs768149272       rs768259397       rs768352760       rs769126162       rs769260553       rs769330422       rs769357817       rs769505098       rs769892075       rs770042147       rs770081013       rs770471689       rs770643351       rs770655221       rs770686356       rs770991173       rs771034089       rs771035607       rs771101454       rs771160179       rs771187443       rs771189618       rs771557434       rs771618433       rs771663758       rs771755701       rs771755715       rs771990041       rs772056647       rs772144730       rs772302362       rs772500244       rs772525961       rs773015594       rs773087988       rs773195678       rs773214905       rs773408266       rs773417859       rs773674379       rs773712833       rs773760518       rs773821085       rs773936681       rs774232166       rs774322009       rs774359835       rs774522758       rs774629799       rs774895014       rs774923586       rs775005977       rs775224918       rs775316561       rs775650617       rs775763558       rs776052801       rs776114766       rs776235094       rs776417466       rs776422672       rs776485907       rs776506037       rs776707217       rs776875028       rs777165132       rs777275448       rs777275626       rs777860777       rs778088196       rs778212538       rs778400360       rs778417494       rs778468065       rs778577241       rs778797304       rs778860261       rs778883139       rs778953735       rs779081043       rs779260719       rs779341446       rs779350522       rs779364692       rs779532580       rs779561428       rs779717688       rs779909963       rs780007469       rs780096311       rs780185953       rs780494549       rs780513959       rs780517640       rs780568065       rs780605486       rs780868118       rs780950869       rs781056236       rs781083965       rs781186154       rs781333544       rs781342530       rs781625627       rs781626488       rs781639533       rs781711453       rs866645107       rs114054207       rs115668102       rs183341869       rs193063661       rs536025361       rs548728577      

基因表达

基因表达

HRG基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向引物Tm值
反向引物序列
反向引物Tm值
rank
CGATTACAGTATTCGTGTGC
57
GATCAGGTCTAGAGCTTTCTC
57
CAAGTTCTGTCTCTTCAGCAC
59
TGTAGCGCTCAGTATCCTC
59
AAGTTCTGTCTCTTCAGCAC
58
CTGTAGCGCTCAGTATCCT
59
CAAGTTCTGTCTCTTCAGCA
58
TGTAGCGCTCAGTATCCTC
59
CGGCGATTACAGTATTCGT
58
CAGGTCTAGAGCTTTCTCAG
57
GGCGATTACAGTATTCGTGTG
60
TCAGGTCTAGAGCTTTCTCAG
59

转录因子

转录因子

      尚未收录相关数据

基因本体信息

HRG基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 溶酶体
  • 内涵体
  • 细胞核
  • 细胞质
  • 液泡
  • 细胞膜
  • 细胞外基质
  • 内质网
  • 线粒体
  • 高尔基体
  • 细胞骨架

HRG基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0001525
P04196(UniProtKB)
IEA
GO:0002576
P04196(UniProtKB)
TAS
GO:0002839
P04196(UniProtKB)
IDA
GO:0004867
P04196(UniProtKB)
IBA
GO:0004869
P04196(UniProtKB)
IEA
GO:0005102
P04196(UniProtKB)
IDA
GO:0005515
P04196(UniProtKB)
IPI
GO:0005515
P04196(UniProtKB)
IPI
GO:0005515
P04196(UniProtKB)
IPI
GO:0005515
P04196(UniProtKB)
IPI
GO:0005515
P04196(UniProtKB)
IPI
GO:0005515
P04196(UniProtKB)
IPI
GO:0005515
P04196(UniProtKB)
IPI
GO:0005515
P04196(UniProtKB)
IPI
GO:0005576
P04196(UniProtKB)
NAS
GO:0005576
P04196(UniProtKB)
IDA
GO:0005576
P04196(UniProtKB)
TAS
GO:0005576
P04196(UniProtKB)
TAS
GO:0005576
P04196(UniProtKB)
TAS
GO:0005886
P04196(UniProtKB)
TAS
GO:0005886
P04196(UniProtKB)
TAS
GO:0005886
P04196(UniProtKB)
TAS
GO:0006935
P04196(UniProtKB)
IEA
GO:0007162
P04196(UniProtKB)
IDA
GO:0008201
P04196(UniProtKB)
IDA
GO:0008201
P04196(UniProtKB)
IDA
GO:0008270
P04196(UniProtKB)
IDA
GO:0008270
P04196(UniProtKB)
IDA
GO:0008270
P04196(UniProtKB)
IDA
GO:0008285
P04196(UniProtKB)
IDA
GO:0010468
P04196(UniProtKB)
IDA
GO:0010543
P04196(UniProtKB)
ISS
GO:0010543
P04196(UniProtKB)
IBA
GO:0010593
P04196(UniProtKB)
IDA
GO:0010951
P04196(UniProtKB)
IEA
GO:0010951
P04196(UniProtKB)
IEA
GO:0015886
P04196(UniProtKB)
IBA
GO:0016525
P04196(UniProtKB)
IDA
GO:0016525
P04196(UniProtKB)
IDA
GO:0016525
P04196(UniProtKB)
IDA
GO:0016525
P04196(UniProtKB)
IDA
GO:0019865
P04196(UniProtKB)
IDA
GO:0020037
P04196(UniProtKB)
IDA
GO:0030168
P04196(UniProtKB)
IDA
GO:0030193
P04196(UniProtKB)
IDA
GO:0030193
P04196(UniProtKB)
IDA
GO:0030308
P04196(UniProtKB)
IDA
GO:0031093
P04196(UniProtKB)
TAS
GO:0032956
P04196(UniProtKB)
IDA
GO:0033629
P04196(UniProtKB)
IDA
GO:0036019
P04196(UniProtKB)
IBA
GO:0042730
P04196(UniProtKB)
TAS
GO:0043065
P04196(UniProtKB)
IDA
GO:0043254
P04196(UniProtKB)
IDA
GO:0043395
P04196(UniProtKB)
IDA
GO:0043395
P04196(UniProtKB)
IDA
GO:0043537
P04196(UniProtKB)
ISS
GO:0046872
P04196(UniProtKB)
IDA
GO:0050730
P04196(UniProtKB)
IDA
GO:0050832
P04196(UniProtKB)
IDA
GO:0051894
P04196(UniProtKB)
IDA
GO:0051894
P04196(UniProtKB)
IDA
GO:0051918
P04196(UniProtKB)
IBA
GO:0070062
P04196(UniProtKB)
IDA
GO:0070062
P04196(UniProtKB)
IDA
GO:0070062
P04196(UniProtKB)
IDA
GO:0072562
P04196(UniProtKB)
IDA
GO:1900747
P04196(UniProtKB)
IDA
GO:2000504
P04196(UniProtKB)
IDA
GO:2001027
P04196(UniProtKB)
IDA
GO:2001027
P04196(UniProtKB)
IDA
GO:2001027
P04196(UniProtKB)
IDA

基因相互作用关系

基因相互作用关系

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因相关microRNA

基因相关microRNA

可能调控HRG基因的相关microRNA：     

基因通路图

基因通路图

基因的通路属性图
通路基因列表

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Thrombophilia Due To Histidine-Rich Glycoprotein Deficiency 0.36 2 1 CLINVAR_ORPHANET_UNIPROT
Mammary Neoplasms 0.120271442 2 0 BeFree_CTD_human
Thrombophilia Due To Elevated Histidine-Rich Glycoprotein 0.12 0 0 CTD_human
Thrombosis 0.002367032 1 0 GAD
Blood Coagulation Disorders, Inherited 0.002367032 1 0 GAD
Malignant neoplasm of breast 0.001900093 7 0 BeFree
Breast Carcinoma 0.001900093 7 0 BeFree
Neoplasm Metastasis 0.001085767 4 0 BeFree
Thrombophilia 0.000814326 3 0 BeFree
Activated Protein C Resistance 0.000542884 2 0 BeFree
THROMBOPHILIA DUE TO ACTIVATED PROTEIN C RESISTANCE (disorder) 0.000542884 2 0 BeFree
Bacterial Infections 0.000271442 1 0 BeFree
Brain Neoplasms 0.000271442 1 0 BeFree
Squamous cell carcinoma 0.000271442 1 0 BeFree
Glioblastoma 0.000271442 1 0 BeFree
Glioma 0.000271442 1 0 BeFree
Myocardial Infarction 0.000271442 1 0 BeFree
Septicemia 0.000271442 1 0 BeFree
Pancreatic carcinoma 0.000271442 1 0 BeFree
Sepsis 0.000271442 1 0 BeFree
Malignant neoplasm of pancreas 0.000271442 1 0 BeFree
Malignant Glioma 0.000271442 1 0 BeFree
Factor V Leiden mutation 0.000271442 1 0 BeFree
Invasive breast carcinoma 0.000271442 1 0 BeFree
Rhabdoid Tumor of the Kidney 0.000271442 1 0 BeFree
Tumor Angiogenesis 0.000271442 1 0 BeFree

基因相关文献

基因相关文献

基因相关服务

基因相关服务

基因评论

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