HOXA9(homeobox A9) 转至新版数据库

基因基本信息

基因基本信息

基因简称(symbol)
    [HGNC]     [GeneCards]     [NCBI]
基因种类(locus group)
同源简称(alias symbol)
基因家族代码(gene_family_id)
    [HGNC]     [GenScript]
omim代码
entrez码
    [Vega]
vega基因码
ensembl基因码
    [Ensembl]
基因家族(gene family)
refseq数据库代号

更多...

基因种类(locus_type)
基因名称状态(status)
location_sortable
同源基因名称(alias name)
基因名称批准使用时间(date_approved_reserved)
基因简称更名时间(date_symbol_changed)
基因名称更名时间(date_name_changed)
更新时间(date_modified)
ucsc码
ena
ccds数据码
uniprot数据码
pubmed代码
mgd码
rgd码
生命科学数据库(lsdb)
更新时间(date modified)
cosmic
mirbase
基因曾用简称(prev symbol)
基因曾用名称(prev name)
homeodb
cosmic
snornabase
bioparadigms slc
orphanet
假基因信息(pseudogeneorg)
horde id
merops
imgt
iuphar
kznf基因类别
mamit-trnadb
cd
LncRNA数据库
酶代码
中间纤维数据库

收起

基因染色体位置

基因染色体位置

7p15.2
基因染色体位置图

基因简述

基因简述

In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. This gene is highly similar to the abdominal-B (Abd-B) gene of Drosophila. A specific translocation event which causes a fusion between this gene and the NUP98 gene has been associated with myeloid leukemogenesis. Read-through transcription exists between this gene and the upstream homeobox A10 (HOXA10) gene.[provided by RefSeq, Mar 2011]

[中文简述(自动翻译):]  在脊椎动物中，编码的类称为同源基因转录因子的基因在命名为A，B，C和D四个不同的染色体簇找到。胚胎发育过程中在空间和时间上调节这些蛋白质的表达。这种基因是7号染色体上的一??个群集的一部分并编码其可以调节基因表达，形态发生和分化的DNA结合转录因子。这个基因是高度相似的果蝇的腹部-B（ABD-B）基因。这将导致该基因与基因NUP98之间的融合的具体易位事件已与髓白血病有关。这个基因和上游同源A10（HOXA10）基因之间存在读通过转录。[由RefSeq的，2011年3月提供]

OMIM数据库中对HOXA9基因的介绍     Wikipedia数据库中对HOXA9基因的介绍

基因序列

基因序列

HOXA9基因的碱基序列：[NCBI]

基因突变

基因突变

HOXA9基因的碱基突变：           显示全部snp
rs11773804       rs17472175       rs145239967       rs181104298       rs186184218       rs190496843       rs191461527       rs377468230       rs530024574       rs532276836       rs537053507       rs541142530       rs548305996       rs549722278       rs552366819       rs554585374       rs565723161       rs568103225       rs572534794       rs574466591       rs1548498       rs3801776       rs3839805       rs6461990       rs6461991       rs7810502       rs10238429       rs10259620       rs11975265       rs11978680       rs12537391       rs17427791       rs17472140       rs17472147       rs17472161       rs17500987       rs17501001      
rs17501014       rs17501021       rs35335761       rs35355140       rs35958560       rs35991882       rs78388547       rs112752252       rs113136669       rs113472504       rs114730856       rs138117599       rs138291525       rs138384516       rs139269747       rs139624353       rs140314505       rs140596580       rs141326540       rs142863523       rs142964255       rs143405265       rs143934224       rs144037880       rs145028851       rs145450895       rs145905865       rs147261225       rs147435417       rs148324732       rs148367989       rs149001266       rs150410478       rs150821305       rs180897643       rs181742818       rs181926392       rs183286970       rs183628488       rs184361393       rs184742039       rs184887356       rs185084360       rs186431923       rs186436314       rs186513011       rs186850263       rs187385585       rs188239370       rs188746889       rs189277058       rs189294601       rs189587233       rs190122610       rs192531486       rs192745579       rs192978689       rs199550076       rs200385248       rs200450890       rs200486389       rs200749905       rs200958902       rs201482064       rs201604729       rs201956538       rs202188799       rs367823279       rs368150554       rs368446662       rs368735379       rs368757601       rs368804154       rs368820871       rs369113257       rs369971422       rs370546155       rs370679767       rs370912761       rs371046943       rs371492511       rs371528874       rs372435851       rs373195636       rs373495802       rs374136295       rs374241221       rs374547527       rs374706205       rs374919224       rs375430231       rs376685820       rs377402962       rs527676043       rs528404917       rs528875297       rs529966141       rs530226198       rs531205413       rs531879692       rs531940044       rs532054403       rs532370978       rs532419038       rs533156165       rs533871459       rs534809856       rs535353485       rs536052658       rs536106075       rs536721422       rs537259388       rs538453360       rs539449195       rs539510908       rs539950262       rs540058601       rs540608230       rs541037562       rs541376745       rs541615479       rs541860912       rs542147750       rs542299762       rs542361021       rs543267619       rs543493227       rs544562956       rs544688204       rs545762644       rs545798927       rs545859037       rs546354313       rs546588205       rs548387720       rs549556036       rs549661153       rs550904347       rs551818435       rs552096220       rs553189182       rs553750216       rs554241005       rs554957950       rs555176822       rs555769201       rs555830369       rs557011928       rs558072339       rs558608639       rs559119879       rs559284320       rs559732995       rs560002926       rs560054182       rs560566829       rs560758373       rs560847167       rs561294242       rs562172659       rs563039998       rs563436500       rs564237365       rs564756018       rs565389385       rs565785890       rs565976296       rs566327028       rs567037909       rs567555088       rs568128306       rs568151369       rs568482094       rs569313107       rs569553321       rs569929002       rs570502030       rs570697486       rs570758665       rs571599296       rs571603400       rs572609950       rs572718918       rs573134752       rs573248243       rs573758059       rs574371099       rs574403665       rs574910782       rs575624549       rs575670067       rs575684117       rs575747103       rs576888641       rs576893232       rs576948299       rs577082710       rs745705983       rs745961026       rs746217061       rs746610879       rs746773228       rs746824728       rs747367756       rs747732627       rs748173136       rs748176047       rs748261114       rs748494260       rs748545530       rs748741516       rs748877017       rs749137808       rs749442438       rs749607053       rs749927554       rs750534571       rs750715019       rs750729932       rs750730778       rs750827678       rs750873747       rs751034299       rs751892246       rs752173750       rs752362815       rs752442358       rs752443691       rs753607805       rs753751095       rs754400549       rs754692619       rs754844230       rs754875967       rs754897047       rs754905237       rs755027883       rs755117477       rs755489506       rs755618823       rs755742946       rs755980926       rs756002962       rs756362881       rs756418004       rs756524220       rs756823593       rs757152358       rs757188294       rs757393231       rs757553885       rs757736764       rs758348726       rs758375108       rs758548883       rs759116325       rs759996173       rs760465140       rs760819841       rs761013640       rs761066551       rs761410366       rs761562140       rs761768279       rs762020875       rs762074015       rs762343509       rs762677209       rs762772939       rs762931951       rs763304806       rs763420906       rs763473658       rs763826633       rs764222340       rs764475721       rs765028183       rs765634210       rs765931391       rs766126446       rs766131525       rs766729460       rs766866768       rs767375509       rs767458451       rs767646325       rs767704574       rs767844804       rs767846825       rs767898055       rs768842404       rs769305804       rs769334217       rs769367273       rs769798424       rs769817684       rs770039638       rs770207656       rs770254606       rs770578169       rs771025386       rs771102538       rs771349569       rs771637254       rs771692377       rs771692391       rs771743626       rs772683648       rs772841955       rs772891366       rs773091352       rs773375500       rs773896730       rs774133022       rs774546939       rs775681084       rs775734551       rs776134481       rs776587908       rs776933242       rs776986040       rs777202871       rs777445429       rs778108044       rs778319802       rs778356060       rs778712347       rs778792261       rs778873169       rs778960235       rs778986596       rs779145878       rs779294546       rs779621046       rs779842113       rs779925283       rs780077831       rs780585301       rs780692577       rs781090714       rs781603083       rs781712176      

基因表达

基因表达

HOXA9基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向引物Tm值
反向引物序列
反向引物Tm值
rank

转录因子

转录因子

转录因子
影响类型
PubMed链接
ARHGEF1
Activation
17379095
CDH3
Unknown
25023983
ID2
Activation
20565746
MYCN
Activation
21261500
NFKB1
Repression
18068911
RELA
Repression
18068911
SELE
Unknown
22269951
SHOX
Unknown
23028966
VCAM1
Unknown
22269951

基因本体信息

HOXA9基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 溶酶体
  • 内涵体
  • 细胞核
  • 细胞质
  • 液泡
  • 细胞膜
  • 细胞外基质
  • 内质网
  • 线粒体
  • 高尔基体
  • 细胞骨架

HOXA9基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0005634
A8MVF3(UniProtKB)
IEA
GO:0006351
A8MVF3(UniProtKB)
IEA
GO:0005515
P31269(UniProtKB)
IPI
GO:0005515
P31269(UniProtKB)
IPI
GO:0005515
P31269(UniProtKB)
IPI
GO:0005634
P31269(UniProtKB)
IDA
GO:0005634
P31269(UniProtKB)
IDA
GO:0005667
P31269(UniProtKB)
IEA
GO:0005737
P31269(UniProtKB)
IEA
GO:0006351
P31269(UniProtKB)
IEA
GO:0006355
P31269(UniProtKB)
IEA
GO:0007275
P31269(UniProtKB)
TAS
GO:0007283
P31269(UniProtKB)
IEA
GO:0007338
P31269(UniProtKB)
IEA
GO:0008584
P31269(UniProtKB)
IEA
GO:0009952
P31269(UniProtKB)
IEA
GO:0009954
P31269(UniProtKB)
IEA
GO:0019899
P31269(UniProtKB)
IPI
GO:0030879
P31269(UniProtKB)
IEA
GO:0035115
P31269(UniProtKB)
IEA
GO:0042118
P31269(UniProtKB)
IMP
GO:0043565
P31269(UniProtKB)
IEA
GO:0045638
P31269(UniProtKB)
ISS
GO:0048706
P31269(UniProtKB)
IEA
GO:0060065
P31269(UniProtKB)
IEA
GO:0060216
P31269(UniProtKB)
IEA

基因相互作用关系

基因相互作用关系

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因相关microRNA

基因相关microRNA

可能调控HOXA9基因的相关microRNA：     

基因通路图

基因通路图

基因的通路属性图
通路基因列表

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Leukemia, Myelocytic, Acute 0.144198053 52 0 BeFree_CTD_human_LHGDN
Bladder Neoplasm 0.12 1 0 CTD_human
melanoma 0.12 1 0 CTD_human
Neoplasm Recurrence, Local 0.12 1 0 CTD_human
leukemia 0.009500466 35 0 BeFree
Leukemogenesis 0.005428837 20 0 BeFree
Blast Phase 0.003810118 5 0 BeFree_LHGDN
MYELODYSPLASTIC SYNDROME 0.003538676 3 0 BeFree_LHGDN
Meningioma 0.002995792 2 0 BeFree_LHGDN
Myeloid Leukemia, Chronic 0.002714419 10 0 BeFree
Congenital clubfoot 0.002367032 1 0 GAD
Tobacco Use Disorder 0.002367032 1 0 GAD
Myeloid Leukemia 0.002171535 8 0 BeFree
Acute lymphocytic leukemia 0.001628651 6 0 BeFree
Myeloproliferative disease 0.001628651 6 0 BeFree
Ovarian Carcinoma 0.001628651 6 0 BeFree
Acute leukemia 0.001628651 6 0 BeFree
Neoplasm Metastasis 0.001357209 5 0 BeFree
Malignant neoplasm of ovary 0.001085767 4 0 BeFree
Malignant neoplasm of breast 0.000814326 3 0 BeFree
Preleukemia 0.000814326 3 0 BeFree
Malignant neoplasm of lung 0.000814326 3 0 BeFree
Carcinoma of lung 0.000814326 3 0 BeFree
Precursor Cell Lymphoblastic Leukemia Lymphoma 0.000814326 3 0 BeFree
Non-Small Cell Lung Carcinoma 0.000542884 2 0 BeFree
Squamous cell carcinoma 0.000542884 2 0 BeFree
Glioblastoma 0.000542884 2 0 BeFree
Glioma 0.000542884 2 0 BeFree
Chronic Obstructive Airway Disease 0.000542884 2 0 BeFree
Greig cephalopolysyndactyly syndrome 0.000542884 2 0 BeFree
Breast Carcinoma 0.000542884 2 0 BeFree
Chronic myeloproliferative disorder 0.000542884 2 0 BeFree
Non-Malignant Ascites Adverse Event 0.000542884 2 0 BeFree
Adenocarcinoma 0.000271442 1 0 BeFree
Congenital chromosomal disease 0.000271442 1 0 BeFree
Hepatitis B 0.000271442 1 0 BeFree
HIV Infections 0.000271442 1 0 BeFree
Ischemia 0.000271442 1 0 BeFree
Chronic Lymphocytic Leukemia 0.000271442 1 0 BeFree
Leukemia, Lymphocytic, Acute, L1 0.000271442 1 0 BeFree
Acute biphenotypic leukemia 0.000271442 1 0 BeFree
Acute Promyelocytic Leukemia 0.000271442 1 0 BeFree
Mesothelioma 0.000271442 1 0 BeFree
Precancerous Conditions 0.000271442 1 0 BeFree
Systemic Scleroderma 0.000271442 1 0 BeFree
Malignant neoplasm of mouth 0.000271442 1 0 BeFree
Malignant neoplasm of brain 0.000271442 1 0 BeFree
Tumor Progression 0.000271442 1 0 BeFree
Cholangiocarcinoma 0.000271442 1 0 BeFree
Adult Acute Myeloblastic Leukemia 0.000271442 1 0 BeFree
Lip and Oral Cavity Carcinoma 0.000271442 1 0 BeFree
Philadelphia chromosome positive chronic myelogenous leukemia 0.000271442 1 0 BeFree
Solid tumour 0.000271442 1 0 BeFree
Acute Undifferentiated Leukemia 0.000271442 1 0 BeFree
Malignant neoplasm of prostate 0.000271442 1 0 BeFree
Carcinogenesis 0.000271442 1 0 BeFree
Prostate carcinoma 0.000271442 1 0 BeFree
Epithelial ovarian cancer 0.000271442 1 0 BeFree
Primary malignant neoplasm of brain 0.000271442 1 0 BeFree
Undifferentiated leukemia 0.000271442 1 0 BeFree
Meningioma, benign, no ICD-O subtype 0.000271442 1 0 BeFree
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma 0.000271442 1 0 BeFree
Leukemia, B-Cell 0.000271442 1 0 BeFree
Liver carcinoma 0.000271442 1 0 BeFree
Promyelocytic leukemia 0.000271442 1 0 BeFree

基因相关文献

基因相关文献

基因相关服务

基因相关服务

基因评论

基因评论

我要说两句
热门评论
还没有评论，赶快来抢沙发吧。

登陆

用户名:

密    码:

联系方式

山东省济南市 高新区 崇华路359号 三庆世纪财富中心C1115室

电话： 0531-88819269

E-mail: product@genelibs.com

微信公众号

扫一扫右方二维码，关注微信订阅号，实时查看信息，关注医学生物学动态。

版权所有 © 2016.Genelibs 济南弘晖生物技术有限公司 鲁ICP备13024435号-2